Publications

Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F and Kleinstein SH: pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics. 2014 Mar 26; Epub 2014 Mar 26. PMID: 24618469


Vaughan K, Peters B, O'Connor KC, Martin R and Sette A: A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data? J Neuroimmunol. 2014 Feb 15;267 (1-2) :73-85. Epub 2013 Dec 12. PMID: 24365494

Keung B, Robeson KR, DiCapua DB, Rosen JB, O'Connor KC, Goldstein JM and Nowak RJ: Long-term benefit of rituximab in MuSK autoantibody myasthenia gravis patients. J Neurol Neurosurg Psychiatry. 2013 Dec;84 (12) :1407-9. Epub 2013 Jun 12. PMID: 23761915


Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L and Robinson WH: Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis. Mult Scler. 2013 Nov;19 (13) :1726-33. Epub 2013 Apr 23. PMID: 23612879


Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, Huttner AJ, Kleinstein SH, Lee JY, Stern JN, Yaari G, Lovato L, Cronk KM and O'Connor KC: The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro Oncol. 2013 Nov;15 (11) :1479-90. Epub 2013 Aug 26. PMID: 23978377


Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee JY, O'Connor KC, Pelletier D and Carson RE: The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Brain Behav Immun. 2013 Oct;33 :131-8. Epub 2013 Jul 9. PMID: 23850810


Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN and O'Connor KC: Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology. 2013 Sep 10;81 (11) :956-63. Epub 2013 Aug 6. PMID: 23921886


Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC and Meffre E: Specific peripheral B cell tolerance defects in patients with multiple sclerosis. J Clin Invest. 2013 Jun 3;123 (6) :2737-41. Epub 2013 May 15. PMID: 23676463


Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC and Elledge SJ: PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J Autoimmun. 2013 Jun;43 :1-9. Epub 2013 Mar 13. PMID: 23497938


Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F and Kleinstein SH: Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol. 2013;4 :358. Epub 2013 Nov 15. PMID: 24298272

Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN and O'Connor KC: Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis. PLoS One. 2012;7 (10) :e46709. Epub 2012 Oct 5. PMID: 23071619

Walker CA, Huttner AJ and O'Connor KC: Cortical injury in multiple sclerosis; the role of the immune system. BMC Neurol. 2011 Dec 6;11 :152. Epub 2011 Dec 6. PMID: 22145746


Kostianovsky A, Maskin P, Noriega MM, Soler C, Bonelli I, Riley CS, O'Connor KC, Saubidet CN and Alvarez PA: Acute demyelinating disease after oral therapy with herbal extracts. Case Rep Neurol. 2011 May;3 (2) :141-6. Epub 2011 Jun 25. PMID: 21738505


Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC and Dornmair K: Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol. 2011 Apr;233 (1-2) :245-8. Epub 2011 Feb 24. PMID: 21353315


Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC and Hafler DA: Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain. 2011 Feb;134 (Pt 2) :534-41. Epub 2011 Jan 7. PMID: 21216828

Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC and Monson NL: A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis. J Neuroimmunol. 2010 Sep 14;226 (1-2) :192-3. Epub 2010 Jul 23. PMID: 20655601


Klawiter EC, Piccio L, Lyons JA, Mikesell R, O'Connor KC and Cross AH: Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis. Arch Neurol. 2010 Sep;67 (9) :1102-8. PMID: 20837855


O'Connor KC, Lopez-Amaya C, Gagne D, Lovato L, Moore-Odom NH, Kennedy J, Krupp L, Tenembaum S, Ness J, Belman A, Boyko A, Bykova O, Mah JK, Stoian CA, Waubant E, Kremenchutzky M, Ruggieri M, Bardini MR, Rensel M, Hahn J, Weinstock-Guttman B, Yeh EA, Farrell K, Freedman MS, Iivanainen M, Bhan V, Dilenge M, Hancock MA, Gano D, Fattahie R, Kopel L, Fournier AE, Moscarello M, Banwell B and Bar-Or A: Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis. J Neuroimmunol. 2010 Jun;223 (1-2) :92-9. Epub 2010 Apr 8. PMID: 20381173

Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA and O'Connor KC: Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain. 2009 Dec;132 (Pt 12) :3318-28. PMID: 19638446


McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B and Wucherpfennig KW: Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15;183 (6) :4067-76. Epub 2009 Aug 17. PMID: 19687098


Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP and Gilden D: Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol. 2009 Jun;65 (6) :639-49. PMID: 19557869


Willis SN, Mallozzi SS, Rodig SJ, Cronk KM, McArdel SL, Caron T, Pinkus GS, Lovato L, Shampain KL, Anderson DE, Anderson RC, Bruce JN and O'Connor KC: The microenvironment of germ cell tumors harbors a prominent antigen-driven humoral response. J Immunol. 2009 Mar 1;182 (5) :3310-7. PMID: 19234230

Wang Y, Imitola J, Rasmussen S, O'Connor KC and Khoury SJ: Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Ann Neurol. 2008 Oct;64 (4) :417-27. PMID: 18991353

Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH and Steinman L: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature. 2007 Jul 26;448 (7152) :474-9. Epub 2007 Jun 13. PMID: 17568699


Lambracht-Washington D, O'Connor KC, Cameron EM, Jowdry A, Ward ES, Frohman E, Racke MK and Monson NL: Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MS. J Neuroimmunol. 2007 May;186 (1-2) :164-76. Epub 2007 Apr 23. PMID: 17451814


O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA and Wucherpfennig KW: Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007 Feb;13 (2) :211-7. Epub 2007 Jan 12. PMID: 17237795


Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA and O'Connor KC: A local antigen-driven humoral response is present in the inflammatory myopathies. J Immunol. 2007 Jan 1;178 (1) :547-56. PMID: 17182595

Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK and Hafler DA: Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006 Jun 12;203 (6) :1413-8. Epub 2006 Jun 5. PMID: 16754722


O'Connor KC, Roy SM, Becker CH, Hafler DA and Kantor AB: Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers. Dis Markers. 2006;22 (4) :213-25. PMID: 17124343

Greenberg SA, Bradshaw EM, Pinkus JL, Pinkus GS, Burleson T, Due B, Bregoli L, O'Connor KC and Amato AA: Plasma cells in muscle in inclusion body myositis and polymyositis. Neurology. 2005 Dec 13;65 (11) :1782-7. PMID: 16344523


O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA and Wucherpfennig KW: Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol. 2005 Aug 1;175 (3) :1974-82. PMID: 16034142


Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT and Hafler DA: Characterization of in vivo expanded OspA-specific human T-cell clones. Clin Immunol. 2005 Jun;115 (3) :313-22. PMID: 15893699


Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P and Baecher-Allan C: Multiple sclerosis. Immunol Rev. 2005 Apr;204 :208-31. PMID: 15790361

Hirano N, Butler MO, Von Bergwelt-Baildon MS, Maecker B, Schultze JL, O'Connor KC, Schur PH, Kojima S, Guinan EC and Nadler LM: Autoantibodies frequently detected in patients with aplastic anemia. Blood. 2003 Dec 15;102 (13) :4567-75. Epub 2003 Aug 28. PMID: 12947009


O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW and Hafler DA: Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol. 2003 Mar;136 (1-2) :140-8. PMID: 12620653

Bar-Or A, Oliveira EM, Anderson DE, Krieger JI, Duddy M, O'Connor KC and Hafler DA: Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. J Immunol. 2001 Nov 15;167 (10) :5669-77. PMID: 11698439


Li J, Fernandez L, O'Connor KC, Imanishi-Kari T and Stollar BD: The rearranged V(H) domain of a physiologically selected anti-single-stranded DNA antibody as a precursor for formation of IgM and IgG antibodies to diverse antigens. J Immunol. 2001 Oct 1;167 (7) :3746-55. PMID: 11564791


O'Connor KC, Bar-Or A and Hafler DA: The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J Clin Immunol. 2001 Mar;21 (2) :81-92. PMID: 11332657


O'Connor KC, Nguyen K and Stollar BD: Recognition of DNA by VH and Fv domains of an IgG anti-poly(dC) antibody with a singly mutated VH domain. J Mol Recognit. 2001 Jan-Feb;14 (1) :18-28. PMID: 11180559

Hines RN, O'Connor KC, Vella G and Warren W: Large-scale purification of plasmid DNA by anion-exchange high-performance liquid chromatography. Biotechniques. 1992 Mar;12 (3) :430-4. PMID: 1571155

Dion DM, O'Connor K, Phillips D, Vella GJ and Warren W: New family of high-resolution ion exchangers for protein and nucleic acid purifications from laboratory to process scales. J Chromatogr. 1990 Dec 28;535 (1-2) :127-45. PMID: 1965192