Publications

Sheppard NC, Brinckmann SA, Gartlan KH, Puthia M, Svanborg C, Krashias G, Eisenbarth SC, Flavell RA, Sattentau QJ and Wegmann F: Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens. Int Immunol. 2014 Oct;26 (10) :531-8. Epub 2014 May 20. PMID: 24844701


Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ and Medzhitov R: Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 2014 Sep 25;513 (7519) :559-63. Epub 2014 Jul 13. PMID: 25043024


Krishnaswamy JK, Liu D and Eisenbarth SC: POP goes the inflammasome. Nat Immunol. 2014 Apr;15 (4) :311-3. PMID: 24646588


Zhang TT, Liu D, Calabro S, Eisenbarth SC, Cattoretti G and Haberman AM: Dynamic expression of BCL6 in murine conventional dendritic cells during in vivo development and activation. PLoS One. 2014;9 (6) :e101208. Epub 2014 Jun 30. PMID: 24979752

Liu D, Rhebergen AM and Eisenbarth SC: Licensing Adaptive Immunity by NOD-Like Receptors. Front Immunol. 2013 Dec 27;4 :486. Epub 2013 Dec 27. PMID: 24409181


Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL and Sutterwala FS: Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013 Aug 22;39 (2) :311-23. Epub 2013 Aug 15. PMID: 23954133


Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, Jin C, Wunderlich C, Wunderlich T, Eisenbarth SC and Flavell RA: Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc Natl Acad Sci U S A. 2013 Jun 11;110 (24) :9862-7. Epub 2013 May 21. PMID: 23696660


Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC and Poynter ME: Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. Am J Respir Cell Mol Biol. 2013 May;48 (5) :655-64. PMID: 23371061


Krishnaswamy JK, Chu T and Eisenbarth SC: Beyond pattern recognition: NOD-like receptors in dendritic cells. Trends Immunol. 2013 May;34 (5) :224-33. Epub 2013 Jan 23. PMID: 23352728


Williams A, Lee GR, Spilianakis CG, Hwang SS, Eisenbarth SC and Flavell RA: Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proc Natl Acad Sci U S A. 2013 Apr 23;110 (17) :6955-60. Epub 2013 Apr 8. PMID: 23569250

Joly S, Eisenbarth SC, Olivier AK, Williams A, Kaplan DH, Cassel SL, Flavell RA and Sutterwala FS: Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol. 2012 Nov 15;189 (10) :4713-7. Epub 2012 Oct 15. PMID: 23071280


Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS and Flavell RA: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25;484 (7395) :510-3. Epub 2012 Apr 25. PMID: 22538615


Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM and Flavell RA: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012 Feb 1;482 (7384) :179-85. Epub 2012 Feb 1. PMID: 22297845

Hendrickson JE, Hod EA, Cadwell CM, Eisenbarth SC, Spiegel DA, Tormey CA, Spitalnik SL and Zimring JC: Rapid clearance of transfused murine red blood cells is associated with recipient cytokine storm and enhanced alloimmunogenicity. Transfusion. 2011 Nov;51 (11) :2445-54. Epub 2011 May 13. PMID: 21569043


Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, Eisenbarth SC and Flavell RA: NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci U S A. 2011 Sep 6;108 (36) :14867-72. Epub 2011 Aug 19. PMID: 21856950


Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC and Poynter ME: Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. J Immunol. 2011 Jul 1;187 (1) :64-73. Epub 2011 May 27. PMID: 21622869


Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI and Flavell RA: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011 May 27;145 (5) :745-57. Epub 2011 May 12. PMID: 21565393

Hu B, Elinav E, Huber S, Booth CJ, Strowig T, Jin C, Eisenbarth SC and Flavell RA: Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A. 2010 Dec 14;107 (50) :21635-40. Epub 2010 Nov 30. PMID: 21118981


Tan AM, Chen HC, Pochard P, Eisenbarth SC, Herrick CA and Bottomly HK: TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J Immunol. 2010 Apr 1;184 (7) :3535-44. Epub 2010 Mar 1. PMID: 20194715


Williams A, Flavell RA and Eisenbarth SC: The role of NOD-like Receptors in shaping adaptive immunity. Curr Opin Immunol. 2010 Feb;22 (1) :34-40. Epub 2010 Feb 9. PMID: 20149616

Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC and Sutterwala FS: Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A. 2009 Dec 1;106 (48) :20388-93. Epub 2009 Nov 16. PMID: 19918053


Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA and Olivier M: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 2009 Aug;5 (8) :e1000559. Epub 2009 Aug 21. PMID: 19696895


Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA and Fahmy TM: Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. 2009 May 18;27 (23) :3013-21. Epub 2009 Apr 3. PMID: 19428913


Eisenbarth SC and Flavell RA: Innate instruction of adaptive immunity revisited: the inflammasome. EMBO Mol Med. 2009 May;1 (2) :92-8. PMID: 20049709

Eisenbarth SC: Use and limitations of alum-based models of allergy. Clin Exp Allergy. 2008 Oct;38 (10) :1572-5. Epub 2008 Jul 17. PMID: 18644021


Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA and Sutterwala FS: The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A. 2008 Jul 1;105 (26) :9035-40. Epub 2008 Jun 24. PMID: 18577586


Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS and Flavell RA: Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 2008 Jun 19;453 (7198) :1122-6. Epub 2008 May 21. PMID: 18496530

Eisenbarth SC, Colegio OR, Iyer A, Cooper D, Bannykh S and Baehring J: Images in neuro-oncology: a case of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes) in a patient with multicentric Castleman's disease. J Neurooncol. 2007 Jan;81 (2) :163-5. Epub 2006 Nov 4. PMID: 17086436

Eisenbarth SC: The innate and adaptive immune systems in allergy: a two-way street. Clin Exp Allergy. 2006 Feb;36 (2) :135-7. PMID: 16433849

Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA and Bottomly K: MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest. 2005 Feb;115 (2) :459-67. PMID: 15650773

Eisenbarth SC, Cassel S and Bottomly K: Understanding asthma pathogenesis: linking innate and adaptive immunity. Curr Opin Pediatr. 2004 Dec;16 (6) :659-66. PMID: 15548929


Eisenbarth SC, Zhadkevich A, Ranney P, Herrick CA and Bottomly K: IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol. 2004 Apr 1;172 (7) :4527-34. PMID: 15034070


Eisenbarth SC and Eisenbarth GS: Primer: immunology/autoimmunity. Adv Exp Med Biol. 2004;552 :1-15. PMID: 15622956

Eisenbarth SC, Piggott DA and Bottomly K: The master regulators of allergic inflammation: dendritic cells in Th2 sensitization. Curr Opin Immunol. 2003 Dec;15 (6) :620-6. PMID: 14630194

Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA and Bottomly K: Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med. 2002 Dec 16;196 (12) :1645-51. PMID: 12486107


Stephens R, Eisenbarth SC and Chaplin DD: T helper type 1 cells in asthma: friend or foe? Curr Opin Allergy Clin Immunol. 2002 Feb;2 (1) :31-7. PMID: 11964748