Research

Research Focus

Dr. Praveen Mannam received his medical degree from Stanley Medical College, Dr. MGR Medical University, Chennai, India. He earned a master’s degree in Microbiology and Molecular biology at Oregon State University and completed both an internship and residency in Internal Medicine at Drexel University, Philadelphia. He then completed fellowship training in Pulmonary and Critical Care Medicine at the Yale University where he joined the faculty in 2011. He is currently an Assistant Professor of Medicine. Dr. Mannam’s clinical and research interests focus on innate immune mechanisms of sepsis. He was mentored in the lab of Dr. Patty J. Lee and is working in close collaboration with her lab to identify new therapeutic targets in sepsis and lung injury. 

Our laboratory is interested in determining the role of innate immune signaling pathways in sepsis and lung injury. Specifically, we are investigating the role of MKK3, a mitogen-activated protein kinase-signaling molecule, in the regulation of endothelial function and septic responses. The endothelium is central to the pathogenesis of sepsis through effects on inflammation, leukocyte recruitment, vascular tone, coagulation and thrombosis. We discovered that endothelial MKK3 controls oxidant and inflammatory responses in sepsis and that inhibition of MKK3 is protective against sepsis and lung injury. The ways in which MKK3 regulates responses to sepsis and injury are novel and include mitochondrial turnover (mitophagy), reactive oxygen species (ROS) generation and regulation of key inflammatory molecules. We have also initiated translational projects in the medical intensive care unit to examine MKK3 activity in critically ill patients and to correlate the findings to outcomes such as lung injury and death. Dr. Mannam is funded by the American Heart Association, the National Institute of Aging and the Claude D. Pepper Center / Yale Program on Aging.

Current Projects

1) Endothelial MKK3 mediates sepsis and lung injury.
2) MKK3 levels in critically ill septic patients.
3) Role of MKK3 in aging.