The Engelman Lab maintains interdisciplinary collaborations with several research groups both inside Yale and with groups around the US:
Andreev and Reshetnyak Groups - Univ. of Rhode Island - Division of Biological and Medical Physics: Former Engelman Lab postdoctoral fellow, Yana Reshetnyak, and Oleg Andreev were central figures in the original discovery of pHLIPs and their translational applications. They have continued leading research on pHLIPs and are at the forefront of new innovations in pHLIP technology. The Engelman Lab continues to collaborate with their groups to perform basic and foundational biophysical research on pHLIPs and to advance these technologies towards translation to the clinic. Click here to learn more.
The Bosenberg Lab: The Bosenberg Lab at the Yale School of Medicine performs research in the field of Dermatopathology. Their development of several transgenic mouse models of malignant melanoma have opened avenues of research into the origins, diagnosis and treatment of the disease. The Engelman Lab is collaborating with the Bosenberg Lab in an effort to adapt both traditional and novel therapeutic agents for the treatment of malignant and metastatic lymphoma through pHLIP delivery. Click here to learn more.
The Braddock Lab: The Braddock Lab at the Yale School of Medicine is leading research in the antitumor properties of human phosphodiesterases. The Engelman Lab is collaborating with the Braddock Lab to couple the tumor targeting activity of pHLIP with the nove antitumor activities of ceratin phosphodiesterases. Click here to learn more.
The DiMaio Lab: The DiMaio Lab at the Yale Medical School performs reasearch investigating the transforming effects of tumor viruses and the insights these give into mechanisms of cell growth control. The Engelman Lab is collaborating with the DiMaio Lab to investigate binding interactions between transmembrane peptides. Using the Bovine Pappiloma Virus E5 protein as a model the Dimaio Lab has identified short transmembrane peptides that are capable of transforming cells by inducing growth factor-independent dimerization and activation of the PDGF-beta receptor. We are currently collaborating in an effort to investigate this activity through Molecular Dynamics simulations of transmembrane peptide interactions. Click here to learn more.
The Glazer Lab: The Glazer Lab at the Yale Medical School performs research in the fields of cancer molecular biology and gene therapy. The Engelman Lab is collaborating with the Glazer Lab in an effort to treat tumors through pHLIP delivery of therapeutic peptide nucleic acids targeting oncogenic microRNAs. Click here to learn more.
The Lewis Lab: The Lewis Lab at the Memorial Sloan-Kettering Cancer Center performs research aimed at advancing PET imaging techniques for the diagnosis and treatment of cancer. The Engelman Lab is collaborating with the Lewis Lab to adapt the tumor-targeting activity of pHLIPs for applications in diagnotic imaging and radiotherapy of cancer. Click here to learn more.
The Saltzman Lab: The Saltzman Lab in Yale's Department of Biomedical Engineering performs research using bio-compatible polymer materials to improve the delivery and control the release of therapeutic agents in the body. The Engelman Lab is collaborating with the Saltzman Lab in an effort to couple the encapsulation and controlled release of drugs using nanoparticles with the tumor-targeting activity of pHLIPs. Click here to learn more.
The Sinusas Lab: The Sinusas Lab at the Yale School of Medicine is a leading figure in cardiac imaging technologies. The Engelman Lab is collaborating with the Sinusas Lab to investigate pHLIP targeting of ischemic tissues for potential diagnostic or therapeutic applications. Click here to learn more.
The Slack Lab: The Slack Lab in the Yale Department of Molecular Cellular and Developmental Biology are investigating the role of ongcogenic microRNAs (onco-miRs) in cancer. The Engelman Lab is collaborating with the Slack Lab to test pHLIP-delivered petide nucleic acid therapeutics targeting onco-miRs in a mouse model of disseminated lymphoma. Click here to learn more.
The Spiegel Lab: The Spiegel Lab in the Yale Department of Chemistry is a leader in the field of synthetic immunology with expertise in both immunobiology and synthetic chemistry. The Engelman Lab is collaborating with the Spiegel Lab in an effort to use pHLIPs to decorate cancer cells with agents to recruit the immune response to tumors, in vivo. Collaborative efforts are also underway to adapt pHLIPs for the intracellular delivery of chemotherapeutic agents. Click here to learn more.