Welcome to the Colón-Ramos Lab


We have established a system in the C. elegans nerve ring (the nematode brain) to study the question of synaptic specificity and circuit development. You can use the header bar above or descriptions below to learn more about the specific ways in which we are addressing these questions in C. elegans.

Image 1

Development of arbors in C. elegans serotonergic neurons»

Serotonin neurons are relatively few in number in the CNS but they modulate a multiplicity of behaviors and physiological processes.
Image 2

Cima-1 regulates synaptic maintenance in C. elegans»

Although neuronal circuits of metazoans are largely established during embryogenesis, they persist throughout the lifetime.
developing embryo

Synapse formation during embryogenesis»

The Colon-Ramos lab is interested in studying how synapses form.
Image 3

Thermotaxis circuit assembly»

Five different neuron pairs have been identified as essential for the proper functioning of the thermotaxis circuit.
glial cells

Glial cells direct circuit assembly»

Glial cells are the most abundant cell type in the vertebrate nervous system, yet their role during the development of the nervous system is not well understood.
Image 4

UNC-40/DCC specifies synaptic connections in AIY»

UNC-40/DCC receptor was originally identified as an axon guidance molecule, and has been shown to regulate cell migration and neuronal polarization.