Publications

Bloch MH, Bartley CA, Zipperer L, Jakubovski E, Landeros-Weisenberger A, Pittenger C and Leckman JF: Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive-compulsive disorder. Mol Psychiatry. 2014 Sep;19 (9) :1025-30. Epub 2014 Jun 10. PMID: 24912494


Pittenger C and Bloch MH: Pharmacological treatment of obsessive-compulsive disorder. Psychiatr Clin North Am. 2014 Sep;37 (3) :375-91. Epub 2014 Jul 24. PMID: 25150568


McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K and Scharf JM: Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014 Aug;53 (8) :910-9. Epub 2014 Jun 24. PMID: 25062598


Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC and Anticevic A: Altered global brain signal in schizophrenia. Proc Natl Acad Sci U S A. 2014 May 20;111 (20) :7438-43. Epub 2014 May 5. PMID: 24799682


Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS and Pittenger C: Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biol Psychiatry. 2014 Apr 15;75 (8) :595-605. Epub 2013 Nov 4. PMID: 24314349


Castellan Baldan L, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW and Pittenger C: Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron. 2014 Jan 8;81 (1) :77-90. PMID: 24411733


Scheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C and Hampson M: Resting state functional connectivity predicts neurofeedback response. Front Behav Neurosci. 2014;8 :338. Epub 2014 Sep 24. PMID: 25309375


Lee AS, André JM and Pittenger C: Lesions of the dorsomedial striatum delay spatial learning and render cue-based navigation inflexible in a water maze task in mice. Front Behav Neurosci. 2014;8 :42. Epub 2014 Feb 13. PMID: 24592223

Pittenger C: Disorders of memory and plasticity in psychiatric disease. Dialogues Clin Neurosci. 2013 Dec;15 (4) :455-63. PMID: 24459412


Bloch MH, Green C, Kichuk SA, Dombrowski PA, Wasylink S, Billingslea E, Landeros-Weisenberger A, Kelmendi B, Goodman WK, Leckman JF, Coric V and Pittenger C: Long-term outcome in adults with obsessive-compulsive disorder. Depress Anxiety. 2013 Aug;30 (8) :716-22. Epub 2013 Mar 26. PMID: 23532944


Niciu MJ, Grunschel BD, Corlett PR, Pittenger C and Bloch MH: Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder. J Psychopharmacol. 2013 Jul;27 (7) :651-4. Epub 2013 May 15. PMID: 23676198


Kichuk SA, Torres AR, Fontenelle LF, Rosário MC, Shavitt RG, Miguel EC, Pittenger C and Bloch MH: Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1;44 :233-9. Epub 2013 Feb 12. PMID: 23410525


Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C and Hampson M: Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Transl Psychiatry. 2013 Apr 30;3 :e250. Epub 2013 Apr 30. PMID: 23632454


Panza KE, Pittenger C and Bloch MH: Age and gender correlates of pulling in pediatric trichotillomania. J Am Acad Child Adolesc Psychiatry. 2013 Mar;52 (3) :241-9. PMID: 23452681


Bloch MH, Panza KE, Grant JE, Pittenger C and Leckman JF: N-Acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial. J Am Acad Child Adolesc Psychiatry. 2013 Mar;52 (3) :231-40. PMID: 23452680


Frick LR, Williams K and Pittenger C: Microglial dysregulation in psychiatric disease. Clin Dev Immunol. 2013;2013 :608654. Epub 2013 Apr 18. PMID: 23690824

Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G and Pittenger C: Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biol Psychiatry. 2012 Dec 1;72 (11) :964-70. Epub 2012 Jul 10. PMID: 22784486


Carty NC, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C and Lombroso PJ: The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Transl Psychiatry. 2012 Jul 10;2 :e137. Epub 2012 Jul 10. PMID: 22781170


Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X and Constable T: Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. J Vis Exp. 2012 Jan 20; (59) Epub 2012 Jan 20. PMID: 22297729

Pittenger C: Pathophysiological modeling of obsessive-compulsive disorder: challenges, and progress. Biol Psychiatry. 2011 Dec 1;70 (11) :1002-3. PMID: 22045035


Pittenger C, Bloch MH and Williams K: Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment. Pharmacol Ther. 2011 Dec;132 (3) :314-32. Epub 2011 Sep 22. PMID: 21963369


Kelmendi B, Holsbach-Beltrame M, McIntosh AM, Hilt L, George ED, Kitchen RR, Carlyle BC, Pittenger C, Coric V, Nolen-Hoeksema S, Sanacora G and Simen AA: Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder. Neurosci Lett. 2011 Jun 8;496 (3) :195-9. Epub 2011 Apr 20. PMID: 21529705


Pittenger C: Epigenetic modification of the BDNF locus by early-life enrichment: towards a molecular correlate of resilience? Neurosci Lett. 2011 May 20;495 (3) :165-7. Epub 2011 Mar 22. PMID: 21435373


Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW and Pittenger C: High levels of histidine decarboxylase in the striatum of mice and rats. Neurosci Lett. 2011 May 16;495 (2) :110-4. Epub 2011 Apr 1. PMID: 21440039


Baldan Ramsey LC, Xu M, Wood N and Pittenger C: Lesions of the dorsomedial striatum disrupt prepulse inhibition. Neuroscience. 2011 Apr 28;180 :222-8. Epub 2011 Feb 15. PMID: 21315809


Bloch M, State M and Pittenger C: Recent advances in Tourette syndrome. Curr Opin Neurol. 2011 Apr;24 (2) :119-25. PMID: 21386676

Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC and Lombroso PJ: Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010 Nov 2;107 (44) :19014-9. Epub 2010 Oct 18. PMID: 20956308


Gourley SL, Lee AS, Howell JL, Pittenger C and Taylor JR: Dissociable regulation of instrumental action within mouse prefrontal cortex. Eur J Neurosci. 2010 Nov;32 (10) :1726-34. Epub 2010 Oct 12. PMID: 21044173


Baldan Ramsey LC and Pittenger C: Cued and spatial learning in the water maze: equivalent learning in male and female mice. Neurosci Lett. 2010 Oct 11;483 (2) :148-51. Epub 2010 Aug 5. PMID: 20691760


Bloch MH, McGuire J, Landeros-Weisenberger A, Leckman JF and Pittenger C: Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder. Mol Psychiatry. 2010 Aug;15 (8) :850-5. Epub 2009 May 26. PMID: 19468281


Bloch MH and Pittenger C: The Genetics of Obsessive-Compulsive Disorder. Curr Psychiatry Rev. 2010 May 1;6 (2) :91-103. PMID: 23970845


Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF and Coric V: Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder. J Affect Disord. 2010 Feb;121 (1-2) :175-9. Epub 2009 Jul 3. PMID: 19577308

Bloch MH, Landeros-Weisenberger A, Rosario MC, Pittenger C and Leckman JF: Meta-analysis of the symptom structure of obsessive-compulsive disorder. Am J Psychiatry. 2008 Dec;165 (12) :1532-42. Epub 2008 Oct 15. PMID: 18923068


Lee AS, Duman RS and Pittenger C: A double dissociation revealing bidirectional competition between striatum and hippocampus during learning. Proc Natl Acad Sci U S A. 2008 Nov 4;105 (44) :17163-8. Epub 2008 Oct 27. PMID: 18955704


Bloch MH, Landeros-Weisenberger A, Sen S, Dombrowski P, Kelmendi B, Coric V, Pittenger C and Leckman JF: Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B (6) :850-8. PMID: 18186076


Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS and Flavell RA: Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med. 2008 Jun;14 (6) :681-7. Epub 2008 Jun 1. PMID: 18516051


Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH and Sanacora G: Riluzole in the treatment of mood and anxiety disorders. CNS Drugs. 2008;22 (9) :761-86. PMID: 18698875


Pittenger C and Duman RS: Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology. 2008 Jan;33 (1) :88-109. Epub 2007 Sep 12. PMID: 17851537

Bloch MH, Landeros-Weisenberger A, Dombrowski P, Kelmendi B, Wegner R, Nudel J, Pittenger C, Leckman JF and Coric V: Systematic review: pharmacological and behavioral treatment for trichotillomania. Biol Psychiatry. 2007 Oct 15;62 (8) :839-46. Epub 2007 Aug 28. PMID: 17727824


Pittenger C, Sanacora G and Krystal JH: The NMDA receptor as a therapeutic target in major depressive disorder. CNS Neurol Disord Drug Targets. 2007 Apr;6 (2) :101-15. PMID: 17430148

Pittenger C, Krystal JH and Coric V: Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. NeuroRx. 2006 Jan;3 (1) :69-81. PMID: 16490414

Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT and Krystal JH: Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Biol Psychiatry. 2005 Sep 1;58 (5) :424-8. PMID: 15993857