The AIMS lab functions as the central MRI core reading, coordinating and image processing unit for Johns Hopkins multi-center study titled, A Randomized Controlled Trial of Vitamin D supplementation in MS. In this ongoing project, the lab receives imaging data from various participating sites via electronic media. The researchers at the lab read brain MRI scans from MS patients to calculate white matter lesion counts. Specialized software developed at the lab is used to generate volumetric measures of brain atrophy and total disease burden. The post-processed imaging measures are sent to Johns Hopkins University.
Glutathione (GSH) is a critical antioxidant that plays a key role in protecting cells against oxidative damage by reactive oxygen species generated in the brain. In particular, GSH provides a first line of defense against singlet oxygen and hydroxyl radicals that are known to cause cellular damage and eventual cell death. Because GSH is consumed in this protective process, a reduction in GSH levels is noted in brain tissue undergoing oxidative stress. In non-disease condition, increased glutathione was observed after stimulation with extra-cellular glutamate, indicating that glutathione might also have a neuroprotective role to minimize glutamate toxicity.The primary objective of this research is to directly estimate the concentration of brain glutathione [glutathione] in vivo using H-MRS at 7T before and after initiation of Tecfidera in established MS patients considering switching therapy or being treatment-naive.