Publications

Hafler Laboratory Publications

Kleinewietfeld M and Hafler DA: Regulatory T cells in autoimmune neuroinflammation. Immunol Rev. 2014 May;259 (1) :231-44. PMID: 24712469

Kleinewietfeld M and Hafler DA: The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol. 2013 Nov 15;25 (4) :305-12. Epub 2013 Nov 5. PMID: 24211039


Lozano E, Joller N, Cao Y, Kuchroo VK and Hafler DA: The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol. 2013 Oct 1;191 (7) :3673-80. Epub 2013 Aug 26. PMID: 23980210


Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN and Hafler DA: Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013 Apr 25;496 (7446) :518-22. Epub 2013 Mar 6. PMID: 23467095


Cotsapas C and Hafler DA: Immune-mediated disease genetics: the shared basis of pathogenesis. Trends Immunol. 2013 Jan;34 (1) :22-6. Epub 2012 Sep 29. PMID: 23031829

Lowther DE and Hafler DA: Regulatory T cells in the central nervous system. Immunol Rev. 2012 Jul;248 (1) :156-69. PMID: 22725960


Lozano E, Dominguez-Villar M, Kuchroo V and Hafler DA: The TIGIT/CD226 axis regulates human T cell function. J Immunol. 2012 Apr 15;188 (8) :3869-75. Epub 2012 Mar 16. PMID: 22427644


Hafler DA: Perspective: Deconstructing a disease. Nature. 2012 Apr 12;484 (7393) :S6. PMID: 22509507


Nylander A and Hafler DA: Multiple sclerosis. J Clin Invest. 2012 Apr 2;122 (4) :1180-8. Epub 2012 Apr 2. PMID: 22466660


Pelletier D and Hafler DA: Fingolimod for multiple sclerosis. N Engl J Med. 2012 Jan 26;366 (4) :339-47. PMID: 22276823


Costantino CM, Spooner E, Ploegh HL and Hafler DA: Class II MHC self-antigen presentation in human B and T lymphocytes. PLoS One. 2012;7 (1) :e29805. Epub 2012 Jan 27. PMID: 22299025

Kofler DM, Severson CA, Mousissian N, De Jager PL and Hafler DA: The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J Immunol. 2011 Sep 15;187 (6) :3286-91. Epub 2011 Aug 17. PMID: 21849685


Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW and Hafler DA: Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol. 2011 Jul 15;187 (2) :1039-46. Epub 2011 Jun 8. PMID: 21653833


Dominguez-Villar M, Baecher-Allan CM and Hafler DA: Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med. 2011 Jun;17 (6) :673-5. Epub 2011 May 3. PMID: 21540856


Dominguez-Villar M and Hafler DA: Immunology. An innate role for IL-17. Science. 2011 Apr 1;332 (6025) :47-8. PMID: 21454778


Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M and Hafler DA: CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol. 2011 Mar 15;186 (6) :3317-26. Epub 2011 Feb 7. PMID: 21300823


Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC and Hafler DA: Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain. 2011 Feb;134 (Pt 2) :534-41. Epub 2011 Jan 7. PMID: 21216828

Cvetanovich GL and Hafler DA: Human regulatory T cells in autoimmune diseases. Curr Opin Immunol. 2010 Dec;22 (6) :753-60. Epub 2010 Sep 24. PMID: 20869862


Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C and Hafler DA: TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 1;185 (1) :46-54. Epub 2010 May 24. PMID: 20498357


Sakaguchi S, Miyara M, Costantino CM and Hafler DA: FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010 Jul;10 (7) :490-500. Epub 2010 Jun 18. PMID: 20559327


Severson C and Hafler DA: T-cells in multiple sclerosis. Results Probl Cell Differ. 2010;51 :75-98. PMID: 19582415

Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC and Hafler DA: Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009 Oct 1;183 (7) :4432-9. Epub 2009 Sep 11. PMID: 19748982


Costantino CM, Ploegh HL and Hafler DA: Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. J Immunol. 2009 Jul 15;183 (2) :945-52. Epub 2009 Jun 24. PMID: 19553543


Maier LM and Hafler DA: Autoimmunity risk alleles in costimulation pathways. Immunol Rev. 2009 May;229 (1) :322-36. PMID: 19426231


Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C and Hafler DA: IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30;113 (18) :4240-9. Epub 2009 Jan 26. PMID: 19171879


De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR and Hafler DA: The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31;106 (13) :5264-9. Epub 2009 Feb 23. PMID: 19237575


Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL and Hafler DA: Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol. 2009 Feb 1;182 (3) :1541-7. PMID: 19155502


Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager PL, Wicker LS, Todd JA and Hafler DA: IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 2009 Jan;5 (1) :e1000322. Epub 2009 Jan 2. PMID: 19119414

Costantino CM, Baecher-Allan C and Hafler DA: Multiple sclerosis and regulatory T cells. J Clin Immunol. 2008 Nov;28 (6) :697-706. Epub 2008 Sep 2. PMID: 18763026


Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK and Hafler DA: IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008 Jul 17;454 (7202) :350-2. Epub 2008 May 11. PMID: 18469800


Costantino CM, Baecher-Allan CM and Hafler DA: Human regulatory T cells and autoimmunity. Eur J Immunol. 2008 Apr;38 (4) :921-4. PMID: 18395861


Yang L, Anderson DE, Kuchroo J and Hafler DA: Lack of TIM-3 immunoregulation in multiple sclerosis. J Immunol. 2008 Apr 1;180 (7) :4409-14. PMID: 18354161


Maier LM and Hafler DA: The developing mosaic of autoimmune disease risk. Nat Genet. 2008 Feb;40 (2) :131-2. PMID: 18227869

Maier LM, Anderson DE, De Jager PL, Wicker LS and Hafler DA: Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proc Natl Acad Sci U S A. 2007 Nov 20;104 (47) :18607-12. Epub 2007 Nov 13. PMID: 18000051


Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK and Hafler DA: Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science. 2007 Nov 16;318 (5853) :1141-3. PMID: 18006747


Astier AL and Hafler DA: Abnormal Tr1 differentiation in multiple sclerosis. J Neuroimmunol. 2007 Nov;191 (1-2) :70-8. Epub 2007 Oct 22. PMID: 17936368


Cai G and Hafler DA: Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes. Eur J Immunol. 2007 Mar;37 (3) :602-12. PMID: 17304631


De Jager PL and Hafler DA: New therapeutic approaches for multiple sclerosis. Annu Rev Med. 2007;58 :417-32. PMID: 17217332

Astier AL, Meiffren G, Freeman S and Hafler DA: Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest. 2006 Dec;116 (12) :3252-7. Epub 2006 Nov 9. PMID: 17099776


Baecher-Allan C and Hafler DA: Human regulatory T cells and their role in autoimmune disease. Immunol Rev. 2006 Aug;212 :203-16. PMID: 16903916


Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK and Hafler DA: Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006 Jun 12;203 (6) :1413-8. Epub 2006 Jun 5. PMID: 16754722


Baecher-Allan CM and Hafler DA: The purification and functional analysis of human CD4+CD25high regulatory T cells. Curr Protoc Immunol. 2006 May;Chapter 7 :Unit 7.4B. PMID: 18432975


Baecher-Allan C, Wolf E and Hafler DA: MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol. 2006 Apr 15;176 (8) :4622-31. PMID: 16585553

Baecher-Allan CM and Hafler DA: Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clin Immunol. 2005 Nov;117 (2) :192; discussion 193. PMID: 16214081


Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B and Hafler DA: Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. J Immunol. 2005 Oct 1;175 (7) :4458-64. PMID: 16177088


Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR and Hafler DA: A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet. 2005 Oct;37 (10) :1113-8. Epub 2005 Sep 25. PMID: 16186815


Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT and Hafler DA: Characterization of in vivo expanded OspA-specific human T-cell clones. Clin Immunol. 2005 Jun;115 (3) :313-22. PMID: 15893699


Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ and Hafler DA: Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature. 2005 May 12;435 (7039) :224-8. PMID: 15889096


Baecher-Allan C, Wolf E and Hafler DA: Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clin Immunol. 2005 Apr;115 (1) :10-8. PMID: 15870015

Baecher-Allan C and Hafler DA: Suppressor T cells in human diseases. J Exp Med. 2004 Aug 2;200 (3) :273-6. Epub 2004 Jul 26. PMID: 15280423


Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK and Hafler DA: Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 1;173 (3) :1689-98. PMID: 15265898


De Jager PL, Walsh EC, Rioux JD and Hafler DA: Re: GAMES issue study: Are international genetic consortia functional? J Neuroimmunol. 2004 Aug;153 (1-2) :5-6. PMID: 15334748


De Jager PL and Hafler DA: Gene expression profiling in MS: what is the clinical relevance? Lancet Neurol. 2004 May;3 (5) :269. PMID: 15099539


Viglietta V, Baecher-Allan C, Weiner HL and Hafler DA: Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004 Apr 5;199 (7) :971-9. PMID: 15067033


Baecher-Allan C, Viglietta V and Hafler DA: Human CD4+CD25+ regulatory T cells. Semin Immunol. 2004 Apr;16 (2) :89-98. PMID: 15036232


Hafler DA: Multiple sclerosis. J Clin Invest. 2004 Mar;113 (6) :788-94. PMID: 15067307


Slavik JM, Lim DG, Burakoff SJ and Hafler DA: Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. J Biol Chem. 2004 Jan 9;279 (2) :910-9. Epub 2003 Oct 22. PMID: 14573608

Lim DG, Slavik JM, Bourcier K, Smith KJ and Hafler DA: Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function. J Exp Med. 2003 Jul 7;198 (1) :99-109. PMID: 12847139


Schmied M, Duda PW, Krieger JI, Trollmo C and Hafler DA: In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis. Clin Immunol. 2003 Mar;106 (3) :163-74. PMID: 12706402


O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW and Hafler DA: Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol. 2003 Mar;136 (1-2) :140-8. PMID: 12620653


Buckle GJ, Höllsberg P and Hafler DA: Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin. Neurology. 2003 Feb 25;60 (4) :702-5. PMID: 12601116


Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI and Hafler DA: CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. J Autoimmun. 2003 Feb;20 (1) :71-81. PMID: 12604314


Baecher-Allan C, Brown JA, Freeman GJ and Hafler DA: CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp. 2003;252 :67-88; discussion 88-91, 106-14. PMID: 14609213

Baecher-Allan C, Viglietta V and Hafler DA: Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol. 2002 Dec 1;169 (11) :6210-7. PMID: 12444126


Lim DG, Höllsberg P and Hafler DA: Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells. Cell Immunol. 2002 May-Jun;217 (1-2) :36-46. PMID: 12425999


Viglietta V, Kent SC, Orban T and Hafler DA: GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest. 2002 Apr;109 (7) :895-903. PMID: 11927616


Hafler DA: Degeneracy, as opposed to specificity, in immunotherapy. J Clin Invest. 2002 Mar;109 (5) :581-4. PMID: 11877465

Bar-Or A, Oliveira EM, Anderson DE, Krieger JI, Duddy M, O'Connor KC and Hafler DA: Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. J Immunol. 2001 Nov 15;167 (10) :5669-77. PMID: 11698439


Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K and Hafler DA: Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. J Virol. 2001 Oct;75 (20) :9836-43. PMID: 11559817


Ohashi T, Yukitake M, Slavin A, Krieger J and Hafler DA: In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG. J Neuroimmunol. 2001 Aug 30;118 (2) :194-202. PMID: 11498254


Baecher-Allan C, Brown JA, Freeman GJ and Hafler DA: CD4+CD25high regulatory cells in human peripheral blood. J Immunol. 2001 Aug 1;167 (3) :1245-53. PMID: 11466340


O'Connor KC, Bar-Or A and Hafler DA: The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J Clin Immunol. 2001 Mar;21 (2) :81-92. PMID: 11332657


Slavik JM, Lim DG, Burakoff SJ and Hafler DA: Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes. J Immunol. 2001 Mar 1;166 (5) :3201-9. PMID: 11207273


Anderson DE and Hafler DA: Immune tolerance and the nervous system. Adv Exp Med Biol. 2001;490 :79-98. PMID: 11505978


Orban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA and Hafler DA: Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset. Autoimmunity. 2001;34 (4) :247-64. PMID: 11905851


Gausling R, Trollmo C and Hafler DA: Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis. Clin Immunol. 2001 Jan;98 (1) :11-7. PMID: 11141321

Duda PW, Krieger JI, Schmied MC, Balentine C and Hafler DA: Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate. J Immunol. 2000 Dec 15;165 (12) :7300-7. PMID: 11120865


Harrison LC and Hafler DA: Antigen-specific therapy for autoimmune disease. Curr Opin Immunol. 2000 Dec;12 (6) :704-11. PMID: 11102776


Lim DG, Bieganowska Bourcier K, Freeman GJ and Hafler DA: Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope. J Immunol. 2000 Dec 1;165 (11) :6214-20. PMID: 11086055


Meyer AL, Trollmo C, Crawford F, Marrack P, Steere AC, Huber BT, Kappler J and Hafler DA: Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc Natl Acad Sci U S A. 2000 Oct 10;97 (21) :11433-8. PMID: 11005833


Hunter SF and Hafler DA: Ubiquitous pathogens: links between infection and autoimmunity in MS? Neurology. 2000 Jul 25;55 (2) :164-5. PMID: 10908883


Kipp B, Bar-Or A, Gausling R, Oliveira EM, Fruhan SA, Stuart WH and Hafler DA: A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis. Eur J Immunol. 2000 Jul;30 (7) :2092-100. PMID: 10940899


Duda PW, Schmied MC, Cook SL, Krieger JI and Hafler DA: Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J Clin Invest. 2000 Apr;105 (7) :967-76. PMID: 10749576


Anderson DE, Bieganowska KD, Bar-Or A, Oliveira EM, Carreno B, Collins M and Hafler DA: Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nat Med. 2000 Feb;6 (2) :211-4. PMID: 10655112

Anderson DE, Sharpe AH and Hafler DA: The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Curr Opin Immunol. 1999 Dec;11 (6) :677-83. PMID: 10631554


Flavell RA and Hafler DA: Autoimmunity. What is the turning point? Curr Opin Immunol. 1999 Dec;11 (6) :635-7. PMID: 10631547


Bar-Or A, Oliveira EM, Anderson DE and Hafler DA: Molecular pathogenesis of multiple sclerosis. J Neuroimmunol. 1999 Dec;100 (1-2) :252-9. PMID: 10695735


Hafler DA: The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis. J Clin Invest. 1999 Sep;104 (5) :527-9. PMID: 10487765


Milner JD, Kent SC, Ashley TA, Wilson SB, Strominger JL and Hafler DA: Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. J Immunol. 1999 Sep 1;163 (5) :2522-9. PMID: 10452989


Semana G, Gausling R, Jackson RA and Hafler DA: T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects. J Autoimmun. 1999 Jun;12 (4) :259-67. PMID: 10330297


Pohl-Koppe A, Logigian EL, Steere AC and Hafler DA: Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis. Cell Immunol. 1999 May 25;194 (1) :118-23. PMID: 10357888


Ausubel LJ, Bieganowska KD and Hafler DA: Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein. Cell Immunol. 1999 Apr 10;193 (1) :99-107. PMID: 10202117


Bieganowska K, Höllsberg P, Buckle GJ, Lim DG, Greten TF, Schneck J, Altman JD, Jacobson S, Ledis SL, Hanchard B, Chin J, Morgan O, Roth PA and Hafler DA: Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. J Immunol. 1999 Feb 1;162 (3) :1765-71. PMID: 9973440

Pohl-Koppe A, Burchett SK, Thiele EA and Hafler DA: Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis. J Neuroimmunol. 1998 Nov 2;91 (1-2) :19-27. PMID: 9846815


Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL and Hafler DA: Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J Neuroimmunol. 1998 Nov 2;91 (1-2) :1-9. PMID: 9846813


Martin R, Ruddle NH, Reingold S and Hafler DA: T helper cell differentiation in multiple sclerosis and autoimmunity. Immunol Today. 1998 Nov;19 (11) :495-8. PMID: 9818541


Pohl-Koppe A, Balashov KE, Steere AC, Logigian EL and Hafler DA: Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection. J Immunol. 1998 Feb 15;160 (4) :1804-10. PMID: 9469440


Scholz C, Patton KT, Anderson DE, Freeman GJ and Hafler DA: Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J Immunol. 1998 Feb 1;160 (3) :1532-8. PMID: 9570577


Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL and Hafler DA: Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature. 1998 Jan 8;391 (6663) :177-81. PMID: 9428763

Dressel A, Chin JL, Sette A, Gausling R, Höllsberg P and Hafler DA: Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. J Immunol. 1997 Nov 15;159 (10) :4943-51. PMID: 9366420


Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ and Hafler DA: Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol. 1997 Nov 15;159 (10) :4799-805. PMID: 9366404


Ausubel LJ, Krieger JI and Hafler DA: Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99. J Immunol. 1997 Sep 1;159 (5) :2502-12. PMID: 9278344


Anderson DE, Ausubel LJ, Krieger J, Höllsberg P, Freeman GJ and Hafler DA: Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. J Immunol. 1997 Aug 15;159 (4) :1669-75. PMID: 9257827


Dangond F, Windhagen A, Groves CJ and Hafler DA: Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. J Neuroimmunol. 1997 Jun;76 (1-2) :132-8. PMID: 9184642


Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W and Hafler DA: Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med. 1997 May 5;185 (9) :1585-94. PMID: 9151896


Kent SC, Fukaura H, Pietrusewicz MJ, Khoury SJ, Weiner HL and Hafler DA: Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients. Ann N Y Acad Sci. 1997 Apr 5;815 :412-22. PMID: 9186687

Ausubel LJ, Kwan CK, Sette A, Kuchroo V and Hafler DA: Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proc Natl Acad Sci U S A. 1996 Dec 24;93 (26) :15317-22. PMID: 8986809


Höllsberg P, Batra V, Dressel A and Hafler DA: Induction of anergy in CD8 T cells by B cell presentation of antigen. J Immunol. 1996 Dec 15;157 (12) :5269-76. PMID: 8955172


Rothenberg ME, Weber WE, Longtine JA and Hafler DA: Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clin Immunol Immunopathol. 1996 Sep;80 (3 Pt 1) :266-72. PMID: 8811046


Windhagen A, Anderson DE, Carrizosa A, Williams RE and Hafler DA: IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol. 1996 Aug 1;157 (3) :1127-31. PMID: 8757617


Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL and Hafler DA: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest. 1996 Jul 1;98 (1) :70-7. PMID: 8690806


Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL and Hafler DA: Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis. Ann N Y Acad Sci. 1996 Feb 13;778 :251-7. PMID: 8610978


Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK and Hafler DA: Role of Th1 and Th2 cells in neurologic disorders. Chem Immunol. 1996;63 :171-86. PMID: 8934837

Windhagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, Cuzner ML and Hafler DA: Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med. 1995 Dec 1;182 (6) :1985-96. PMID: 7500044


Markovic-Plese S, Fukaura H, Zhang J, al-Sabbagh A, Southwood S, Sette A, Kuchroo VK and Hafler DA: T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J Immunol. 1995 Jul 15;155 (2) :982-92. PMID: 7541828


Wucherpfennig KW and Hafler DA: A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Ann N Y Acad Sci. 1995 Jul 7;756 :241-58. PMID: 7544075


Höllsberg P, Weber WE, Dangond F, Batra V, Sette A and Hafler DA: Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proc Natl Acad Sci U S A. 1995 Apr 25;92 (9) :4036-40. PMID: 7732026


Windhagen A, Scholz C, Höllsberg P, Fukaura H, Sette A and Hafler DA: Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity. 1995 Apr;2 (4) :373-80. PMID: 7536622


Dangond F, Daza JS, Rosania A, Quin MJ, Zaninovic V, Chaplin B, Marlink R and Hafler DA: Tropical spastic paraparesis on the Caribbean coast of Colombia. Am J Trop Med Hyg. 1995 Feb;52 (2) :155-8. PMID: 7872443


Höllsberg P and Hafler DA: What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis? Ann Neurol. 1995 Feb;37 (2) :143-5. PMID: 7847855


Weiner HL, Hohol MJ, Khoury SJ, Dawson DM and Hafler DA: Therapy for multiple sclerosis. Neurol Clin. 1995 Feb;13 (1) :173-96. PMID: 7739502

Höllsberg P, Ausubel LJ and Hafler DA: Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression. J Immunol. 1994 Jul 15;153 (2) :566-73. PMID: 8021495


LaSalle JM and Hafler DA: T cell anergy. FASEB J. 1994 Jun;8 (9) :601-8. PMID: 8005388


Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K and Hafler DA: Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol. 1994 Jun 1;152 (11) :5581-92. PMID: 7514641


Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL and Hafler DA: Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med. 1994 Mar 1;179 (3) :973-84. PMID: 7509366


Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE and Hafler DA: Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol. 1994;12 :809-37. PMID: 8011298


Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL and Hafler DA: Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med. 1994 Jan 1;179 (1) :279-90. PMID: 7505801

LaSalle JM, Toneguzzo F, Saadeh M, Golan DE, Taber R and Hafler DA: T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. J Immunol. 1993 Jul 15;151 (2) :649-57. PMID: 7687620


Höllsberg P, Melinek J, Benjamin D and Hafler DA: Increased protein kinase C activity in human memory T cells. Cell Immunol. 1993 Jun;149 (1) :170-9. PMID: 8099849


Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL and Hafler DA: Biological activity of recombinant human myelin basic protein. J Neuroimmunol. 1993 May;44 (2) :157-62. PMID: 7685037


Höllsberg P and Hafler DA: Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection. N Engl J Med. 1993 Apr 22;328 (16) :1173-82. PMID: 8455685


Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM and Hafler DA: Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science. 1993 Feb 26;259 (5099) :1321-4. PMID: 7680493

LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM and Hafler DA: Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J Exp Med. 1992 Jul 1;176 (1) :177-86. PMID: 1535366


Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE and Hafler DA: Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. J Immunol. 1992 May 15;148 (10) :3256-63. PMID: 1374452


Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML and Hafler DA: Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acad Sci U S A. 1992 May 15;89 (10) :4588-92. PMID: 1374907


Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML and Hafler DA: T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. J Exp Med. 1992 Apr 1;175 (4) :993-1002. PMID: 1348083


Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D and Hafler DA: T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proc Natl Acad Sci U S A. 1992 Mar 15;89 (6) :2110-4. PMID: 1549569


Zhang J, Weiner HL and Hafler DA: Autoreactive T cells in multiple sclerosis. Int Rev Immunol. 1992;9 (3) :183-201. PMID: 1285060

LaSalle JM and Hafler DA: The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cell Immunol. 1991 Nov;138 (1) :197-206. PMID: 1833074


Wucherpfennig KW, Weiner HL and Hafler DA: T-cell recognition of myelin basic protein. Immunol Today. 1991 Aug;12 (8) :277-82. PMID: 1716903


Brod SA, Benjamin D and Hafler DA: Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease. J Immunol. 1991 Aug 1;147 (3) :810-5. PMID: 1907306


LaSalle JM, Ota K and Hafler DA: Presentation of autoantigen by human T cells. J Immunol. 1991 Aug 1;147 (3) :774-80. PMID: 1713605


Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL and Hafler DA: Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann Neurol. 1991 Jan;29 (1) :33-40. PMID: 1847614

Brod SA, Purvee M, Benjamin D and Hafler DA: T-T cell interactions are mediated by adhesion molecules. Eur J Immunol. 1990 Oct;20 (10) :2259-68. PMID: 1700751


Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL and Hafler DA: T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 1990 Jul 12;346 (6280) :183-7. PMID: 1694970


Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL and Hafler DA: Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science. 1990 May 25;248 (4958) :1016-9. PMID: 1693015


Brod SA, Purvee M, Benjamin D and Hafler DA: Frequency analysis of CD4+CD8+ T cells cloned with IL-4. Cell Immunol. 1990 Feb;125 (2) :426-36. PMID: 2105169


Hafler DA: Review of immunology. Res Publ Assoc Res Nerv Ment Dis. 1990;68 :23-35. PMID: 2183313

Brod SA, Rudd CE, Purvee M and Hafler DA: Lymphokine regulation of CD45R expression on human T cell clones. J Exp Med. 1989 Dec 1;170 (6) :2147-52. PMID: 2531196


Chofflon M, González V, Weiner HL and Hafler DA: Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells. Eur J Immunol. 1989 Oct;19 (10) :1791-5. PMID: 2479560


Chofflon M, Weiner HL, Morimoto C and Hafler DA: Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Ann Neurol. 1989 May;25 (5) :494-9. PMID: 2528316


Duby AD, Weiner HL, Benjamin DS, Seidman JG and Hafler DA: Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis. J Neuroimmunol. 1989 Mar;22 (1) :63-8. PMID: 2465314

Chofflon M, Weiner HL, Morimoto C and Hafler DA: Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann Neurol. 1988 Aug;24 (2) :185-91. PMID: 2972249


Weiner HL and Hafler DA: Immunotherapy of multiple sclerosis. Ann Neurol. 1988 Mar;23 (3) :211-22. PMID: 3288084


Chofflon M, Weiner HL and Hafler DA: Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann N Y Acad Sci. 1988;540 :330-2. PMID: 2905122

Ang SL, Seidman JG, Peterman GM, Duby AD, Benjamin D, Lee SJ and Hafler DA: Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones. J Exp Med. 1987 May 1;165 (5) :1453-8. PMID: 3106557

All Publications

Kleinewietfeld M and Hafler DA: Regulatory T cells in autoimmune neuroinflammation. Immunol Rev. 2014 May;259 (1) :231-44. PMID: 24712469


Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F and Kleinstein SH: pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics. 2014 Mar 26; Epub 2014 Mar 26. PMID: 24618469


Liu BS, Cao Y, Huizinga TW, Hafler DA and Toes RE: TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014 Mar 19; Epub 2014 Mar 19. PMID: 24737107


Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A and Hacohen N: Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science. 2014 Mar 7;343 (6175) :1246980. PMID: 24604203


Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA and Kleinewietfeld M: Role of "Western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep. 2014 Jan;14 (1) :404. PMID: 24338487

Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA and De Jager PL: Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 2013 Nov 26;81 (22) :1891-9. Epub 2013 Oct 30. PMID: 24174586


Kleinewietfeld M and Hafler DA: The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol. 2013 Nov 15;25 (4) :305-12. Epub 2013 Nov 5. PMID: 24211039


Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L and Robinson WH: Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis. Mult Scler. 2013 Nov;19 (13) :1726-33. Epub 2013 Apr 23. PMID: 23612879


Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL and de Bakker PI: Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet. 2013 Nov;9 (11) :e1003926. Epub 2013 Nov 21. PMID: 24278027


Lozano E, Joller N, Cao Y, Kuchroo VK and Hafler DA: The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol. 2013 Oct 1;191 (7) :3673-80. Epub 2013 Aug 26. PMID: 23980210


Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN and O'Connor KC: Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology. 2013 Sep 10;81 (11) :956-63. Epub 2013 Aug 6. PMID: 23921886


Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ and Erdman SE: Microbial reprogramming inhibits Western diet-associated obesity. PLoS One. 2013;8 (7) :e68596. Epub 2013 Jul 10. PMID: 23874682


Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC and Meffre E: Specific peripheral B cell tolerance defects in patients with multiple sclerosis. J Clin Invest. 2013 Jun 3;123 (6) :2737-41. Epub 2013 May 15. PMID: 23676463


Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC and Elledge SJ: PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J Autoimmun. 2013 Jun;43 :1-9. Epub 2013 Mar 13. PMID: 23497938


Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN and Hafler DA: Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013 Apr 25;496 (7446) :518-22. Epub 2013 Mar 6. PMID: 23467095


Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F and Kleinstein SH: Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol. 2013;4 :358. Epub 2013 Nov 15. PMID: 24298272


Cotsapas C and Hafler DA: Immune-mediated disease genetics: the shared basis of pathogenesis. Trends Immunol. 2013 Jan;34 (1) :22-6. Epub 2012 Sep 29. PMID: 23031829

Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A and Kuchroo VK: Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012 Oct;13 (10) :991-9. Epub 2012 Sep 9. PMID: 22961052


Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL and De Jager PL: An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Sci Transl Med. 2012 Sep 26;4 (153) :153ra131. PMID: 23019656


Lowther DE and Hafler DA: Regulatory T cells in the central nervous system. Immunol Rev. 2012 Jul;248 (1) :156-69. PMID: 22725960


Kickler K, Maltby K, Ni Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN and Astier AL: Prostaglandin E2 affects T cell responses through modulation of CD46 expression. J Immunol. 2012 Jun 1;188 (11) :5303-10. Epub 2012 Apr 27. PMID: 22544928


Lozano E, Dominguez-Villar M, Kuchroo V and Hafler DA: The TIGIT/CD226 axis regulates human T cell function. J Immunol. 2012 Apr 15;188 (8) :3869-75. Epub 2012 Mar 16. PMID: 22427644


Hafler DA: Perspective: Deconstructing a disease. Nature. 2012 Apr 12;484 (7393) :S6. PMID: 22509507


Nylander A and Hafler DA: Multiple sclerosis. J Clin Invest. 2012 Apr 2;122 (4) :1180-8. Epub 2012 Apr 2. PMID: 22466660


Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA and Love JC: Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A. 2012 Jan 31;109 (5) :1607-12. Epub 2011 Dec 12. PMID: 22160692


Pelletier D and Hafler DA: Fingolimod for multiple sclerosis. N Engl J Med. 2012 Jan 26;366 (4) :339-47. PMID: 22276823


Costantino CM, Spooner E, Ploegh HL and Hafler DA: Class II MHC self-antigen presentation in human B and T lymphocytes. PLoS One. 2012;7 (1) :e29805. Epub 2012 Jan 27. PMID: 22299025

Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA and de Bakker PI: Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol. 2011 Dec;70 (6) :897-912. PMID: 22190364


Kofler DM, Severson CA, Mousissian N, De Jager PL and Hafler DA: The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J Immunol. 2011 Sep 15;187 (6) :3286-91. Epub 2011 Aug 17. PMID: 21849685


Vosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BM, Crusius JB, van der Pouw Kraan TC, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH and Verweij CL: Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis. Genes Immun. 2011 Sep;12 (6) :466-72. Epub 2011 Apr 7. PMID: 21471993


Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP and Haines JL: Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. Hum Mol Genet. 2011 Sep 1;20 (17) :3517-24. Epub 2011 Jun 8. PMID: 21653641


Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Martinelli Boneschi F, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters K, Comi G, Cossburn M, Cournu-Rebeix I, Cox MB, Cozen W, Cree BA, Cross AH, Cusi D, Daly MJ, Davis E, de Bakker PI, Debouverie M, D'hooghe MB, Dixon K, Dobosi R, Dubois B, Ellinghaus D, Elovaara I, Esposito F, Fontenille C, Foote S, Franke A, Galimberti D, Ghezzi A, Glessner J, Gomez R, Gout O, Graham C, Grant SF, Guerini FR, Hakonarson H, Hall P, Hamsten A, Hartung HP, Heard RN, Heath S, Hobart J, Hoshi M, Infante-Duarte C, Ingram G, Ingram W, Islam T, Jagodic M, Kabesch M, Kermode AG, Kilpatrick TJ, Kim C, Klopp N, Koivisto K, Larsson M, Lathrop M, Lechner-Scott JS, Leone MA, Leppä V, Liljedahl U, Bomfim IL, Lincoln RR, Link J, Liu J, Lorentzen AR, Lupoli S, Macciardi F, Mack T, Marriott M, Martinelli V, Mason D, McCauley JL, Mentch F, Mero IL, Mihalova T, Montalban X, Mottershead J, Myhr KM, Naldi P, Ollier W, Page A, Palotie A, Pelletier J, Piccio L, Pickersgill T, Piehl F, Pobywajlo S, Quach HL, Ramsay PP, Reunanen M, Reynolds R, Rioux JD, Rodegher M, Roesner S, Rubio JP, Rückert IM, Salvetti M, Salvi E, Santaniello A, Schaefer CA, Schreiber S, Schulze C, Scott RJ, Sellebjerg F, Selmaj KW, Sexton D, Shen L, Simms-Acuna B, Skidmore S, Sleiman PM, Smestad C, Sørensen PS, Søndergaard HB, Stankovich J, Strange RC, Sulonen AM, Sundqvist E, Syvänen AC, Taddeo F, Taylor B, Blackwell JM, Tienari P, Bramon E, Tourbah A, Brown MA, Tronczynska E, Casas JP, Tubridy N, Corvin A, Vickery J, Jankowski J, Villoslada P, Markus HS, Wang K, Mathew CG, Wason J, Palmer CN, Wichmann HE, Plomin R, Willoughby E, Rautanen A, Winkelmann J, Wittig M, Trembath RC, Yaouanq J, Viswanathan AC, Zhang H, Wood NW, Zuvich R, Deloukas P, Langford C, Duncanson A, Oksenberg JR, Pericak-Vance MA, Haines JL, Olsson T, Hillert J, Ivinson AJ, De Jager PL, Peltonen L, Stewart GJ, Hafler DA, Hauser SL, McVean G, Donnelly P and Compston A: Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011 Aug 10;476 (7359) :214-9. Epub 2011 Aug 10. PMID: 21833088


Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC, Behrens T, Cho J, De Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, Siminovitch KA, van Heel DA, Wijmenga C, Worthington J, Todd JA, Hafler DA, Rich SS and Daly MJ: Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet. 2011 Aug;7 (8) :e1002254. Epub 2011 Aug 10. PMID: 21852963


Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW and Hafler DA: Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol. 2011 Jul 15;187 (2) :1039-46. Epub 2011 Jun 8. PMID: 21653833


Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL and Ritchie MD: A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes Immun. 2011 Jul;12 (5) :335-40. Epub 2011 Feb 24. PMID: 21346779


Dominguez-Villar M, Baecher-Allan CM and Hafler DA: Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med. 2011 Jun;17 (6) :673-5. Epub 2011 May 3. PMID: 21540856


Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC and Dornmair K: Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol. 2011 Apr;233 (1-2) :245-8. Epub 2011 Feb 24. PMID: 21353315


Gross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA and De Jager PL: Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. J Neuroimmunol. 2011 Apr;233 (1-2) :168-74. Epub 2010 Nov 27. PMID: 21115201


Dominguez-Villar M and Hafler DA: Immunology. An innate role for IL-17. Science. 2011 Apr 1;332 (6025) :47-8. PMID: 21454778


Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M and Hafler DA: CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol. 2011 Mar 15;186 (6) :3317-26. Epub 2011 Feb 7. PMID: 21300823


Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC and Hafler DA: Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain. 2011 Feb;134 (Pt 2) :534-41. Epub 2011 Jan 7. PMID: 21216828


Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE and Oksenberg JR: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med. 2011 Jan 18;3 (1) :3. Epub 2011 Jan 18. PMID: 21244703


Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA and Yarmush ML: Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosens Bioelectron. 2011 Jan 15;26 (5) :2707-10. Epub 2010 Sep 15. PMID: 20888750


Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC and Seidman CE: Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PLoS One. 2011;6 (9) :e24593. Epub 2011 Sep 30. PMID: 21980348

Cvetanovich GL and Hafler DA: Human regulatory T cells in autoimmune diseases. Curr Opin Immunol. 2010 Dec;22 (6) :753-60. Epub 2010 Sep 24. PMID: 20869862


Ban M, McCauley JL, Zuvich R, Baker A, Bergamaschi L, Cox M, Kemppinen A, D'Alfonso S, Guerini FR, Lechner-Scott J, Dudbridge F, Wason J, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, Sexton D, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines J, Compston A and Sawcer S: A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis. Genes Immun. 2010 Dec;11 (8) :660-4. Epub 2010 Jun 24. PMID: 20574445


Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL and Barcellos LF: Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Hum Mol Genet. 2010 Nov 1;19 (21) :4286-95. Epub 2010 Aug 10. PMID: 20699326


Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC and Monson NL: A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis. J Neuroimmunol. 2010 Sep 14;226 (1-2) :192-3. Epub 2010 Jul 23. PMID: 20655601


Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S and Reddy S: A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Arch Neurol. 2010 Sep;67 (9) :1055-61. PMID: 20837847


Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR and De Jager PL: HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 2010 Aug 17;75 (7) :634-40. PMID: 20713950


Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL and Barcellos LF: Variation within DNA repair pathway genes and risk of multiple sclerosis. Am J Epidemiol. 2010 Jul 15;172 (2) :217-24. Epub 2010 Jun 3. PMID: 20522537


Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C and Hafler DA: TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 1;185 (1) :46-54. Epub 2010 May 24. PMID: 20498357


Sakaguchi S, Miyara M, Costantino CM and Hafler DA: FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010 Jul;10 (7) :490-500. Epub 2010 Jun 18. PMID: 20559327


Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg JR and Hauser SL: A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS One. 2010 Jun 25;5 (6) :e11296. Epub 2010 Jun 25. PMID: 20593013


Han Q, Bradshaw EM, Nilsson B, Hafler DA and Love JC: Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip. 2010 Jun 7;10 (11) :1391-400. Epub 2010 Apr 8. PMID: 20376398


Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL, Hauser SL, Oksenberg JR and Barcellos LF: CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet. 2010 Jun 1;19 (11) :2331-40. Epub 2010 Mar 8. PMID: 20211854


Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I, Olsson T, Hillert J, Ban M, Baker A, Kemppinen A, Sawcer S, Compston A, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, McCauley JL, Pericak-Vance MA, Oksenberg JR, Hauser SL, Sexton D and Haines J: Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nat Genet. 2010 Jun;42 (6) :469-70; author reply 470-1. PMID: 20502484


Zuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, Aubin C, Cross AH, Piccio L, Aggarwal NT, Evans D, Hafler DA, Compston A, Hauser SL, Pericak-Vance MA and Haines JL: Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Hum Genet. 2010 Mar;127 (5) :525-35. Epub 2010 Jan 30. PMID: 20112030


Jakkula E, Leppä V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML, Elovaara I, Pirttilä T, Reunanen M, Aromaa A, Oturai AB, Søndergaard HB, Harbo HF, Mero IL, Gabriel SB, Mirel DB, Hauser SL, Kappos L, Polman C, De Jager PL, Hafler DA, Daly MJ, Palotie A, Saarela J and Peltonen L: Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet. 2010 Feb 12;86 (2) :285-91. PMID: 20159113


Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA and Love JC: On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem. 2010 Jan 15;82 (2) :473-7. PMID: 20000848


Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA and Hacohen N: RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. J Immunol. 2010 Jan 15;184 (2) :685-93. Epub 2009 Dec 16. PMID: 20018615


Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y and Rigby AC: Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. J Phys Chem B. 2010 Jan 14;114 (1) :585-91. PMID: 19954153


Severson C and Hafler DA: T-cells in multiple sclerosis. Results Probl Cell Differ. 2010;51 :75-98. PMID: 19582415

Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA and O'Connor KC: Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain. 2009 Dec;132 (Pt 12) :3318-28. PMID: 19638446


De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler DA and Karlson EW: Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol. 2009 Dec;8 (12) :1111-9. Epub 2009 Oct 29. PMID: 19879194


Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR and Hauser SL: Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A. 2009 Nov 3;106 (44) :18680-5. Epub 2009 Oct 21. PMID: 19846760


Liu DV, Maier LM, Hafler DA and Wittrup KD: Engineered interleukin-2 antagonists for the inhibition of regulatory T cells. J Immunother. 2009 Nov-Dec;32 (9) :887-94. PMID: 19816193


Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC and Hafler DA: Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009 Oct 1;183 (7) :4432-9. Epub 2009 Sep 11. PMID: 19748982


McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B and Wucherpfennig KW: Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15;183 (6) :4067-76. Epub 2009 Aug 17. PMID: 19687098


Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA and Kuchroo VK: TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep;39 (9) :2492-501. PMID: 19676072


Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, Eavey RD, Plenge RM, Shadick NA, Weinblatt ME, De Jager PL, Hafler DA, Breitbart RE, Seidman JG and Seidman CE: De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet. 2009 Aug;41 (8) :931-5. Epub 2009 Jul 13. PMID: 19597493


Costantino CM, Ploegh HL and Hafler DA: Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. J Immunol. 2009 Jul 15;183 (2) :945-52. Epub 2009 Jun 24. PMID: 19553543


De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA and Oksenberg JR: Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 Jul;41 (7) :776-82. Epub 2009 Jun 14. PMID: 19525953


Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP and Gilden D: Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol. 2009 Jun;65 (6) :639-49. PMID: 19557869


Pyne S, Hu X, Wang K, Rossin E, Lin TI, Maier LM, Baecher-Allan C, McLachlan GJ, Tamayo P, Hafler DA, De Jager PL and Mesirov JP: Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A. 2009 May 26;106 (21) :8519-24. Epub 2009 May 14. PMID: 19443687


Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L and Saarela J: Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Hum Mol Genet. 2009 May 1;18 (9) :1670-83. Epub 2009 Feb 16. PMID: 19221116


Maier LM and Hafler DA: Autoimmunity risk alleles in costimulation pathways. Immunol Rev. 2009 May;229 (1) :322-36. PMID: 19426231


Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C and Hafler DA: IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30;113 (18) :4240-9. Epub 2009 Jan 26. PMID: 19171879


De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR and Hafler DA: The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31;106 (13) :5264-9. Epub 2009 Feb 23. PMID: 19237575


Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL and Hafler DA: Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol. 2009 Feb 1;182 (3) :1541-7. PMID: 19155502


Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager PL, Wicker LS, Todd JA and Hafler DA: IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 2009 Jan;5 (1) :e1000322. Epub 2009 Jan 2. PMID: 19119414

Hafler DA and Kuchroo V: TIMs: central regulators of immune responses. J Exp Med. 2008 Nov 24;205 (12) :2699-701. Epub 2008 Nov 17. PMID: 19015312


Costantino CM, Baecher-Allan C and Hafler DA: Multiple sclerosis and regulatory T cells. J Clin Immunol. 2008 Nov;28 (6) :697-706. Epub 2008 Sep 2. PMID: 18763026


Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA and Love JC: Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol. 2008 Oct;129 (1) :10-8. PMID: 18675591


Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR and Khoury SJ: CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 2008 Sep 16;71 (12) :917-24. PMID: 18794494


Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK and Hafler DA: IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008 Jul 17;454 (7202) :350-2. Epub 2008 May 11. PMID: 18469800


Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T and Cagliero E: Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation. 2008 Jul 15;86 (1) :54-62. PMID: 18622278


De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O'Brien C, Freeman S, Granados S, Parker A, Roubenoff R, Mesirov JP, Khoury SJ, Hafler DA and Weiner HL: Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain. 2008 Jul;131 (Pt 7) :1701-11. Epub 2008 Jun 21. PMID: 18567923


Costantino CM, Baecher-Allan CM and Hafler DA: Human regulatory T cells and autoimmunity. Eur J Immunol. 2008 Apr;38 (4) :921-4. PMID: 18395861


Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB and Kuchroo VK: TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol. 2008 Apr 1;180 (7) :4706-13. PMID: 18354194


Yang L, Anderson DE, Kuchroo J and Hafler DA: Lack of TIM-3 immunoregulation in multiple sclerosis. J Immunol. 2008 Apr 1;180 (7) :4409-14. PMID: 18354161


De Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA and Ascherio A: Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. Neurology. 2008 Mar 25;70 (13 Pt 2) :1113-8. Epub 2008 Feb 13. PMID: 18272866


Costantino CM, Hang HC, Kent SC, Hafler DA and Ploegh HL: Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol. 2008 Mar 1;180 (5) :2876-85. PMID: 18292509


Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL and Weiner HL: Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol. 2008 Mar;195 (1-2) :140-5. Epub 2008 Apr 10. PMID: 18403025


Maier LM and Hafler DA: The developing mosaic of autoimmune disease risk. Nat Genet. 2008 Feb;40 (2) :131-2. PMID: 18227869

Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ and Altshuler D: Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet. 2007 Dec;39 (12) :1477-82. Epub 2007 Nov 4. PMID: 17982456


Maier LM, Anderson DE, De Jager PL, Wicker LS and Hafler DA: Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proc Natl Acad Sci U S A. 2007 Nov 20;104 (47) :18607-12. Epub 2007 Nov 13. PMID: 18000051


Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK and Hafler DA: Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science. 2007 Nov 16;318 (5853) :1141-3. PMID: 18006747


Astier AL and Hafler DA: Abnormal Tr1 differentiation in multiple sclerosis. J Neuroimmunol. 2007 Nov;191 (1-2) :70-8. Epub 2007 Oct 22. PMID: 17936368


Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR and Hauser SL: Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007 Aug 30;357 (9) :851-62. Epub 2007 Jul 29. PMID: 17660530


Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH and Steinman L: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature. 2007 Jul 26;448 (7152) :474-9. Epub 2007 Jun 13. PMID: 17568699


De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA and Rioux JD: The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes Immun. 2007 Jul;8 (5) :387-97. Epub 2007 May 31. PMID: 17538633


Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, Trowsdale J, Caillier SJ, Ivinson AJ, Green T, Pobywajlo S, Lander ES, Pericak-Vance MA, Haines JL, Daly MJ, Oksenberg JR, Hauser SL, Compston A, Hafler DA, Rioux JD and Sawcer S: A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol. 2007 Mar;61 (3) :228-36. PMID: 17252545


Cai G and Hafler DA: Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes. Eur J Immunol. 2007 Mar;37 (3) :602-12. PMID: 17304631


O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA and Wucherpfennig KW: Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007 Feb;13 (2) :211-7. Epub 2007 Jan 12. PMID: 17237795


De Jager PL and Hafler DA: New therapeutic approaches for multiple sclerosis. Annu Rev Med. 2007;58 :417-32. PMID: 17217332


Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA and O'Connor KC: A local antigen-driven humoral response is present in the inflammatory myopathies. J Immunol. 2007 Jan 1;178 (1) :547-56. PMID: 17182595

Astier AL, Meiffren G, Freeman S and Hafler DA: Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest. 2006 Dec;116 (12) :3252-7. Epub 2006 Nov 9. PMID: 17099776


de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P and Rioux JD: A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet. 2006 Oct;38 (10) :1166-72. Epub 2006 Sep 24. PMID: 16998491


Baecher-Allan C and Hafler DA: Human regulatory T cells and their role in autoimmune disease. Immunol Rev. 2006 Aug;212 :203-16. PMID: 16903916


Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK and Hafler DA: Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006 Jun 12;203 (6) :1413-8. Epub 2006 Jun 5. PMID: 16754722


De Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ and Rioux JD: The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes Immun. 2006 Jun;7 (4) :327-34. Epub 2006 Apr 27. PMID: 16642031


Baecher-Allan CM and Hafler DA: The purification and functional analysis of human CD4+CD25high regulatory T cells. Curr Protoc Immunol. 2006 May;Chapter 7 :Unit 7.4B. PMID: 18432975


Baecher-Allan C, Wolf E and Hafler DA: MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol. 2006 Apr 15;176 (8) :4622-31. PMID: 16585553


De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA and Rioux JD: Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. Eur J Hum Genet. 2006 Mar;14 (3) :317-21. PMID: 16391555


O'Connor KC, Roy SM, Becker CH, Hafler DA and Kantor AB: Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers. Dis Markers. 2006;22 (4) :213-25. PMID: 17124343

Baecher-Allan CM and Hafler DA: Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clin Immunol. 2005 Nov;117 (2) :192; discussion 193. PMID: 16214081


Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B and Hafler DA: Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. J Immunol. 2005 Oct 1;175 (7) :4458-64. PMID: 16177088


Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR and Hafler DA: A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet. 2005 Oct;37 (10) :1113-8. Epub 2005 Sep 25. PMID: 16186815


Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ and Haines JL: A high-density screen for linkage in multiple sclerosis. Am J Hum Genet. 2005 Sep;77 (3) :454-67. Epub 2005 Jul 29. PMID: 16080120


O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA and Wucherpfennig KW: Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol. 2005 Aug 1;175 (3) :1974-82. PMID: 16034142


Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT and Hafler DA: Characterization of in vivo expanded OspA-specific human T-cell clones. Clin Immunol. 2005 Jun;115 (3) :313-22. PMID: 15893699


Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ and Hafler DA: Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature. 2005 May 12;435 (7039) :224-8. PMID: 15889096


Baecher-Allan C, Wolf E and Hafler DA: Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clin Immunol. 2005 Apr;115 (1) :10-8. PMID: 15870015


Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P and Baecher-Allan C: Multiple sclerosis. Immunol Rev. 2005 Apr;204 :208-31. PMID: 15790361


Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK and Altmann DM: High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J Immunol. 2005 Feb 15;174 (4) :1938-46. PMID: 15699121


Hafler DA and De Jager PL: Applying a new generation of genetic maps to understand human inflammatory disease. Nat Rev Immunol. 2005 Jan;5 (1) :83-91. PMID: 15630431

Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, Pericak-Vance MA, Barcellos L, Hauser SL, Oksenberg JR, Kenealy SJ and Haines JL: Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet. 2004 Sep 1;13 (17) :1943-9. Epub 2004 Jul 6. PMID: 15238506


Baecher-Allan C and Hafler DA: Suppressor T cells in human diseases. J Exp Med. 2004 Aug 2;200 (3) :273-6. Epub 2004 Jul 26. PMID: 15280423


Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA and Freeman GJ: PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol. 2004 Aug;230 (2) :89-98. PMID: 15598424


Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK and Hafler DA: Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 1;173 (3) :1689-98. PMID: 15265898


De Jager PL, Walsh EC, Rioux JD and Hafler DA: Re: GAMES issue study: Are international genetic consortia functional? J Neuroimmunol. 2004 Aug;153 (1-2) :5-6. PMID: 15334748


Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK and Altmann DM: Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur J Immunol. 2004 Jul;34 (7) :1839-48. PMID: 15214032


Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F and Wallström E: T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol. 2004 Jun 1;172 (11) :7169-76. PMID: 15153541


Smith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, De The G, Essex M, Sankale JL, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O'Brien SJ and Reich D: A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet. 2004 May;74 (5) :1001-13. Epub 2004 Apr 14. PMID: 15088270


Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ and Reich D: Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004 May;74 (5) :979-1000. Epub 2004 Apr 14. PMID: 15088269


Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS and Kuchroo VK: An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 2004 May;20 (5) :563-75. PMID: 15142525


De Jager PL and Hafler DA: Gene expression profiling in MS: what is the clinical relevance? Lancet Neurol. 2004 May;3 (5) :269. PMID: 15099539


Viglietta V, Baecher-Allan C, Weiner HL and Hafler DA: Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004 Apr 5;199 (7) :971-9. PMID: 15067033


Baecher-Allan C, Viglietta V and Hafler DA: Human CD4+CD25+ regulatory T cells. Semin Immunol. 2004 Apr;16 (2) :89-98. PMID: 15036232


Hafler DA: Multiple sclerosis. J Clin Invest. 2004 Mar;113 (6) :788-94. PMID: 15067307


Slavik JM, Lim DG, Burakoff SJ and Hafler DA: Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. J Biol Chem. 2004 Jan 9;279 (2) :910-9. Epub 2003 Oct 22. PMID: 14573608

Walsh EC, Guschwan-McMahon S, Daly MJ, Hafler DA and Rioux JD: Genetic analysis of multiple sclerosis. J Autoimmun. 2003 Sep;21 (2) :111-6. PMID: 12935779


Lim DG, Slavik JM, Bourcier K, Smith KJ and Hafler DA: Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function. J Exp Med. 2003 Jul 7;198 (1) :99-109. PMID: 12847139


Schmied M, Duda PW, Krieger JI, Trollmo C and Hafler DA: In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis. Clin Immunol. 2003 Mar;106 (3) :163-74. PMID: 12706402


O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW and Hafler DA: Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol. 2003 Mar;136 (1-2) :140-8. PMID: 12620653


Buckle GJ, Höllsberg P and Hafler DA: Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin. Neurology. 2003 Feb 25;60 (4) :702-5. PMID: 12601116


Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI and Hafler DA: CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. J Autoimmun. 2003 Feb;20 (1) :71-81. PMID: 12604314


Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, de Andrade M, Hafler DA and Weinshenker BG: CTLA4 is associated with susceptibility to multiple sclerosis. J Neuroimmunol. 2003 Jan;134 (1-2) :133-41. PMID: 12507781


Baecher-Allan C, Brown JA, Freeman GJ and Hafler DA: CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp. 2003;252 :67-88; discussion 88-91, 106-14. PMID: 14609213

Baecher-Allan C, Viglietta V and Hafler DA: Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol. 2002 Dec 1;169 (11) :6210-7. PMID: 12444126


Lim DG, Höllsberg P and Hafler DA: Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells. Cell Immunol. 2002 May-Jun;217 (1-2) :36-46. PMID: 12425999


Viglietta V, Kent SC, Orban T and Hafler DA: GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest. 2002 Apr;109 (7) :895-903. PMID: 11927616


Hafler DA: Degeneracy, as opposed to specificity, in immunotherapy. J Clin Invest. 2002 Mar;109 (5) :581-4. PMID: 11877465

Bar-Or A, Oliveira EM, Anderson DE, Krieger JI, Duddy M, O'Connor KC and Hafler DA: Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. J Immunol. 2001 Nov 15;167 (10) :5669-77. PMID: 11698439


Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K and Hafler DA: Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. J Virol. 2001 Oct;75 (20) :9836-43. PMID: 11559817


Ohashi T, Yukitake M, Slavin A, Krieger J and Hafler DA: In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG. J Neuroimmunol. 2001 Aug 30;118 (2) :194-202. PMID: 11498254


Baecher-Allan C, Brown JA, Freeman GJ and Hafler DA: CD4+CD25high regulatory cells in human peripheral blood. J Immunol. 2001 Aug 1;167 (3) :1245-53. PMID: 11466340


Trollmo C, Meyer AL, Steere AC, Hafler DA and Huber BT: Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells. J Immunol. 2001 Apr 15;166 (8) :5286-91. PMID: 11290815


O'Connor KC, Bar-Or A and Hafler DA: The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J Clin Immunol. 2001 Mar;21 (2) :81-92. PMID: 11332657


Slavik JM, Lim DG, Burakoff SJ and Hafler DA: Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes. J Immunol. 2001 Mar 1;166 (5) :3201-9. PMID: 11207273


Anderson DE and Hafler DA: Immune tolerance and the nervous system. Adv Exp Med Biol. 2001;490 :79-98. PMID: 11505978


Orban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA and Hafler DA: Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset. Autoimmunity. 2001;34 (4) :247-64. PMID: 11905851


Gausling R, Trollmo C and Hafler DA: Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis. Clin Immunol. 2001 Jan;98 (1) :11-7. PMID: 11141321

Duda PW, Krieger JI, Schmied MC, Balentine C and Hafler DA: Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate. J Immunol. 2000 Dec 15;165 (12) :7300-7. PMID: 11120865


Harrison LC and Hafler DA: Antigen-specific therapy for autoimmune disease. Curr Opin Immunol. 2000 Dec;12 (6) :704-11. PMID: 11102776


Lim DG, Bieganowska Bourcier K, Freeman GJ and Hafler DA: Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope. J Immunol. 2000 Dec 1;165 (11) :6214-20. PMID: 11086055


Meyer AL, Trollmo C, Crawford F, Marrack P, Steere AC, Huber BT, Kappler J and Hafler DA: Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc Natl Acad Sci U S A. 2000 Oct 10;97 (21) :11433-8. PMID: 11005833


Kiefer R, Dangond F, Mueller M, Toyka KV, Hafler DA and Hartung HP: Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies. J Neurol Neurosurg Psychiatry. 2000 Sep;69 (3) :362-8. PMID: 10945811


Hunter SF and Hafler DA: Ubiquitous pathogens: links between infection and autoimmunity in MS? Neurology. 2000 Jul 25;55 (2) :164-5. PMID: 10908883


Kipp B, Bar-Or A, Gausling R, Oliveira EM, Fruhan SA, Stuart WH and Hafler DA: A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis. Eur J Immunol. 2000 Jul;30 (7) :2092-100. PMID: 10940899


Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, Hafler DA, Strominger JL and Byrne MC: Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proc Natl Acad Sci U S A. 2000 Jun 20;97 (13) :7411-6. PMID: 10840051


Duda PW, Schmied MC, Cook SL, Krieger JI and Hafler DA: Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J Clin Invest. 2000 Apr;105 (7) :967-76. PMID: 10749576


Anderson DE, Bieganowska KD, Bar-Or A, Oliveira EM, Carreno B, Collins M and Hafler DA: Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nat Med. 2000 Feb;6 (2) :211-4. PMID: 10655112

Anderson DE, Sharpe AH and Hafler DA: The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Curr Opin Immunol. 1999 Dec;11 (6) :677-83. PMID: 10631554


Flavell RA and Hafler DA: Autoimmunity. What is the turning point? Curr Opin Immunol. 1999 Dec;11 (6) :635-7. PMID: 10631547


Bar-Or A, Oliveira EM, Anderson DE and Hafler DA: Molecular pathogenesis of multiple sclerosis. J Neuroimmunol. 1999 Dec;100 (1-2) :252-9. PMID: 10695735


Hohol MJ, Olek MJ, Orav EJ, Stazzone L, Hafler DA, Khoury SJ, Dawson DM and Weiner HL: Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease. Mult Scler. 1999 Dec;5 (6) :403-9. PMID: 10618696


Kent SC, Hafler DA, Strominger JL and Wilson SB: Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d. Hum Immunol. 1999 Nov;60 (11) :1080-9. PMID: 10600006


Hafler DA: The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis. J Clin Invest. 1999 Sep;104 (5) :527-9. PMID: 10487765


Milner JD, Kent SC, Ashley TA, Wilson SB, Strominger JL and Hafler DA: Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. J Immunol. 1999 Sep 1;163 (5) :2522-9. PMID: 10452989


She JX, Ellis TM, Wilson SB, Wasserfall CH, Marron M, Reimsneider S, Kent SC, Hafler DA, Neuberg DS, Muir A, Strominger JL and Atkinson MA: Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes. Proc Natl Acad Sci U S A. 1999 Jul 6;96 (14) :8116-9. PMID: 10393957


Semana G, Gausling R, Jackson RA and Hafler DA: T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects. J Autoimmun. 1999 Jun;12 (4) :259-67. PMID: 10330297


Pohl-Koppe A, Logigian EL, Steere AC and Hafler DA: Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis. Cell Immunol. 1999 May 25;194 (1) :118-23. PMID: 10357888


Smith D, Buckle GJ, Hafler DA, Frank DA and Höllsberg P: HTLV-I-infected T cells evade the antiproliferative action of IFN-beta. Virology. 1999 May 10;257 (2) :314-21. PMID: 10329542


Ausubel LJ, Bieganowska KD and Hafler DA: Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein. Cell Immunol. 1999 Apr 10;193 (1) :99-107. PMID: 10202117


Bieganowska K, Höllsberg P, Buckle GJ, Lim DG, Greten TF, Schneck J, Altman JD, Jacobson S, Ledis SL, Hanchard B, Chin J, Morgan O, Roth PA and Hafler DA: Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. J Immunol. 1999 Feb 1;162 (3) :1765-71. PMID: 9973440

Pohl-Koppe A, Burchett SK, Thiele EA and Hafler DA: Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis. J Neuroimmunol. 1998 Nov 2;91 (1-2) :19-27. PMID: 9846815


Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL and Hafler DA: Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J Neuroimmunol. 1998 Nov 2;91 (1-2) :1-9. PMID: 9846813


Martin R, Ruddle NH, Reingold S and Hafler DA: T helper cell differentiation in multiple sclerosis and autoimmunity. Immunol Today. 1998 Nov;19 (11) :495-8. PMID: 9818541


Takashima H, Smith DR, Fukaura H, Khoury SJ, Hafler DA and Weiner HL: Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients. Clin Immunol Immunopathol. 1998 Jul;88 (1) :28-34. PMID: 9683547


Pohl-Koppe A, Balashov KE, Steere AC, Logigian EL and Hafler DA: Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection. J Immunol. 1998 Feb 15;160 (4) :1804-10. PMID: 9469440


Scholz C, Patton KT, Anderson DE, Freeman GJ and Hafler DA: Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J Immunol. 1998 Feb 1;160 (3) :1532-8. PMID: 9570577


Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N and Gullans SR: Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. Biochem Biophys Res Commun. 1998 Jan 26;242 (3) :648-52. PMID: 9464271


Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL and Hafler DA: Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature. 1998 Jan 8;391 (6663) :177-81. PMID: 9428763

Hafler DA, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL and Fukaura H: Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Ann N Y Acad Sci. 1997 Dec 19;835 :120-31. PMID: 9616767


Dressel A, Chin JL, Sette A, Gausling R, Höllsberg P and Hafler DA: Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. J Immunol. 1997 Nov 15;159 (10) :4943-51. PMID: 9366420


Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ and Hafler DA: Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol. 1997 Nov 15;159 (10) :4799-805. PMID: 9366404


Smith DR, Balashov KE, Hafler DA, Khoury SJ and Weiner HL: Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Ann Neurol. 1997 Sep;42 (3) :313-8. PMID: 9307252


Ausubel LJ, Krieger JI and Hafler DA: Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99. J Immunol. 1997 Sep 1;159 (5) :2502-12. PMID: 9278344


Anderson DE, Ausubel LJ, Krieger J, Höllsberg P, Freeman GJ and Hafler DA: Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. J Immunol. 1997 Aug 15;159 (4) :1669-75. PMID: 9257827


Dangond F, Windhagen A, Groves CJ and Hafler DA: Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. J Neuroimmunol. 1997 Jun;76 (1-2) :132-8. PMID: 9184642


Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W and Hafler DA: Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med. 1997 May 5;185 (9) :1585-94. PMID: 9151896


Nussenblatt RB, Gery I, Weiner HL, Ferris FL, Shiloach J, Remaley N, Perry C, Caspi RR, Hafler DA, Foster CS and Whitcup SM: Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. Am J Ophthalmol. 1997 May;123 (5) :583-92. PMID: 9152063


Richardson JH, Höllsberg P, Windhagen A, Child LA, Hafler DA and Lever AM: Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I. Blood. 1997 May 1;89 (9) :3303-14. PMID: 9129036


Kent SC, Fukaura H, Pietrusewicz MJ, Khoury SJ, Weiner HL and Hafler DA: Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients. Ann N Y Acad Sci. 1997 Apr 5;815 :412-22. PMID: 9186687


Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Höllsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ and Kuchroo VK: B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. J Immunol. 1997 Mar 1;158 (5) :2025-34. PMID: 9036945


Balashov KE, Smith DR, Khoury SJ, Hafler DA and Weiner HL: Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc Natl Acad Sci U S A. 1997 Jan 21;94 (2) :599-603. PMID: 9012830

Ausubel LJ, Kwan CK, Sette A, Kuchroo V and Hafler DA: Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proc Natl Acad Sci U S A. 1996 Dec 24;93 (26) :15317-22. PMID: 8986809


Höllsberg P, Batra V, Dressel A and Hafler DA: Induction of anergy in CD8 T cells by B cell presentation of antigen. J Immunol. 1996 Dec 15;157 (12) :5269-76. PMID: 8955172


Hafler DA and Flavell R: Autoimmunity. How to know thy self. Curr Opin Immunol. 1996 Dec;8 (6) :805-7. PMID: 8994859


Scholz C, Freeman GJ, Greenfield EA, Hafler DA and Höllsberg P: Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation. J Immunol. 1996 Oct 1;157 (7) :2932-8. PMID: 8816399


Scholz C, Hafler DA and Höllsberg P: Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells. J Neurosci Res. 1996 Sep 15;45 (6) :786-94. PMID: 8892090


Rothenberg ME, Weber WE, Longtine JA and Hafler DA: Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clin Immunol Immunopathol. 1996 Sep;80 (3 Pt 1) :266-72. PMID: 8811046


Windhagen A, Anderson DE, Carrizosa A, Williams RE and Hafler DA: IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol. 1996 Aug 1;157 (3) :1127-31. PMID: 8757617


Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL and Hafler DA: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest. 1996 Jul 1;98 (1) :70-7. PMID: 8690806


Hafler DA, Saadeh MG, Kuchroo VK, Milford E and Steinman L: TCR usage in human and experimental demyelinating disease. Immunol Today. 1996 Apr;17 (4) :152-9. PMID: 8871344


Matsui M, Hafler DA and Weiner HL: Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency. Ann N Y Acad Sci. 1996 Feb 13;778 :398-404. PMID: 8611003


Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL and Hafler DA: Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis. Ann N Y Acad Sci. 1996 Feb 13;778 :251-7. PMID: 8610978


Hohol MJ, Khoury SJ, Cook SL, Orav EJ, Hafler DA and Weiner HL: Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Ann N Y Acad Sci. 1996 Feb 13;778 :243-50. PMID: 8610977


Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK and Hafler DA: Role of Th1 and Th2 cells in neurologic disorders. Chem Immunol. 1996;63 :171-86. PMID: 8934837


Buckle GJ, Hafler DA and Höllsberg P: HTLV-I-induced T-cell activation. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1 :S107-13. PMID: 8797712

Windhagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, Cuzner ML and Hafler DA: Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med. 1995 Dec 1;182 (6) :1985-96. PMID: 7500044


Wucherpfennig KW, Hafler DA and Strominger JL: Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proc Natl Acad Sci U S A. 1995 Sep 12;92 (19) :8896-900. PMID: 7568039


Markovic-Plese S, Fukaura H, Zhang J, al-Sabbagh A, Southwood S, Sette A, Kuchroo VK and Hafler DA: T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J Immunol. 1995 Jul 15;155 (2) :982-92. PMID: 7541828


Wucherpfennig KW and Hafler DA: A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Ann N Y Acad Sci. 1995 Jul 7;756 :241-58. PMID: 7544075


Balashov KE, Khoury SJ, Hafler DA and Weiner HL: Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest. 1995 Jun;95 (6) :2711-9. PMID: 7769110


Stinissen P, Vandevyver C, Medaer R, Vandegaer L, Nies J, Tuyls L, Hafler DA, Raus J and Zhang J: Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. J Immunol. 1995 May 1;154 (9) :4883-94. PMID: 7722338


Höllsberg P, Weber WE, Dangond F, Batra V, Sette A and Hafler DA: Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proc Natl Acad Sci U S A. 1995 Apr 25;92 (9) :4036-40. PMID: 7732026


Windhagen A, Scholz C, Höllsberg P, Fukaura H, Sette A and Hafler DA: Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity. 1995 Apr;2 (4) :373-80. PMID: 7536622


Hafler DA and Weiner HL: Immunologic mechanisms and therapy in multiple sclerosis. Immunol Rev. 1995 Apr;144 :75-107. PMID: 7590822


Dangond F, Daza JS, Rosania A, Quin MJ, Zaninovic V, Chaplin B, Marlink R and Hafler DA: Tropical spastic paraparesis on the Caribbean coast of Colombia. Am J Trop Med Hyg. 1995 Feb;52 (2) :155-8. PMID: 7872443


Höllsberg P and Hafler DA: What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis? Ann Neurol. 1995 Feb;37 (2) :143-5. PMID: 7847855


McLaurin JA, Hafler DA and Antel JP: Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter. J Neurol Sci. 1995 Feb;128 (2) :205-11. PMID: 7537795


Weiner HL, Hohol MJ, Khoury SJ, Dawson DM and Hafler DA: Therapy for multiple sclerosis. Neurol Clin. 1995 Feb;13 (1) :173-96. PMID: 7739502


Hafler DA and Weiner HL: Antigen specific therapies for the treatment of autoimmune diseases. Agents Actions Suppl. 1995;47 :59-77. PMID: 7785504


Hafler DA and Weiner HL: Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease. Chem Immunol. 1995;60 :126-49. PMID: 7857525


Hafler DA and Weiner HL: Antigen-specific therapies for the treatment of autoimmune diseases. Springer Semin Immunopathol. 1995;17 (1) :61-76. PMID: 7482227

Chung S, Wucherpfennig KW, Friedman SM, Hafler DA and Strominger JL: Functional three-domain single-chain T-cell receptors. Proc Natl Acad Sci U S A. 1994 Dec 20;91 (26) :12654-8. PMID: 7809095


Chen Y, Kuchroo VK, Inobe J, Hafler DA and Weiner HL: Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994 Aug 26;265 (5176) :1237-40. PMID: 7520605


Höllsberg P, Ausubel LJ and Hafler DA: Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression. J Immunol. 1994 Jul 15;153 (2) :566-73. PMID: 8021495


Zoubak S, Richardson JH, Rynditch A, Höllsberg P, Hafler DA, Boeri E, Lever AM and Bernardi G: Regional specificity of HTLV-I proviral integration in the human genome. Gene. 1994 Jun 10;143 (2) :155-63. PMID: 8206368


LaSalle JM and Hafler DA: T cell anergy. FASEB J. 1994 Jun;8 (9) :601-8. PMID: 8005388


Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K and Hafler DA: Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol. 1994 Jun 1;152 (11) :5581-92. PMID: 7514641


Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG and Weiner HL: T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. J Exp Med. 1994 May 1;179 (5) :1659-64. PMID: 8163944


Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL and Hafler DA: Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med. 1994 Mar 1;179 (3) :973-84. PMID: 7509366


Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE and Hafler DA: Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol. 1994;12 :809-37. PMID: 8011298


Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL and Hafler DA: Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med. 1994 Jan 1;179 (1) :279-90. PMID: 7505801

Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA and Weiner HL: Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24;261 (5129) :1727-30. PMID: 8378772


LaSalle JM, Toneguzzo F, Saadeh M, Golan DE, Taber R and Hafler DA: T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. J Immunol. 1993 Jul 15;151 (2) :649-57. PMID: 7687620


Höllsberg P, Melinek J, Benjamin D and Hafler DA: Increased protein kinase C activity in human memory T cells. Cell Immunol. 1993 Jun;149 (1) :170-9. PMID: 8099849


Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL and Hafler DA: Biological activity of recombinant human myelin basic protein. J Neuroimmunol. 1993 May;44 (2) :157-62. PMID: 7685037


Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL and Turel A: Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology. 1993 May;43 (5) :910-8. PMID: 8388090


Höllsberg P and Hafler DA: Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection. N Engl J Med. 1993 Apr 22;328 (16) :1173-82. PMID: 8455685


Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL and Wucherpfeffnig K: The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8 :S39-40. PMID: 7686832


Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM and Hafler DA: Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science. 1993 Feb 26;259 (5099) :1321-4. PMID: 7680493


Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA and Strominger JL: Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. J Exp Med. 1993 Feb 1;177 (2) :425-32. PMID: 8093893

Freeman GJ, Lombard DB, Gimmi CD, Brod SA, Lee K, Laning JC, Hafler DA, Dorf ME, Gray GS and Reiser H: CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J Immunol. 1992 Dec 15;149 (12) :3795-801. PMID: 1281186


LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM and Hafler DA: Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J Exp Med. 1992 Jul 1;176 (1) :177-86. PMID: 1535366


Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE and Hafler DA: Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. J Immunol. 1992 May 15;148 (10) :3256-63. PMID: 1374452


Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML and Hafler DA: Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acad Sci U S A. 1992 May 15;89 (10) :4588-92. PMID: 1374907


Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML and Hafler DA: T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. J Exp Med. 1992 Apr 1;175 (4) :993-1002. PMID: 1348083


Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D and Hafler DA: T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proc Natl Acad Sci U S A. 1992 Mar 15;89 (6) :2110-4. PMID: 1549569


Hafler DA, Cohen I, Benjamin DS and Weiner HL: T cell vaccination in multiple sclerosis: a preliminary report. Clin Immunol Immunopathol. 1992 Mar;62 (3) :307-13. PMID: 1541056


Zhang J, Weiner HL and Hafler DA: Autoreactive T cells in multiple sclerosis. Int Rev Immunol. 1992;9 (3) :183-201. PMID: 1285060

Hafler DA, Matsui M, Wucherpfennig KW, Ota K and Weiner HL: The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Ann N Y Acad Sci. 1991 Dec 30;636 :251-65. PMID: 1724362


Miller A, Hafler DA and Weiner HL: Immunotherapy in autoimmune diseases. Curr Opin Immunol. 1991 Dec;3 (6) :936-40. PMID: 1793539


LaSalle JM and Hafler DA: The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cell Immunol. 1991 Nov;138 (1) :197-206. PMID: 1833074


Miller A, Hafler DA and Weiner HL: Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. FASEB J. 1991 Aug;5 (11) :2560-6. PMID: 1868980


Wucherpfennig KW, Weiner HL and Hafler DA: T-cell recognition of myelin basic protein. Immunol Today. 1991 Aug;12 (8) :277-82. PMID: 1716903


Brod SA, Benjamin D and Hafler DA: Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease. J Immunol. 1991 Aug 1;147 (3) :810-5. PMID: 1907306


LaSalle JM, Ota K and Hafler DA: Presentation of autoantigen by human T cells. J Immunol. 1991 Aug 1;147 (3) :774-80. PMID: 1713605


Brod SA, al-Sabbagh A, Sobel RA, Hafler DA and Weiner HL: Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig. Ann Neurol. 1991 Jun;29 (6) :615-22. PMID: 1716432


Hafler DA, Orav J, Gertz R, Stazzone L and Weiner HL: Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. J Neuroimmunol. 1991 May;32 (2) :149-58. PMID: 1672870


Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL and Hafler DA: Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann Neurol. 1991 Jan;29 (1) :33-40. PMID: 1847614


Hafler DA, Chofflon M, Kurt-Jones E and Weiner HL: Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. Clin Immunol Immunopathol. 1991 Jan;58 (1) :115-25. PMID: 1670583

Brod SA, Purvee M, Benjamin D and Hafler DA: T-T cell interactions are mediated by adhesion molecules. Eur J Immunol. 1990 Oct;20 (10) :2259-68. PMID: 1700751


Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL and Hafler DA: T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 1990 Jul 12;346 (6280) :183-7. PMID: 1694970


Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL and Hafler DA: Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science. 1990 May 25;248 (4958) :1016-9. PMID: 1693015


Brod SA, Purvee M, Benjamin D and Hafler DA: Frequency analysis of CD4+CD8+ T cells cloned with IL-4. Cell Immunol. 1990 Feb;125 (2) :426-36. PMID: 2105169


Dang NH, Hafler DA, Schlossman SF and Breitmeyer JB: FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation. Cell Immunol. 1990 Jan;125 (1) :42-57. PMID: 2152856


Hafler DA: Review of immunology. Res Publ Assoc Res Nerv Ment Dis. 1990;68 :23-35. PMID: 2183313

Brod SA, Rudd CE, Purvee M and Hafler DA: Lymphokine regulation of CD45R expression on human T cell clones. J Exp Med. 1989 Dec 1;170 (6) :2147-52. PMID: 2531196


Chofflon M, González V, Weiner HL and Hafler DA: Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells. Eur J Immunol. 1989 Oct;19 (10) :1791-5. PMID: 2479560


Chofflon M, Weiner HL, Morimoto C and Hafler DA: Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Ann Neurol. 1989 May;25 (5) :494-9. PMID: 2528316


Hafler DA, Chofflon M, Benjamin D, Dang NH and Breitmeyer J: Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression. J Immunol. 1989 Apr 15;142 (8) :2590-6. PMID: 2564857


Hafler DA and Weiner HL: MS: a CNS and systemic autoimmune disease. Immunol Today. 1989 Mar;10 (3) :104-7. PMID: 2472810


Duby AD, Weiner HL, Benjamin DS, Seidman JG and Hafler DA: Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis. J Neuroimmunol. 1989 Mar;22 (1) :63-8. PMID: 2465314


Hafler DA, Brod SA and Weiner HL: Immunoregulation in multiple sclerosis. Res Immunol. 1989 Feb;140 (2) :233-9; discussion 245-8. PMID: 2525796

Chofflon M, Weiner HL, Morimoto C and Hafler DA: Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann Neurol. 1988 Aug;24 (2) :185-91. PMID: 2972249


Hafler DA, Ritz J, Schlossman SF and Weiner HL: Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. J Immunol. 1988 Jul 1;141 (1) :131-8. PMID: 2454256


Hafler DA and Weiner HL: Immunosuppression with monoclonal antibodies in multiple sclerosis. Neurology. 1988 Jul;38 (7 Suppl 2) :42-7. PMID: 3260356


Carter JL, Hafler DA, Dawson DM, Orav J and Weiner HL: Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients. Neurology. 1988 Jul;38 (7 Suppl 2) :9-14. PMID: 2838768


Borst J, van Dongen JJ, Bolhuis RL, Peters PJ, Hafler DA, de Vries E and van de Griend RJ: Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody. J Exp Med. 1988 May 1;167 (5) :1625-44. PMID: 2966845


Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG and Weiner HL: Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. J Exp Med. 1988 Apr 1;167 (4) :1313-22. PMID: 3258624


Sobel RA, Hafler DA, Castro EE, Morimoto C and Weiner HL: The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. J Immunol. 1988 Apr 1;140 (7) :2210-4. PMID: 2965183


Weiner HL and Hafler DA: Immunotherapy of multiple sclerosis. Ann Neurol. 1988 Mar;23 (3) :211-22. PMID: 3288084


Blue ML, Hafler DA, Daley JF, Levine H, Craig KA, Breitmeyer JB and Schlossman SF: Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities. J Immunol. 1988 Jan 15;140 (2) :376-83. PMID: 2891768


Hafler DA and Weiner HL: Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses. Ann N Y Acad Sci. 1988;540 :557-9. PMID: 2905125


Chofflon M, Weiner HL and Hafler DA: Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann N Y Acad Sci. 1988;540 :330-2. PMID: 2905122


Sobel RA, Hafler DA, Castro EE, Morimoto C and Weiner HL: Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue. Ann N Y Acad Sci. 1988;540 :306-8. PMID: 2905121


Carter JL, Dawson DM, Hafler DA, Fallis RJ, Stazzone L, Orav J and Weiner HL: Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis. Ann N Y Acad Sci. 1988;540 :535-6. PMID: 2849902

Blue ML, Hafler DA, Craig KA, Levine H and Schlossman SF: Phosphorylation of CD4 and CD8 molecules following T cell triggering. J Immunol. 1987 Dec 15;139 (12) :3949-54. PMID: 2961801


Hafler DA and Weiner HL: T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunol Rev. 1987 Dec;100 :307-32. PMID: 3326824


Hafler DA, Fox DA, Benjamin D, Blue ML and Weiner HL: Secondary immune amplification following live poliovirus immunization in humans. Clin Immunol Immunopathol. 1987 Sep;44 (3) :321-8. PMID: 3040309


Hafler DA and Weiner HL: In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis. Ann Neurol. 1987 Jul;22 (1) :89-93. PMID: 3498435


Hafler DA, Benjamin DS, Burks J and Weiner HL: Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. J Immunol. 1987 Jul 1;139 (1) :68-72. PMID: 2438352


Ang SL, Seidman JG, Peterman GM, Duby AD, Benjamin D, Lee SJ and Hafler DA: Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones. J Exp Med. 1987 May 1;165 (5) :1453-8. PMID: 3106557


Dawson DM, Carter JL, Hafler DA and Weiner HL: Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies. Riv Neurol. 1987 Mar-Apr;57 (2) :88-91. PMID: 3039645


Morimoto C, Hafler DA, Weiner HL, Letvin NL, Hagan M, Daley J and Schlossman SF: Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody. N Engl J Med. 1987 Jan 8;316 (2) :67-72. PMID: 2946956

Johnson D, Hafler DA, Fallis RJ, Lees MB, Brady RO, Quarles RH and Weiner HL: Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J Neuroimmunol. 1986 Nov;13 (1) :99-108. PMID: 2428837


Hafler DA, Fox DA, Benjamin D and Weiner HL: Antigen reactive memory T cells are defined by Ta1. J Immunol. 1986 Jul 15;137 (2) :414-8. PMID: 3013990


Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL and Weiner HL: Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology. 1986 Jun;36 (6) :777-84. PMID: 3486383


Hafler DA, Johnson D, Kelly JJ, Panitch H, Kyle R and Weiner HL: Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics. Neurology. 1986 Jan;36 (1) :75-8. PMID: 2417161

Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL and Weiner HL: Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol. 1985 Nov;37 (2) :163-71. PMID: 3930113


Hafler DA, Buchsbaum M, Johnson D and Weiner HL: Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis. Ann Neurol. 1985 Oct;18 (4) :451-8. PMID: 2416267


Hafler DA, Buchsbaum M and Weiner HL: Decreased autologous mixed lymphocyte reaction in multiple sclerosis. J Neuroimmunol. 1985 Oct;9 (6) :339-47. PMID: 2931449


Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL and Weiner HL: In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med. 1985 May 30;312 (22) :1405-11. PMID: 2985995

Tardieu M, Powers ML, Hafler DA, Hauser SL and Weiner HL: Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. Eur J Immunol. 1984 Jun;14 (6) :561-5. PMID: 6329771


Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA and Hauser SL: Altered blood T-cell subsets in patients with multiple sclerosis. J Neuroimmunol. 1984 Apr;6 (2) :115-21. PMID: 6373819


Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA and Hauser SL: T cell subsets in patients with multiple sclerosis. An overview. Ann N Y Acad Sci. 1984;436 :281-93. PMID: 6152384


Weiner HL, Hauser SL, Hafler DA, Fallis RJ, Lehrich JR and Dawson DM: The use of cyclophosphamide in the treatment of multiple sclerosis. Ann N Y Acad Sci. 1984;436 :373-81. PMID: 6099707

Devinsky O, Hafler DA and Victor J: Embarrassment as the aura of a complex partial seizure. Neurology. 1982 Nov;32 (11) :1284-5. PMID: 6890164

Brem SS, Hafler DA, Van Uitert RL, Ruff RL and Reichert WH: Spinal subarachnoid hematoma: a hazard of lumbar puncture resulting in reversible paraplegia. N Engl J Med. 1981 Apr 23;304 (17) :1020-1. PMID: 7207553