Recent Publications

Meador CB, Jin H, de Stanchina E, Nebhan CA, Pirazzoli V, Wang L, Lu P, Vuong H, Hutchinson KE, Jia P, Chen X, Eisenberg R, Ladanyi M, Politi K, Zhao Z, Lovly CM, Cross DA and Pao W: Optimizing the sequence of anti-EGFR targeted therapy in EGFR-mutant lung cancer. Mol Cancer Ther. 2014 Dec 4; Epub 2014 Dec 4. PMID: 25477325


Politi K and Gettinger S: Perfect ALKemy: Optimizing the Use of ALK-Directed Therapies in Lung Cancer. Clin Cancer Res. 2014 Nov 15;20 (22) :5576-8. Epub 2014 Sep 16. PMID: 25228532


Bantikassegn A, Song X and Politi K: Isolation of Epithelial, Endothelial, and Immune Cells From Lungs of Transgenic Mice with Oncogene-Induced Lung Adenocarcinomas. Am J Respir Cell Mol Biol. 2014 Oct 27; Epub 2014 Oct 27. PMID: 25347711


Yamulla RJ, Kane EG, Moody AE, Politi KA, Lock NE, Foley AV and Roberts DM: Testing Models of the APC Tumor Suppressor/β-Catenin Interaction Reshapes Our View of the Destruction Complex in Wnt Signaling. Genetics. 2014 Aug;197 (4) :1285-302. Epub 2014 Jun 14. PMID: 24931405


Pirazzoli V, Nebhan C, Song X, Wurtz A, Walther Z, Cai G, Zhao Z, Jia P, de Stanchina E, Shapiro EM, Gale M, Yin R, Horn L, Carbone DP, Stephens PJ, Miller V, Gettinger S, Pao W and Politi K: Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1. Cell Rep. 2014 May 22;7 (4) :999-1008. Epub 2014 May 9. PMID: 24813888


de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, Varmus H, Bernards R, Smit EF, Politi K and Downward J: Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer Discov. 2014 May;4 (5) :606-19. Epub 2014 Feb 17. PMID: 24535670


Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE and Przedborski S: Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron. 2014 Mar 5;81 (5) :1001-8. Epub 2014 Feb 6. PMID: 24508385


Lockwood W and Politi K: MYCxing it up with FGFR1 in squamous cell lung cancer. Cancer Discov. 2014 Feb;4 (2) :152-4. PMID: 24501305


Pirazzoli V and Politi K: Generation of drug-resistant tumors using intermittent dosing of tyrosine kinase inhibitors in mouse. Cold Spring Harb Protoc. 2014 Feb 1;2014 (2) :178-81. Epub 2014 Feb 1. PMID: 24492774


Olive KP and Politi K: Translational therapeutics in genetically engineered mouse models of cancer. Cold Spring Harb Protoc. 2014 Feb 1;2014 (2) :131-43. Epub 2014 Feb 1. PMID: 24492770


Chacón KM, Petti LM, Scheideman EH, Pirazzoli V, Politi K and DiMaio D: De novo selection of oncogenes. Proc Natl Acad Sci U S A. 2014 Jan 7;111 (1) :E6-E14. Epub 2013 Dec 16. PMID: 24344264

Jia P, Jin H, Meador CB, Xia J, Ohashi K, Liu L, Pirazzoli V, Dahlman KB, Politi K, Michor F, Zhao Z and Pao W: Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance. Genome Res. 2013 Sep;23 (9) :1434-45. Epub 2013 Jun 3. PMID: 23733853


Lee HJ, Schaefer G, Heffron TP, Shao L, Ye X, Sideris S, Malek S, Chan E, Merchant M, La H, Ubhayakar S, Yauch RL, Pirazzoli V, Politi K and Settleman J: Noncovalent wild-type-sparing inhibitors of EGFR T790M. Cancer Discov. 2013 Feb;3 (2) :168-81. Epub 2012 Dec 10. PMID: 23229345


Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE and Pandolfi PP: DOK2 inhibits EGFR-mutated lung adenocarcinoma. PLoS One. 2013;8 (11) :e79526. Epub 2013 Nov 8. PMID: 24255704

Takezawa K, Pirazzoli V, Arcila ME, Nebhan CA, Song X, de Stanchina E, Ohashi K, Janjigian YY, Spitzler PJ, Melnick MA, Riely GJ, Kris MG, Miller VA, Ladanyi M, Politi K and Pao W: HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov. 2012 Oct;2 (10) :922-33. Epub 2012 Sep 5. PMID: 22956644


Sangodkar J, Dhawan NS, Melville H, Singh VJ, Yuan E, Rana H, Izadmehr S, Farrington C, Mazhar S, Katz S, Albano T, Arnovitz P, Okrent R, Ohlmeyer M, Galsky M, Burstein D, Zhang D, Politi K, Difeo A and Narla G: Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response. J Clin Invest. 2012 Jul 2;122 (7) :2637-51. Epub 2012 Jun 1. PMID: 22653055


Topalidou I, Keller C, Kalebic N, Nguyen KC, Somhegyi H, Politi KA, Heppenstall P, Hall DH and Chalfie M: Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization. Curr Biol. 2012 Jun 19;22 (12) :1057-65. Epub 2012 May 31. PMID: 22658602


Politi K and Lynch TJ: Two sides of the same coin: EGFR exon 19 deletions and insertions in lung cancer. Clin Cancer Res. 2012 Mar 15;18 (6) :1490-2. Epub 2012 Feb 8. PMID: 22317760


Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH and Strauss KA: Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012;7 (1) :e28936. Epub 2012 Jan 17. PMID: 22279524

Varela A, Katsiboulas M, Tousoulis D, Politi K, Papaioannou TG, Vaina S, Davos CH, Piperi C, Stefanadis C, Basdra EK and Papavassiliou AG: Early shear stress signaling on vascular endothelium by a modified partial carotid ligation model. Int J Cardiol. 2011 Nov 3;152 (3) :413-6. Epub 2011 Sep 13. PMID: 21917331


Politi K, Kivity S, Goldberg-Stern H, Halevi A and Shuper A: Selective mutism and abnormal electroencephalography (EEG) tracings. J Child Neurol. 2011 Nov;26 (11) :1377-82. Epub 2011 May 18. PMID: 21596703


Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE and Hanash SM: Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 2011 Sep 13;20 (3) :289-99. PMID: 21907921


Politi K and Pao W: How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol. 2011 Jun 1;29 (16) :2273-81. Epub 2011 Jan 24. PMID: 21263096


Politi K, Shemer-Meiri L, Shuper A and Aharoni S: The ketogenic diet 2011: how it works. Epilepsy Res Treat. 2011;2011 :963637. Epub 2011 Jun 5. PMID: 22937236

Mimouni-Bloch A, Schneider C, Politi KE, Konen O, Gothelf D, Stark B, Yaniv I and Shuper A: Neuropsychiatric manifestations in Langerhans' cell histiocytosis disease: a case report and review of the literature. J Child Neurol. 2010 Jul;25 (7) :884-7. PMID: 20595698


Politi K, Fan PD, Shen R, Zakowski M and Varmus H: Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Dis Model Mech. 2010 Jan-Feb;3 (1-2) :111-9. Epub 2009 Dec 9. PMID: 20007486

Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W and Thomas RK: Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A. 2009 Oct 27;106 (43) :18351-6. Epub 2009 Oct 5. PMID: 19805051


Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA and Pao W: Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009 Oct;119 (10) :3000-10. Epub 2009 Sep 14. PMID: 19759520

Trimis G, Chatzistamou I, Politi K, Kiaris H and Papavassiliou AG: Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors. Hum Mol Genet. 2008 Nov 15;17 (22) :3596-600. Epub 2008 Aug 18. PMID: 18713757


Podsypanina K, Politi K, Beverly LJ and Varmus HE: Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proc Natl Acad Sci U S A. 2008 Apr 1;105 (13) :5242-7. Epub 2008 Mar 20. PMID: 18356293


Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS, States DJ and Hanash SM: A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol. 2008;9 (6) :R93. Epub 2008 Jun 3. PMID: 18522751

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X and Pao W: Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med. 2007 Oct 9;4 (10) :e294. PMID: 17927446


Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF and Pao W: Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors. PLoS One. 2007 Aug 29;2 (8) :e810. Epub 2007 Aug 29. PMID: 17726540

Riely GJ, Politi KA, Miller VA and Pao W: Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res. 2006 Dec 15;12 (24) :7232-41. PMID: 17189394


Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M and Wong KK: BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models. J Thorac Oncol. 2006 Nov;1 (9 Suppl) :S2-7. PMID: 17409996


Cheretis C, Dietrich F, Chatzistamou I, Politi K, Angelidou E, Kiaris H, Mkrtchian S and Koutselini H: Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma. Am J Dermatopathol. 2006 Oct;28 (5) :410-2. PMID: 17012915


Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S and Efstratiadis A: Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A. 2006 Jun 13;103 (24) :9262-7. Epub 2006 Jun 2. PMID: 16751266


Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W and Varmus HE: Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev. 2006 Jun 1;20 (11) :1496-510. Epub 2006 May 16. PMID: 16705038


Markakis C, Dalezios M, Chatzicostas C, Chalkiadaki A, Politi K and Agouridakis PJ: Evaluation of a risk score for interhospital transport of critically ill patients. Emerg Med J. 2006 Apr;23 (4) :313-7. PMID: 16549583

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG and Varmus H: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005 Mar;2 (3) :e73. Epub 2005 Feb 22. PMID: 15737014


Varmus H, Pao W, Politi K, Podsypanina K and Du YC: Oncogenes come of age. Cold Spring Harb Symp Quant Biol. 2005;70 :1-9. PMID: 16869733

Politi K, Feirt N and Kitajewski J: Notch in mammary gland development and breast cancer. Semin Cancer Biol. 2004 Oct;14 (5) :341-7. PMID: 15288259


Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M and Varmus H: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004 Sep 7;101 (36) :13306-11. Epub 2004 Aug 25. PMID: 15329413


Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A and Artavanis-Tsakonas S: Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol. 2004 Aug;165 (2) :695-705. PMID: 15277242


Politi K, Kljuic A, Szabolcs M, Fisher P, Ludwig T and Efstratiadis A: 'Designer' tumors in mice. Oncogene. 2004 Feb 26;23 (8) :1558-65. PMID: 14661057


Politi K, Szabolcs M, Fisher P, Kljuic A, Ludwig T and Efstratiadis A: A mouse model of uterine leiomyosarcoma. Am J Pathol. 2004 Jan;164 (1) :325-36. PMID: 14695345

Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D and Efstratiadis A: Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest. 2002 Oct;110 (7) :1011-9. PMID: 12370279

Scita G, Darwiche N, Greenwald E, Rosenberg M, Politi K and De Luca LM: Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation. J Biol Chem. 1996 Mar 15;271 (11) :6502-8. PMID: 8626453

Papaevangelou G, Roumeliotou-Karayannis A, Tassopoulos N, Richardson SC, Stathopoulou P, Papadoyannakis N, Tsantoulis N, Politi K and Tassiopoulou A: Evaluation of methods of pre-vaccination screening for markers of hepatitis B infection. Eur J Epidemiol. 1985 Jun;1 (2) :100-3. PMID: 2946600

Skoutelis AT, Lianou E, Papavassiliou T, Karamerou A, Politi K and Bassaris HP: Defective phagocytic and bactericidal function of polymorphonuclear leucocytes in patients with beta-thalassaemia major. J Infect. 1984 Mar;8 (2) :118-22. PMID: 6373946