Publications

DiMaio D: Viral miniproteins. Annu Rev Microbiol. 2014 Sep 8;68 :21-43. Epub 2014 Apr 10. PMID: 24742054


Carney DW, Nelson CD, Ferris BD, Stevens JP, Lipovsky A, Kazakov T, DiMaio D, Atwood WJ and Sello JK: Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22 (17) :4836-47. Epub 2014 Jul 10. PMID: 25087050


Dimaio D: Is virology dead? MBio. 2014 Mar 25;5 (2) :e01003-14. Epub 2014 Mar 25. PMID: 24667711


Chacón KM, Petti LM, Scheideman EH, Pirazzoli V, Politi K and DiMaio D: De novo selection of oncogenes. Proc Natl Acad Sci U S A. 2014 Jan 7;111 (1) :E6-E14. Epub 2013 Dec 16. PMID: 24344264


Cohen EB, Jun SJ, Bears Z, Barrera FN, Alonso M, Engelman DM and DiMaio D: Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor. PLoS One. 2014;9 (4) :e95593. Epub 2014 Apr 30. PMID: 24788775


Goodwin EC, Motamedi N, Lipovsky A, Fernández-Busnadiego R and DiMaio D: Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure. PLoS One. 2014;9 (4) :e94322. Epub 2014 Apr 14. PMID: 24732912

Edwards AP, Xie Y, Bowers L and DiMaio D: Compensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction. J Virol. 2013 Oct;87 (20) :10936-45. Epub 2013 Aug 7. PMID: 23926343


DiMaio D and Petti LM: The E5 proteins. Virology. 2013 Oct;445 (1-2) :99-114. Epub 2013 May 31. PMID: 23731971


Iijima N, Goodwin EC, Dimaio D and Iwasaki A: High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells. Virology. 2013 Sep;444 (1-2) :257-62. Epub 2013 Jul 18. PMID: 23871219


Lipovsky A, Popa A, Pimienta G, Wyler M, Bhan A, Kuruvilla L, Guie MA, Poffenberger AC, Nelson CD, Atwood WJ and DiMaio D: Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus. Proc Natl Acad Sci U S A. 2013 Apr 30;110 (18) :7452-7. Epub 2013 Apr 8. PMID: 23569269

Scheideman EH, Marlatt SA, Xie Y, Hu Y, Sutton RE and DiMaio D: Transmembrane protein aptamers that inhibit CCR5 expression and HIV coreceptor function. J Virol. 2012 Oct;86 (19) :10281-92. Epub 2012 Jul 18. PMID: 22811524


Magaldi TG, Buch MH, Murata H, Erickson KD, Neu U, Garcea RL, Peden K, Stehle T and DiMaio D: Mutations in the GM1 binding site of simian virus 40 VP1 alter receptor usage and cell tropism. J Virol. 2012 Jul;86 (13) :7028-42. Epub 2012 Apr 18. PMID: 22514351


DiMaio D: Viruses, masters at downsizing. Cell Host Microbe. 2012 Jun 14;11 (6) :560-1. PMID: 22704616


Magaldi TG, Almstead LL, Bellone S, Prevatt EG, Santin AD and DiMaio D: Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation. Virology. 2012 Jan 5;422 (1) :114-24. Epub 2011 Nov 5. PMID: 22056390

Martinez I and Dimaio D: B-Myb, cancer, senescence, and microRNAs. Cancer Res. 2011 Aug 15;71 (16) :5370-3. Epub 2011 Aug 9. PMID: 21828240


Goodwin EC, Lipovsky A, Inoue T, Magaldi TG, Edwards AP, Van Goor KE, Paton AW, Paton JC, Atwood WJ, Tsai B and DiMaio D: BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. MBio. 2011;2 (3) :e00101-11. Epub 2011 Jun 14. PMID: 21673190


Marlatt SA, Kong Y, Cammett TJ, Korbel G, Noonan JP and Dimaio D: Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering. Protein Eng Des Sel. 2011 Mar;24 (3) :311-20. Epub 2010 Dec 10. PMID: 21149273


Martinez I, Almstead LL and DiMaio D: MicroRNAs and senescence. Aging (Albany NY). 2011 Feb;3 (2) :77-8. PMID: 21304181


Martinez I, Cazalla D, Almstead LL, Steitz JA and DiMaio D: miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci U S A. 2011 Jan 11;108 (2) :522-7. Epub 2010 Dec 27. PMID: 21187425

Cammett TJ, Jun SJ, Cohen EB, Barrera FN, Engelman DM and Dimaio D: Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci U S A. 2010 Feb 23;107 (8) :3447-52. Epub 2010 Feb 8. PMID: 20142506

Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM and Dimaio D: Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor. J Virol. 2009 Oct;83 (19) :9773-85. Epub 2009 Jul 15. PMID: 19605488


Goodwin EC, Atwood WJ and DiMaio D: High-throughput cell-based screen for chemicals that inhibit infection by simian virus 40 and human polyomaviruses. J Virol. 2009 Jun;83 (11) :5630-9. Epub 2009 Mar 18. PMID: 19297472


Talbert-Slagle K and DiMaio D: The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango. Virology. 2009 Feb 20;384 (2) :345-51. Epub 2008 Nov 6. PMID: 18990418

Yates KE, Korbel GA, Shtutman M, Roninson IB and DiMaio D: Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell. 2008 Oct;7 (5) :609-21. Epub 2008 Jul 24. PMID: 18616636


Liao JB, Publicover J, Rose JK and DiMaio D: Single-dose, therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein. Clin Vaccine Immunol. 2008 May;15 (5) :817-24. Epub 2008 Mar 12. PMID: 18337377


Psyrri A and DiMaio D: Human papillomavirus in cervical and head-and-neck cancer. Nat Clin Pract Oncol. 2008 Jan;5 (1) :24-31. PMID: 18097454

Lang T, Dalal S, Chikova A, DiMaio D and Sweasy JB: The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol. 2007 Aug;27 (15) :5587-96. Epub 2007 May 25. PMID: 17526740


Ptacek JB, Edwards AP, Freeman-Cook LL and DiMaio D: Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptor. Proc Natl Acad Sci U S A. 2007 Jul 17;104 (29) :11945-50. Epub 2007 Jul 3. PMID: 17609376


Horner SM and DiMaio D: The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. J Virol. 2007 Jun;81 (12) :6254-64. Epub 2007 Mar 28. PMID: 17392356


Johung K, Goodwin EC and DiMaio D: Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J Virol. 2007 Mar;81 (5) :2102-16. Epub 2006 Dec 20. PMID: 17182682

DiMaio D and Miller G: Thirty years into the genomics era: tumor viruses led the way. Yale J Biol Med. 2006 Dec;79 (3-4) :179-85. PMID: 17940630


Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D and Hwang ES: Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 2006 Apr;5 (2) :187-95. PMID: 16626397


Sweasy JB, Lang T and DiMaio D: Is base excision repair a tumor suppressor mechanism? Cell Cycle. 2006 Feb;5 (3) :250-9. Epub 2006 Feb 14. PMID: 16418580


DiMaio D and Liao JB: Human papillomaviruses and cervical cancer. Adv Virus Res. 2006;66 :125-59. PMID: 16877060

Freeman-Cook LL and Dimaio D: Modulation of cell function by small transmembrane proteins modeled on the bovine papillomavirus E5 protein. Oncogene. 2005 Nov 21;24 (52) :7756-62. PMID: 16299535


Sweasy JB, Lang T, Starcevic D, Sun KW, Lai CC, Dimaio D and Dalal S: Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation. Proc Natl Acad Sci U S A. 2005 Oct 4;102 (40) :14350-5. Epub 2005 Sep 22. PMID: 16179390


Lai CC, Edwards AP and DiMaio D: Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor. J Virol. 2005 Feb;79 (3) :1924-9. PMID: 15650217


Freeman-Cook LL, Edwards AP, Dixon AM, Yates KE, Ely L, Engelman DM and Dimaio D: Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor. J Mol Biol. 2005 Jan 28;345 (4) :907-21. PMID: 15588835

Freeman-Cook LL, Dixon AM, Frank JB, Xia Y, Ely L, Gerstein M, Engelman DM and DiMaio D: Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor. J Mol Biol. 2004 May 14;338 (5) :907-20. PMID: 15111056


Psyrri A, DeFilippis RA, Edwards AP, Yates KE, Manuelidis L and DiMaio D: Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res. 2004 May 1;64 (9) :3079-86. PMID: 15126344


Horner SM, DeFilippis RA, Manuelidis L and DiMaio D: Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. J Virol. 2004 Apr;78 (8) :4063-73. PMID: 15047823

Irusta PM, Luo Y, Bakht O, Lai CC, Smith SO and DiMaio D: Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor. J Biol Chem. 2002 Oct 11;277 (41) :38627-34. Epub 2002 Aug 13. PMID: 12181311

DiMaio D and Mattoon D: Mechanisms of cell transformation by papillomavirus E5 proteins. Oncogene. 2001 Nov 26;20 (54) :7866-73. PMID: 11753669


Goodwin EC and DiMaio D: Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Cell Growth Differ. 2001 Nov;12 (11) :525-34. PMID: 11714633


Mattoon D, Gupta K, Doyon J, Loll PJ and DiMaio D: Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein. Oncogene. 2001 Jun 28;20 (29) :3824-34. PMID: 11439346

DiMaio D, Lai CC and Mattoon D: The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein. Cytokine Growth Factor Rev. 2000 Dec;11 (4) :283-93. PMID: 10959076


Goodwin EC and DiMaio D: Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc Natl Acad Sci U S A. 2000 Nov 7;97 (23) :12513-8. PMID: 11070078


Wu L, Goodwin EC, Naeger LK, Vigo E, Galaktionov K, Helin K and DiMaio D: E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression. Mol Cell Biol. 2000 Oct;20 (19) :7059-67. PMID: 10982822


Goodwin EC, Yang E, Lee CJ, Lee HW, DiMaio D and Hwang ES: Rapid induction of senescence in human cervical carcinoma cells. Proc Natl Acad Sci U S A. 2000 Sep 26;97 (20) :10978-83. PMID: 11005870


Lai CC, Henningson C and DiMaio D: Bovine papillomavirus E5 protein induces the formation of signal transduction complexes containing dimeric activated platelet-derived growth factor beta receptor and associated signaling proteins. J Biol Chem. 2000 Mar 31;275 (13) :9832-40. PMID: 10734138

Lai CC, Henningson C and DiMaio D: Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor. Proc Natl Acad Sci U S A. 1998 Dec 22;95 (26) :15241-6. PMID: 9860953


Irusta PM and DiMaio D: A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation. EMBO J. 1998 Dec 1;17 (23) :6912-23. PMID: 9843497


Surti T, Klein O, Aschheim K, DiMaio D and Smith SO: Structural models of the bovine papillomavirus E5 protein. Proteins. 1998 Dec 1;33 (4) :601-12. PMID: 9849943


Klein O, Polack GW, Surti T, Kegler-Ebo D, Smith SO and DiMaio D: Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation. J Virol. 1998 Nov;72 (11) :8921-32. PMID: 9765437


Goodwin EC, Naeger LK, Breiding DE, Androphy EJ and DiMaio D: Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J Virol. 1998 May;72 (5) :3925-34. PMID: 9557678


Petti LM, Irusta PM and DiMaio D: Oncogenic activation of the PDGF beta receptor by the transmembrane domain of p185neu*. Oncogene. 1998 Feb 19;16 (7) :843-51. PMID: 9484775


DiMaio D, Lai CC and Klein O: Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu Rev Microbiol. 1998;52 :397-421. PMID: 9891803

Drummond-Barbosa D and DiMaio D: Virocrine transformation. Biochim Biophys Acta. 1997 Feb 22;1332 (1) :M1-17. PMID: 9061007

Hwang ES, Naeger LK and DiMaio D: Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene. Oncogene. 1996 Feb 15;12 (4) :795-803. PMID: 8632901


Kegler-Ebo DM, Polack GW and DiMaio D: Use of codon cassette mutagenesis for saturation mutagenesis. Methods Mol Biol. 1996;57 :297-310. PMID: 8850016

Andrews EM and DiMaio D: Hierarchy of polyadenylation site usage by bovine papillomavirus in transformed mouse cells. J Virol. 1993 Dec;67 (12) :7705-10. PMID: 7901430


Hwang ES, Riese DJ 2nd, Settleman J, Nilson LA, Honig J, Flynn S and DiMaio D: Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol. 1993 Jul;67 (7) :3720-9. PMID: 8389903


Nilson LA and DiMaio D: Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein. Mol Cell Biol. 1993 Jul;13 (7) :4137-45. PMID: 8321218

Riese DJ 2nd, Settleman J, Neary K and DiMaio D: Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity. J Virol. 1990 Feb;64 (2) :944-9. PMID: 2153255

Settleman J and DiMaio D: Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus. Proc Natl Acad Sci U S A. 1988 Dec;85 (23) :9007-11. PMID: 2848252


Prakash SS, Horwitz BH, Zibello T, Settleman J and DiMaio D: Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene. J Virol. 1988 Oct;62 (10) :3608-13. PMID: 2843663


Horwitz BH, Burkhardt AL, Schlegel R and DiMaio D: 44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids. Mol Cell Biol. 1988 Oct;8 (10) :4071-8. PMID: 2847028


DiMaio D and Settleman J: Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation. EMBO J. 1988 Apr;7 (4) :1197-204. PMID: 2841117