Slide 12

Hyperpolarization Strongly Decreases Neuronal Responsiveness

A. Response of a simple cell to the presentation of a sinewave grating visual stimulus while the cell is positioned to different average membrane potentials. The top trace is the raw recording, while the bottom trace is a histogram indicating firing rate. B. Peristimlus histogram for the response of the cell at different membrane potentials. C. Spike rate versus average membrane potential for the data in A. Note that the spike rate falls off dramatically as the cell is hyperpolarized from -60 to -80 mV.