Katerina Politi PhD

Assistant Professor of Medicine (Medical Oncology) and of Pathology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Office of Student ResearchStem Cell Center, YaleCancer Center, Yale: Signal TransductionPathology: Politi Lab; ExPath

Research Interests

Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy more...


  • Ph.D., Columbia University, 2003

Selected Publications

  • Politi K, Fan PD, Shen R, Zakowski M and Varmus H. Erlotinib Resistance in Mouse Models of EGFR-Induced Lung Adenocarcinoma Resembles Drug Resistance in the Human Disease. Dis Model Mech. 2010 Jan-Feb;3(1-2):111-9. Epub 2009 Dec 9. PMCID: 2806903
  • Regales L, Gong Y, Shen R, De Stanchina E, Vivanco I, Goel A, Koutcher J, Spassova M, Oerfelli O, Mellingohoff I, Zakowski M, Politi K and Pao W. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009 Oct;119(10):3000-10. doi: 10.1172/JCI38746. Epub 2009 Sep 14. PMCID: PMC2752070
  • Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF, Pao W. Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors. PLoS ONE. 2007 Aug 29;2(8):e810. PMCID: 1950079



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