Slide 23

How Does Changes in Presynaptic Membrane Potential Enhance Synaptic Transmission? Clues from the Calyx of Held: A Preparation that allows for Simultaneous Pre and Postsynaptic Recordings

Figure 23. The calyx of Held is a giant synapse in the brainstem auditory pathway and is located in the MNTB (medial nucleus of the trapezoid body).  The synapse is so large that it is possible to patch both the pre and postsynaptic components.  Lower right:  Injection of a fluorescent dye reveals the morphology of the presynaptic terminal.