Slide 24

Animal Model of Absence or "Spike-and-Wave" Seizures

Systemic injection of high doses of penicillin in the cat results in the slow transformation of normal spindle waves into "spike-and-wave" seizures. These results further indicate that absence seizures may be a perverse form of thalamocortical rhythm. 

From Kostopoulos, G., Gloor, P., Pellegrini, A. & Gotman, J. (1981a). A study of the transition from spindles to spike and wave discharge in feline generalized penicillin epilepsy: Microphysiological features

Experimental Neurology 73, 55-77. 

Kostopoulos, G., Gloor, P., Pellegrini, A. & Siatitsas, I. (1981b). A study of the transition from spindles to spike and wave discharge in feline generalized penicillin epilepsy: EEG features. Experimental Neurology 73, 43-54.