Our research centers on how the innate branch of the immune system regulates adaptive immunity in disease states such as allergy, autoimmunity and alloimmunization and in beneficial states such as vaccination and spans both mouse and human studies. We are currently focused on the function of a more recently discovered family of innate immune receptors, the NOD-like receptors (NLRs).
In particular, we recently identified an unusual role for one structurally unique NLR, NLRP10, in regulating adaptive immunity via dendritic cell migration. In a process that was not previously known to require an innate immune signal, the emigration of activated dendritic cells from inflamed tissue is a crucial decision point in the generation of a productive lymphocyte-driven adaptive immune response. Yet how NLRP10 regulates this step or the immunological consequences of its activation remain unanswered questions that we are actively studying.