Welcome to the Grutzendler Lab
The dynamics and logic of cell-cell interactions in the neurovascular unit
The overall interest of our laboratory centers around cells in the so called "neurovascular unit" (neurons, endothelium, astrocytes, pericytes and microglia). We aim at learning about their dynamic properties and how cell-cell interactions are disrupted in vascular and neurodegenerative pathologies. Experiments in the laboratory involve mouse models of various cerebral disorders including microvascular injury and Alzheimer's disease. The majority of projects are imaging-oriented. We use a variety of techniques including transcranial in vivo two photon microscopy, high-resolution confocal and electron microscopy in combination with differential fluorescent cell labeling and genetic/pharmacological manipulations.