Publications

Bian S, Navaratnam D and Santos-Sacchi J: Real time measures of prestin charge and fluorescence during plasma membrane trafficking reveal sub-tetrameric activity. PLoS One. 2013;8 (6) :e66078. Epub 2013 Jun 10. PMID: 23762468

Surguchev A, Bai JP, Joshi P and Navaratnam D: Hair cell BK channels interact with RACK1, and PKC increases its expression on the cell surface by indirect phosphorylation. Am J Physiol Cell Physiol. 2012 Jul 15;303 (2) :C143-50. Epub 2012 Apr 25. PMID: 22538239


Bai JP, Surguchev A, Joshi P, Gross L and Navaratnam D: CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation. Am J Physiol Cell Physiol. 2012 Mar 1;302 (5) :C766-80. Epub 2011 Nov 16. PMID: 22094329

Frucht CS, Uduman M, Kleinstein SH, Santos-Sacchi J and Navaratnam DS: Gene expression gradients along the tonotopic axis of the chicken auditory epithelium. J Assoc Res Otolaryngol. 2011 Aug;12 (4) :423-35. Epub 2011 Mar 12. PMID: 21399991


Frucht CS, Santos-Sacchi J and Navaratnam DS: MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium. Neurosci Lett. 2011 Apr 8;493 (1-2) :44-8. Epub 2011 Feb 21. PMID: 21316421


Bai JP, Surguchev A and Navaratnam D: β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells. Am J Physiol Cell Physiol. 2011 Mar;300 (3) :C435-46. Epub 2010 Dec 22. PMID: 21178105


Bian S, Bai JP, Chapin H, Le Moellic C, Dong H, Caplan M, Sigworth FJ and Navaratnam DS: Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression. PLoS One. 2011;6 (12) :e28264. Epub 2011 Dec 14. PMID: 22194818

Bian S, Koo BW, Kelleher S, Santos-Sacchi J and Navaratnam DS: A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events. Am J Physiol Cell Physiol. 2010 Oct;299 (4) :C828-35. Epub 2010 Jul 14. PMID: 20631244


Frucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J and Navaratnam DS: Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation. PLoS One. 2010 Jul 9;5 (7) :e11502. Epub 2010 Jul 9. PMID: 20634979


Bai JP, Surguchev A, Bian S, Song L, Santos-Sacchi J and Navaratnam D: Combinatorial cysteine mutagenesis reveals a critical intramonomer role for cysteines in prestin voltage sensing. Biophys J. 2010 Jul 7;99 (1) :85-94. PMID: 20655836


Bai JP, Surguchev A, Ogando Y, Song L, Bian S, Santos-Sacchi J and Navaratnam D: Prestin surface expression and activity are augmented by interaction with MAP1S, a microtubule-associated protein. J Biol Chem. 2010 Jul 2;285 (27) :20834-43. Epub 2010 Apr 23. PMID: 20418376


Brown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D and Kaczmarek LK: Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nat Neurosci. 2010 Jul;13 (7) :819-21. Epub 2010 May 30. PMID: 20512134

Bai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J and Navaratnam D: Prestin's anion transport and voltage-sensing capabilities are independent. Biophys J. 2009 Apr 22;96 (8) :3179-86. PMID: 19383462


Navaratnam DS: Yeast two-hybrid screening to test for protein-protein interactions in the auditory system. Methods Mol Biol. 2009;493 :257-68. PMID: 18839352

Bai JP, Navaratnam D, Samaranayake H and Santos-Sacchi J: En block C-terminal charge cluster reversals in prestin (SLC26A5): effects on voltage-dependent electromechanical activity. Neurosci Lett. 2006 Sep 1;404 (3) :270-5. Epub 2006 Jul 12. PMID: 16839688


Santos-Sacchi J, Rybalchenko V, Bai JP, Song L and Navaratnam D: On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin. Pflugers Arch. 2006 Jun;452 (3) :283-9. Epub 2006 Mar 7. PMID: 16521020

Navaratnam D, Bai JP, Samaranayake H and Santos-Sacchi J: N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein. Biophys J. 2005 Nov;89 (5) :3345-52. Epub 2005 Aug 19. PMID: 16113116

Samaranayake H, Saunders JC, Greene MI and Navaratnam DS: Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradients. J Physiol. 2004 Oct 1;560 (Pt 1) :13-20. Epub 2004 Jul 22. PMID: 15272029