Publications

Heyn P, Kalinka AT, Tomancak P and Neugebauer KM: Introns and gene expression: Cellular constraints, transcriptional regulation, and evolutionary consequences. Bioessays. 2014 Nov 14; Epub 2014 Nov 14. PMID: 25400101


Heyn P, Kircher M, Dahl A, Kelso J, Tomancak P, Kalinka AT and Neugebauer KM: The earliest transcribed zygotic genes are short, newly evolved, and different across species. Cell Rep. 2014 Jan 30;6 (2) :285-92. Epub 2014 Jan 16. PMID: 24440719


Bieberstein NI, Straube K and Neugebauer KM: Chromatin immunoprecipitation approaches to determine co-transcriptional nature of splicing. Methods Mol Biol. 2014;1126 :315-23. PMID: 24549674


Müller-McNicoll M and Neugebauer KM: Good cap/bad cap: how the cap-binding complex determines RNA fate. Nat Struct Mol Biol. 2014 Jan;21 (1) :9-12. PMID: 24389545

Pabis M, Neufeld N, Steiner MC, Bojic T, Shav-Tal Y and Neugebauer KM: The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. RNA. 2013 Aug;19 (8) :1054-63. Epub 2013 Jun 21. PMID: 23793891


Brugiolo M, Herzel L and Neugebauer KM: Counting on co-transcriptional splicing. F1000Prime Rep. 2013;5 :9. Epub 2013 Apr 2. PMID: 23638305


Müller-McNicoll M and Neugebauer KM: How cells get the message: dynamic assembly and function of mRNA-protein complexes. Nat Rev Genet. 2013 Apr;14 (4) :275-87. Epub 2013 Mar 12. PMID: 23478349


Machyna M, Heyn P and Neugebauer KM: Cajal bodies: where form meets function. Wiley Interdiscip Rev RNA. 2013 Jan-Feb;4 (1) :17-34. Epub 2012 Oct 5. PMID: 23042601

Bieberstein NI, Carrillo Oesterreich F, Straube K and Neugebauer KM: First exon length controls active chromatin signatures and transcription. Cell Rep. 2012 Jul 26;2 (1) :62-8. Epub 2012 Jul 20. PMID: 22840397


Ankö ML and Neugebauer KM: RNA-protein interactions in vivo: global gets specific. Trends Biochem Sci. 2012 Jul;37 (7) :255-62. Epub 2012 Mar 15. PMID: 22425269


Änkö ML, Müller-McNicoll M, Brandl H, Curk T, Gorup C, Henry I, Ule J and Neugebauer KM: The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Genome Biol. 2012;13 (3) :R17. PMID: 22436691

Görnemann J, Barrandon C, Hujer K, Rutz B, Rigaut G, Kotovic KM, Faux C, Neugebauer KM and Séraphin B: Cotranscriptional spliceosome assembly and splicing are independent of the Prp40p WW domain. RNA. 2011 Dec;17 (12) :2119-29. Epub 2011 Oct 21. PMID: 22020974


Tripsianes K, Madl T, Machyna M, Fessas D, Englbrecht C, Fischer U, Neugebauer KM and Sattler M: Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins. Nat Struct Mol Biol. 2011 Nov 20;18 (12) :1414-20. Epub 2011 Nov 20. PMID: 22101937


Krastev DB, Slabicki M, Paszkowski-Rogacz M, Hubner NC, Junqueira M, Shevchenko A, Mann M, Neugebauer KM and Buchholz F: A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Nat Cell Biol. 2011 Jun 5;13 (7) :809-18. Epub 2011 Jun 5. PMID: 21642980


Carrillo Oesterreich F, Bieberstein N and Neugebauer KM: Pause locally, splice globally. Trends Cell Biol. 2011 Jun;21 (6) :328-35. Epub 2011 Apr 27. PMID: 21530266


Domingues AM, Neugebauer KM and Fern R: Identification of four functional NR3B isoforms in developing white matter reveals unexpected diversity among glutamate receptors. J Neurochem. 2011 May;117 (3) :449-60. Epub 2011 Mar 14. PMID: 21320125


Brody Y, Neufeld N, Bieberstein N, Causse SZ, Böhnlein EM, Neugebauer KM, Darzacq X and Shav-Tal Y: The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing. PLoS Biol. 2011 Jan 11;9 (1) :e1000573. Epub 2011 Jan 11. PMID: 21264352

Carrillo Oesterreich F, Preibisch S and Neugebauer KM: Global analysis of nascent RNA reveals transcriptional pausing in terminal exons. Mol Cell. 2010 Nov 24;40 (4) :571-81. PMID: 21095587


Huranová M, Ivani I, Benda A, Poser I, Brody Y, Hof M, Shav-Tal Y, Neugebauer KM and Stanek D: The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells. J Cell Biol. 2010 Oct 4;191 (1) :75-86. PMID: 20921136


Ankö ML and Neugebauer KM: Long noncoding RNAs add another layer to pre-mRNA splicing regulation. Mol Cell. 2010 Sep 24;39 (6) :833-4. PMID: 20864030


Pabis M, Neufeld N, Shav-Tal Y and Neugebauer KM: Binding properties and dynamic localization of an alternative isoform of the cap-binding complex subunit CBP20. Nucleus. 2010 Sep-Oct;1 (5) :412-21. PMID: 21326824


Ankö ML, Morales L, Henry I, Beyer A and Neugebauer KM: Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. Nat Struct Mol Biol. 2010 Aug;17 (8) :962-70. Epub 2010 Jul 18. PMID: 20639886


Strzelecka M, Trowitzsch S, Weber G, Lührmann R, Oates AC and Neugebauer KM: Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nat Struct Mol Biol. 2010 Apr;17 (4) :403-9. Epub 2010 Mar 28. PMID: 20357773


Müller M, Neugebauer KM and Eckmann C: mRNA: a complex(ed) life. Genome Biol. 2010;11 (5) :304. Epub 2010 May 25. PMID: 20500909


Strzelecka M, Oates AC and Neugebauer KM: Dynamic control of Cajal body number during zebrafish embryogenesis. Nucleus. 2010 Jan-Feb;1 (1) :96-108. PMID: 21327108

Sapra AK, Ankö ML, Grishina I, Lorenz M, Pabis M, Poser I, Rollins J, Weiland EM and Neugebauer KM: SR protein family members display diverse activities in the formation of nascent and mature mRNPs in vivo. Mol Cell. 2009 Apr 24;34 (2) :179-90. PMID: 19394295

Martinez J and Neugebauer KM: El Sur también existe: processing RNA in the Argentine Patagonia. Meetings on 'Cell Biology, Signaling and Alternative Splicing' and 'Gene Expression and RNA Processing'. EMBO Rep. 2008 Jun;9 (6) :516-20. Epub 2008 May 9. PMID: 18464796


Stanek D, Pridalová-Hnilicová J, Novotný I, Huranová M, Blazíková M, Wen X, Sapra AK and Neugebauer KM: Spliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies. Mol Biol Cell. 2008 Jun;19 (6) :2534-43. Epub 2008 Mar 26. PMID: 18367544

Listerman I, Bledau AS, Grishina I and Neugebauer KM: Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. PLoS Genet. 2007 Nov;3 (11) :e212. PMID: 18039033

Klingauf M, Stanek D and Neugebauer KM: Enhancement of U4/U6 small nuclear ribonucleoprotein particle association in Cajal bodies predicted by mathematical modeling. Mol Biol Cell. 2006 Dec;17 (12) :4972-81. Epub 2006 Sep 20. PMID: 16987958


Stanek D and Neugebauer KM: The Cajal body: a meeting place for spliceosomal snRNPs in the nuclear maze. Chromosoma. 2006 Oct;115 (5) :343-54. Epub 2006 Mar 31. PMID: 16575476


Listerman I, Sapra AK and Neugebauer KM: Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells. Nat Struct Mol Biol. 2006 Sep;13 (9) :815-22. Epub 2006 Aug 20. PMID: 16921380


Neugebauer KM: Please hold--the next available exon will be right with you. Nat Struct Mol Biol. 2006 May;13 (5) :385-6. PMID: 16738604


Neugebauer KM: Keeping tabs on the women: life scientists in Europe. PLoS Biol. 2006 Apr;4 (4) :e97. Epub 2006 Apr 11. PMID: 16602822

Görnemann J, Kotovic KM, Hujer K and Neugebauer KM: Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex. Mol Cell. 2005 Jul 1;19 (1) :53-63. PMID: 15989964

Stanĕk D and Neugebauer KM: Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. J Cell Biol. 2004 Sep 27;166 (7) :1015-25. PMID: 15452143


Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT, Neugebauer KM, Matera AG and Misteli T: In vivo kinetics of Cajal body components. J Cell Biol. 2004 Mar 15;164 (6) :831-42. PMID: 15024031

Kotovic KM, Lockshon D, Boric L and Neugebauer KM: Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast. Mol Cell Biol. 2003 Aug;23 (16) :5768-79. PMID: 12897147


Schaft D, Roguev A, Kotovic KM, Shevchenko A, Sarov M, Shevchenko A, Neugebauer KM and Stewart AF: The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation. Nucleic Acids Res. 2003 May 15;31 (10) :2475-82. PMID: 12736296


Stanĕk D, Rader SD, Klingauf M and Neugebauer KM: Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. J Cell Biol. 2003 Feb 17;160 (4) :505-16. Epub 2003 Feb 10. PMID: 12578909

Neugebauer KM: On the importance of being co-transcriptional. J Cell Sci. 2002 Oct 15;115 (Pt 20) :3865-71. PMID: 12244124