Publications

Zhang Y, Sauler M, Shinn AS, Gong H, Haslip M, Shan P, Mannam P and Lee PJ: Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury. J Immunol. 2014 Jun 1;192 (11) :5296-304. Epub 2014 Apr 28. PMID: 24778451


Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA and Lee PJ: MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306 (7) :L604-19. Epub 2014 Jan 31. PMID: 24487387


Sauler M, Leng L, Trentalange M, Haslip M, Shan P, Piecychna M, Zhang Y, Andrews N, Mannam P, Allore H, Fried T, Bucala R and Lee PJ: Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306 (6) :L487-96. Epub 2014 Jan 17. PMID: 24441872

Zhang Y, Jiang G, Sauler M and Lee PJ: Lung endothelial HO-1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury. FASEB J. 2013 Oct;27 (10) :4041-58. Epub 2013 Jun 14. PMID: 23771928


Zhang Y, Zhang X, Shan P, Hunt CR, Pandita TK and Lee PJ: A protective Hsp70-TLR4 pathway in lethal oxidant lung injury. J Immunol. 2013 Aug 1;191 (3) :1393-403. Epub 2013 Jul 1. PMID: 23817427


Mannam P, Zhang X, Shan P, Zhang Y, Shinn AS, Zhang Y and Lee PJ: Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury. J Immunol. 2013 Feb 1;190 (3) :1264-75. Epub 2012 Dec 28. PMID: 23275604


Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA and Lee CG: IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15;304 (2) :L112-24. Epub 2012 Nov 2. PMID: 23125252


Knauert M, Vangala S, Haslip M and Lee PJ: Therapeutic applications of carbon monoxide. Oxid Med Cell Longev. 2013;2013 :360815. Epub 2013 Dec 4. PMID: 24648866

Volkova M, Zhang Y, Shaw AC and Lee PJ: The role of Toll-like receptors in age-associated lung diseases. J Gerontol A Biol Sci Med Sci. 2012 Mar;67 (3) :247-53. Epub 2012 Mar 5. PMID: 22396470


Song Y, Shen H, Schenten D, Shan P, Lee PJ and Goldstein DR: Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2012 Jan;32 (1) :103-9. Epub 2011 Oct 27. PMID: 22034510

Raval CM and Lee PJ: Heme oxygenase-1 in lung disease. Curr Drug Targets. 2010 Dec;11 (12) :1532-40. PMID: 20704548

Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ and Elias JA: Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol. 2007 Nov 15;179 (10) :7030-41. PMID: 17982094


Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA and Lee PJ: VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo. FASEB J. 2007 May;21 (7) :1422-32. Epub 2007 Jan 30. PMID: 17264168

Zhang X, Shan P, Jiang G, Cohn L and Lee PJ: Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest. 2006 Nov;116 (11) :3050-9. Epub 2006 Oct 19. PMID: 17053835


Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR and Elias JA: Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov;12 (11) :1286-93. Epub 2006 Nov 5. PMID: 17086189


Zhang X, Shan P, Jiang G, Zhang SS, Otterbein LE, Fu XY and Lee PJ: Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. FASEB J. 2006 Oct;20 (12) :2156-8. Epub 2006 Sep 13. PMID: 16971418


Ma B, Liu W, Homer RJ, Lee PJ, Coyle AJ, Lora JM, Lee CG and Elias JA: Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2006 Apr 15;176 (8) :4968-78. PMID: 16585593


Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA and Lee CG: Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. J Biol Chem. 2006 Mar 24;281 (12) :8161-8. Epub 2006 Jan 26. PMID: 16439363


Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT and Elias JA: ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006 Jan;116 (1) :163-73. Epub 2005 Dec 22. PMID: 16374521

Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R and Noble PW: Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005 Nov;11 (11) :1173-9. Epub 2005 Oct 23. PMID: 16244651


Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW and Lee PJ: Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol. 2005 Oct 15;175 (8) :4834-8. PMID: 16210584


Zhang X, Shan P, Alam J, Fu XY and Lee PJ: Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. J Biol Chem. 2005 Mar 11;280 (10) :8714-21. Epub 2004 Dec 7. PMID: 15590660

Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ and Elias JA: Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med. 2004 Aug 2;200 (3) :377-89. PMID: 15289506


Zhang X, Shan P, Jiang D, Noble PW, Abraham NG, Kappas A and Lee PJ: Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J Biol Chem. 2004 Mar 12;279 (11) :10677-84. Epub 2003 Dec 18. PMID: 14688267

Lee PJ and Choi AM: Pathways of cell signaling in hyperoxia. Free Radic Biol Med. 2003 Aug 15;35 (4) :341-50. PMID: 12899937


Zhang X, Shan P, Alam J, Davis RJ, Flavell RA and Lee PJ: Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem. 2003 Jun 13;278 (24) :22061-70. Epub 2003 Apr 10. PMID: 12690100


Zhang X, Shan P, Sasidhar M, Chupp GL, Flavell RA, Choi AM and Lee PJ: Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am J Respir Cell Mol Biol. 2003 Mar;28 (3) :305-15. PMID: 12594056


Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM and Lee PJ: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2003 Jan 10;278 (2) :1248-58. Epub 2002 Oct 23. PMID: 12399465

Zhang X, Bedard EL, Potter R, Zhong R, Alam J, Choi AM and Lee PJ: Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283 (4) :L815-29. PMID: 12225959

Lee PJ, Camhi SL, Chin BY, Alam J and Choi AM: AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1. Am J Physiol Lung Cell Mol Physiol. 2000 Jul;279 (1) :L175-82. PMID: 10893216