Publications

Kim LK, Morita R, Kobayashi Y, Eisenbarth SC, Lee CG, Elias J, Eynon EE, Flavell RA: AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proc Natl Acad Sci U S A. 2015 Jun 2; 2015 May 18. PMID: 26038565

Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC: Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci U S A. 2015 Mar 10; 2015 Feb 23. PMID: 25713392

Sheppard NC, Brinckmann SA, Gartlan KH, Puthia M, Svanborg C, Krashias G, Eisenbarth SC, Flavell RA, Sattentau QJ, Wegmann F: Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens. Int Immunol. 2014 Oct; 2014 May 20. PMID: 24844701

Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R: Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 2014 Sep 25; 2014 Jul 13. PMID: 25043024

Krishnaswamy JK, Liu D, Eisenbarth SC: POP goes the inflammasome. Nat Immunol. 2014 Apr. PMID: 24646588

Zhang TT, Liu D, Calabro S, Eisenbarth SC, Cattoretti G, Haberman AM: Dynamic expression of BCL6 in murine conventional dendritic cells during in vivo development and activation. PLoS One. 2014; 2014 Jun 30. PMID: 24979752

Liu D, Rhebergen AM, Eisenbarth SC: Licensing Adaptive Immunity by NOD-Like Receptors. Front Immunol. 2013 Dec 27; 2013 Dec 27. PMID: 24409181

Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS: Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013 Aug 22; 2013 Aug 15. PMID: 23954133

Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, Jin C, Wunderlich C, Wunderlich T, Eisenbarth SC, Flavell RA: Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc Natl Acad Sci U S A. 2013 Jun 11; 2013 May 21. PMID: 23696660

Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC, Poynter ME: Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. Am J Respir Cell Mol Biol. 2013 May. PMID: 23371061

Krishnaswamy JK, Chu T, Eisenbarth SC: Beyond pattern recognition: NOD-like receptors in dendritic cells. Trends Immunol. 2013 May; 2013 Jan 23. PMID: 23352728

Williams A, Lee GR, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA: Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proc Natl Acad Sci U S A. 2013 Apr 23; 2013 Apr 8. PMID: 23569250

Joly S, Eisenbarth SC, Olivier AK, Williams A, Kaplan DH, Cassel SL, Flavell RA, Sutterwala FS: Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol. 2012 Nov 15; 2012 Oct 15. PMID: 23071280

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25; 2012 Apr 25. PMID: 22538615

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012 Feb 1; 2012 Feb 1. PMID: 22297845

Hendrickson JE, Hod EA, Cadwell CM, Eisenbarth SC, Spiegel DA, Tormey CA, Spitalnik SL, Zimring JC: Rapid clearance of transfused murine red blood cells is associated with recipient cytokine storm and enhanced alloimmunogenicity. Transfusion. 2011 Nov; 2011 May 13. PMID: 21569043

Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, Eisenbarth SC, Flavell RA: NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci U S A. 2011 Sep 6; 2011 Aug 19. PMID: 21856950

Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME: Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. J Immunol. 2011 Jul 1; 2011 May 27. PMID: 21622869

Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011 May 27; 2011 May 12. PMID: 21565393

Hu B, Elinav E, Huber S, Booth CJ, Strowig T, Jin C, Eisenbarth SC, Flavell RA: Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A. 2010 Dec 14; 2010 Nov 30. PMID: 21118981

Tan AM, Chen HC, Pochard P, Eisenbarth SC, Herrick CA, Bottomly HK: TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J Immunol. 2010 Apr 1; 2010 Mar 1. PMID: 20194715

Williams A, Flavell RA, Eisenbarth SC: The role of NOD-like Receptors in shaping adaptive immunity. Curr Opin Immunol. 2010 Feb; 2010 Feb 9. PMID: 20149616

Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS: Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A. 2009 Dec 1; 2009 Nov 16. PMID: 19918053

Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, Olivier M: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 2009 Aug; 2009 Aug 21. PMID: 19696895

Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM: Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. 2009 May 18; 2009 Apr 3. PMID: 19428913

Eisenbarth SC, Flavell RA: Innate instruction of adaptive immunity revisited: the inflammasome. EMBO Mol Med. 2009 May. PMID: 20049709

Eisenbarth SC: Use and limitations of alum-based models of allergy. Clin Exp Allergy. 2008 Oct; 2008 Jul 17. PMID: 18644021

Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS: The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A. 2008 Jul 1; 2008 Jun 24. PMID: 18577586

Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA: Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 2008 Jun 19; 2008 May 21. PMID: 18496530

Eisenbarth SC: The innate and adaptive immune systems in allergy: a two-way street. Clin Exp Allergy. 2006 Feb. PMID: 16433849

Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K: MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest. 2005 Feb. PMID: 15650773

Eisenbarth SC, Cassel S, Bottomly K: Understanding asthma pathogenesis: linking innate and adaptive immunity. Curr Opin Pediatr. 2004 Dec. PMID: 15548929

Eisenbarth SC, Zhadkevich A, Ranney P, Herrick CA, Bottomly K: IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol. 2004 Apr 1. PMID: 15034070

Eisenbarth SC, Eisenbarth GS: Primer: immunology/autoimmunity. Adv Exp Med Biol. 2004. PMID: 15622956

Eisenbarth SC, Piggott DA, Bottomly K: The master regulators of allergic inflammation: dendritic cells in Th2 sensitization. Curr Opin Immunol. 2003 Dec. PMID: 14630194

Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K: Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med. 2002 Dec 16. PMID: 12486107

Stephens R, Eisenbarth SC, Chaplin DD: T helper type 1 cells in asthma: friend or foe? Curr Opin Allergy Clin Immunol. 2002 Feb. PMID: 11964748