Bio Profile

Mark Hochstrasser, PhD

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Research Interests

Enzymes; Molecular Biology; Saccharomyces cerevisiae; Mass Spectrometry; Transcription Factors; Microscopy, Immunoelectron; Gene Deletion; Ubiquitin; Cell Growth Processes; Mutant Chimeric Proteins

Part of the Yale faculty since 2000, Prof. Mark Hochstrasser holds appointments in the Department of Molecular Biophysics and Biochemistry, the Department of Molecular, Cellular and Developmental Biology and the School of Medicine’s Biological and Biomedical Sciences Program. He earned his B.A. at Rutgers University and his Ph.D. at the University of California, San Francisco, and conducted postdoctoral research at the Massachusetts Institute of Technology. He has earned numerous honors for...

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John Beckmann

Postdoctoral Associate in Molecular Biophysics and Biochemistry


Biochemistry; Entomology

BA in Art and Physiology, University of Minnesota;

PhD in Entomology, University of Minnesota;

I study the biochemistry and genetics of Wolbachia induced Cytoplasmic Incompatibility in hopes to utilize it as a tool for insect population control.

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Jason Berk, PhD

Postdoctoral Fellow in Molecular Biophysics and Biochemistry

Christopher Hickey, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

Christopher Hickey is a postdoctoral associate in the laboratory of Mark Hochstrasser. He earned a B.S. in Nutritional Sciences from Cornell University and a Ph.D. in Biochemistry at the Geisel School of Medicine at Dartmouth. Dr. Hickey has published extensively on diverse topics within the biological sciences, including metabolism, infectious disease, cellular organization and dynamics, and protein structure and function. His current research focuses on the roles of the ubiquitin and SUMO...

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Yanjie Li, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

Hong-Yeoul Rhu, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

Judith Ronau, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

I received my B.S. in Biology from Marquette University where I spent some time in the lab of James Maki investigating adhesion of quagga mussels to various biofilms. For graduate school I attended Purdue University where I joined Mahdi Abu-Omar's research group in 2008 to study substrate binding in the metabolic metalloenzyme, phenylalanine hydroxylase. During this time, I was co-advised by both Mahdi and Chitta Das. Before joining Mark Hochstrasser's lab here at Yale, I stayed on as a postdoc...

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Jennifer Gillies

Graduate Students
Regulation of sumoylation and desumoylation

B.Sc. University of Pittsburgh


Nicole Wilson

Graduate Student
Cellular functions of SUMO

B.S. Brown University


Lauren Budenholzer

Graduate Student
Assembly and localization of the proteasome

B.A. Pomona College

    • Ethanol-induced differential gene expression and acetyl-CoA metabolism in a longevity model of the nematode Caenorhabditis elegans.Patananan AN, Budenholzer LM, Eskin A, Torres ER, Clarke SG. Exp Gerontol. 2015 Jan;61:20-30.
    • Patananan AN, Budenholzer LM, Pedraza ME, Torres ER, Adler LN, Clarke SG. Arch Biochem Biophys. 2015 Mar 1; 569:32-44.

Chin Leng Cheng

Graduate Student 
Assembly of the proteasome base

B.Sc. University of Wisconsin, Madison


  • A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Desai KK, Cheng CL, Bingman CA, Phillips GN Jr, Raines RT. Nucleic Acids Res. 2014 Apr; 42:3931-3942.
  • Structure of RNA 3′-phosphate cyclase bound to substrate RNA. Desai KK, Bingman CA, Cheng CL, Phillips GN Jr, Raines RT. RNA. 2014 Oct; 20:1560-1566.


Arendt, Casey S.
Triathalon coach
Austin, TX 

Bebiana Vigário da Silva Sá Moura, Maria
Currently a Post Doc

Chen, Ping
Associate Professor
Department of Cell Biology
Emory University School of Medicine

Connerly, Pamela L.
Assistant Professor of Biology
Indiana University Southeast (New Albany, IN)

Felberbaum, Rachael
Manager of Scientific Communications
Protein Sciences Corporation (Meriden, CT) 

Hannich, Thomas
Postdoctoral Fellow (Howard Riezman lab)
Dept. of Biochemistry 
University of Geneva (Switzerland)

Johnson (Roberts), Phoebe
Associate Research Fellow
Pfizer (Boston)

Kroetz, Mary
Postdoc (David Zarkower lab)
Dept. Genetics, Cell Biology, and Development 
University of Minnesota

Kunjappu, Mary
Scientific Solutions at Envision Pharma Group
B.A. Barnard College, Columbia University

Lewis, Alaron
Postdoctoral Fellow (Susan Brockerhoff and Rachel Wong labs)
Dept. Biochemistry 
University of Washington (Seattle, WA)

Papa, Feroz
Associate Professor
Department of Medicine
UCSF (San Francisco, CA)

Schiffer, Linda
Staff Scientist
Dept. Medicine
University of Illinois (Chicago, IL)



emptySwanson, Robert
Associate Professor
Department of Biology
Valparaiso University (Valparaiso, IN)

Swaminathan, Sowmya
Chief Editor
Nature Cell Biology (London, UK)

Xie, Yang
Presidential Postdoctoral Fellow 
ovartis Institutes for Biomedical Research (Cambridge, MA) 

Zattas, Dimitrios
Research Fellow (Christopher Lima's Lab)
Memorial Sloan Kettering Institute (New York, NY)


Adle, David
Quality Control Scientist
Protein Sciences Corporation (Meriden, CT)

Amerik, Alexander (Sasha)

Bloom, Joanna
Scientific Writer
Envision Pharma

Deng, Min
Dentistry Resident (University of Connecticut)

Funakoshi, Minoru
Section of Educational System Center for Faculty Development 
Okayama University (Okayama, Japan)

Kerscher, Oliver
Associate Professor 
Department of Biology
College of William & Mary (Williamsburg, VA)

Kreft, Stefan
Junior Group Leader
Dept. of Biochemistry
University Konstanz (Germany)

Kusmierczyk, Andrew
Assistant Professor
Department of Biology
Indiana University-Purdue University Indianapolis

Laney, Jeff
Assistant Professor
Department of Mol. & Cell. Biology
University of Arizona (Tucson, AZ)

Li, Shyr-Jiann
Senior Research Scientist
Exelixis, Inc. (South San Francisco, CA)

Li, Xia
Senior Research Associate (Lab of Peter Novick)
Dept. of Cellular & Molecular Medicine 
University of California, San Diego 

Padhanabhan, Achuth 
Postdoctoral Associate 
Dept. of Molecular & Cell Biology 
Baylor College of Medicine

Pals-Rylaarsdam, Robin 

Dept. Biological Science
Benedictine University, (Lisle, IL)

Radke, Susanne
Research Scientist
Kolltan Pharmaceuticals, Inc. (New Haven, CT)

Ravid, Tommer
Assistant Professor
Dept. of Biological Chemistry
Hebrew University (Jerusalem, Israel)

RubensteinEric (V.J.)  
Assistant Professor
Department of Biology
Ball State University (Muncie, Indiana)

Sakata, Eri
Group Leader at Max Planck Institute

Schwartz, David
Data analyst
Bureau of Western Hemisphere Affairs
Department of State (DC)

Su, Dan   

Tomko Jr.,  Robert J.
Assistant Professor
Department of Biomedical Sciences
Florida State University (Tallahassee, Florida)

Velichutina, Irina
Research Scientist
Albert Einstein College of Medicine

Wang, Lin
Peking Union Medical College (Beijing, China)


Rakhilina, Larissa
Staff Scientist
Regeneron Pharmaceuticals (Tarrytown, NY)