Selected Publications
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- Highlighted Reviews
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All Publications
2024
- Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis.Cross AH, Gelfand JM, Thebault S, Bennett JL, von Büdingen HC, Cameron B, Carruthers R, Edwards K, Fallis R, Gerstein R, Giacomini PS, Greenberg B, Hafler DA, Ionete C, Kaunzner UW, Kodama L, Lock C, Longbrake EE, Musch B, Pardo G, Piehl F, Weber MS, Yuen S, Ziemssen T, Bose G, Freedman MS, Anania VG, Ramesh A, Winger RC, Jia X, Herman A, Harp C, Bar-Or A. JAMA Neurol. 2024 Mar 11; 2024 Mar 11. PMID: 38466277.
- The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases.Sumida TS, Cheru NT, Hafler DA. Nat Rev Immunol. 2024 Feb 19; 2024 Feb 19. PMID: 38374298.
- Systems Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis.Wei J, Moon J, Yasumizu Y, Zhang L, Radassi K, Buitrago-Pocasangre N, Deerhake ME, Strauli N, Chan A, Herman A, Pedotte R, Raposo C, Tackenberg B, Yim I, Pappalardo J, Longbrake EE, Sumida TS, Axisa PP, Hafler DA. bioRxiv. 2024 Feb 9; 2024 Feb 9. PMID: 38370778.
- Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, Dandekar R, Shannon CP, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Sesma AF, Simon V, van Bakel H, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS, Erle DJ, Langelier CR, Eckalbar W, Bosinger SE, Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC, Montgomery RR, Becker PM, Rouphael N. Nat Commun. 2024 Jan 3; 2024 Jan 3. PMID: 38172101.
2023
- scNAT: a deep learning method for integrating paired single-cell RNA and T cell receptor sequencing profiles.Zhu B, Wang Y, Ku LT, van Dijk D, Zhang L, Hafler DA, Zhao H. Genome Biol. 2023 Dec 18; 2023 Dec 18. PMID: 38111007.
- Early cellular and molecular signatures correlate with severity of West Nile virus infection.Lee HJ, Zhao Y, Fleming I, Mehta S, Wang X, Wyk BV, Ronca SE, Kang H, Chou CH, Fatou B, Smolen KK, Levy O, Clish CB, Xavier RJ, Steen H, Hafler DA, Love JC, Shalek AK, Guan L, Murray KO, Kleinstein SH, Montgomery RR. iScience. 2023 Dec 15; 2023 Nov 2. PMID: 38047068.
- Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208].Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Agudelo Higuita NI, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N. EBioMedicine. 2023 Dec; 2023 Nov 1. PMID: 37918220.
- Microfluidic Immuno-Serolomic Assay Reveals Systems Level Association with COVID-19 Pathology and Vaccine Protection.Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. Small Methods. 2023 Oct; 2023 Jun 13. PMID: 37312418.
- Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination.Asashima H, Kim D, Wang K, Lele N, Buitrago-Pocasangre NC, Lutz R, Cruz I, Raddassi K, Ruff WE, Racke MK, Wilson JE, Givens TS, Grifoni A, Weiskopf D, Sette A, Kleinstein SH, Montgomery RR, Shaw AC, Li F, Fan R, Hafler DA, Tomayko MM, Longbrake EE. JCI Insight. 2023 Aug 22; 2023 Aug 22. PMID: 37606046.
- ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis.Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. J Immunother Cancer. 2023 Aug. PMID: 37586769.
- Cytokines in New-Onset Refractory Status Epilepticus Predict Outcomes.Hanin A, Cespedes J, Dorgham K, Pulluru Y, Gopaul M, Gorochov G, Hafler DA, Navarro V, Gaspard N, Hirsch LJ. Ann Neurol. 2023 Jul; 2023 Mar 17. PMID: 36871188.
- Common genetic factors among autoimmune diseases.Harroud A, Hafler DA. Science. 2023 May 5; 2023 May 4. PMID: 37141355.
- Regulatory T cells in peripheral tissue tolerance and diseases.Cheru N, Hafler DA, Sumida TS. Front Immunol. 2023; 2023 May 1. PMID: 37197653.
- Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type and sex specificity of gene expression with novel genetic risk for MERTK in female.Zhang L, He CH, Coffey S, Yin D, Hsu IU, Su C, Ye Y, Zhang C, Spurrier J, Nicholson L, Rothlin CV, Ghosh S, Gopal PP, Hafler DA, Zhao H, Strittmatter SM. medRxiv. 2023 Feb 23; 2023 Feb 23. PMID: 36865305.
- Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.Côrte-Real BF, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen MW, Kurniawan H, Wagner A, Yosef N, Weiss SNY, Schmetterer KG, Schröder A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois LJ, Brenner D, Kempa S, Hafler DA, Stegbauer J, Linker RA, Jantsch J, Müller DN, Kleinewietfeld M. Cell Metab. 2023 Feb 7. PMID: 36754020.
- PD-1(high)CXCR5(-)CD4(+) peripheral helper T cells promote CXCR3(+) plasmablasts in human acute viral infection.Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein SH, Montgomery RR, Iwasaki A, Dela Cruz CS, Kaminski N, Shaw AC, Hafler DA, Sumida TS. Cell Rep. 2023 Jan 31; 2023 Jan 2. PMID: 36596303.
- Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity.Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A. Proc Natl Acad Sci U S A. 2023 Jan 17; 2023 Jan 12. PMID: 36634138.
2022
- A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.Axisa PP, Yoshida TM, Lucca LE, Kasler HG, Lincoln MR, Pham GH, Del Priore D, Carpier JM, Lucas CL, Verdin E, Sumida TS, Hafler DA. Sci Transl Med. 2022 Dec 14; 2022 Dec 14. PMID: 36516268.
- Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure.Qu R, Kluger Y, Yang J, Zhao J, Hafler DA, Krause DS, Bersenev A, Bosenberg M, Hurwitz M, Lucca L, Kluger HM. Mol Cancer. 2022 Dec 14; 2022 Dec 14. PMID: 36514045.
- The CELLO trial: Protocol of a planned phase 4 study to assess the efficacy of Ocrelizumab in patients with radiologically isolated syndrome.Longbrake EE, Hua LH, Mowry EM, Gauthier SA, Alvarez E, Cross AH, Pei J, Priest J, Raposo C, Hafler DA, Winger RC. Mult Scler Relat Disord. 2022 Dec; 2022 Aug 22. PMID: 36031693.
- Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis.Asashima H, Axisa PP, Pham THG, Longbrake EE, Ruff WE, Lele N, Cohen I, Raddassi K, Sumida TS, Hafler DA. J Clin Invest. 2022 Oct 17; 2022 Oct 17. PMID: 36250467.
- Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity.Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. bioRxiv. 2022 Sep 2; 2022 Sep 2. PMID: 36093346.
- Neuroimmune interactions in health and disease.Hafler DA, Sansing LH. Semin Immunopathol. 2022 Sep. PMID: 36171280.
- Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N. EBioMedicine. 2022 Sep; 2022 Aug 8. PMID: 35952496.
- Basic principles of neuroimmunology.Yoshida TM, Wang A, Hafler DA. Semin Immunopathol. 2022 Sep; 2022 Jun 22. PMID: 35732977.
- Fatty Acid Metabolism and T Cells in Multiple Sclerosis.Pompura SL, Hafler DA, Dominguez-Villar M. Front Immunol. 2022; 2022 May 4. PMID: 35603182.
- Population genetics meets single-cell sequencing.Sumida TS, Hafler DA. Science. 2022 Apr 8; 2022 Apr 7. PMID: 35389792.
- Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells.Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Nat Immunol. 2022 Apr; 2022 Mar 17. PMID: 35301508.
- Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain.Marsh SE, Walker AJ, Kamath T, Dissing-Olesen L, Hammond TR, de Soysa TY, Young AMH, Murphy S, Abdulraouf A, Nadaf N, Dufort C, Walker AC, Lucca LE, Kozareva V, Vanderburg C, Hong S, Bulstrode H, Hutchinson PJ, Gaffney DJ, Hafler DA, Franklin RJM, Macosko EZ, Stevens B. Nat Neurosci. 2022 Mar; 2022 Mar 8. PMID: 35260865.
- TCR-sequencing in cancer and autoimmunity: barcodes and beyond.Pauken KE, Lagattuta KA, Lu BY, Lucca LE, Daud AI, Hafler DA, Kluger HM, Raychaudhuri S, Sharpe AH. Trends Immunol. 2022 Mar; 2022 Jan 25. PMID: 35090787.
- Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study.Nowak RJ, Coffey CS, Goldstein JM, Dimachkie MM, Benatar M, Kissel JT, Wolfe GI, Burns TM, Freimer ML, Nations S, Granit V, Smith AG, Richman DP, Ciafaloni E, Al-Lozi MT, Sams LA, Quan D, Ubogu E, Pearson B, Sharma A, Yankey JW, Uribe L, Shy M, Amato AA, Conwit R, O'Connor KC, Hafler DA, Cudkowicz ME, Barohn RJ. Neurology. 2022 Jan 25; 2022 Jan 25. PMID: 34857535.
- Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Commun. 2022 Jan 21; 2022 Jan 21. PMID: 35064122.
2021
- The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity.Kuchroo JR, Hafler DA, Sharpe AH, Lucca LE. Sci Immunol. 2021 Nov 5; 2021 Nov 5. PMID: 34739340.
- (23)Na imaging: Worth its salt for understanding multiple sclerosis.Longbrake EE, Hafler DA. Proc Natl Acad Sci U S A. 2021 Aug 17. PMID: 34376559.
- Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells.Jiang R, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. JCI Insight. 2021 Jun 22; 2021 Jun 22. PMID: 34061047.
- Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19.Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. J Immunol. 2021 Jun 15; 2021 May 28. PMID: 34049971.
- NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data.He L, Davila-Velderrain J, Sumida TS, Hafler DA, Kellis M, Kulminski AM. Commun Biol. 2021 May 26; 2021 May 26. PMID: 34040149.
- Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells.Lucca LE, Axisa PP, Lu B, Harnett B, Jessel S, Zhang L, Raddassi K, Zhang L, Olino K, Clune J, Singer M, Kluger HM, Hafler DA. J Exp Med. 2021 Apr 5. PMID: 33651881.
- Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. medRxiv. 2021 Apr 3; 2021 Apr 3. PMID: 33300011.
- Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells.Tran TT, Rane CK, Zito CR, Weiss SA, Jessel S, Lucca L, Lu BY, Oria VO, Adeniran A, Chiang VL, Omay SB, Hafler DA, Kluger HM, Jilaveanu LB. Cancers (Basel). 2021 Mar 2; 2021 Mar 2. PMID: 33801444.
- Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis.Pompura SL, Wagner A, Kitz A, LaPerche J, Yosef N, Dominguez-Villar M, Hafler DA. J Clin Invest. 2021 Jan 19. PMID: 33170805.
2020
- Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity.Lincoln MR, Axisa PP, Hafler DA. Curr Opin Immunol. 2020 Dec; 2020 Sep 23. PMID: 32977183.
- Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Sumida TS, Dulberg S, Schupp J, Stillwell HA, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. bioRxiv. 2020 Oct 31; 2020 Oct 31. PMID: 33140047.
- Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans.Nakatsuka N, Patterson N, Patsopoulos NA, Altemose N, Tandon A, Beecham AH, McCauley JL, Isobe N, Hauser S, De Jager PL, Hafler DA, Oksenberg JR, Reich D. Sci Rep. 2020 Oct 9; 2020 Oct 9. PMID: 33037294.
- Transcriptomic and clonal characterization of T cells in the human central nervous system.Pappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA. Sci Immunol. 2020 Sep 18. PMID: 32948672.
- Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS.Lucca LE, Lerner BA, Park C, DeBartolo D, Harnett B, Kumar VP, Ponath G, Raddassi K, Huttner A, Hafler DA, Pitt D. Neurol Neuroimmunol Neuroinflamm. 2020 May 4; 2020 Apr 8. PMID: 32269065.
- CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome.Choileáin SN, Kleinewietfeld M, Raddassi K, Hafler DA, Ruff WE, Longbrake EE. J Transl Autoimmun. 2020; 2019 Dec 20. PMID: 32743517.
2019
- Siponimod Chips Away at Progressive MS.Longbrake EE, Hafler DA. Cell. 2019 Dec 12; 2019 Dec 12. PMID: 31951523.
- AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.Kitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M. EMBO Rep. 2019 Aug. PMID: 31379130.
- Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Nat Microbiol. 2019 Jun; 2019 Mar 11. PMID: 30858571.
- Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity.Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O'Connor KC. J Immunol. 2019 Apr 15; 2019 Mar 1. PMID: 30824481.
- Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients.James JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, Harley JB, Robinson W, Hafler DA, O'Connor KC, Buckner J, Guthridge JM, Norris JM, Holers VM. EBioMedicine. 2019 Apr; 2019 Apr 3. PMID: 30952617.
- From Big Data to Precision Medicine.Hulsen T, Jamuar SS, Moody AR, Karnes JH, Varga O, Hedensted S, Spreafico R, Hafler DA, McKinney EF. Front Med (Lausanne). 2019; 2019 Mar 1. PMID: 30881956.
- TIGIT signaling restores suppressor function of Th1 Tregs.Lucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA. JCI Insight. 2019 Feb 7; 2019 Feb 7. PMID: 30728325.
- Multiple sclerosis enters a grey area.Pappalardo JL, Hafler DA. Nature. 2019 Feb. PMID: 30809050.
- Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. J Autoimmun. 2019 Jan; 2018 Aug 16. PMID: 30122421.
2018
- Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.Ponath G, Lincoln MR, Levine-Ritterman M, Park C, Dahlawi S, Mubarak M, Sumida T, Airas L, Zhang S, Isitan C, Nguyen TD, Raine CS, Hafler DA, Pitt D. Nat Commun. 2018 Dec 17; 2018 Dec 17. PMID: 30559390.
- Activated β-catenin in Foxp3(+) regulatory T cells links inflammatory environments to autoimmunity.Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Nat Immunol. 2018 Dec; 2018 Oct 29. PMID: 30374130.
- Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV.Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. JCI Insight. 2018 Sep 20; 2018 Sep 20. PMID: 30232286.
- Regulatory T cells in autoimmune disease.Dominguez-Villar M, Hafler DA. Nat Immunol. 2018 Jul; 2018 Jun 20. PMID: 29925983.
2017
- Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. Front Immunol. 2017; 2018 Jan 15. PMID: 29379498.
- Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.Goods BA, Hernandez AL, Lowther DE, Lucca LE, Lerner BA, Gunel M, Raddassi K, Coric V, Hafler DA, Love JC. PLoS One. 2017; 2017 Sep 7. PMID: 28880903.
- Podoplanin is a negative regulator of Th17 inflammation.Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. JCI Insight. 2017 Sep 7; 2017 Sep 7. PMID: 28878118.
- Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment.Lucca LE, Hafler DA. J Clin Invest. 2017 Apr 3; 2017 Mar 20. PMID: 28319049.
- Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.Lucca LE, Hafler DA. Immunol Rev. 2017 Mar. PMID: 28258696.
- Solving Immunology?Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC. Trends Immunol. 2017 Feb; 2016 Dec 13. PMID: 27986392.
- TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage.Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. J Clin Invest. 2017 Jan 3; 2016 Nov 28. PMID: 27893460.
2016
- The Human Functional Genomics Project: Understanding Generation of Diversity.Pappalardo JL, Hafler DA. Cell. 2016 Nov 3. PMID: 27814519.
- National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence.Oh YS, Appel LJ, Galis ZS, Hafler DA, He J, Hernandez AL, Joe B, Karumanchi SA, Maric-Bilkan C, Mattson D, Mehta NN, Randolph G, Ryan M, Sandberg K, Titze J, Tolunay E, Toney GM, Harrison DG. Hypertension. 2016 Aug; 2016 Jun 20. PMID: 27324228.
- AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.Kitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M. EMBO Rep. 2016 Aug; 2016 Jun 16. PMID: 27312110.
- Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail.Longbrake EE, Hafler DA. JAMA Neurol. 2016 Jul 1. PMID: 27244583.
- Power estimation for non-standardized multisite studies.Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BMJ, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F, Hauser SL, Oksenberg JR, Henry RG. Neuroimage. 2016 Jul 1; 2016 Apr 1. PMID: 27039700.
- Multiple sclerosis: genetics, biomarkers, treatments.Axisa PP, Hafler DA. Curr Opin Neurol. 2016 Jun. PMID: 27058221.
- Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells.Arterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD. J Immunol. 2016 May 15; 2016 Apr 18. PMID: 27183637.
- PD-1 marks dysfunctional regulatory T cells in malignant gliomas.Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA. JCI Insight. 2016 Apr 21. PMID: 27182555.
- CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment.Cao Y, Nylander A, Ramanan S, Goods BA, Ponath G, Zabad R, Chiang VL, Vortmeyer AO, Hafler DA, Pitt D. Neurology. 2016 Apr 19; 2016 Mar 16. PMID: 26984943.
- Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis.Chastre A, Hafler DA, O'Connor KC. N Engl J Med. 2016 Apr 14. PMID: 27074083.
- The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.Kofler DM, Farkas A, von Bergwelt-Baildon M, Hafler DA. Curr Drug Targets. 2016. PMID: 26844569.
2015
- Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins.Willis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O'Connor KC. Front Immunol. 2015; 2015 Nov 25. PMID: 26648933.
- Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. J Clin Invest. 2015 Nov 2; 2015 Oct 20. PMID: 26524592.
- Biomarkers in multiple sclerosis.Housley WJ, Pitt D, Hafler DA. Clin Immunol. 2015 Nov; 2015 Jul 2. PMID: 26143623.
- Class II HLA interactions modulate genetic risk for multiple sclerosis.Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TMC, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J, Kockum I, Leslie S, Lill CM, Martinelli-Boneschi F, Oksenberg JR, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CCA, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S, McVean G. Nat Genet. 2015 Oct; 2015 Sep 7. PMID: 26343388.
- Prospects of immune checkpoint modulators in the treatment of glioblastoma.Preusser M, Lim M, Hafler DA, Reardon DA, Sampson JH. Nat Rev Neurol. 2015 Sep; 2015 Aug 11. PMID: 26260659.
- Sodium-activated macrophages: the salt mine expands.Lucca LE, Hafler DA. Cell Res. 2015 Aug; 2015 Jul 28. PMID: 26215700.
- Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Sci Transl Med. 2015 Jun 10. PMID: 26062845.
- Monoallelic expression of the human FOXP2 speech gene.Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A. Proc Natl Acad Sci U S A. 2015 Jun 2; 2014 Nov 24. PMID: 25422445.
- Genetic basis of autoimmunity.Marson A, Housley WJ, Hafler DA. J Clin Invest. 2015 Jun; 2015 Jun 1. PMID: 26030227.
- Thymic selection: to thine own self be true.Kitz A, Hafler DA. Immunity. 2015 May 19. PMID: 25992854.
- Editorial: T cell regulation by the environment.Hafler DA, Astier AL. Front Immunol. 2015; 2015 May 13. PMID: 26029214.
- Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Sci Transl Med. 2015 May 13. PMID: 25972006.
- Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC. J Infect Dis. 2015 Apr 1; 2014 Nov 2. PMID: 25367297.
- Multiple sclerosis-a quiet revolution.Ransohoff RM, Hafler DA, Lucchinetti CF. Nat Rev Neurol. 2015 Mar; 2015 Feb 17. PMID: 25686758.
- Genetic and epigenetic fine mapping of causal autoimmune disease variants.Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Nature. 2015 Feb 19; 2014 Oct 29. PMID: 25363779.
- TLR7 induces anergy in human CD4(+) T cells.Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA. Nat Immunol. 2015 Jan; 2014 Nov 17. PMID: 25401424.
2014
- Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA. Eur J Immunol. 2014 Sep; 2014 Jun 16. PMID: 24838857.
- B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC. Sci Transl Med. 2014 Aug 6. PMID: 25100741.
- TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells.Liu BS, Cao Y, Huizinga TW, Hafler DA, Toes RE. Eur J Immunol. 2014 Jul; 2014 Apr 16. PMID: 24737107.
- pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires.Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH. Bioinformatics. 2014 Jul 1; 2014 Mar 10. PMID: 24618469.
- Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. J Clin Invest. 2014 Jun; 2014 May 8. PMID: 24812667.
- Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL. Science. 2014 May 2. PMID: 24786080.
- Regulatory T cells in autoimmune neuroinflammation.Kleinewietfeld M, Hafler DA. Immunol Rev. 2014 May. PMID: 24712469.
- Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Immunity. 2014 Apr 17. PMID: 24745333.
- Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Immunity. 2014 Apr 17. PMID: 24745332.
- Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N. Science. 2014 Mar 7. PMID: 24604203.
- Role of "Western diet" in inflammatory autoimmune diseases.Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Curr Allergy Asthma Rep. 2014 Jan. PMID: 24338487.
2013
- Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Neurology. 2013 Nov 26; 2013 Oct 30. PMID: 24174586.
- Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data.Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F, Kleinstein SH. Front Immunol. 2013; 2013 Nov 15. PMID: 24298272.
- The plasticity of human Treg and Th17 cells and its role in autoimmunity.Kleinewietfeld M, Hafler DA. Semin Immunol. 2013 Nov 15; 2013 Nov 5. PMID: 24211039.
- Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL, de Bakker PI. PLoS Genet. 2013 Nov; 2013 Nov 21. PMID: 24278027.
- Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis.Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Mult Scler. 2013 Nov; 2013 Apr 23. PMID: 23612879.
- The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.Lozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. J Immunol. 2013 Oct 1; 2013 Aug 26. PMID: 23980210.
- Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Neurology. 2013 Sep 10; 2013 Aug 6. PMID: 23921886.
- Microbial reprogramming inhibits Western diet-associated obesity.Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ, Erdman SE. PLoS One. 2013; 2013 Jul 10. PMID: 23874682.
- Specific peripheral B cell tolerance defects in patients with multiple sclerosis.Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. J Clin Invest. 2013 Jun; 2013 May 15. PMID: 23676463.
- PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ. J Autoimmun. 2013 Jun; 2013 Mar 13. PMID: 23497938.
- Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Nature. 2013 Apr 25; 2013 Mar 6. PMID: 23467095.
- Immune-mediated disease genetics: the shared basis of pathogenesis.Cotsapas C, Hafler DA. Trends Immunol. 2013 Jan; 2012 Sep 29. PMID: 23031829.
2012
- Induction and molecular signature of pathogenic TH17 cells.Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Nat Immunol. 2012 Oct; 2012 Sep 9. PMID: 22961052.
- An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL. Sci Transl Med. 2012 Sep 26. PMID: 23019656.
- Regulatory T cells in the central nervous system.Lowther DE, Hafler DA. Immunol Rev. 2012 Jul. PMID: 22725960.
- Prostaglandin E2 affects T cell responses through modulation of CD46 expression.Kickler K, Maltby K, Ni Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN, Astier AL. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544928.
- The TIGIT/CD226 axis regulates human T cell function.Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. J Immunol. 2012 Apr 15; 2012 Mar 16. PMID: 22427644.
- Perspective: Deconstructing a disease.Hafler DA. Nature. 2012 Apr 12. PMID: 22509507.
- Multiple sclerosis.Nylander A, Hafler DA. J Clin Invest. 2012 Apr; 2012 Apr 2. PMID: 22466660.
- Polyfunctional responses by human T cells result from sequential release of cytokines.Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Proc Natl Acad Sci U S A. 2012 Jan 31; 2011 Dec 12. PMID: 22160692.
- Fingolimod for multiple sclerosis.Pelletier D, Hafler DA. N Engl J Med. 2012 Jan 26. PMID: 22276823.
- Class II MHC self-antigen presentation in human B and T lymphocytes.Costantino CM, Spooner E, Ploegh HL, Hafler DA. PLoS One. 2012; 2012 Jan 27. PMID: 22299025.
2011
- Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PI. Ann Neurol. 2011 Dec. PMID: 22190364.
- The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. J Immunol. 2011 Sep 15; 2011 Aug 17. PMID: 21849685.
- Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL. Hum Mol Genet. 2011 Sep 1; 2011 Jun 8. PMID: 21653641.
- Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis.Vosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BM, Crusius JB, van der Pouw Kraan TC, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH, Verweij CL. Genes Immun. 2011 Sep; 2011 Apr 7. PMID: 21471993.
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Martinelli Boneschi F, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters K, Comi G, Cossburn M, Cournu-Rebeix I, Cox MB, Cozen W, Cree BA, Cross AH, Cusi D, Daly MJ, Davis E, de Bakker PI, Debouverie M, D'hooghe MB, Dixon K, Dobosi R, Dubois B, Ellinghaus D, Elovaara I, Esposito F, Fontenille C, Foote S, Franke A, Galimberti D, Ghezzi A, Glessner J, Gomez R, Gout O, Graham C, Grant SF, Guerini FR, Hakonarson H, Hall P, Hamsten A, Hartung HP, Heard RN, Heath S, Hobart J, Hoshi M, Infante-Duarte C, Ingram G, Ingram W, Islam T, Jagodic M, Kabesch M, Kermode AG, Kilpatrick TJ, Kim C, Klopp N, Koivisto K, Larsson M, Lathrop M, Lechner-Scott JS, Leone MA, Leppä V, Liljedahl U, Bomfim IL, Lincoln RR, Link J, Liu J, Lorentzen AR, Lupoli S, Macciardi F, Mack T, Marriott M, Martinelli V, Mason D, McCauley JL, Mentch F, Mero IL, Mihalova T, Montalban X, Mottershead J, Myhr KM, Naldi P, Ollier W, Page A, Palotie A, Pelletier J, Piccio L, Pickersgill T, Piehl F, Pobywajlo S, Quach HL, Ramsay PP, Reunanen M, Reynolds R, Rioux JD, Rodegher M, Roesner S, Rubio JP, Rückert IM, Salvetti M, Salvi E, Santaniello A, Schaefer CA, Schreiber S, Schulze C, Scott RJ, Sellebjerg F, Selmaj KW, Sexton D, Shen L, Simms-Acuna B, Skidmore S, Sleiman PM, Smestad C, Sørensen PS, Søndergaard HB, Stankovich J, Strange RC, Sulonen AM, Sundqvist E, Syvänen AC, Taddeo F, Taylor B, Blackwell JM, Tienari P, Bramon E, Tourbah A, Brown MA, Tronczynska E, Casas JP, Tubridy N, Corvin A, Vickery J, Jankowski J, Villoslada P, Markus HS, Wang K, Mathew CG, Wason J, Palmer CN, Wichmann HE, Plomin R, Willoughby E, Rautanen A, Winkelmann J, Wittig M, Trembath RC, Yaouanq J, Viswanathan AC, Zhang H, Wood NW, Zuvich R, Deloukas P, Langford C, Duncanson A, Oksenberg JR, Pericak-Vance MA, Haines JL, Olsson T, Hillert J, Ivinson AJ, De Jager PL, Peltonen L, Stewart GJ, Hafler DA, Hauser SL, McVean G, Donnelly P, Compston A. Nature. 2011 Aug 10; 2011 Aug 10. PMID: 21833088.
- Pervasive sharing of genetic effects in autoimmune disease.Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC, Behrens T, Cho J, De Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, Siminovitch KA, van Heel DA, Wijmenga C, Worthington J, Todd JA, Hafler DA, Rich SS, Daly MJ. PLoS Genet. 2011 Aug; 2011 Aug 10. PMID: 21852963.
- Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. J Immunol. 2011 Jul 15; 2011 Jun 8. PMID: 21653833.
- A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility.Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD. Genes Immun. 2011 Jul; 2011 Feb 24. PMID: 21346779.
- Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Nat Med. 2011 Jun; 2011 May 3. PMID: 21540856.
- Immunology. An innate role for IL-17.Dominguez-Villar M, Hafler DA. Science. 2011 Apr 1. PMID: 21454778.
- Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. J Neuroimmunol. 2011 Apr; 2011 Feb 24. PMID: 21353315.
- Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.Gross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA, De Jager PL. J Neuroimmunol. 2011 Apr; 2010 Nov 27. PMID: 21115201.
- CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. J Immunol. 2011 Mar 15; 2011 Feb 7. PMID: 21300823.
- Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA. Brain. 2011 Feb; 2011 Jan 7. PMID: 21216828.
- Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JR. Genome Med. 2011 Jan 18; 2011 Jan 18. PMID: 21244703.
- Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine.Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML. Biosens Bioelectron. 2011 Jan 15; 2010 Sep 15. PMID: 20888750.
- Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery.Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE. PLoS One. 2011; 2011 Sep 30. PMID: 21980348.
2010
- Human regulatory T cells in autoimmune diseases.Cvetanovich GL, Hafler DA. Curr Opin Immunol. 2010 Dec; 2010 Sep 24. PMID: 20869862.
- A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.Ban M, McCauley JL, Zuvich R, Baker A, Bergamaschi L, Cox M, Kemppinen A, D'Alfonso S, Guerini FR, Lechner-Scott J, Dudbridge F, Wason J, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, Sexton D, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines J, Compston A, Sawcer S. Genes Immun. 2010 Dec; 2010 Jun 24. PMID: 20574445.
- Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF. Hum Mol Genet. 2010 Nov 1; 2010 Aug 10. PMID: 20699326.
- A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC, Monson NL. J Neuroimmunol. 2010 Sep 14; 2010 Jul 23. PMID: 20655601.
- A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. Arch Neurol. 2010 Sep. PMID: 20837847.
- HLA B*44: protective effects in MS susceptibility and MRI outcome measures.Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR, De Jager PL. Neurology. 2010 Aug 17. PMID: 20713950.
- Variation within DNA repair pathway genes and risk of multiple sclerosis.Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF. Am J Epidemiol. 2010 Jul 15; 2010 Jun 3. PMID: 20522537.
- FOXP3+ regulatory T cells in the human immune system.Sakaguchi S, Miyara M, Costantino CM, Hafler DA. Nat Rev Immunol. 2010 Jul; 2010 Jun 18. PMID: 20559327.
- TGF-beta induces IL-9 production from human Th17 cells.Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. J Immunol. 2010 Jul 1; 2010 May 24. PMID: 20498357.
- A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg JR, Hauser SL. PLoS One. 2010 Jun 25; 2010 Jun 25. PMID: 20593013.
- Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving.Han Q, Bradshaw EM, Nilsson B, Hafler DA, Love JC. Lab Chip. 2010 Jun 7; 2010 Apr 8. PMID: 20376398.
- Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I, Olsson T, Hillert J, Ban M, Baker A, Kemppinen A, Sawcer S, Compston A, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, McCauley JL, Pericak-Vance MA, Oksenberg JR, Hauser SL, Sexton D, Haines J. Nat Genet. 2010 Jun. PMID: 20502484.
- CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL, Hauser SL, Oksenberg JR, Barcellos LF. Hum Mol Genet. 2010 Jun 1; 2010 Mar 8. PMID: 20211854.
- Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.Zuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, Aubin C, Cross AH, Piccio L, Aggarwal NT, Evans D, Hafler DA, Compston A, Hauser SL, Pericak-Vance MA, Haines JL. Hum Genet. 2010 Mar; 2010 Jan 30. PMID: 20112030.
- Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.Jakkula E, Leppä V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML, Elovaara I, Pirttilä T, Reunanen M, Aromaa A, Oturai AB, Søndergaard HB, Harbo HF, Mero IL, Gabriel SB, Mirel DB, Hauser SL, Kappos L, Polman C, De Jager PL, Hafler DA, Daly MJ, Palotie A, Saarela J, Peltonen L. Am J Hum Genet. 2010 Feb 12. PMID: 20159113.
- RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels.Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N. J Immunol. 2010 Jan 15; 2009 Dec 16. PMID: 20018615.
- On-chip activation and subsequent detection of individual antigen-specific T cells.Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. Anal Chem. 2010 Jan 15. PMID: 20000848.
- Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry.Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. J Phys Chem B. 2010 Jan 14. PMID: 19954153.
- T-cells in multiple sclerosis.Severson C, Hafler DA. Results Probl Cell Differ. 2010. PMID: 19582415.
2009
- Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler DA, Karlson EW. Lancet Neurol. 2009 Dec; 2009 Oct 29. PMID: 19879194.
- Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O'Connor KC. Brain. 2009 Dec. PMID: 19638446.
- Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL. Proc Natl Acad Sci U S A. 2009 Nov 3; 2009 Oct 21. PMID: 19846760.
- Engineered interleukin-2 antagonists for the inhibition of regulatory T cells.Liu DV, Maier LM, Hafler DA, Wittrup KD. J Immunother. 2009 Nov-Dec. PMID: 19816193.
- Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. J Immunol. 2009 Oct 1; 2009 Sep 11. PMID: 19748982.
- Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. J Immunol. 2009 Sep 15; 2009 Aug 17. PMID: 19687098.
- TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. Eur J Immunol. 2009 Sep. PMID: 19676072.
- De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, Eavey RD, Plenge RM, Shadick NA, Weinblatt ME, De Jager PL, Hafler DA, Breitbart RE, Seidman JG, Seidman CE. Nat Genet. 2009 Aug; 2009 Jul 13. PMID: 19597493.
- Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells.Costantino CM, Ploegh HL, Hafler DA. J Immunol. 2009 Jul 15; 2009 Jun 24. PMID: 19553543.
- Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR. Nat Genet. 2009 Jul; 2009 Jun 14. PMID: 19525953.
- Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid.Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP, Gilden D. Ann Neurol. 2009 Jun. PMID: 19557869.
- Automated high-dimensional flow cytometric data analysis.Pyne S, Hu X, Wang K, Rossin E, Lin TI, Maier LM, Baecher-Allan C, McLachlan GJ, Tamayo P, Hafler DA, De Jager PL, Mesirov JP. Proc Natl Acad Sci U S A. 2009 May 26; 2009 May 14. PMID: 19443687.
- Autoimmunity risk alleles in costimulation pathways.Maier LM, Hafler DA. Immunol Rev. 2009 May. PMID: 19426231.
- Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J. Hum Mol Genet. 2009 May 1; 2009 Feb 16. PMID: 19221116.
- IL-17-producing human peripheral regulatory T cells retain suppressive function.Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. Blood. 2009 Apr 30; 2009 Jan 26. PMID: 19171879.
- The role of the CD58 locus in multiple sclerosis.De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. Proc Natl Acad Sci U S A. 2009 Mar 31; 2009 Feb 23. PMID: 19237575.
- Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. J Immunol. 2009 Feb 1. PMID: 19155502.
- IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager PL, Wicker LS, Todd JA, Hafler DA. PLoS Genet. 2009 Jan; 2009 Jan 2. PMID: 19119414.
2008
- TIMs: central regulators of immune responses.Hafler DA, Kuchroo V. J Exp Med. 2008 Nov 24; 2008 Nov 17. PMID: 19015312.
- Multiple sclerosis and regulatory T cells.Costantino CM, Baecher-Allan C, Hafler DA. J Clin Immunol. 2008 Nov; 2008 Sep 2. PMID: 18763026.
- Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Clin Immunol. 2008 Oct. PMID: 18675591.
- CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. Neurology. 2008 Sep 16. PMID: 18794494.
- IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. Nature. 2008 Jul 17; 2008 May 11. PMID: 18469800.
- Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss.Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Transplantation. 2008 Jul 15. PMID: 18622278.
- Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells.De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O'Brien C, Freeman S, Granados S, Parker A, Roubenoff R, Mesirov JP, Khoury SJ, Hafler DA, Weiner HL. Brain. 2008 Jul; 2008 Jun 21. PMID: 18567923.
- Human regulatory T cells and autoimmunity.Costantino CM, Baecher-Allan CM, Hafler DA. Eur J Immunol. 2008 Apr. PMID: 18395861.
- TIM-4 expressed on APCs induces T cell expansion and survival.Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. J Immunol. 2008 Apr 1. PMID: 18354194.
- Lack of TIM-3 immunoregulation in multiple sclerosis.Yang L, Anderson DE, Kuchroo J, Hafler DA. J Immunol. 2008 Apr 1. PMID: 18354161.
- Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.De Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA, Ascherio A. Neurology. 2008 Mar 25; 2008 Feb 13. PMID: 18272866.
- Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis.Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. J Neuroimmunol. 2008 Mar; 2008 Apr 10. PMID: 18403025.
- Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation.Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. J Immunol. 2008 Mar 1. PMID: 18292509.
- The developing mosaic of autoimmune disease risk.Maier LM, Hafler DA. Nat Genet. 2008 Feb. PMID: 18227869.
2007
- Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D. Nat Genet. 2007 Dec; 2007 Nov 4. PMID: 17982456.
- Allelic variant in CTLA4 alters T cell phosphorylation patterns.Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA. Proc Natl Acad Sci U S A. 2007 Nov 20; 2007 Nov 13. PMID: 18000051.
- Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Science. 2007 Nov 16. PMID: 18006747.
- Abnormal Tr1 differentiation in multiple sclerosis.Astier AL, Hafler DA. J Neuroimmunol. 2007 Nov; 2007 Oct 22. PMID: 17936368.
- Risk alleles for multiple sclerosis identified by a genomewide study.Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL. N Engl J Med. 2007 Aug 30; 2007 Jul 29. PMID: 17660530.
- Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L. Nature. 2007 Jul 26; 2007 Jun 13. PMID: 17568699.
- The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases.De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA, Rioux JD. Genes Immun. 2007 Jul; 2007 May 31. PMID: 17538633.
- Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes.Cai G, Hafler DA. Eur J Immunol. 2007 Mar. PMID: 17304631.
- A second major histocompatibility complex susceptibility locus for multiple sclerosis.Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, Trowsdale J, Caillier SJ, Ivinson AJ, Green T, Pobywajlo S, Lander ES, Pericak-Vance MA, Haines JL, Daly MJ, Oksenberg JR, Hauser SL, Compston A, Hafler DA, Rioux JD, Sawcer S. Ann Neurol. 2007 Mar. PMID: 17252545.
- Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Nat Med. 2007 Feb; 2007 Jan 12. PMID: 17237795.
- New therapeutic approaches for multiple sclerosis.De Jager PL, Hafler DA. Annu Rev Med. 2007. PMID: 17217332.
- A local antigen-driven humoral response is present in the inflammatory myopathies.Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O'Connor KC. J Immunol. 2007 Jan 1. PMID: 17182595.
2006
- Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.Astier AL, Meiffren G, Freeman S, Hafler DA. J Clin Invest. 2006 Dec; 2006 Nov 9. PMID: 17099776.
- A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD. Nat Genet. 2006 Oct; 2006 Sep 24. PMID: 16998491.
- Human regulatory T cells and their role in autoimmune disease.Baecher-Allan C, Hafler DA. Immunol Rev. 2006 Aug. PMID: 16903916.
- Dysregulated T cell expression of TIM3 in multiple sclerosis.Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. J Exp Med. 2006 Jun 12; 2006 Jun 5. PMID: 16754722.
- The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.De Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ, Rioux JD. Genes Immun. 2006 Jun; 2006 Apr 27. PMID: 16642031.
- The purification and functional analysis of human CD4+CD25high regulatory T cells.Baecher-Allan CM, Hafler DA. Curr Protoc Immunol. 2006 May. PMID: 18432975.
- MHC class II expression identifies functionally distinct human regulatory T cells.Baecher-Allan C, Wolf E, Hafler DA. J Immunol. 2006 Apr 15. PMID: 16585553.
- Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD. Eur J Hum Genet. 2006 Mar. PMID: 16391555.
- Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers.O'Connor KC, Roy SM, Becker CH, Hafler DA, Kantor AB. Dis Markers. 2006. PMID: 17124343.
2005
- Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells.Baecher-Allan CM, Hafler DA. Clin Immunol. 2005 Nov. PMID: 16214081.
- A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. Nat Genet. 2005 Oct; 2005 Sep 25. PMID: 16186815.
- Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells.Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. J Immunol. 2005 Oct 1. PMID: 16177088.
- A high-density screen for linkage in multiple sclerosis.Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. Am J Hum Genet. 2005 Sep; 2005 Jul 29. PMID: 16080120.
- Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. J Immunol. 2005 Aug 1. PMID: 16034142.
- Characterization of in vivo expanded OspA-specific human T-cell clones.Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Clin Immunol. 2005 Jun. PMID: 15893699.
- Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Nature. 2005 May 12. PMID: 15889096.
- Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells.Baecher-Allan C, Wolf E, Hafler DA. Clin Immunol. 2005 Apr. PMID: 15870015.
- Multiple sclerosis.Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Immunol Rev. 2005 Apr. PMID: 15790361.
- High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model.Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, Altmann DM. J Immunol. 2005 Feb 15. PMID: 15699121.
- Applying a new generation of genetic maps to understand human inflammatory disease.Hafler DA, De Jager PL. Nat Rev Immunol. 2005 Jan. PMID: 15630431.
2004
- Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, Pericak-Vance MA, Barcellos L, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. Hum Mol Genet. 2004 Sep 1; 2004 Jul 6. PMID: 15238506.
- Suppressor T cells in human diseases.Baecher-Allan C, Hafler DA. J Exp Med. 2004 Aug 2; 2004 Jul 26. PMID: 15280423.
- PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells.Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ. Cell Immunol. 2004 Aug. PMID: 15598424.
- Re: GAMES issue study: Are international genetic consortia functional?De Jager PL, Walsh EC, Rioux JD, Hafler DA. J Neuroimmunol. 2004 Aug. PMID: 15334748.
- Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. J Immunol. 2004 Aug 1. PMID: 15265898.
- Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis.Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Eur J Immunol. 2004 Jul. PMID: 15214032.
- T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. J Immunol. 2004 Jun 1. PMID: 15153541.
- An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. Immunity. 2004 May. PMID: 15142525.
- Gene expression profiling in MS: what is the clinical relevance?De Jager PL, Hafler DA. Lancet Neurol. 2004 May. PMID: 15099539.
- A high-density admixture map for disease gene discovery in african americans.Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De The G, Essex M, Sankale JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien SJ, Reich D. Am J Hum Genet. 2004 May; 2004 Apr 14. PMID: 15088270.
- Methods for high-density admixture mapping of disease genes.Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Am J Hum Genet. 2004 May; 2004 Apr 14. PMID: 15088269.
- Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis.Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. J Exp Med. 2004 Apr 5. PMID: 15067033.
- Human CD4+CD25+ regulatory T cells.Baecher-Allan C, Viglietta V, Hafler DA. Semin Immunol. 2004 Apr. PMID: 15036232.
- Multiple sclerosis.Hafler DA. J Clin Invest. 2004 Mar. PMID: 15067307.
- Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity.Slavik JM, Lim DG, Burakoff SJ, Hafler DA. J Biol Chem. 2004 Jan 9; 2003 Oct 22. PMID: 14573608.
2003
- Genetic analysis of multiple sclerosis.Walsh EC, Guschwan-McMahon S, Daly MJ, Hafler DA, Rioux JD. J Autoimmun. 2003 Sep. PMID: 12935779.
- Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function.Lim DG, Slavik JM, Bourcier K, Smith KJ, Hafler DA. J Exp Med. 2003 Jul 7. PMID: 12847139.
- In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis.Schmied M, Duda PW, Krieger JI, Trollmo C, Hafler DA. Clin Immunol. 2003 Mar. PMID: 12706402.
- Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions.O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. J Neuroimmunol. 2003 Mar. PMID: 12620653.
- Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.Buckle GJ, Höllsberg P, Hafler DA. Neurology. 2003 Feb 25. PMID: 12601116.
- CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls.Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. J Autoimmun. 2003 Feb. PMID: 12604314.
- CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo.Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. Novartis Found Symp. 2003. PMID: 14609213.
- CTLA4 is associated with susceptibility to multiple sclerosis.Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, de Andrade M, Hafler DA, Weinshenker BG. J Neuroimmunol. 2003 Jan. PMID: 12507781.