Jonathan Koff MD

Assistant Professor of Medicine (Pulmonary); Director, Adult Cystic Fibrosis Program

Departments & Organizations

Adult Cystic Fibrosis Program

Internal Medicine: Pulmonary, Critical Care & Sleep Medicine: Winchester Chest Clinic

Research Interests

Airway epithelial inflammation; Innate immunity; Mucosal immunology; EGFR signaling  more...


  • BACH OTHER, Hamilton College, 1993
  • M.D., Case Western Reserve University School of Medicine, 2000

Selected Publications

  • Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. (2013) Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med Sep 23;210(10):1929-36
  • Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP. Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection. Clin Transplant. 2013 Jan-Feb;27(1):E64-71.
  • Zhou Y, Lee JY, Lee CM, Cho WK, Kang MJ, Koff JL, Yoon PO, Chae J, Park HO, Elias JA, Lee CG. Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-ß-induced pulmonary fibrosis. J Biol Chem. 2012 Dec 7;287(50):41991-2000



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