Mark Hochstrasser

Tomko RJ Jr and Hochstrasser M: The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis. Mol Cell. 2014 Feb 6;53 (3) :433-43. Epub 2014 Jan 9. PMID: 24412063


Kunjappu MJ and Hochstrasser M: Assembly of the 20S proteasome. Biochim Biophys Acta. 2014 Jan;1843 (1) :2-12. Epub 2013 Mar 16. PMID: 23507199

Sá-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J and Hochstrasser M: A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem. 2013 Nov 22;288 (47) :33682-96. Epub 2013 Oct 11. PMID: 24121501


Zattas D, Adle DJ, Rubenstein EM and Hochstrasser M: N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Mol Biol Cell. 2013 Apr;24 (7) :890-900. Epub 2013 Jan 30. PMID: 23363603


Tomko RJ Jr and Hochstrasser M: Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem. 2013;82 :415-45. Epub 2013 Mar 13. PMID: 23495936

Hickey CM, Wilson NR and Hochstrasser M: Function and regulation of SUMO proteases. Nat Rev Mol Cell Biol. 2012 Dec;13 (12) :755-66. PMID: 23175280


Rubenstein EM, Kreft SG, Greenblatt W, Swanson R and Hochstrasser M: Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol. 2012 Jun 11;197 (6) :761-73. PMID: 22689655


Gillies J and Hochstrasser M: A new class of SUMO proteases. EMBO Rep. 2012 Apr 2;13 (4) :284-5. Epub 2012 Apr 2. PMID: 22422001


Hochstrasser M and Funakoshi M: Disulfide engineering to map subunit interactions in the proteasome and other macromolecular complexes. Methods Mol Biol. 2012;832 :349-62. PMID: 22350897


Felberbaum R, Wilson NR, Cheng D, Peng J and Hochstrasser M: Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol Cell Biol. 2012 Jan;32 (1) :64-75. Epub 2011 Oct 24. PMID: 22025676

Tomko RJ Jr and Hochstrasser M: Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining. Mol Cell. 2011 Dec 23;44 (6) :907-17. PMID: 22195964


Kreft SG and Hochstrasser M: An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme. J Biol Chem. 2011 Jun 10;286 (23) :20163-74. Epub 2011 Apr 5. PMID: 21467040


Tomko RJ Jr and Hochstrasser M: Order of the proteasomal ATPases and eukaryotic proteasome assembly. Cell Biochem Biophys. 2011 Jun;60 (1-2) :13-20. PMID: 21461838


Kusmierczyk AR, Kunjappu MJ, Kim RY and Hochstrasser M: A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. Nat Struct Mol Biol. 2011 May;18 (5) :622-9. Epub 2011 Apr 17. PMID: 21499243

Rubenstein EM and Hochstrasser M: Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor. Cell Cycle. 2010 Nov 1;9 (21) :4282-5. Epub 2010 Nov 22. PMID: 20980825


Su D and Hochstrasser M: A WLM protein with SUMO-directed protease activity. Mol Cell Biol. 2010 Aug;30 (15) :3734-6. Epub 2010 Jun 21. PMID: 20566698


Tomko RJ Jr, Funakoshi M, Schneider K, Wang J and Hochstrasser M: Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell. 2010 May 14;38 (3) :393-403. PMID: 20471945


Xie Y, Rubenstein EM, Matt T and Hochstrasser M: SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Genes Dev. 2010 May;24 (9) :893-903. Epub 2010 Apr 13. PMID: 20388728

Funakoshi M, Tomko RJ Jr, Kobayashi H and Hochstrasser M: Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell. 2009 May 29;137 (5) :887-99. Epub 2009 May 14. PMID: 19446322


Kroetz MB, Su D and Hochstrasser M: Essential role of nuclear localization for yeast Ulp2 SUMO protease function. Mol Biol Cell. 2009 Apr;20 (8) :2196-206. Epub 2009 Feb 18. PMID: 19225149


Hochstrasser M: Origin and function of ubiquitin-like proteins. Nature. 2009 Mar 26;458 (7237) :422-9. PMID: 19325621


Funakoshi M and Hochstrasser M: Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae. Yeast. 2009 Mar;26 (3) :185-92. PMID: 19243080


Kroetz MB and Hochstrasser M: Identification of SUMO-interacting proteins by yeast two-hybrid analysis. Methods Mol Biol. 2009;497 :107-20. PMID: 19107413

Wang L, Dong H, Soroka CJ, Wei N, Boyer JL and Hochstrasser M: Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology. 2008 Nov;48 (5) :1558-69. PMID: 18798335


Kusmierczyk AR and Hochstrasser M: Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis. Biol Chem. 2008 Sep;389 (9) :1143-51. PMID: 18713001


Kusmierczyk AR, Kunjappu MJ, Funakoshi M and Hochstrasser M: A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol. 2008 Mar;15 (3) :237-44. Epub 2008 Feb 17. PMID: 18278055


Felberbaum R and Hochstrasser M: Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis. Cell Cycle. 2008 Jan 1;7 (1) :52-6. Epub 2007 Oct 28. PMID: 18196960

Xie Y, Kerscher O, Kroetz MB, McConchie HF, Sung P and Hochstrasser M: The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem. 2007 Nov 23;282 (47) :34176-84. Epub 2007 Sep 11. PMID: 17848550


Schwartz DC, Felberbaum R and Hochstrasser M: The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint. Mol Cell Biol. 2007 Oct;27 (19) :6948-61. Epub 2007 Jul 30. PMID: 17664284


Lewis A, Felberbaum R and Hochstrasser M: A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. J Cell Biol. 2007 Aug 27;178 (5) :813-27. PMID: 17724121


Hochstrasser M: Ubiquitin ligation without a ligase. Dev Cell. 2007 Jul;13 (1) :4-6. PMID: 17609103


Li X, Kusmierczyk AR, Wong P, Emili A and Hochstrasser M: beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J. 2007 May 2;26 (9) :2339-49. Epub 2007 Apr 12. PMID: 17431397


Ravid T and Hochstrasser M: Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat Cell Biol. 2007 Apr;9 (4) :422-7. Epub 2007 Feb 21. PMID: 17310239

Deng M and Hochstrasser M: Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature. 2006 Oct 19;443 (7113) :827-31. PMID: 17051211


Arteaga MF, Wang L, Ravid T, Hochstrasser M and Canessa CM: An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A. 2006 Jul 25;103 (30) :11178-83. Epub 2006 Jul 17. PMID: 16847254


Hochstrasser M and Cohen R: Cecile M. Pickart 1954-2006. Nat Cell Biol. 2006 Jun;8 (6) :542-3. PMID: 16738698


Kreft SG, Wang L and Hochstrasser M: Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem. 2006 Feb 24;281 (8) :4646-53. Epub 2005 Dec 22. PMID: 16373356


Ravid T, Kreft SG and Hochstrasser M: Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J. 2006 Feb 8;25 (3) :533-43. Epub 2006 Jan 26. PMID: 16437165


Hochstrasser M: Lingering mysteries of ubiquitin-chain assembly. Cell. 2006 Jan 13;124 (1) :27-34. PMID: 16413479


Kerscher O, Felberbaum R and Hochstrasser M: Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol. 2006;22 :159-80. PMID: 16753028

Hannich JT, Lewis A, Kroetz MB, Li SJ, Heide H, Emili A and Hochstrasser M: Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem. 2005 Feb 11;280 (6) :4102-10. Epub 2004 Dec 6. PMID: 15590687

Amerik AY and Hochstrasser M: Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta. 2004 Nov 29;1695 (1-3) :189-207. PMID: 15571815


Ravid T and Hochstrasser M: NF-kappaB signaling: flipping the switch with polyubiquitin chains. Curr Biol. 2004 Oct 26;14 (20) :R898-900. PMID: 15498483


Velichutina I, Connerly PL, Arendt CS, Li X and Hochstrasser M: Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J. 2004 Feb 11;23 (3) :500-10. Epub 2004 Jan 22. PMID: 14739934

Laney JD and Hochstrasser M: Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state. Genes Dev. 2003 Sep 15;17 (18) :2259-70. Epub 2003 Sep 2. PMID: 12952895


Schwartz DC and Hochstrasser M: A superfamily of protein tags: ubiquitin, SUMO and related modifiers. Trends Biochem Sci. 2003 Jun;28 (6) :321-8. PMID: 12826404


Li SJ and Hochstrasser M: The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J Cell Biol. 2003 Mar 31;160 (7) :1069-81. Epub 2003 Mar 24. PMID: 12654900

Laney JD and Hochstrasser M: Analysis of protein ubiquitination. Curr Protoc Protein Sci. 2002 Nov;Chapter 14 :Unit 14.5. PMID: 18429222


Hochstrasser M: Molecular biology. New proteases in a ubiquitin stew. Science. 2002 Oct 18;298 (5593) :549-52. PMID: 12386321


Hochstrasser M: New structural clues to substrate specificity in the "ubiquitin system". Mol Cell. 2002 Mar;9 (3) :453-4. PMID: 11931752


Laney JD and Hochstrasser M: Assaying protein ubiquitination in Saccharomyces cerevisiae. Methods Enzymol. 2002;351 :248-57. PMID: 12073348

Lab Member Papers

Chisholm, C, Padmanabhan, A, Guan, B, Li, X, Kalra, S, Bieberich, CJ: Protein Kinase CK2 controls the stability of prostate derived ETS factor. The Open Cancer Journal. 2010, 3, 109-115.