Selected Publications

Haskins JW, Nguyen DX and Stern DF: Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration. Sci Signal. 2014 Dec 9;7 (355) :ra116. Epub 2014 Dec 9. PMID: 25492965


Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ and Westbrook TF: The Oncogenic STP Axis Promotes Triple-Negative Breast Cancer via Degradation of the REST Tumor Suppressor. Cell Rep. 2014 Nov 20;9 (4) :1318-32. Epub 2014 Nov 6. PMID: 25453754


Colavito SA, Zou MR, Yan Q, Nguyen DX and Stern DF: Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NF¿B) pathway. Breast Cancer Res. 2014 Sep 25;16 (5) :444. Epub 2014 Sep 25. PMID: 25252859


Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ and Greco V: Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nat Commun. 2014 Mar 26;5 :3543. Epub 2014 Mar 26. PMID: 24667544


Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX and Yan Q: Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep. 2014 Mar 13;6 (5) :868-77. Epub 2014 Feb 27. PMID: 24582965

Breindel JL, Haskins JW, Cowell EP, Zhao M, Nguyen DX and Stern DF: EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res. 2013 Aug 15;73 (16) :5053-65. Epub 2013 Jun 21. PMID: 23794705


Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF and Nguyen DX: Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell. 2013 Jun 10;23 (6) :725-38. Epub 2013 May 23. PMID: 23707782

Cao PD, Cheung WK and Nguyen DX: Cell lineage specification in tumor progression and metastasis. Discov Med. 2011 Oct;12 (65) :329-40. PMID: 22031670


Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ and Westbrook TF: Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 4;144 (5) :703-18. PMID: 21376233


Nguyen DX: Tracing the origins of metastasis. J Pathol. 2011 Jan;223 (2) :195-204. Epub 2010 Oct 29. PMID: 21125675

Bos PD, Nguyen DX and Massagué J: Modeling metastasis in the mouse. Curr Opin Pharmacol. 2010 Oct;10 (5) :571-7. Epub 2010 Jul 1. PMID: 20598638

Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L and Massagué J: Tumor self-seeding by circulating cancer cells. Cell. 2009 Dec 24;139 (7) :1315-26. PMID: 20064377


Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL and Massagué J: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell. 2009 Jul 10;138 (1) :51-62. Epub 2009 Jul 2. PMID: 19576624


Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA and Massagué J: Genes that mediate breast cancer metastasis to the brain. Nature. 2009 Jun 18;459 (7249) :1005-9. Epub 2009 May 6. PMID: 19421193


Nguyen DX, Bos PD and Massagué J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009 Apr;9 (4) :274-84. PMID: 19308067

Nguyen DX and Massagué J: Genetic determinants of cancer metastasis. Nat Rev Genet. 2007 May;8 (5) :341-52. PMID: 17440531


Minn AJ, Gupta GP, Padua D, Bos P, Nguyen DX, Nuyten D, Kreike B, Zhang Y, Wang Y, Ishwaran H, Foekens JA, van de Vijver M and Massagué J: Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A. 2007 Apr 17;104 (16) :6740-5. Epub 2007 Apr 9. PMID: 17420468


Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K and Massagué J: Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature. 2007 Apr 12;446 (7137) :765-70. PMID: 17429393