Publications

Electrophysiology of the Neuron - This book and single neuron simulation program is available free!

Cerebellum: Essential Involvement in a Simple Learned Response. My Ph.D. Dissertation from 1983 - an oldie but goodie!

McCormick Lab in the News: Scientific American

Selected Publications

Modulation of metastable ensemble dynamics explains optimal coding at moderate arousal in auditory cortex.Papadopoulos L, Jo S, Zumwalt K, Wehr M, McCormick DA, Mazzucato L. bioRxiv. 2024 Apr 8; 2024 Apr 8. PMID: 38617286.
Decision-making dynamics are predicted by arousal and uninstructed movements.Hulsey D, Zumwalt K, Mazzucato L, McCormick DA, Jaramillo S. Cell Rep. 2024 Feb 27; 2024 Jan 26. PMID: 38280196.
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice.Vickers ED, McCormick DA. bioRxiv. 2024 Feb 5; 2024 Feb 5. PMID: 37961229.
The h-current controls cortical recurrent network activity through modulation of dendrosomatic communication.Shu Y, Hasenstaub A, McCormick DA. bioRxiv. 2023 Jul 13; 2023 Jul 13. PMID: 37502942.
Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex.Collins L, Francis J, Emanuel B, McCormick DA. Elife. 2023 Apr 27; 2023 Apr 27. PMID: 37102362.
Decision-making dynamics are predicted by arousal and uninstructed movements.Hulsey D, Zumwalt K, Mazzucato L, McCormick DA, Jaramillo S. bioRxiv. 2023 Mar 28; 2023 Mar 28. PMID: 37034793.
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations.Nestvogel DB, McCormick DA. Neuron. 2022 Jan 5; 2021 Oct 22. PMID: 34687663.
Neuromodulation of Brain State and Behavior.McCormick DA, Nestvogel DB, He BJ. Annu Rev Neurosci. 2020 Jul 8; 2020 Apr 6. PMID: 32250724.
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task.Salkoff DB, Zagha E, McCarthy E, McCormick DA. Cereb Cortex. 2020 Jan 10. PMID: 31711133.
Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance.Neske GT, Nestvogel D, Steffan PJ, McCormick DA. J Neurosci. 2019 Dec 11; 2019 Oct 31. PMID: 31672787.
Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus.Andrews JP, Yue Z, Ryu JH, Neske G, McCormick DA, Blumenfeld H. Exp Neurol. 2019 Apr; 2018 Dec 10. PMID: 30543800.
Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells.Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Cereb Cortex. 2017 Jun 1. PMID: 27269961.
Corrigendum: Knockout of Foxp2 disrupts vocal development in mice.Castellucci GA, McGinley MJ, McCormick DA. Sci Rep. 2017 Jan 12; 2017 Jan 12. PMID: 28079190.
Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice.Hadzipasic M, Ni W, Nagy M, Steenrod N, McGinley MJ, Kaushal A, Thomas E, McCormick DA, Horwich AL. Proc Natl Acad Sci U S A. 2016 Nov 22; 2016 Nov 7. PMID: 27821773.
Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex.Reimer J, McGinley MJ, Liu Y, Rodenkirch C, Wang Q, McCormick DA, Tolias AS. Nat Commun. 2016 Nov 8; 2016 Nov 8. PMID: 27824036.
Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model.Zagha E, Murray JD, McCormick DA. eNeuro. 2016 Jul-Aug; 2016 Aug 31. PMID: 27595137.
Knockout of Foxp2 disrupts vocal development in mice.Castellucci GA, McGinley MJ, McCormick DA. Sci Rep. 2016 Mar 16; 2016 Mar 16. PMID: 26980647.
Cortical Interneuron Subtypes Vary in Their Axonal Action Potential Properties.Casale AE, Foust AJ, Bal T, McCormick DA. J Neurosci. 2015 Nov 25. PMID: 26609152.
Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output.Zagha E, Ge X, McCormick DA. Neuron. 2015 Nov 4; 2015 Oct 22. PMID: 26593093.
Waking State: Rapid Variations Modulate Neural and Behavioral Responses.McGinley MJ, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell CR, Tolias AS, Cardin JA, McCormick DA. Neuron. 2015 Sep 23. PMID: 26402600.
Synaptic Mechanisms of Tight Spike Synchrony at Gamma Frequency in Cerebral Cortex.Salkoff DB, Zagha E, Yüzgeç Ö, McCormick DA. J Neurosci. 2015 Jul 15. PMID: 26180200.
Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection.McGinley MJ, David SV, McCormick DA. Neuron. 2015 Jul 1; 2015 Jun 11. PMID: 26074005.
Brain state dependent activity in the cortex and thalamus.McCormick DA, McGinley MJ, Salkoff DB. Curr Opin Neurobiol. 2015 Apr; 2014 Oct 22. PMID: 25460069.
Editorial overview: neuromodulation: tuning the properties of neurons, networks and behavior.McCormick DA, Nusbaum MP. Curr Opin Neurobiol. 2014 Dec; 2014 Nov 4. PMID: 25457725.
Neural control of brain state.Zagha E, McCormick DA. Curr Opin Neurobiol. 2014 Dec; 2014 Oct 10. PMID: 25310628.
Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS.Hadzipasic M, Tahvildari B, Nagy M, Bian M, Horwich AL, McCormick DA. Proc Natl Acad Sci U S A. 2014 Nov 25; 2014 Nov 10. PMID: 25385594.
Chronic cellular imaging of entire cortical columns in awake mice using microprisms.Andermann ML, Gilfoy NB, Goldey GJ, Sachdev RN, Wölfel M, McCormick DA, Reid RC, Levene MJ. Neuron. 2013 Nov 20; 2013 Oct 17. PMID: 24139817.
Motor cortex feedback influences sensory processing by modulating network state.Zagha E, Casale AE, Sachdev RN, McGinley MJ, McCormick DA. Neuron. 2013 Aug 7; 2013 Jul 11. PMID: 23850595.
Selective functional interactions between excitatory and inhibitory cortical neurons and differential contribution to persistent activity of the slow oscillation.Tahvildari B, Wölfel M, Duque A, McCormick DA. J Neurosci. 2012 Aug 29. PMID: 22933799.
Warm body temperature facilitates energy efficient cortical action potentials.Yu Y, Hill AP, McCormick DA. PLoS Comput Biol. 2012; 2012 Apr 12. PMID: 22511855.
Active action potential propagation but not initiation in thalamic interneuron dendrites.Casale AE, McCormick DA. J Neurosci. 2011 Dec 14. PMID: 22171033.
Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons.Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA. J Neurosci. 2011 Oct 26. PMID: 22031895.
The spatio-temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study.Popovic MA, Foust AJ, McCormick DA, Zecevic D. J Physiol. 2011 Sep 1; 2011 Jun 13. PMID: 21669974.
Endogenous electric fields may guide neocortical network activity.Fröhlich F, McCormick DA. Neuron. 2010 Jul 15. PMID: 20624597.
Action potentials initiate in the axon initial segment and propagate through axon collaterals reliably in cerebellar Purkinje neurons.Foust A, Popovic M, Zecevic D, McCormick DA. J Neurosci. 2010 May 19. PMID: 20484631.
Circuit-based localization of ferret prefrontal cortex.Duque A, McCormick DA. Cereb Cortex. 2010 May; 2009 Sep 7. PMID: 19737780.
Spatial and temporal features of synaptic to discharge receptive field transformation in cat area 17.Nowak LG, Sanchez-Vives MV, McCormick DA. J Neurophysiol. 2010 Feb; 2009 Nov 11. PMID: 19906874.
Synaptic and network mechanisms of sparse and reliable visual cortical activity during nonclassical receptive field stimulation.Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Neuron. 2010 Jan 14. PMID: 20152117.
Neocortical networks entrain neuronal circuits in cerebellar cortex.Ros H, Sachdev RN, Yu Y, Sestan N, McCormick DA. J Neurosci. 2009 Aug 19. PMID: 19692605.
Rapid neocortical dynamics: cellular and network mechanisms.Haider B, McCormick DA. Neuron. 2009 Apr 30. PMID: 19409263.
Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics.Yu Y, Shu Y, McCormick DA. J Neurosci. 2008 Jul 16. PMID: 18632930.
Lack of orientation and direction selectivity in a subgroup of fast-spiking inhibitory interneurons: cellular and synaptic mechanisms and comparison with other electrophysiological cell types.Nowak LG, Sanchez-Vives MV, McCormick DA. Cereb Cortex. 2008 May; 2007 Aug 23. PMID: 17720684.
State changes rapidly modulate cortical neuronal responsiveness.Hasenstaub A, Sachdev RN, McCormick DA. J Neurosci. 2007 Sep 5. PMID: 17804621.
Selective control of cortical axonal spikes by a slowly inactivating K+ current.Shu Y, Yu Y, Yang J, McCormick DA. Proc Natl Acad Sci U S A. 2007 Jul 3; 2007 Jun 20. PMID: 17581873.
Thalamic synchrony and dynamic regulation of global forebrain oscillations.Huguenard JR, McCormick DA. Trends Neurosci. 2007 Jul; 2007 Jun 4. PMID: 17544519.
Enhancement of visual responsiveness by spontaneous local network activity in vivo.Haider B, Duque A, Hasenstaub AR, Yu Y, McCormick DA. J Neurophysiol. 2007 Jun; 2007 Apr 4. PMID: 17409168.
Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. Cell. 2007 Apr 20. PMID: 17448997.
Neurophysiology: Hodgkin and Huxley model--still standing?McCormick DA, Shu Y, Yu Y. Nature. 2007 Jan 4. PMID: 17203021.
Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings.Shu Y, Duque A, Yu Y, Haider B, McCormick DA. J Neurophysiol. 2007 Jan; 2006 Nov 8. PMID: 17093120.
Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential.Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA. Nature. 2006 Jun 8; 2006 Apr 12. PMID: 16625207.
Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition.Haider B, Duque A, Hasenstaub AR, McCormick DA. J Neurosci. 2006 Apr 26. PMID: 16641233.
Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks.Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick DA. Neuron. 2005 Aug 4. PMID: 16055065.
Neuronal networks: flip-flops in the brain.McCormick DA. Curr Biol. 2005 Apr 26. PMID: 15854894.
Role of synaptic and intrinsic membrane properties in short-term receptive field dynamics in cat area 17.Nowak LG, Sanchez-Vives MV, McCormick DA. J Neurosci. 2005 Feb 16. PMID: 15716423.
Excitatory effects of thyrotropin-releasing hormone in the thalamus.Broberger C, McCormick DA. J Neurosci. 2005 Feb 16. PMID: 15716402.
Slow adaptation in fast-spiking neurons of visual cortex.Descalzo VF, Nowak LG, Brumberg JC, McCormick DA, Sanchez-Vives MV. J Neurophysiol. 2005 Feb; 2004 Sep 22. PMID: 15385594.
Multiple large inputs to principal cells in the mouse medial nucleus of the trapezoid body.Bergsman JB, De Camilli P, McCormick DA. J Neurophysiol. 2004 Jul. PMID: 15212444.
Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons.Lee KH, Broberger C, Kim U, McCormick DA. Proc Natl Acad Sci U S A. 2004 Apr 27; 2004 Apr 19. PMID: 15096604.
System to monitor task chair seating.McCormick DA, Tubergen RG. Clin Biomech (Bristol, Avon). 2003 Dec. PMID: 14580843.
Barrages of synaptic activity control the gain and sensitivity of cortical neurons.Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA. J Neurosci. 2003 Nov 12. PMID: 14614098.
Persistent cortical activity: mechanisms of generation and effects on neuronal excitability.McCormick DA, Shu Y, Hasenstaub A, Sanchez-Vives M, Badoual M, Bal T. Cereb Cortex. 2003 Nov. PMID: 14576213.
Adaptation and temporal decorrelation by single neurons in the primary visual cortex.Wang XJ, Liu Y, Sanchez-Vives MV, McCormick DA. J Neurophysiol. 2003 Jun; 2003 Mar 20. PMID: 12649312.
Turning on and off recurrent balanced cortical activity.Shu Y, Hasenstaub A, McCormick DA. Nature. 2003 May 15. PMID: 12748642.
Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model.Compte A, Sanchez-Vives MV, McCormick DA, Wang XJ. J Neurophysiol. 2003 May; 2003 Jan 15. PMID: 12612051.
Electrophysiological classes of cat primary visual cortical neurons in vivo as revealed by quantitative analyses.Nowak LG, Azouz R, Sanchez-Vives MV, Gray CM, McCormick DA. J Neurophysiol. 2003 Mar. PMID: 12626627.
Inhibitory interactions between ferret thalamic reticular neurons.Shu Y, McCormick DA. J Neurophysiol. 2002 May. PMID: 11976393.
Neuromodulatory role of serotonin in the ferret thalamus.Monckton JE, McCormick DA. J Neurophysiol. 2002 Apr. PMID: 11929930.
Cortical and subcortical generators of normal and abnormal rhythmicity.McCormick DA. Int Rev Neurobiol. 2002. PMID: 12040908.
Synaptojanin 1 contributes to maintaining the stability of GABAergic transmission in primary cultures of cortical neurons.Luthi A, Di Paolo G, Cremona O, Daniell L, De Camilli P, McCormick DA. J Neurosci. 2001 Dec 1. PMID: 11717343.
Brain calculus: neural integration and persistent activity.McCormick DA. Nat Neurosci. 2001 Feb. PMID: 11175863.
On the cellular and network bases of epileptic seizures.McCormick DA, Contreras D. Annu Rev Physiol. 2001. PMID: 11181977.
Cellular and network mechanisms of rhythmic recurrent activity in neocortex.Sanchez-Vives MV, McCormick DA. Nat Neurosci. 2000 Oct. PMID: 11017176.
Corticothalamic inputs control the pattern of activity generated in thalamocortical networks.Blumenfeld H, McCormick DA. J Neurosci. 2000 Jul 1. PMID: 10864972.
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.Brumberg JC, Nowak LG, McCormick DA. J Neurosci. 2000 Jul 1. PMID: 10864940.
Cellular mechanisms of long-lasting adaptation in visual cortical neurons in vitro.Sanchez-Vives MV, Nowak LG, McCormick DA. J Neurosci. 2000 Jun 1. PMID: 10818164.
Membrane mechanisms underlying contrast adaptation in cat area 17 in vivo.Sanchez-Vives MV, Nowak LG, McCormick DA. J Neurosci. 2000 Jun 1. PMID: 10818163.
Are thalamocortical rhythms the Rosetta Stone of a subset of neurological disorders?McCormick DA. Nat Med. 1999 Dec. PMID: 10581069.
Essential role of phosphoinositide metabolism in synaptic vesicle recycling.Cremona O, Di Paolo G, Wenk MR, Lüthi A, Kim WT, Takei K, Daniell L, Nemoto Y, Shears SB, Flavell RA, McCormick DA, De Camilli P. Cell. 1999 Oct 15. PMID: 10535736.
Spontaneous activity: signal or noise?McCormick DA. Science. 1999 Jul 23. PMID: 10447487.
Modulation of a pacemaker current through Ca(2+)-induced stimulation of cAMP production.Lüthi A, McCormick DA. Nat Neurosci. 1999 Jul. PMID: 10404196.
Ca(2+)-mediated up-regulation of Ih in the thalamus. How cell-intrinsic ionic currents may shape network activity.Lüthi A, McCormick DA. Ann N Y Acad Sci. 1999 Apr 30. PMID: 10414362.
Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges.Destexhe A, McCormick DA, Sejnowski TJ. Prog Brain Res. 1999. PMID: 10551033.
Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus.von Krosigk M, Monckton JE, Reiner PB, McCormick DA. Neuroscience. 1999. PMID: 10336055.
The functional influence of burst and tonic firing mode on synaptic interactions in the thalamus.Kim U, McCormick DA. J Neurosci. 1998 Nov 15. PMID: 9801387.
Functional and ionic properties of a slow afterhyperpolarization in ferret perigeniculate neurons in vitro.Kim U, McCormick DA. J Neurophysiol. 1998 Sep. PMID: 9744934.
H-current: properties of a neuronal and network pacemaker.Lüthi A, McCormick DA. Neuron. 1998 Jul. PMID: 9697847.
Periodicity of thalamic spindle waves is abolished by ZD7288,a blocker of Ih.Lüthi A, Bal T, McCormick DA. J Neurophysiol. 1998 Jun. PMID: 9636128.
Periodicity of thalamic synchronized oscillations: the role of Ca2+-mediated upregulation of Ih.Lüthi A, McCormick DA. Neuron. 1998 Mar. PMID: 9539128.
Inhibitory interactions between perigeniculate GABAergic neurons.Sanchez-Vives MV, Bal T, McCormick DA. J Neurosci. 1997 Nov 15. PMID: 9348356.
Functional properties of perigeniculate inhibition of dorsal lateral geniculate nucleus thalamocortical neurons in vitro.Sanchez-Vives MV, McCormick DA. J Neurosci. 1997 Nov 15. PMID: 9348355.
Functional dynamics of GABAergic inhibition in the thalamus.Kim U, Sanchez-Vives MV, McCormick DA. Science. 1997 Oct 3. PMID: 9311919.
Physiological properties of inhibitory interneurons in cat striate cortex.Azouz R, Gray CM, Nowak LG, McCormick DA. Cereb Cortex. 1997 Sep. PMID: 9276178.
Influence of low and high frequency inputs on spike timing in visual cortical neurons.Nowak LG, Sanchez-Vives MV, McCormick DA. Cereb Cortex. 1997 Sep. PMID: 9276174.
Synchronized oscillations in the inferior olive are controlled by the hyperpolarization-activated cation current I(h).Bal T, McCormick DA. J Neurophysiol. 1997 Jun. PMID: 9212264.
Modulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro.Lee KH, McCormick DA. Neuroscience. 1997 Mar. PMID: 9472394.
Sleep and arousal: thalamocortical mechanisms.McCormick DA, Bal T. Annu Rev Neurosci. 1997. PMID: 9056712.
Chattering cells: superficial pyramidal neurons contributing to the generation of synchronous oscillations in the visual cortex.Gray CM, McCormick DA. Science. 1996 Oct 4. PMID: 8810245.
Are the interlaminar zones of the ferret dorsal lateral geniculate nucleus actually part of the perigeniculate nucleus?Sanchez-Vives MV, Bal T, Kim U, von Krosigk M, McCormick DA. J Neurosci. 1996 Oct 1. PMID: 8815875.
Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices.Destexhe A, Bal T, McCormick DA, Sejnowski TJ. J Neurophysiol. 1996 Sep. PMID: 8890314.
Abolition of spindle oscillations by serotonin and norepinephrine in the ferret lateral geniculate and perigeniculate nuclei in vitro.Lee KH, McCormick DA. Neuron. 1996 Aug. PMID: 8780654.