Recent Publications

Crisci I, Aragona M, Politi KS, Daniele G, Del Prato S: GLP-1 receptor agonists in type 1 diabetes: a proof-of-concept approach. Acta Diabetol. 2015 Aug 21; 2015 Aug 21. PMID: 26293127

Ikiz B, Alvarez MJ, Ré DB, Le Verche V, Politi K, Lotti F, Phani S, Pradhan R, Yu C, Croft GF, Jacquier A, Henderson CE, Califano A, Przedborski S: The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis. Cell Rep. 2015 Jul 14; 2015 Jul 2. PMID: 26146077

Ayeni D, Politi K, Goldberg SB: Emerging Agents and New Mutations in EGFR-Mutant Lung Cancer. Clin Cancer Res. 2015 Jul 13; 2015 Jul 13. PMID: 26169963

Politi K, Ayeni D, Lynch T: The Next Wave of EGFR Tyrosine Kinase Inhibitors Enter the Clinic. Cancer Cell. 2015 Jun 8. PMID: 26058074

Politi K, Herbst RS: Lung cancer in the era of precision medicine. Clin Cancer Res. 2015 May 15. PMID: 25979927

Maity TK, Venugopalan A, Linnoila I, Cultraro CM, Giannakou A, Nemati R, Zhang X, Webster JD, Ritt D, Ghosal S, Hoschuetzky H, Simpson RM, Biswas R, Politi K, Morrison DK, Varmus HE, Guha U: Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. Cancer Discov. 2015 May; 2015 Mar 3. PMID: 25735773

Morgensztern D, Politi K, Herbst RS: EGFR Mutations in Non-Small-Cell Lung Cancer: Find, Divide, and Conquer. JAMA Oncol. 2015 May 1. PMID: 26181013

Bantikassegn A, Song X, Politi K: Isolation of epithelial, endothelial, and immune cells from lungs of transgenic mice with oncogene-induced lung adenocarcinomas. Am J Respir Cell Mol Biol. 2015 Apr. PMID: 25347711

Song X, Fan PD, Bantikassegn A, Guha U, Threadgill DW, Varmus H, Politi K: ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. Cancer Res. 2015 Mar 15; 2015 Jan 16. PMID: 25596284

Meador CB, Jin H, de Stanchina E, Nebhan CA, Pirazzoli V, Wang L, Lu P, Vuong H, Hutchinson KE, Jia P, Chen X, Eisenberg R, Ladanyi M, Politi K, Zhao Z, Lovly CM, Cross DA, Pao W: Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer. Mol Cancer Ther. 2015 Feb; 2014 Dec 4. PMID: 25477325

Politi K, Gettinger S: Perfect ALKemy: optimizing the use of ALK-directed therapies in lung cancer. Clin Cancer Res. 2014 Nov 15; 2014 Sep 16. PMID: 25228532

Yamulla RJ, Kane EG, Moody AE, Politi KA, Lock NE, Foley AV, Roberts DM: Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling. Genetics. 2014 Aug; 2014 Jun 14. PMID: 24931405

Pirazzoli V, Nebhan C, Song X, Wurtz A, Walther Z, Cai G, Zhao Z, Jia P, de Stanchina E, Shapiro EM, Gale M, Yin R, Horn L, Carbone DP, Stephens PJ, Miller V, Gettinger S, Pao W, Politi K: Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1. Cell Rep. 2014 May 22; 2014 May 9. PMID: 24813888

de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, Varmus H, Bernards R, Smit EF, Politi K, Downward J: Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer Discov. 2014 May; 2014 Feb 17. PMID: 24535670

Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S: Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron. 2014 Mar 5; 2014 Feb 6. PMID: 24508385

Lockwood W, Politi K: MYCxing it up with FGFR1 in squamous cell lung cancer. Cancer Discov. 2014 Feb. PMID: 24501305

Pirazzoli V, Politi K: Generation of drug-resistant tumors using intermittent dosing of tyrosine kinase inhibitors in mouse. Cold Spring Harb Protoc. 2014 Feb 1; 2014 Feb 1. PMID: 24492774

Olive KP, Politi K: Translational therapeutics in genetically engineered mouse models of cancer. Cold Spring Harb Protoc. 2014 Feb 1; 2014 Feb 1. PMID: 24492770

Chacón KM, Petti LM, Scheideman EH, Pirazzoli V, Politi K, DiMaio D: De novo selection of oncogenes. Proc Natl Acad Sci U S A. 2014 Jan 7; 2013 Dec 16. PMID: 24344264

Jia P, Jin H, Meador CB, Xia J, Ohashi K, Liu L, Pirazzoli V, Dahlman KB, Politi K, Michor F, Zhao Z, Pao W: Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance. Genome Res. 2013 Sep; 2013 Jun 3. PMID: 23733853

Lee HJ, Schaefer G, Heffron TP, Shao L, Ye X, Sideris S, Malek S, Chan E, Merchant M, La H, Ubhayakar S, Yauch RL, Pirazzoli V, Politi K, Settleman J: Noncovalent wild-type-sparing inhibitors of EGFR T790M. Cancer Discov. 2013 Feb; 2012 Dec 10. PMID: 23229345

Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP: DOK2 inhibits EGFR-mutated lung adenocarcinoma. PLoS One. 2013; 2013 Nov 8. PMID: 24255704

Takezawa K, Pirazzoli V, Arcila ME, Nebhan CA, Song X, de Stanchina E, Ohashi K, Janjigian YY, Spitzler PJ, Melnick MA, Riely GJ, Kris MG, Miller VA, Ladanyi M, Politi K, Pao W: HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov. 2012 Oct; 2012 Sep 5. PMID: 22956644

Sangodkar J, Dhawan NS, Melville H, Singh VJ, Yuan E, Rana H, Izadmehr S, Farrington C, Mazhar S, Katz S, Albano T, Arnovitz P, Okrent R, Ohlmeyer M, Galsky M, Burstein D, Zhang D, Politi K, Difeo A, Narla G: Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response. J Clin Invest. 2012 Jul; 2012 Jun 1. PMID: 22653055

Topalidou I, Keller C, Kalebic N, Nguyen KC, Somhegyi H, Politi KA, Heppenstall P, Hall DH, Chalfie M: Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization. Curr Biol. 2012 Jun 19; 2012 May 31. PMID: 22658602

Politi K, Lynch TJ: Two sides of the same coin: EGFR exon 19 deletions and insertions in lung cancer. Clin Cancer Res. 2012 Mar 15; 2012 Feb 8. PMID: 22317760

Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA: Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012; 2012 Jan 17. PMID: 22279524

Varela A, Katsiboulas M, Tousoulis D, Politi K, Papaioannou TG, Vaina S, Davos CH, Piperi C, Stefanadis C, Basdra EK, Papavassiliou AG: Early shear stress signaling on vascular endothelium by a modified partial carotid ligation model. Int J Cardiol. 2011 Nov 3; 2011 Sep 13. PMID: 21917331

Politi K, Kivity S, Goldberg-Stern H, Halevi A, Shuper A: Selective mutism and abnormal electroencephalography (EEG) tracings. J Child Neurol. 2011 Nov; 2011 May 18. PMID: 21596703

Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM: Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 2011 Sep 13. PMID: 21907921

Politi K, Pao W: How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol. 2011 Jun 1; 2011 Jan 24. PMID: 21263096

Politi K, Shemer-Meiri L, Shuper A, Aharoni S: The ketogenic diet 2011: how it works. Epilepsy Res Treat. 2011; 2011 Jun 5. PMID: 22937236

Mimouni-Bloch A, Schneider C, Politi KE, Konen O, Gothelf D, Stark B, Yaniv I, Shuper A: Neuropsychiatric manifestations in Langerhans' cell histiocytosis disease: a case report and review of the literature. J Child Neurol. 2010 Jul. PMID: 20595698

Politi K, Fan PD, Shen R, Zakowski M, Varmus H: Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Dis Model Mech. 2010 Jan-Feb; 2009 Dec 9. PMID: 20007486

Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK: Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A. 2009 Oct 27; 2009 Oct 5. PMID: 19805051

Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W: Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009 Oct; 2009 Sep 14. PMID: 19759520

Trimis G, Chatzistamou I, Politi K, Kiaris H, Papavassiliou AG: Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors. Hum Mol Genet. 2008 Nov 15; 2008 Aug 18. PMID: 18713757

Podsypanina K, Politi K, Beverly LJ, Varmus HE: Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proc Natl Acad Sci U S A. 2008 Apr 1; 2008 Mar 20. PMID: 18356293

Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS, States DJ, Hanash SM: A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol. 2008; 2008 Jun 3. PMID: 18522751

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W: Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med. 2007 Oct 9. PMID: 17927446

Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF, Pao W: Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors. PLoS One. 2007 Aug 29; 2007 Aug 29. PMID: 17726540

Riely GJ, Politi KA, Miller VA, Pao W: Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res. 2006 Dec 15. PMID: 17189394

Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK: BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models. J Thorac Oncol. 2006 Nov. PMID: 17409996

Cheretis C, Dietrich F, Chatzistamou I, Politi K, Angelidou E, Kiaris H, Mkrtchian S, Koutselini H: Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma. Am J Dermatopathol. 2006 Oct. PMID: 17012915

Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A: Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A. 2006 Jun 13; 2006 Jun 2. PMID: 16751266

Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE: Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev. 2006 Jun 1; 2006 May 16. PMID: 16705038

Markakis C, Dalezios M, Chatzicostas C, Chalkiadaki A, Politi K, Agouridakis PJ: Evaluation of a risk score for interhospital transport of critically ill patients. Emerg Med J. 2006 Apr. PMID: 16549583

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005 Mar; 2005 Feb 22. PMID: 15737014

Varmus H, Pao W, Politi K, Podsypanina K, Du YC: Oncogenes come of age. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869733

Politi K, Feirt N, Kitajewski J: Notch in mammary gland development and breast cancer. Semin Cancer Biol. 2004 Oct. PMID: 15288259

Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004 Sep 7; 2004 Aug 25. PMID: 15329413

Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S: Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol. 2004 Aug. PMID: 15277242

Politi K, Kljuic A, Szabolcs M, Fisher P, Ludwig T, Efstratiadis A: 'Designer' tumors in mice. Oncogene. 2004 Feb 26. PMID: 14661057

Politi K, Szabolcs M, Fisher P, Kljuic A, Ludwig T, Efstratiadis A: A mouse model of uterine leiomyosarcoma. Am J Pathol. 2004 Jan. PMID: 14695345

Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D, Efstratiadis A: Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest. 2002 Oct. PMID: 12370279

Scita G, Darwiche N, Greenwald E, Rosenberg M, Politi K, De Luca LM: Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation. J Biol Chem. 1996 Mar 15. PMID: 8626453

Papaevangelou G, Roumeliotou-Karayannis A, Tassopoulos N, Richardson SC, Stathopoulou P, Papadoyannakis N, Tsantoulis N, Politi K, Tassiopoulou A: Evaluation of methods of pre-vaccination screening for markers of hepatitis B infection. Eur J Epidemiol. 1985 Jun. PMID: 2946600

Skoutelis AT, Lianou E, Papavassiliou T, Karamerou A, Politi K, Bassaris HP: Defective phagocytic and bactericidal function of polymorphonuclear leucocytes in patients with beta-thalassaemia major. J Infect. 1984 Mar. PMID: 6373946