Welcome to the Colón-Ramos Lab
We have established a system in the C. elegans nerve ring (the nematode brain) to study the question of synaptic specificity and circuit development. You can use the header bar above or descriptions below to learn more about the specific ways in which we are addressing these questions in C. elegans.
Synaptic development in the nematode brain»During development, neurons contact many potential synaptic partners, yet connect only to a selected subset. What are the the cellular and molecular mechanisms that instruct this precise assembly of synapses in vivo?
Maintaining the circuit architecture during growth»Many circuits are assembled during embryogenesis. After hatching, C. elegans grow over 100 fold in volume, but the relative positions of the synaptic contacts are maintained. What are the mechanisms that maintain synaptic positions as animals grow?
Modifying the architecture to form memories»During thermotaxis behavior, animals learn to prefer a temperature in which they encountered food, and this preference persists as a memory. How does the cell biology of the synapse encode this memory?