Publications

Wyatt LC, Lewis JS, Andreev OA, Reshetnyak YK, Engelman DM: Applications of pHLIP Technology for Cancer Imaging and Therapy. Trends Biotechnol. 2017 Apr 21; 2017 Apr 21. PMID: 28438340

Golijanin J, Amin A, Moshnikova A, Brito JM, Tran TY, Adochite RC, Andreev GO, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D: Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo. Proc Natl Acad Sci U S A. 2016 Oct 18; 2016 Sep 29. PMID: 27688767

Demoin DW, Wyatt LC, Edwards KJ, Abdel-Atti D, Sarparanta M, Pourat J, Longo VA, Carlin SD, Engelman DM, Andreev OA, Reshetnyak YK, Viola-Villegas N, Lewis JS: PET Imaging of Extracellular pH in Tumors with (64)Cu- and (18)F-Labeled pHLIP Peptides: A Structure-Activity Optimization Study. Bioconjug Chem. 2016 Sep 21; 2016 Jul 21. PMID: 27396694

Anderson M, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA: Probe for the measurement of cell surface pH in vivo and ex vivo. Proc Natl Acad Sci U S A. 2016 Jul 19; 2016 Jul 5. PMID: 27382181

Svoronos AA, Engelman DM, Slack FJ: OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer. Cancer Res. 2016 Jul 1; 2016 Jun 20. PMID: 27325641

Popot JL, Engelman DM: Membranes Do Not Tell Proteins How To Fold. Biochemistry. 2016 Jan 12; 2015 Dec 19. PMID: 26649989

Heim EN, Marston JL, Federman RS, Edwards AP, Karabadzhak AG, Petti LM, Engelman DM, DiMaio D: Biologically active LIL proteins built with minimal chemical diversity. Proc Natl Acad Sci U S A. 2015 Aug 25; 2015 Aug 10. PMID: 26261320

Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ: The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A. 2015 Aug 4; 2015 Jul 20. PMID: 26195776

Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ: MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature. 2015 Feb 5; 2014 Nov 17. PMID: 25409146

Deacon JC, Engelman DM, Barrera FN: Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP. Arch Biochem Biophys. 2015 Jan 1; 2014 Nov 18. PMID: 25444855

Karabadzhak AG, An M, Yao L, Langenbacher R, Moshnikova A, Adochite RC, Andreev OA, Reshetnyak YK, Engelman DM: pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol. 2014 Nov 21; 2014 Sep 10. PMID: 25184440

Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS: Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A. 2014 May 20; 2014 May 1. PMID: 24785505

Cohen EB, Jun SJ, Bears Z, Barrera FN, Alonso M, Engelman DM, DiMaio D: Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor. PLoS One. 2014; 2014 Apr 30. PMID: 24788775

Andreev OA, Engelman DM, Reshetnyak YK: Targeting diseased tissues by pHLIP insertion at low cell surface pH. Front Physiol. 2014; 2014 Mar 13. PMID: 24659971

Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD: Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. J Virol. 2014 Jan; 2013 Oct 30. PMID: 24173222

Fendos J, Barrera FN, Engelman DM: Aspartate embedding depth affects pHLIP's insertion pKa. Biochemistry. 2013 Jul 9; 2013 Jun 27. PMID: 23721379

Weerakkody D, Moshnikova A, Thakur MS, Moshnikova V, Daniels J, Engelman DM, Andreev OA, Reshetnyak YK: Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A. 2013 Apr 9; 2013 Mar 25. PMID: 23530249

Li N, Yin L, Thévenin D, Yamada Y, Limmon G, Chen J, Chow VT, Engelman DM, Engelward BP: Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol. 2013 Feb. PMID: 23374130

Yao L, Daniels J, Moshnikova A, Kuznetsov S, Ahmed A, Engelman DM, Reshetnyak YK, Andreev OA: pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci U S A. 2013 Jan 8; 2012 Dec 24. PMID: 23267062

Sosunov EA, Anyukhovsky EP, Sosunov AA, Moshnikova A, Wijesinghe D, Engelman DM, Reshetnyak YK, Andreev OA: pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A. 2013 Jan 2; 2012 Dec 17. PMID: 23248283

Macholl S, Morrison MS, Iveson P, Arbo BE, Andreev OA, Reshetnyak YK, Engelman DM, Johannesen E: In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol. 2012 Dec. PMID: 22371188

Barrera FN, Fendos J, Engelman DM: Membrane physical properties influence transmembrane helix formation. Proc Natl Acad Sci U S A. 2012 Sep 4; 2012 Aug 20. PMID: 22908237

Karabadzhak AG, Weerakkody D, Wijesinghe D, Thakur MS, Engelman DM, Andreev OA, Markin VS, Reshetnyak YK: Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J. 2012 Apr 18. PMID: 22768940

Reshetnyak YK, Yao L, Zheng S, Kuznetsov S, Engelman DM, Andreev OA: Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol. 2011 Dec. PMID: 21181501

Wijesinghe D, Engelman DM, Andreev OA, Reshetnyak YK: Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry. 2011 Nov 29; 2011 Nov 4. PMID: 22029270

Barrera FN, Weerakkody D, Anderson M, Andreev OA, Reshetnyak YK, Engelman DM: Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol. 2011 Oct 21; 2011 Aug 23. PMID: 21888917

Matthews EE, Thévenin D, Rogers JM, Gotow L, Lira PD, Reiter LA, Brissette WH, Engelman DM: Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation. FASEB J. 2011 Jul; 2011 Mar 14. PMID: 21402716

An M, Wijesinghe D, Andreev OA, Reshetnyak YK, Engelman DM: pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci U S A. 2010 Nov 23; 2010 Nov 3. PMID: 21048084

Miyauchi K, Curran AR, Long Y, Kondo N, Iwamoto A, Engelman DM, Matsuda Z: The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein. Retrovirology. 2010 Nov 13; 2010 Nov 13. PMID: 21073746

Andreev OA, Engelman DM, Reshetnyak YK: pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol. 2010 Oct; 2010 Oct 13. PMID: 20939768

Patel PV, Gianoulis TA, Bjornson RD, Yip KY, Engelman DM, Gerstein MB: Analysis of membrane proteins in metagenomics: networks of correlated environmental features and protein families. Genome Res. 2010 Jul; 2010 Apr 29. PMID: 20430783

Musial-Siwek M, Karabadzhak A, Andreev OA, Reshetnyak YK, Engelman DM: Tuning the insertion properties of pHLIP. Biochim Biophys Acta. 2010 Jun; 2009 Sep 18. PMID: 19766589

Andreev OA, Karabadzhak AG, Weerakkody D, Andreev GO, Engelman DM, Reshetnyak YK: pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A. 2010 Mar 2; 2010 Feb 16. PMID: 20160113

Cammett TJ, Jun SJ, Cohen EB, Barrera FN, Engelman DM, Dimaio D: Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci U S A. 2010 Feb 23; 2010 Feb 8. PMID: 20142506

Arinaminpathy Y, Khurana E, Engelman DM, Gerstein MB: Computational analysis of membrane proteins: the largest class of drug targets. Drug Discov Today. 2009 Dec; 2009 Sep 3. PMID: 19733256

Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM, Dimaio D: Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor. J Virol. 2009 Oct; 2009 Jul 15. PMID: 19605488

Kim JH, Hartley TL, Curran AR, Engelman DM: Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1. Biochim Biophys Acta. 2009 Sep; 2009 Jun 21. PMID: 19540828

Segala J, Engelman DM, Reshetnyak YK, Andreev OA: Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci. 2009 Aug 4; 2009 Aug 4. PMID: 20111691

Thévenin D, An M, Engelman DM: pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol. 2009 Jul 31. PMID: 19635412

Vāvere AL, Biddlecombe GB, Spees WM, Garbow JR, Wijesinghe D, Andreev OA, Engelman DM, Reshetnyak YK, Lewis JS: A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res. 2009 May 15; 2009 May 5. PMID: 19417132

Andreev OA, Engelman DM, Reshetnyak YK: Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chim Oggi. 2009 Mar 1. PMID: 20037661

Reshetnyak YK, Andreev OA, Segala M, Markin VS, Engelman DM: Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc Natl Acad Sci U S A. 2008 Oct 7; 2008 Sep 30. PMID: 18829441

Zoonens M, Reshetnyak YK, Engelman DM: Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J. 2008 Jul; 2008 Mar 21. PMID: 18359793

Gohon Y, Dahmane T, Ruigrok RW, Schuck P, Charvolin D, Rappaport F, Timmins P, Engelman DM, Tribet C, Popot JL, Ebel C: Bacteriorhodopsin/amphipol complexes: structural and functional properties. Biophys J. 2008 May 1; 2008 Jan 11. PMID: 18192360

Dupuy AD, Engelman DM: Protein area occupancy at the center of the red blood cell membrane. Proc Natl Acad Sci U S A. 2008 Feb 26; 2008 Feb 19. PMID: 18287056

Yip KY, Patel P, Kim PM, Engelman DM, McDermott D, Gerstein M: An integrated system for studying residue coevolution in proteins. Bioinformatics. 2008 Jan 15; 2007 Dec 1. PMID: 18056067

Reshetnyak YK, Segala M, Andreev OA, Engelman DM: A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J. 2007 Oct 1; 2007 Jun 8. PMID: 17557792

Andreev OA, Dupuy AD, Segala M, Sandugu S, Serra DA, Chichester CO, Engelman DM, Reshetnyak YK: Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A. 2007 May 8; 2007 May 1. PMID: 17483464

Matthews EE, Zoonens M, Engelman DM: Dynamic helix interactions in transmembrane signaling. Cell. 2006 Nov 3. PMID: 17081964

Finger C, Volkmer T, Prodöhl A, Otzen DE, Engelman DM, Schneider D: The stability of transmembrane helix interactions measured in a biological membrane. J Mol Biol. 2006 May 19; 2006 Mar 13. PMID: 16574146

Dixon AM, Stanley BJ, Matthews EE, Dawson JP, Engelman DM: Invariant chain transmembrane domain trimerization: a step in MHC class II assembly. Biochemistry. 2006 Apr 25. PMID: 16618111

Reshetnyak YK, Andreev OA, Lehnert U, Engelman DM: Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A. 2006 Apr 25; 2006 Apr 11. PMID: 16608910

Miyauchi K, Curran R, Matthews E, Komano J, Hoshino T, Engelman DM, Matsuda Z: Mutations of conserved glycine residues within the membrane-spanning domain of human immunodeficiency virus type 1 gp41 can inhibit membrane fusion and incorporation of Env onto virions. Jpn J Infect Dis. 2006 Apr. PMID: 16632906

Sachs JN, Engelman DM: Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function. Annu Rev Biochem. 2006. PMID: 16756508

Engelman DM: Membranes are more mosaic than fluid. Nature. 2005 Dec 1. PMID: 16319876

Chin CN, Sachs JN, Engelman DM: Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett. 2005 Jul 4. PMID: 15978577

Freeman-Cook LL, Edwards AP, Dixon AM, Yates KE, Ely L, Engelman DM, Dimaio D: Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor. J Mol Biol. 2005 Jan 28. PMID: 15588835

Schneider D, Engelman DM: Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. J Mol Biol. 2004 Oct 29. PMID: 15476801

Braun R, Engelman DM, Schulten K: Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices. Biophys J. 2004 Aug. PMID: 15298884

Freeman-Cook LL, Dixon AM, Frank JB, Xia Y, Ely L, Gerstein M, Engelman DM, DiMaio D: Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor. J Mol Biol. 2004 May 14. PMID: 15111056

Lehnert U, Xia Y, Royce TE, Goh CS, Liu Y, Senes A, Yu H, Zhang ZL, Engelman DM, Gerstein M: Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions. Q Rev Biophys. 2004 May. PMID: 15999419

Melnyk RA, Kim S, Curran AR, Engelman DM, Bowie JU, Deber CM: The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J Biol Chem. 2004 Apr 16; 2004 Feb 5. PMID: 14766751

Mitra K, Ubarretxena-Belandia I, Taguchi T, Warren G, Engelman DM: Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Natl Acad Sci U S A. 2004 Mar 23; 2004 Mar 11. PMID: 15016920

Schneider D, Engelman DM: Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. J Biol Chem. 2004 Mar 12; 2003 Dec 16. PMID: 14681217

Liu Y, Gerstein M, Engelman DM: Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism. Proc Natl Acad Sci U S A. 2004 Mar 9; 2004 Mar 1. PMID: 14993608

Engelman DM, Chen Y, Chin CN, Curran AR, Dixon AM, Dupuy AD, Lee AS, Lehnert U, Matthews EE, Reshetnyak YK, Senes A, Popot JL: Membrane protein folding: beyond the two stage model. FEBS Lett. 2003 Nov 27. PMID: 14630331

Fisher LE, Engelman DM, Sturgis JN: Effect of detergents on the association of the glycophorin a transmembrane helix. Biophys J. 2003 Nov. PMID: 14581210

Constantinescu SN, Keren T, Russ WP, Ubarretxena-Belandia I, Malka Y, Kubatzky KF, Engelman DM, Lodish HF, Henis YI: The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem. 2003 Oct 31; 2003 Aug 20. PMID: 12930840

Popot JL, Berry EA, Charvolin D, Creuzenet C, Ebel C, Engelman DM, Flötenmeyer M, Giusti F, Gohon Y, Hong Q, Lakey JH, Leonard K, Shuman HA, Timmins P, Warschawski DE, Zito F, Zoonens M, Pucci B, Tribet C: Amphipols: polymeric surfactants for membrane biology research. Cell Mol Life Sci. 2003 Aug. PMID: 14513831

Curran AR, Engelman DM: Sequence motifs, polar interactions and conformational changes in helical membrane proteins. Curr Opin Struct Biol. 2003 Aug. PMID: 12948770

Dawson JP, Melnyk RA, Deber CM, Engelman DM: Sequence context strongly modulates association of polar residues in transmembrane helices. J Mol Biol. 2003 Aug 1. PMID: 12875850

Schneider D, Engelman DM: GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane. J Biol Chem. 2003 Jan 31; 2002 Nov 21. PMID: 12446730

Engelman DM: Electrostatic fasteners hold the T cell receptor-CD3 complex together. Mol Cell. 2003 Jan. PMID: 12535514

Bowen ME, Engelman DM, Brunger AT: Mutational analysis of synaptobrevin transmembrane domain oligomerization. Biochemistry. 2002 Dec 31. PMID: 12501216

Schneider D, Liu Y, Gerstein M, Engelman DM: Thermostability of membrane protein helix-helix interaction elucidated by statistical analysis. FEBS Lett. 2002 Dec 4. PMID: 12459496

Liu Y, Engelman DM, Gerstein M: Genomic analysis of membrane protein families: abundance and conserved motifs. Genome Biol. 2002 Sep 19; 2002 Sep 19. PMID: 12372142

Mitra K, Steitz TA, Engelman DM: Rational design of 'water-soluble' bacteriorhodopsin variants. Protein Eng. 2002 Jun. PMID: 12082167

Dawson JP, Weinger JS, Engelman DM: Motifs of serine and threonine can drive association of transmembrane helices. J Mol Biol. 2002 Feb 22. PMID: 11866532

Fleming KG, Engelman DM: Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants. Proc Natl Acad Sci U S A. 2001 Dec 4; 2001 Nov 27. PMID: 11724930

Fleming KG, Engelman DM: Computation and mutagenesis suggest a right-handed structure for the synaptobrevin transmembrane dimer. Proteins. 2001 Dec 1. PMID: 11746678

Leeds JA, Boyd D, Huber DR, Sonoda GK, Luu HT, Engelman DM, Beckwith J: Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library. J Mol Biol. 2001 Oct 12. PMID: 11601855

Senes A, Ubarretxena-Belandia I, Engelman DM: The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci U S A. 2001 Jul 31. PMID: 11481472

Li H, Cocco MJ, Steitz TA, Engelman DM: Conversion of phospholamban into a soluble pentameric helical bundle. Biochemistry. 2001 Jun 5. PMID: 11380258

Fisher LE, Engelman DM: High-yield synthesis and purification of an alpha-helical transmembrane domain. Anal Biochem. 2001 Jun 1. PMID: 11373085

Ubarretxena-Belandia I, Engelman DM: Helical membrane proteins: diversity of functions in the context of simple architecture. Curr Opin Struct Biol. 2001 Jun. PMID: 11406389

Zhou FX, Merianos HJ, Brunger AT, Engelman DM: Polar residues drive association of polyleucine transmembrane helices. Proc Natl Acad Sci U S A. 2001 Feb 27; 2001 Feb 13. PMID: 11226225

Petrache HI, Grossfield A, MacKenzie KR, Engelman DM, Woolf TB: Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations. J Mol Biol. 2000 Sep 22. PMID: 10986130

Bu Z, Neumann DA, Lee SH, Brown CM, Engelman DM, Han CC: A view of dynamics changes in the molten globule-native folding step by quasielastic neutron scattering. J Mol Biol. 2000 Aug 11. PMID: 10926525

Senes A, Gerstein M, Engelman DM: Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. J Mol Biol. 2000 Feb 25. PMID: 10677292

Russ WP, Engelman DM: The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol. 2000 Feb 25. PMID: 10677291

Zhou FX, Cocco MJ, Russ WP, Brunger AT, Engelman DM: Interhelical hydrogen bonding drives strong interactions in membrane proteins. Nat Struct Biol. 2000 Feb. PMID: 10655619

Koide S, Huang X, Link K, Koide A, Bu Z, Engelman DM: Design of single-layer beta-sheets without a hydrophobic core. Nature. 2000 Jan 27. PMID: 10667801

Popot JL, Engelman DM: Helical membrane protein folding, stability, and evolution. Annu Rev Biochem. 2000. PMID: 10966478

Fisher LE, Engelman DM, Sturgis JN: Detergents modulate dimerization, but not helicity, of the glycophorin A transmembrane domain. J Mol Biol. 1999 Oct 29. PMID: 10543956

McNew JA, Weber T, Engelman DM, Söllner TH, Rothman JE: The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion. Mol Cell. 1999 Sep. PMID: 10518222

Bu Z, Engelman DM: A method for determining transmembrane helix association and orientation in detergent micelles using small angle x-ray scattering. Biophys J. 1999 Aug. PMID: 10423450

Schubert C, Hirsch JA, Gurevich VV, Engelman DM, Sigler PB, Fleming KG: Visual arrestin activity may be regulated by self-association. J Biol Chem. 1999 Jul 23. PMID: 10409673

Koide S, Bu Z, Risal D, Pham TN, Nakagawa T, Tamura A, Engelman DM: Multistep denaturation of Borrelia burgdorferi OspA, a protein containing a single-layer beta-sheet. Biochemistry. 1999 Apr 13. PMID: 10200164

Russ WP, Engelman DM: TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc Natl Acad Sci U S A. 1999 Feb 2. PMID: 9927659

Bu Z, Koide S, Engelman DM: A solution SAXS study of Borrelia burgdorferi OspA, a protein containing a single-layer beta-sheet. Protein Sci. 1998 Dec. PMID: 9865964

Adams PD, Lee AS, Brünger AT, Engelman DM: Models for the transmembrane region of the phospholamban pentamer: which is correct? Ann N Y Acad Sci. 1998 Sep 16. PMID: 10603945

MacKenzie KR, Engelman DM: Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization. Proc Natl Acad Sci U S A. 1998 Mar 31. PMID: 9520409

Hunt JF, Rath P, Rothschild KJ, Engelman DM: Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry. 1997 Dec 9. PMID: 9398245

Hunt JF, Earnest TN, Bousché O, Kalghatgi K, Reilly K, Horváth C, Rothschild KJ, Engelman DM: A biophysical study of integral membrane protein folding. Biochemistry. 1997 Dec 9. PMID: 9398244

Hunt JF, McCrea PD, Zaccaï G, Engelman DM: Assessment of the aggregation state of integral membrane proteins in reconstituted phospholipid vesicles using small angle neutron scattering. J Mol Biol. 1997 Nov 14. PMID: 9367787

Fleming KG, Ackerman AL, Engelman DM: The effect of point mutations on the free energy of transmembrane alpha-helix dimerization. J Mol Biol. 1997 Sep 19. PMID: 9299353

Arkin IT, Brünger AT, Engelman DM: Are there dominant membrane protein families with a given number of helices? Proteins. 1997 Aug. PMID: 9261863

MacKenzie KR, Prestegard JH, Engelman DM: A transmembrane helix dimer: structure and implications. Science. 1997 Apr 4. PMID: 9082985

Burke CL, Lemmon MA, Coren BA, Engelman DM, Stern DF: Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation. Oncogene. 1997 Feb 13. PMID: 9038376

Arkin IT, Adams PD, Brünger AT, Aimoto S, Engelman DM, Smith SO: Structure of the transmembrane cysteine residues in phospholamban. J Membr Biol. 1997 Feb 1. PMID: 9050443

Lemmon MA, Bu Z, Ladbury JE, Zhou M, Pinchasi D, Lax I, Engelman DM, Schlessinger J: Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J. 1997 Jan 15. PMID: 9029149

Arkin IT, Adams PD, Brünger AT, Smith SO, Engelman DM: Structural perspectives of phospholamban, a helical transmembrane pentamer. Annu Rev Biophys Biomol Struct. 1997. PMID: 9241417

Engelman DM: Crossing the hydrophobic barrier: insertion of membrane proteins. Science. 1996 Dec 13. PMID: 8984645

Adams PD, Engelman DM, Brünger AT: Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching. Proteins. 1996 Nov. PMID: 8953647

Smith CK, Bu Z, Anderson KS, Sturtevant JM, Engelman DM, Regan L: Surface point mutations that significantly alter the structure and stability of a protein's denatured state. Protein Sci. 1996 Oct. PMID: 8897601

Rodgers KK, Bu Z, Fleming KG, Schatz DG, Engelman DM, Coleman JE: A zinc-binding domain involved in the dimerization of RAG1. J Mol Biol. 1996 Jul 5. PMID: 8676393

Peled-Zehavi H, Arkin IT, Engelman DM, Shai Y: Coassembly of synthetic segments of shaker K+ channel within phospholipid membranes. Biochemistry. 1996 May 28. PMID: 8639634

MacKenzie KR, Prestegard JH, Engelman DM: Leucine side-chain rotamers in a glycophorin A transmembrane peptide as revealed by three-bond carbon-carbon couplings and 13C chemical shifts. J Biomol NMR. 1996 May. PMID: 8785502

Ludlam CF, Arkin IT, Liu XM, Rothman MS, Rath P, Aimoto S, Smith SO, Engelman DM, Rothschild KJ: Fourier transform infrared spectroscopy and site-directed isotope labeling as a probe of local secondary structure in the transmembrane domain of phospholamban. Biophys J. 1996 Apr. PMID: 8785331

Arkin IT, MacKenzie KR, Fisher L, Aimoto S, Engelman DM, Smith SO: Mapping the lipid-exposed surfaces of membrane proteins. Nat Struct Biol. 1996 Mar. PMID: 8605625

Hare BJ, Prestegard JH, Engelman DM: Small angle x-ray scattering studies of magnetically oriented lipid bilayers. Biophys J. 1995 Nov. PMID: 8580332

Arkin IT, Rothman M, Ludlam CF, Aimoto S, Engelman DM, Rothschild KJ, Smith SO: Structural model of the phospholamban ion channel complex in phospholipid membranes. J Mol Biol. 1995 May 12. PMID: 7752243

Adams PD, Arkin IT, Engelman DM, Brünger AT: Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban. Nat Struct Biol. 1995 Feb. PMID: 7749920

Arkin IT, Adams PD, MacKenzie KR, Lemmon MA, Brünger AT, Engelman DM: Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. EMBO J. 1994 Oct 17. PMID: 7525269

Lemmon MA, Engelman DM: Specificity and promiscuity in membrane helix interactions. FEBS Lett. 1994 Jun 6. PMID: 8206151

Adair BD, Engelman DM: Glycophorin A helical transmembrane domains dimerize in phospholipid bilayers: a resonance energy transfer study. Biochemistry. 1994 May 10. PMID: 8180176

Lemmon MA, Engelman DM: Specificity and promiscuity in membrane helix interactions. Q Rev Biophys. 1994 May. PMID: 7984776

Samatey FA, Zaccaï G, Engelman DM, Etchebest C, Popot JL: Rotational orientation of transmembrane alpha-helices in bacteriorhodopsin. A neutron diffraction study. J Mol Biol. 1994 Mar 4. PMID: 8120889

Lemmon MA, Treutlein HR, Adams PD, Brünger AT, Engelman DM: A dimerization motif for transmembrane alpha-helices. Nat Struct Biol. 1994 Mar. PMID: 7656033

Flanagan JM, Kataoka M, Fujisawa T, Engelman DM: Mutations can cause large changes in the conformation of a denatured protein. Biochemistry. 1993 Oct 5. PMID: 8399179

Engelman DM, Adair BD, Brünger A, Flanagan JM, Hunt JF, Lemmon MA, Treutlein H, Zhang J: Dimerization of glycophorin A transmembrane helices: mutagenesis and modeling. Soc Gen Physiol Ser. 1993. PMID: 8503039

Treutlein HR, Lemmon MA, Engelman DM, Brünger AT: The glycophorin A transmembrane domain dimer: sequence-specific propensity for a right-handed supercoil of helices. Biochemistry. 1992 Dec 29. PMID: 1463744

Lemmon MA, Flanagan JM, Treutlein HR, Zhang J, Engelman DM: Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry. 1992 Dec 29. PMID: 1463743

Cramer WA, Engelman DM, Von Heijne G, Rees DC: Forces involved in the assembly and stabilization of membrane proteins. FASEB J. 1992 Dec. PMID: 1464373

Kataoka M, Kahn TW, Tsujiuchi Y, Engelman DM, Tokunaga F: Bacteriorhodopsin reconstituted from two individual helices and the complementary five-helix fragment is photoactive. Photochem Photobiol. 1992 Dec. PMID: 1492135

Kahn TW, Sturtevant JM, Engelman DM: Thermodynamic measurements of the contributions of helix-connecting loops and of retinal to the stability of bacteriorhodopsin. Biochemistry. 1992 Sep 22. PMID: 1390670

Kahn TW, Engelman DM: Bacteriorhodopsin can be refolded from two independently stable transmembrane helices and the complementary five-helix fragment. Biochemistry. 1992 Jul 7. PMID: 1627558

Lemmon MA, Flanagan JM, Hunt JF, Adair BD, Bormann BJ, Dempsey CE, Engelman DM: Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. J Biol Chem. 1992 Apr 15. PMID: 1560003

Flanagan JM, Kataoka M, Shortle D, Engelman DM: Truncated staphylococcal nuclease is compact but disordered. Proc Natl Acad Sci U S A. 1992 Jan 15. PMID: 1731350

Bormann BJ, Engelman DM: Intramembrane helix-helix association in oligomerization and transmembrane signaling. Annu Rev Biophys Biomol Struct. 1992. PMID: 1326354

Popot JL, Engelman DM: Membrane protein folding and oligomerization: the two-stage model. Biochemistry. 1990 May 1. PMID: 1694455

Popot JL, Engelman DM, Zaccai G, de Vitry C: The "microassembly" of integral membrane proteins: applications & implications. Prog Clin Biol Res. 1990. PMID: 2198582

Popot JL, Engelman DM, Gurel O, Zaccaï G: Tertiary structure of bacteriorhodopsin. Positions and orientations of helices A and B in the structural map determined by neutron diffraction. J Mol Biol. 1989 Dec 20. PMID: 2614846

Kataoka M, Head JF, Seaton BA, Engelman DM: Melittin binding causes a large calcium-dependent conformational change in calmodulin. Proc Natl Acad Sci U S A. 1989 Sep. PMID: 2780551

Burks C, Hong S, Ho M, Engelman DM: Limitations of the lipid state hypothesis for atherosclerosis are revealed by X-ray diffraction measurements. Atherosclerosis. 1989 May. PMID: 2719761

McCrea PD, Engelman DM, Popot JL: Topography of integral membrane proteins: hydrophobicity analysis vs. immunolocalization. Trends Biochem Sci. 1988 Aug. PMID: 3154280

Capel MS, Kjeldgaard M, Engelman DM, Moore PB: Positions of S2, S13, S16, S17, S19 and S21 in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol. 1988 Mar 5. PMID: 3288761

Popot JL, Gerchman SE, Engelman DM: Refolding of bacteriorhodopsin in lipid bilayers. A thermodynamically controlled two-stage process. J Mol Biol. 1987 Dec 20. PMID: 3430624

Capel MS, Engelman DM, Freeborn BR, Kjeldgaard M, Langer JA, Ramakrishnan V, Schindler DG, Schneider DK, Schoenborn BP, Sillers IY: A complete mapping of the proteins in the small ribosomal subunit of Escherichia coli. Science. 1987 Dec 4. PMID: 3317832

McCrea PD, Popot JL, Engelman DM: Transmembrane topography of the nicotinic acetylcholine receptor delta subunit. EMBO J. 1987 Dec 1. PMID: 3428268

Trewhella J, Popot JL, Zaccaï G, Engelman DM: Localization of two chymotryptic fragments in the structure of renatured bacteriorhodopsin by neutron diffraction. EMBO J. 1986 Nov. PMID: 3792306

Popot JL, Trewhella J, Engelman DM: Reformation of crystalline purple membrane from purified bacteriorhodopsin fragments. EMBO J. 1986 Nov. PMID: 3792305

Engelman DM, Steitz TA, Goldman A: Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu Rev Biophys Biophys Chem. 1986. PMID: 3521657

Moore PB, Capel M, Kjeldgaard M, Engelman DM: Quaternary Organization of the 30S Ribosomal Subunit of Escherichia Coli. Biophys J. 1986 Jan. PMID: 19431616

Seaton BA, Head JF, Engelman DM, Richards FM: Calcium-induced increase in the radius of gyration and maximum dimension of calmodulin measured by small-angle X-ray scattering. Biochemistry. 1985 Nov 19. PMID: 4074724

Dumont ME, Trewhella J, Engelman DM, Richards FM: Stability of transmembrane regions in bacteriorhodopsin studied by progressive proteolysis. J Membr Biol. 1985. PMID: 3913776

Gogol EP, Engelman DM: Neutron scattering shows that cytochrome b5 penetrates deeply into the lipid bilayer. Biophys J. 1984 Oct. PMID: 6498267

Ramakrishnan V, Capel M, Kjeldgaard M, Engelman DM, Moore PB: Positions of proteins S14, S18 and S20 in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol. 1984 Apr 5. PMID: 6371250

Engelman DM, Dianoux AJ, Cusack S, Jacrot B: Inelastic neutron scattering studies of hexokinase in solution. Basic Life Sci. 1984. PMID: 6712571

Moore PB, Engelman DM, Langer JA, Ramakrishnan VR, Schindler DG, Schoenborn BP, Sillers IY, Yabuki S: Neutron scattering and the 30 S ribosomal subunit of E. coli. Basic Life Sci. 1984. PMID: 6370225

Gogol EP, Engelman DM, Zaccai G: Neutron diffraction analysis of cytochrome b5 reconstituted in deuterated lipid multilayers. Biophys J. 1983 Sep. PMID: 6626669

Pearson LT, Chan SI, Lewis BA, Engelman DM: Pair distribution functions of bacteriorhodopsin and rhodopsin in model bilayers. Biophys J. 1983 Aug. PMID: 6616005

Lewis BA, Engelman DM: Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles. J Mol Biol. 1983 May 15. PMID: 6854644

Lewis BA, Engelman DM: Bacteriorhodopsin remains dispersed in fluid phospholipid bilayers over a wide range of bilayer thicknesses. J Mol Biol. 1983 May 15. PMID: 6854643

Ramakrishnan VR, Yabuki S, Sillers IY, Schindler DG, Engelman DM, Moore PB: Positions of proteins S6, S11 and S15 in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol. 1981 Dec 15. PMID: 7040690

Burks C, Engelman DM: Cholesteryl myristate conformation in liquid crystalline mesophases determined by neutron scattering. Proc Natl Acad Sci U S A. 1981 Nov. PMID: 6947261

Goodsaid-Zalduondo F, Engelman DM: Conformation of liquid N-alkanes. Biophys J. 1981 Sep. PMID: 7272453

Engelman DM, Steitz TA: The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis. Cell. 1981 Feb. PMID: 7471207

Engelman DM, Zaccai G: Bacteriorhodopsin is an inside-out protein. Proc Natl Acad Sci U S A. 1980 Oct. PMID: 6934521

Engelman DM, Henderson R, McLachlan AD, Wallace BA: Path of the polypeptide in bacteriorhodopsin. Proc Natl Acad Sci U S A. 1980 Apr. PMID: 6929535

Pickover CA, McKay DB, Engelman DM, Steitz TA: Substrate binding closes the cleft between the domains of yeast phosphoglycerate kinase. J Biol Chem. 1979 Nov 25. PMID: 387770

Schindler DG, Langer JA, Engelman DM, Moore PB: Positions of proteins S10, S11 and S12 in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol. 1979 Nov 5. PMID: 395318

McDonald RC, Engelman DM, Steitz TA: Small angle X-ray scattering of dimeric yeast hexokinase in solution. J Biol Chem. 1979 Apr 25. PMID: 372185

McDonald RC, Steitz TA, Engelman DM: Yeast hexokinase in solution exhibits a large conformational change upon binding glucose or glucose 6-phosphate. Biochemistry. 1979 Jan 23. PMID: 369601

Engelman DM: Neutron-scattering measurement of protein pair scattering functions from ribosomes containing deuterated proteins. Methods Enzymol. 1979. PMID: 440090

Moore PB, Engelman DM: On the feasibility and interpretation of intersubunit distance measurements using neutron scattering. Methods Enzymol. 1979. PMID: 440089

Moore PB, Engelman DM: Model calculations of protein pair interference functions. J Mol Biol. 1977 May 15. PMID: 875017

Moore PB, Langer JA, Schoenborn BP, Engelman DM: Triangulation of proteins in the 30 S ribosomal subunit of Exherichia coli. J Mol Biol. 1977 May 15. PMID: 327074

Wallace BA, Richards FM, Engelman DM: The influence of lipid state on the planar distribution of membrane proteins in Acholeplasma laidlawii. J Mol Biol. 1976 Nov 5. PMID: 1003469

Engelman DM, Hillman GM: Molecular organization of the cholesteryl ester droplets in the fatty streaks of human aorta. J Clin Invest. 1976 Oct. PMID: 965500

Hillman GM, Engelman DM: Compositional mapping of cholesteryl ester droplets in the fatty streaks of human aorta. J Clin Invest. 1976 Oct. PMID: 965482

Engelman DM, Moore PB: Neutron-scattering studies of the ribosome. Sci Am. 1976 Oct. PMID: 968478

Moore PB, Engelman DM: The production of deuterated E. coli. Brookhaven Symp Biol. 1976 May. PMID: 786448

Engelman DM, Moore PB, Schoenborn BP: Protein pair distance determination in the 30 S ribosomal subunit of E. coli. Brookhaven Symp Biol. 1976 May. PMID: 786445

Engelman DM, Moore PB, Schoenborn BP: Neutron scattering measurements of separation and shape of proteins in 30S ribosomal subunit of Escherichia coli: S2-S5, S5-S8, S3-S7. Proc Natl Acad Sci U S A. 1975 Oct. PMID: 1105567

Engelman DM: The use of x-ray scattering in the study of lipid bilayer planar organization. Biophys J. 1975 Sep. PMID: 1182268

Moore PB, Engelman DM, Schoenborn BP: A neutron scattering study of the distribution of protein and RNA in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol. 1975 Jan 5. PMID: 1102695

Engelman DM, Moore PB: Determination of quaternary structure by small angle neutron scattering. Annu Rev Biophys Bioeng. 1975. PMID: 1098555

Moore PB, Engelman DM, Schoenborn BP: Asymmetry in the 50S ribosomal subunit of Escherichia coli. Proc Natl Acad Sci U S A. 1974 Jan. PMID: 4589891

Engelman DM, Moore PB: A new method for the determination of biological quarternary structure by neutron scattering. Proc Natl Acad Sci U S A. 1972 Aug. PMID: 4506067

Engelman DM, Rothman JE: The planar organization of lecithin-cholesterol bilayers. J Biol Chem. 1972 Jun 10. PMID: 5030638

Rothman JE, Engelman DM: Molecular mechanism for the interaction of phospholipid with cholesterol. Nat New Biol. 1972 May 10. PMID: 4503742

Engelman DM: The molecular structure of the membrane of Acholeplasma laidlawii. Chem Phys Lipids. 1972 May. PMID: 5041943

Metcalfe SM, Metcalfe JC, Engelman DM: Structural comparisons of native and reaggregated membranes from Mycoplasma laidawii and erythrocytes using a fluorescence probe. Biochim Biophys Acta. 1971 Aug 13. PMID: 5159792

Metcalfe JC, Metcalfe SM, Engelman DM: Structural comparisons of native and reaggregated membranes from Mycoplasma laidlawii and erythrocytes by x-ray diffraction and nuclear magnetic resonance techniques. Biochim Biophys Acta. 1971 Aug 13. PMID: 5159791

Engelman DM: Lipid bilayer structure in the membrane of Mycoplasma laidlawii. J Mol Biol. 1971 May 28. PMID: 5088924

Wilkins MH, Blaurock AE, Engelman DM: Bilayer structure in membranes. Nat New Biol. 1971 Mar 17. PMID: 5279041

Engelman DM, Metcalfe JC, Metcalfe SM: Structural comparisons of native and reaggregated membranes. Br J Pharmacol. 1971 Feb. PMID: 5572285

Engelman DM: Surface area per lipid molecule in the intact membrane of the human red cell. Nature. 1969 Sep 20. PMID: 5811911

Stoeckenius W, Engelman DM: Current models for the structure of biological membranes. J Cell Biol. 1969 Sep. PMID: 4895596

Terry TM, Engelman DM, Morowitz HJ: Characterization of the plasma membrane of Mycoplasma laidlawii. II. Modes of aggregation of solubilized membrane components. Biochim Biophys Acta. 1967 Jul 3. PMID: 6058126

Engelman DM, Terry TM, Morowitz HJ: Characterization of the plasma membrane of Mycoplasma laidlawii. I. Sodium dodecyl sulfate solubilization. Biochim Biophys Acta. 1967 Jul 3. PMID: 6048810