Welcome to the Grutzendler Lab
The dynamics and logic of neuro-glio-vascular interactions in health and disease
The overall goal of our laboratory is to uncover rules that govern the complex interactions between all brain cell types in their unperturbed in vivo environment and to determine how these dynamic cell-cell interactions are disrupted in a variety of disease states.We combine high-resolution cellular imaging in vivo and fixed tissues of single cells and small clusters of interacting cells with novel optical sensors of cellular physiology, optogenetics, chemogenetics, genome editing techniques delivered by viral vectors or in utero electroporation. Our studies are initially exploratory and hypothesis generating but as we observe unique and interesting features we develop novel experimental approaches to test such hypotheses. Because of this approach, our results take us in very different directions such that projects in the lab can have a neuronal, glial or vascular focus and can be geared towards understanding normal physiology or neuropathology (such as Alzheimer's disease, microvascular and demyelinating disorders).