People

Christopher Pittenger

Principal Investigator

Christopher Pittenger earned his MD and Ph.D. degrees from Columbia University, where his graduate work was done with Nobel Prize recipient Eric Kandel. He returned to Yale University - where had done his undergraduate studies - for residency and research training in psychiatry in 2003. He joined the faculty as an Assistant Professor in 2007 and was promoted to the rank of Associate Professor in 2013.


Jessica M. André

Postdoctoral Associate in Psychiatry

Biography

Jessica has been a postdoc in the laboratory since 2011. Her focus is in obtaining a better understanding of neuropsychiatric diseases through assaying the behavior of animal models. She enjoys working in academia and aims to establish myself as an effective researcher and administrator. She intends to make important contributions taking advantage not only of her scientific expertise, but also her administrative, organizational, and mentoring skills.


Luciana R Frick

Postdoctoral Associate in Psychiatry


Lina Li

Research Assistant, PittLab

Biography

Lina is currently working in the Pittenger Lab as a Research Assistant. Over the past twenty years she has previously worked in laboratories at the University of Michigan, Pfizer, and Yale University. She is the co-author of fourteen publications, and her skills lie in basic animal research, with a focus on molecular and cellular techniques.


Maximiliano Rapanelli

Postdoctoral Associate in Psychiatry


Meiyu Xu

Associate Research Scientist in Psychiatry

Biography

Meiyu has been a postdoc in the laboratory since 2009. Her focus has been studying the cellular and molecular mechanisms underlying the pathophysiology of Tourette syndrome (TS) using virus tools and mouse models. She received a grant award in 2011 from the Tourette Syndrome Association.

Meiyu has been a postdoc in the laboratory since 2009. Her focus has been studying the cellular and molecular mechanisms underlying the pathophysiology of Tourette syndrome (TS) using virus tools and mouse models. She received a grant award in 2011 from the Tourette Syndrome Association.

Meiyu's Ph.D. researches focused on the regulation of food intake and growth regulation by some endocrine hormones, e.g. prepro-orexin (OX), PACAP-related peptide, preprosomatostatin, etc.

Representative publications

Meiyu Xu, Lina Li, Hiroshi Ohtsu, Christopher Pittenger. Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show enhanced stereotypy following fear stress. Submitted to Neuroscience letters.

Meiyu Xu, Andrew Kobets, Jung-Chieh Du, Jessica B. Lennington, Lina Li, Mouna Banasr, Ronald S. Duman, Flora Vaccarino, Ralph DiLeone,.Christopher Pittenger, Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Submittted to PNAS

Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C. (2011) High levels of histidine decarboxylase in the striatum of mice and rats. Neurosci Lett. 495(2):110-4

Baldan Ramsey LC, Xu M, Wood N, Pittenger C. (2011) Lesions of the dorsomedial striatum disrupt prepulse inhibition. Neuroscience. 180:222-8.

Xu M., Volkoff H. (2009) Molecular characterization of ghrelin and gastrin-releasing peptide in Atlantic cod (Gadus morhua): Cloning, localization, developmental profile and role in food intake regulation. Gen Comp Endocrinol 160: 250–258

Xu M., Volkoff H. (2009) Cloning, tissue distribution and effects of food deprivation on pituitary adenylate cyclase activating polypeptide (PACAP)/PACAP-related peptide (PRP) and preprosomatostatin 1 (PPSS 1) in Atlantic cod (Gadus morhua). Peptides 30:766-76

Xu M., Volkoff H. (2007) Molecular characterization of prepro-orexin in Atlantic cod (Gadus morhua): Cloning, localization, developmental profile and role in food intake regulation. Mol Cell Endocrinol 271:28-37

Chen S., Xu M., Ji X., Yu G., Liu Y. (2005) Cloning, characterization, and expression analysis of hepicidin gene from red sea bream (Chrysophrys major). Antimicrob Agents Chemother 49:1608-12

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