Publications

Rapanelli M, Frick LR, Horn KD, Schwarcz R, Pogorelov V, Nairn AC, Pittenger C: The histamine H3 receptor differentially modulates MAPK and Akt signaling in striatonigral and striatopallidal neurons. J Biol Chem. 2016 Aug 10; 2016 Aug 10. PMID: 27510032

Gruner P, Pittenger C: Cognitive inflexibility in Obsessive-Compulsive Disorder. Neuroscience. 2016 Aug 1; 2016 Aug 1. PMID: 27491478

Frick L, Rapanelli M, Abbasi E, Ohtsu H, Pittenger C: Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation. Brain Behav Immun. 2016 Jul 2; 2016 Jul 2. PMID: 27381299

Rapanelli M, Pittenger C: Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions. Neuropharmacology. 2016 Jul; 2015 Aug 14. PMID: 26282120

Xu M, Li L, Pittenger C: Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming. Neuroscience. 2016 Jun 2; 2016 Mar 8. PMID: 26968763

Pittenger C, Adams TG Jr, Gallezot JD, Crowley MJ, Nabulsi N, James Ropchan, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE: OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. J Affect Disord. 2016 May 15; 2016 Feb 9. PMID: 26919057

Issaria Y, Jakubovski E, Bartley CA, Pittenger C, Bloch MH: Early onset of response with selective serotonin reuptake inhibitors in obsessive-compulsive disorder: a meta-analysis. J Clin Psychiatry. 2016 May. PMID: 27249090

Radua J, Stoica T, Scheinost D, Pittenger C, Hampson M: Neural correlates of success and failure signals during neurofeedback learning. Neuroscience. 2016 Apr 5; 2016 Apr 5. PMID: 27063101

Kelmendi B, Adams T Jr, Jakubovski E, Hawkins KA, Coric V, Pittenger C: Probing Implicit Learning in Obsessive-Compulsive Disorder: Moderating Role of Medication on the Weather Prediction Task. J Obsessive Compuls Relat Disord. 2016 Apr. PMID: 27134820

Gruner P, Anticevic A, Lee D, Pittenger C: Arbitration between Action Strategies in Obsessive-Compulsive Disorder. Neuroscientist. 2016 Apr; 2015 Jan 20. PMID: 25605642

Van Schalkwyk GI, Bhalla IP, Griepp M, Kelmendi B, Davidson L, Pittenger C: Toward understanding the heterogeneity in obsessive-compulsive disorder: Evidence from narratives in adult patients. Aust N Z J Psychiatry. 2016 Jan; 2015 Apr 8. PMID: 25855685

Pushkarskaya H, Tolin D, Ruderman L, Kirshenbaum A, Kelly JM, Pittenger C, Levy I: Decision-making under uncertainty in obsessive-compulsive disorder. J Psychiatr Res. 2015 Oct; 2015 Aug 12. PMID: 26343609

Pittenger C: Glutamatergic agents for OCD and related disorders. Curr Treat Options Psychiatry. 2015 Sep. PMID: 26301176

Pittenger C, Bloch MH, Wasylink S, Billingslea E, Simpson R, Jakubovski E, Kelmendi B, Sanacora G, Coric V: Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a pilot randomized placebo-controlled trial. J Clin Psychiatry. 2015 Aug. PMID: 26214725

Pittenger C: Glutamate modulators in the treatment of obsessive-compulsive disorder. Psychiatr Ann. 2015 Jun. PMID: 26236057

Xu M, Li L, Ohtsu H, Pittenger C: Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear. Neurosci Lett. 2015 May 19; 2015 Apr 1. PMID: 25841792

Pogorelov V, Xu M, Smith HR, Buchanan GF, Pittenger C: Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition. Exp Neurol. 2015 Mar; 2015 Jan 15. PMID: 25597650

Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C: Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561540

Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL: Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry. 2015 Jan; 2014 Oct 31. PMID: 25158072

Fernandez TV, King RA, Pittenger C: Tourette's syndrome and translational clinical science. J Am Acad Child Adolesc Psychiatry. 2015 Jan. PMID: 25524784

Rapanelli M, Frick LR, Pogorelov V, Ota KT, Abbasi E, Ohtsu H, Pittenger C: Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome. Eur Neuropsychopharmacol. 2014 Dec; 2014 Nov 4. PMID: 25464894

Bloch MH, Bartley CA, Zipperer L, Jakubovski E, Landeros-Weisenberger A, Pittenger C, Leckman JF: Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive-compulsive disorder. Mol Psychiatry. 2014 Sep; 2014 Jun 10. PMID: 24912494

Pittenger C, Bloch MH: Pharmacological treatment of obsessive-compulsive disorder. Psychiatr Clin North Am. 2014 Sep; 2014 Jul 24. PMID: 25150568

McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM: Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 2014 Jun 24. PMID: 25062598

Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A: Altered global brain signal in schizophrenia. Proc Natl Acad Sci U S A. 2014 May 20; 2014 May 5. PMID: 24799682

Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C: Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biol Psychiatry. 2014 Apr 15; 2013 Nov 4. PMID: 24314349

Castellan Baldan L, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C: Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron. 2014 Jan 8. PMID: 24411733

Scheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C, Hampson M: Resting state functional connectivity predicts neurofeedback response. Front Behav Neurosci. 2014; 2014 Sep 24. PMID: 25309375

Lee AS, André JM, Pittenger C: Lesions of the dorsomedial striatum delay spatial learning and render cue-based navigation inflexible in a water maze task in mice. Front Behav Neurosci. 2014; 2014 Feb 13. PMID: 24592223

Pittenger C: Disorders of memory and plasticity in psychiatric disease. Dialogues Clin Neurosci. 2013 Dec. PMID: 24459412

Bloch MH, Green C, Kichuk SA, Dombrowski PA, Wasylink S, Billingslea E, Landeros-Weisenberger A, Kelmendi B, Goodman WK, Leckman JF, Coric V, Pittenger C: Long-term outcome in adults with obsessive-compulsive disorder. Depress Anxiety. 2013 Aug; 2013 Mar 26. PMID: 23532944

Niciu MJ, Grunschel BD, Corlett PR, Pittenger C, Bloch MH: Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder. J Psychopharmacol. 2013 Jul; 2013 May 15. PMID: 23676198

Kichuk SA, Torres AR, Fontenelle LF, Rosário MC, Shavitt RG, Miguel EC, Pittenger C, Bloch MH: Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1; 2013 Feb 12. PMID: 23410525

Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M: Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Transl Psychiatry. 2013 Apr 30; 2013 Apr 30. PMID: 23632454

Panza KE, Pittenger C, Bloch MH: Age and gender correlates of pulling in pediatric trichotillomania. J Am Acad Child Adolesc Psychiatry. 2013 Mar. PMID: 23452681

Bloch MH, Panza KE, Grant JE, Pittenger C, Leckman JF: N-Acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial. J Am Acad Child Adolesc Psychiatry. 2013 Mar. PMID: 23452680

Frick LR, Williams K, Pittenger C: Microglial dysregulation in psychiatric disease. Clin Dev Immunol. 2013; 2013 Apr 18. PMID: 23690824

Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C: Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biol Psychiatry. 2012 Dec 1; 2012 Jul 10. PMID: 22784486

Carty NC, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ: The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Transl Psychiatry. 2012 Jul 10; 2012 Jul 10. PMID: 22781170

Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T: Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. J Vis Exp. 2012 Jan 20; 2012 Jan 20. PMID: 22297729

Pittenger C: Pathophysiological modeling of obsessive-compulsive disorder: challenges, and progress. Biol Psychiatry. 2011 Dec 1. PMID: 22045035

Pittenger C, Bloch MH, Williams K: Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment. Pharmacol Ther. 2011 Dec; 2011 Sep 22. PMID: 21963369

Kelmendi B, Holsbach-Beltrame M, McIntosh AM, Hilt L, George ED, Kitchen RR, Carlyle BC, Pittenger C, Coric V, Nolen-Hoeksema S, Sanacora G, Simen AA: Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder. Neurosci Lett. 2011 Jun 8; 2011 Apr 20. PMID: 21529705

Pittenger C: Epigenetic modification of the BDNF locus by early-life enrichment: towards a molecular correlate of resilience? Neurosci Lett. 2011 May 20; 2011 Mar 22. PMID: 21435373

Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C: High levels of histidine decarboxylase in the striatum of mice and rats. Neurosci Lett. 2011 May 16; 2011 Apr 1. PMID: 21440039

Baldan Ramsey LC, Xu M, Wood N, Pittenger C: Lesions of the dorsomedial striatum disrupt prepulse inhibition. Neuroscience. 2011 Apr 28; 2011 Feb 15. PMID: 21315809

Bloch M, State M, Pittenger C: Recent advances in Tourette syndrome. Curr Opin Neurol. 2011 Apr. PMID: 21386676

Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ: Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010 Nov 2; 2010 Oct 18. PMID: 20956308

Gourley SL, Lee AS, Howell JL, Pittenger C, Taylor JR: Dissociable regulation of instrumental action within mouse prefrontal cortex. Eur J Neurosci. 2010 Nov; 2010 Oct 12. PMID: 21044173

Baldan Ramsey LC, Pittenger C: Cued and spatial learning in the water maze: equivalent learning in male and female mice. Neurosci Lett. 2010 Oct 11; 2010 Aug 5. PMID: 20691760

Bloch MH, McGuire J, Landeros-Weisenberger A, Leckman JF, Pittenger C: Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder. Mol Psychiatry. 2010 Aug; 2009 May 26. PMID: 19468281

Bloch MH, Pittenger C: The Genetics of Obsessive-Compulsive Disorder. Curr Psychiatry Rev. 2010 May 1. PMID: 23970845

Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V: Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder. J Affect Disord. 2010 Feb; 2009 Jul 3. PMID: 19577308

Bloch MH, Landeros-Weisenberger A, Rosario MC, Pittenger C, Leckman JF: Meta-analysis of the symptom structure of obsessive-compulsive disorder. Am J Psychiatry. 2008 Dec; 2008 Oct 15. PMID: 18923068

Lee AS, Duman RS, Pittenger C: A double dissociation revealing bidirectional competition between striatum and hippocampus during learning. Proc Natl Acad Sci U S A. 2008 Nov 4; 2008 Oct 27. PMID: 18955704

Bloch MH, Landeros-Weisenberger A, Sen S, Dombrowski P, Kelmendi B, Coric V, Pittenger C, Leckman JF: Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5. PMID: 18186076

Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA: Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med. 2008 Jun; 2008 Jun 1. PMID: 18516051

Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH, Sanacora G: Riluzole in the treatment of mood and anxiety disorders. CNS Drugs. 2008. PMID: 18698875

Pittenger C, Duman RS: Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology. 2008 Jan; 2007 Sep 12. PMID: 17851537

Bloch MH, Landeros-Weisenberger A, Dombrowski P, Kelmendi B, Wegner R, Nudel J, Pittenger C, Leckman JF, Coric V: Systematic review: pharmacological and behavioral treatment for trichotillomania. Biol Psychiatry. 2007 Oct 15; 2007 Aug 28. PMID: 17727824

Pittenger C, Sanacora G, Krystal JH: The NMDA receptor as a therapeutic target in major depressive disorder. CNS Neurol Disord Drug Targets. 2007 Apr. PMID: 17430148

Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH: Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Biol Psychiatry. 2005 Sep 1. PMID: 15993857