Research

Our main research focus includes:

CoordinationImage

Coordination of Transcription and Splicing

All protein-coding genes are transcribed by RNA polymerase II (Pol II); the resulting pre-mRNA transcripts are spliced by a distinct macromolecular machine, the spliceosome, to produce mRNA. These...

Zebrafish

Cajal bodies and the macromolecular assembly of RNPs

Cajal bodies (CBs) were identified more than 100 years ago by Ramon y Cajal in vertebrate neurons. The function of these 0.5-1 mm spherical structures, which like other cellular subcompartments (PML...

mrnp rectangle

mRNP formation, composition and function

Genomes encode many hundreds of RNA binding proteins that have roles in transcription, splicing, subcellular localization, stability and translation. Yet we do not have a comprehensive handle on how...