Slide 19

Enhancement of PSP amplitude by presynaptic membrane potential occurs at many synapses and has kinetically fast and slow components

Figure 19. A.  Intermixing the periods of depolarization and hyperpolarization of the presynaptic neuron still results (B) in a significant increase in amplitude of the evoked EPSP in the postsynaptic cell during the depolarized periods.  C.  Fifteen of the 24 cells tested had a significant enhancment.  The median enhancement was 30%.  The cells in blue had no significant effect.  D.  Time course of the enhancement.  Depolarization of the presynaptic neuron results in enhancement that had both fast and slow time courses.