Publications

Sauler M, Bucala R, Lee PJ: Role of macrophage migration inhibitory factor in age-related lung disease. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1; 2015 May 8. PMID: 25957294

Srivastava A, McGinniss J, Wong Y, Shinn AS, Lam TT, Lee PJ, Mannam P: MKK3 deletion improves mitochondrial quality. Free Radic Biol Med. 2015 Jun 25; 2015 Jun 25. PMID: 26119780

Srivastava A, Shinn AS, Lee PJ, Mannam P: MKK3 mediates inflammatory response through modulation of mitochondrial function. Free Radic Biol Med. 2015 Jun; 2015 Feb 17. PMID: 25697779

Haslip M, Dostanic I, Huang Y, Zhang Y, Russell KS, Jurczak MJ, Mannam P, Giordano F, Erzurum SC, Lee PJ: Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia. Arterioscler Thromb Vasc Biol. 2015 May; 2015 Mar 26. PMID: 25814675

Sauler M, Zhang Y, Min JN, Leng L, Shan P, Roberts S, Jorgensen WL, Bucala R, Lee PJ: Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. FASEB J. 2015 May; 2015 Jan 21. PMID: 25609432

Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM: Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nat Commun. 2015 Feb 10; 2015 Feb 10. PMID: 25665524

Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ: Cathepsin E promotes pulmonary emphysema via mitochondrial fission. Am J Pathol. 2014 Oct. PMID: 25239563

Zhang Y, Sauler M, Shinn AS, Gong H, Haslip M, Shan P, Mannam P, Lee PJ: Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury. J Immunol. 2014 Jun 1; 2014 Apr 28. PMID: 24778451

Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ: MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1; 2014 Jan 31. PMID: 24487387

Sauler M, Leng L, Trentalange M, Haslip M, Shan P, Piecychna M, Zhang Y, Andrews N, Mannam P, Allore H, Fried T, Bucala R, Lee PJ: Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15; 2014 Jan 17. PMID: 24441872

Mannam P, Srivastava A, Sugunaraj JP, Lee PJ, Sauler M: Oxidants in Acute and Chronic Lung Disease. J Blood Lymph. 2014. PMID: 25705575

Zhang Y, Jiang G, Sauler M, Lee PJ: Lung endothelial HO-1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury. FASEB J. 2013 Oct; 2013 Jun 14. PMID: 23771928

Zhang Y, Zhang X, Shan P, Hunt CR, Pandita TK, Lee PJ: A protective Hsp70-TLR4 pathway in lethal oxidant lung injury. J Immunol. 2013 Aug 1; 2013 Jul 1. PMID: 23817427

Mannam P, Zhang X, Shan P, Zhang Y, Shinn AS, Zhang Y, Lee PJ: Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury. J Immunol. 2013 Feb 1; 2012 Dec 28. PMID: 23275604

Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG: IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 2012 Nov 2. PMID: 23125252

Knauert M, Vangala S, Haslip M, Lee PJ: Therapeutic applications of carbon monoxide. Oxid Med Cell Longev. 2013; 2013 Dec 4. PMID: 24648866

Volkova M, Zhang Y, Shaw AC, Lee PJ: The role of Toll-like receptors in age-associated lung diseases. J Gerontol A Biol Sci Med Sci. 2012 Mar; 2012 Mar 5. PMID: 22396470

Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR: Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2012 Jan; 2011 Oct 27. PMID: 22034510

Raval CM, Lee PJ: Heme oxygenase-1 in lung disease. Curr Drug Targets. 2010 Dec. PMID: 20704548

Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA: Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol. 2007 Nov 15. PMID: 17982094

Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ: VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo. FASEB J. 2007 May; 2007 Jan 30. PMID: 17264168

Zhang X, Shan P, Jiang G, Cohn L, Lee PJ: Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest. 2006 Nov; 2006 Oct 19. PMID: 17053835

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA: Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov; 2006 Nov 5. PMID: 17086189

Zhang X, Shan P, Jiang G, Zhang SS, Otterbein LE, Fu XY, Lee PJ: Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. FASEB J. 2006 Oct; 2006 Sep 13. PMID: 16971418

Ma B, Liu W, Homer RJ, Lee PJ, Coyle AJ, Lora JM, Lee CG, Elias JA: Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2006 Apr 15. PMID: 16585593

Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG: Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. J Biol Chem. 2006 Mar 24; 2006 Jan 26. PMID: 16439363

Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA: ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006 Jan; 2005 Dec 22. PMID: 16374521

Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW: Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005 Nov; 2005 Oct 23. PMID: 16244651

Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ: Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol. 2005 Oct 15. PMID: 16210584

Zhang X, Shan P, Alam J, Fu XY, Lee PJ: Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. J Biol Chem. 2005 Mar 11; 2004 Dec 7. PMID: 15590660

Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA: Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med. 2004 Aug 2. PMID: 15289506

Zhang X, Shan P, Jiang D, Noble PW, Abraham NG, Kappas A, Lee PJ: Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J Biol Chem. 2004 Mar 12; 2003 Dec 18. PMID: 14688267

Lee PJ, Choi AM: Pathways of cell signaling in hyperoxia. Free Radic Biol Med. 2003 Aug 15. PMID: 12899937

Zhang X, Shan P, Alam J, Davis RJ, Flavell RA, Lee PJ: Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem. 2003 Jun 13; 2003 Apr 10. PMID: 12690100

Zhang X, Shan P, Sasidhar M, Chupp GL, Flavell RA, Choi AM, Lee PJ: Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am J Respir Cell Mol Biol. 2003 Mar. PMID: 12594056

Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2003 Jan 10; 2002 Oct 23. PMID: 12399465

Zhang X, Bedard EL, Potter R, Zhong R, Alam J, Choi AM, Lee PJ: Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Oct. PMID: 12225959

Lee PJ, Camhi SL, Chin BY, Alam J, Choi AM: AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1. Am J Physiol Lung Cell Mol Physiol. 2000 Jul. PMID: 10893216