Publications

Britto CJ and Cohn L: BPIFA1 (SPLUNC1) in Airway Host Protection and Respiratory Disease. Am J Respir Cell Mol Biol. 2014 Sep 29; Epub 2014 Sep 29. PMID: 25265466


Cohn L and Woodruff PG: Update in asthma 2013. Am J Respir Crit Care Med. 2014 Jun 15;189 (12) :1487-93. PMID: 24930529

Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L and Elias JA: VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. J Exp Med. 2013 Sep 23;210 (10) :1993-2010. Epub 2013 Sep 16. PMID: 24043765


Britto CJ, Liu Q, Curran DR, Patham B, Dela Cruz CS and Cohn L: Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity. Am J Respir Cell Mol Biol. 2013 Jun;48 (6) :717-24. PMID: 23470624

Chatterjee B, Smed-Sörensen A, Cohn L, Chalouni C, Vandlen R, Lee BC, Widger J, Keler T, Delamarre L and Mellman I: Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells. Blood. 2012 Sep 6;120 (10) :2011-20. Epub 2012 Jul 12. PMID: 22791285

Mitchell C, Provost K, Niu N, Homer R and Cohn L: IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. J Immunol. 2011 Oct 1;187 (7) :3815-20. Epub 2011 Aug 26. PMID: 21873527

Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L and Sessa WC: Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J Exp Med. 2010 Nov 22;207 (12) :2595-607. Epub 2010 Oct 25. PMID: 20975041


Curran DR and Cohn L: Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease. Am J Respir Cell Mol Biol. 2010 Mar;42 (3) :268-75. Epub 2009 Jun 11. PMID: 19520914

Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L and Wu D: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem. 2009 Oct 16;284 (42) :28599-606. Epub 2009 Aug 27. PMID: 19713215


Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K and Elias JA: Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Clin Immunol. 2009 Sep;132 (3) :371-84. Epub 2009 Jun 24. PMID: 19553159


Niu N, Laufer T, Homer RJ and Cohn L: Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. J Immunol. 2009 Aug 1;183 (3) :1523-7. Epub 2009 Jul 13. PMID: 19596982


Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM and Jordt SE: A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A. 2009 Jun 2;106 (22) :9099-104. Epub 2009 May 19. PMID: 19458046


Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA and Elias JA: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009 May 11;206 (5) :1149-66. Epub 2009 May 4. PMID: 19414556

Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L and Jordt SE: TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 2008 May;118 (5) :1899-910. PMID: 18398506

Niu N, Le Goff MK, Li F, Rahman M, Homer RJ and Cohn L: A novel pathway that regulates inflammatory disease in the respiratory tract. J Immunol. 2007 Mar 15;178 (6) :3846-55. PMID: 17339484

Zhang X, Shan P, Jiang G, Cohn L and Lee PJ: Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest. 2006 Nov;116 (11) :3050-9. Epub 2006 Oct 19. PMID: 17053835


Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S and Elias JA: Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291 (3) :L502-11. Epub 2006 Mar 23. PMID: 16556727


Cohn L: Mucus in chronic airway diseases: sorting out the sticky details. J Clin Invest. 2006 Feb;116 (2) :306-8. PMID: 16453018

Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM and Elias JA: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 2004 Oct;10 (10) :1095-103. Epub 2004 Sep 19. PMID: 15378055


Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q and Elias JA: Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science. 2004 Jun 11;304 (5677) :1678-82. PMID: 15192232


Cohn L, Elias JA and Chupp GL: Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol. 2004;22 :789-815. PMID: 15032597

Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ and Cohn L: Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Am J Respir Cell Mol Biol. 2002 Nov;27 (5) :593-602. PMID: 12397019


Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR and Elias JA: Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem. 2002 Sep 20;277 (38) :35466-74. Epub 2002 Jul 9. PMID: 12107190


Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Puré E, Henson PM and Noble PW: Resolution of lung inflammation by CD44. Science. 2002 Apr 5;296 (5565) :155-8. PMID: 11935029


Cohn L, Whittaker L, Niu N and Homer RJ: Cytokine regulation of mucus production in a model of allergic asthma. Novartis Found Symp. 2002;248 :201-13; discussion 213-20, 277-82. PMID: 12568496

Cohn L: Food for thought: can immunological tolerance be induced to treat asthma? Am J Respir Cell Mol Biol. 2001 May;24 (5) :509-12. PMID: 11350818


Cohn L, Herrick C, Niu N, Homer R and Bottomly K: IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol. 2001 Feb 15;166 (4) :2760-7. PMID: 11160342


Das J, Chen CH, Yang L, Cohn L, Ray P and Ray A: A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol. 2001 Jan;2 (1) :45-50. PMID: 11135577

Ray A and Cohn L: Altering the Th1/Th2 balance as a therapeutic strategy in asthmatic diseases. Curr Opin Investig Drugs. 2000 Dec;1 (4) :442-8. PMID: 11249697


Cohn L and Ray A: T-helper type 2 cell-directed therapy for asthma. Pharmacol Ther. 2000 Nov;88 (2) :187-96. PMID: 11150597


Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S and Elias JA: IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. J Immunol. 2000 Aug 15;165 (4) :2222-31. PMID: 10925310

Cohn L, Homer RJ, Niu N and Bottomly K: T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med. 1999 Nov 1;190 (9) :1309-18. PMID: 10544202


Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P and Ray A: Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity. 1999 Oct;11 (4) :473-82. PMID: 10549629


Ray A and Cohn L: Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J Clin Invest. 1999 Oct;104 (8) :985-93. PMID: 10525032


Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F and Bottomly K: Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol. 1999 May 15;162 (10) :6178-83. PMID: 10229862

Yang L, Cohn L, Zhang DH, Homer R, Ray A and Ray P: Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med. 1998 Nov 2;188 (9) :1739-50. PMID: 9802985


Cohn L, Tepper JS and Bottomly K: IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol. 1998 Oct 15;161 (8) :3813-6. PMID: 9780144

Cohn L, Homer RJ, Marinov A, Rankin J and Bottomly K: Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med. 1997 Nov 17;186 (10) :1737-47. PMID: 9362533


Zhang DH, Cohn L, Ray P, Bottomly K and Ray A: Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem. 1997 Aug 22;272 (34) :21597-603. PMID: 9261181