Publications

Sakhatskyy P, Gabino Miranda GA, Newton J, Lee CG, Choudhary G, Vang A, Rounds S and Lu Q: Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvasc Res. 2014 Jul;94 :80-9. Epub 2014 May 20. PMID: 24853558


Tran HT, Lee IA, Low D, Kamba A, Mizoguchi A, Shi HN, Lee CG, Elias JA and Mizoguchi E: Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis. Inflamm Bowel Dis. 2014 May;20 (5) :835-46. PMID: 24694795


Lee CM, Park JW, Cho WK, Zhou Y, Han B, Yoon PO, Chae J, Elias JA and Lee CG: Modifiers of TGF-β1 effector function as novel therapeutic targets of pulmonary fibrosis. Korean J Intern Med. 2014 May;29 (3) :281-90. Epub 2014 Apr 29. PMID: 24851060

Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L and Elias JA: VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. J Exp Med. 2013 Sep 23;210 (10) :1993-2010. Epub 2013 Sep 16. PMID: 24043765


Zhou Y, Kang MJ, Jha BK, Silverman RH, Lee CG and Elias JA: Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. J Immunol. 2013 Sep 1;191 (5) :2637-46. Epub 2013 Aug 2. PMID: 23913960


He CH, Lee CG, Dela Cruz CS, Lee CM, Zhou Y, Ahangari F, Ma B, Herzog EL, Rosenberg SA, Li Y, Nour AM, Parikh CR, Schmidt I, Modis Y, Cantley L and Elias JA: Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2. Cell Rep. 2013 Aug 29;4 (4) :830-41. Epub 2013 Aug 22. PMID: 23972995


Schmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR and Cantley LG: Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function. J Am Soc Nephrol. 2013 Feb;24 (2) :309-19. Epub 2013 Jan 4. PMID: 23291472


Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA and Lee CG: IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15;304 (2) :L112-24. Epub 2012 Nov 2. PMID: 23125252

Zhou Y, Lee JY, Lee CM, Cho WK, Kang MJ, Koff JL, Yoon PO, Chae J, Park HO, Elias JA and Lee CG: Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis. J Biol Chem. 2012 Dec 7;287 (50) :41991-2000. Epub 2012 Oct 19. PMID: 23086930


Lee CG, Herzog EL, Ahangari F, Zhou Y, Gulati M, Lee CM, Peng X, Feghali-Bostwick C, Jimenez SA, Varga J and Elias JA: Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling. J Immunol. 2012 Sep 1;189 (5) :2635-44. Epub 2012 Jul 23. PMID: 22826322


Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG and Elias JA: Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. Cell Host Microbe. 2012 Jul 19;12 (1) :34-46. PMID: 22817986


Kang MJ, Choi JM, Kim BH, Lee CM, Cho WK, Choe G, Kim DH, Lee CG and Elias JA: IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13. Am J Respir Crit Care Med. 2012 Jun 1;185 (11) :1205-17. Epub 2012 Mar 1. PMID: 22383501


Lee CG, Dela Cruz CS, Ma B, Ahangari F, Zhou Y, Halaban R, Sznol M and Elias JA: Chitinase-like proteins in lung injury, repair, and metastasis. Proc Am Thorac Soc. 2012 May;9 (2) :57-61. PMID: 22550243

Lee CG, Ma B, Takyar S, Ahangari F, Delacruz C, He CH and Elias JA: Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2011 Nov;8 (6) :512-5. PMID: 22052929


Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA and Lee CG: Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. Am J Respir Cell Mol Biol. 2011 Jun;44 (6) :777-86. Epub 2010 Jul 23. PMID: 20656949


Homer RJ, Elias JA, Lee CG and Herzog E: Modern concepts on the role of inflammation in pulmonary fibrosis. Arch Pathol Lab Med. 2011 Jun;135 (6) :780-8. PMID: 21631273


Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG and Elias JA: RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Am J Respir Crit Care Med. 2011 May 15;183 (10) :1322-35. Epub 2011 Jan 28. PMID: 21278304


Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S and Elias JA: Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 2011;73 :479-501. PMID: 21054166


Dela Cruz CS, Kang MJ, Cho WK and Lee CG: Transgenic modelling of cytokine polarization in the lung. Immunology. 2011 Jan;132 (1) :9-17. Epub 2010 Nov 23. PMID: 21091906

Da Silva CA, Pochard P, Lee CG and Elias JA: Chitin particles are multifaceted immune adjuvants. Am J Respir Crit Care Med. 2010 Dec 15;182 (12) :1482-91. Epub 2010 Jul 23. PMID: 20656945


Lee CG and Elias JA: Role of breast regression protein-39/YKL-40 in asthma and allergic responses. Allergy Asthma Immunol Res. 2010 Jan;2 (1) :20-7. Epub 2009 Dec 30. PMID: 20224674

Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K and Elias JA: Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Clin Immunol. 2009 Sep;132 (3) :371-84. Epub 2009 Jun 24. PMID: 19553159


Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA and Elias JA: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009 May 11;206 (5) :1149-66. Epub 2009 May 4. PMID: 19414556


Hartl D, He CH, Koller B, Da Silva CA, Kobayashi Y, Lee CG, Flavell RA and Elias JA: Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism. J Immunol. 2009 Apr 15;182 (8) :5098-106. PMID: 19342690


Da Silva CA, Chalouni C, Williams A, Hartl D, Lee CG and Elias JA: Chitin is a size-dependent regulator of macrophage TNF and IL-10 production. J Immunol. 2009 Mar 15;182 (6) :3573-82. PMID: 19265136


Lee CG: Chitin, chitinases and chitinase-like proteins in allergic inflammation and tissue remodeling. Yonsei Med J. 2009 Feb 28;50 (1) :22-30. Epub 2009 Feb 24. PMID: 19259344


Hartl D, Lee CG, Da Silva CA, Chupp GL and Elias JA: Novel biomarkers in asthma: chemokines and chitinase-like proteins. Curr Opin Allergy Clin Immunol. 2009 Feb;9 (1) :60-6. PMID: 19532094

Lee CG, Hartl D, Matsuura H, Dunlop FM, Scotney PD, Fabri LJ, Nash AD, Chen NY, Tang CY, Chen Q, Homer RJ, Baca M and Elias JA: Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. Am J Respir Cell Mol Biol. 2008 Dec;39 (6) :739-46. Epub 2008 Jul 10. PMID: 18617680


Lee CG, Da Silva CA, Lee JY, Hartl D and Elias JA: Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol. 2008 Dec;20 (6) :684-9. Epub 2008 Nov 1. PMID: 18938241


Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG and Elias JA: Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. J Biol Chem. 2008 Nov 28;283 (48) :33472-82. Epub 2008 Sep 29. PMID: 18824549


Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ and Elias JA: Developmental regulation of NO-mediated VEGF-induced effects in the lung. Am J Respir Cell Mol Biol. 2008 Oct;39 (4) :420-30. Epub 2008 Apr 25. PMID: 18441284


Da Silva CA, Hartl D, Liu W, Lee CG and Elias JA: TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol. 2008 Sep 15;181 (6) :4279-86. PMID: 18768886


Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, Enelow R and Elias JA: Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest. 2008 Aug;118 (8) :2771-84. PMID: 18654661


Yamasaki M, Kang HR, Homer RJ, Chapoval SP, Cho SJ, Lee BJ, Elias JA and Lee CG: P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway. Am J Respir Cell Mol Biol. 2008 Mar;38 (3) :346-53. Epub 2007 Oct 11. PMID: 17932374

Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M and Elias JA: A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med. 2007 Nov 15;357 (20) :2016-27. PMID: 18003958


Kang HR, Lee CG, Homer RJ and Elias JA: Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. J Exp Med. 2007 May 14;204 (5) :1083-93. Epub 2007 May 7. PMID: 17485510


Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA and Lee PJ: VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo. FASEB J. 2007 May;21 (7) :1422-32. Epub 2007 Jan 30. PMID: 17264168


Kang HR, Cho SJ, Lee CG, Homer RJ and Elias JA: Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem. 2007 Mar 9;282 (10) :7723-32. Epub 2007 Jan 5. PMID: 17209037


Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ and Elias JA: IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol. 2007 Feb 1;178 (3) :1948-59. PMID: 17237446

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR and Elias JA: Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov;12 (11) :1286-93. Epub 2006 Nov 5. PMID: 17086189


Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S and Elias JA: Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291 (3) :L502-11. Epub 2006 Mar 23. PMID: 16556727


Kang MJ, Lee CG, Cho SJ, Homer RJ and Elias JA: IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema. Proc Am Thorac Soc. 2006 Aug;3 (6) :517-8. PMID: 16921135


Elias JA, Kang MJ, Crothers K, Homer R and Lee CG: State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proc Am Thorac Soc. 2006 Aug;3 (6) :494-8. PMID: 16921126


Lee CG, Cho S, Homer RJ and Elias JA: Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung. Proc Am Thorac Soc. 2006 Aug;3 (6) :476-477. PMID: 16921114


Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC and Elias JA: Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 2006 Jul 18;103 (29) :11021-6. Epub 2006 Jul 10. PMID: 16832062


Lee CG, Kang HR, Homer RJ, Chupp G and Elias JA: Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling. Proc Am Thorac Soc. 2006 Jul;3 (5) :418-23. PMID: 16799085


Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW and Elias JA: Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. J Clin Invest. 2006 May;116 (5) :1274-83. PMID: 16670768


Ma B, Liu W, Homer RJ, Lee PJ, Coyle AJ, Lora JM, Lee CG and Elias JA: Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2006 Apr 15;176 (8) :4968-78. PMID: 16585593


Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA and Lee CG: Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. J Biol Chem. 2006 Mar 24;281 (12) :8161-8. Epub 2006 Jan 26. PMID: 16439363


Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT and Elias JA: ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006 Jan;116 (1) :163-73. Epub 2005 Dec 22. PMID: 16374521

Ma B, Kang MJ, Lee CG, Chapoval S, Liu W, Chen Q, Coyle AJ, Lora JM, Picarella D, Homer RJ and Elias JA: Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. J Clin Invest. 2005 Dec;115 (12) :3460-72. Epub 2005 Nov 10. PMID: 16284650


Elias JA, Homer RJ, Hamid Q and Lee CG: Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma. J Allergy Clin Immunol. 2005 Sep;116 (3) :497-500. PMID: 16159614


Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Underwood S, Graupe M, Flavell RA, Schmidt JA and Elias JA: Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol. 2005 Jun 15;174 (12) :8106-15. PMID: 15944319


He CH, Waxman AB, Lee CG, Link H, Rabach ME, Ma B, Chen Q, Zhu Z, Zhong M, Nakayama K, Nakayama KI, Homer R and Elias JA: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J Clin Invest. 2005 Apr;115 (4) :1039-48. PMID: 15841185


Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ and Elias JA: IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2005 Feb 15;174 (4) :2305-13. PMID: 15699166

Vicencio AG, Lee CG, Cho SJ, Eickelberg O, Chuu Y, Haddad GG and Elias JA: Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia? Am J Respir Cell Mol Biol. 2004 Dec;31 (6) :650-6. Epub 2004 Aug 27. PMID: 15333328


Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM and Elias JA: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 2004 Oct;10 (10) :1095-103. Epub 2004 Sep 19. PMID: 15378055


Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ and Elias JA: Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med. 2004 Aug 2;200 (3) :377-89. PMID: 15289506

Wang J, Chen Q, Corne J, Zhu Z, Lee CG, Bhandari V, Homer RJ and Elias JA: Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia. J Biol Chem. 2003 Aug 15;278 (33) :31226-32. Epub 2003 Jun 2. PMID: 12782633


Elias JA, Lee CG, Zheng T, Shim Y and Zhu Z: Interleukin-13 and leukotrienes: an intersection of pathogenetic schema. Am J Respir Cell Mol Biol. 2003 Apr;28 (4) :401-4. PMID: 12654627


Zheng T, Zhu Z, Liu W, Lee CG, Chen Q, Homer RJ and Elias JA: Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. J Allergy Clin Immunol. 2003 Apr;111 (4) :720-8. PMID: 12704349


Elias JA, Zheng T, Lee CG, Homer RJ, Chen Q, Ma B, Blackburn M and Zhu Z: Transgenic modeling of interleukin-13 in the lung. Chest. 2003 Mar;123 (3 Suppl) :339S-45S. PMID: 12628967


Elias JA, Lee CG, Zheng T, Ma B, Homer RJ and Zhu Z: New insights into the pathogenesis of asthma. J Clin Invest. 2003 Feb;111 (3) :291-7. PMID: 12569150

Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR and Elias JA: Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem. 2002 Sep 20;277 (38) :35466-74. Epub 2002 Jul 9. PMID: 12107190


Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM and Elias JA: Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest. 2002 Aug;110 (4) :463-74. PMID: 12189240


Zhu Z, Zheng T, Lee CG, Homer RJ and Elias JA: Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin Cell Dev Biol. 2002 Apr;13 (2) :121-8. PMID: 12127145


Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P and Elias JA: IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2002 Mar 15;168 (6) :2953-62. PMID: 11884467

Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q and Elias JA: Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice. Am J Respir Crit Care Med. 2001 Nov 15;164 (10 Pt 2) :S67-70. PMID: 11734470


Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM and Elias JA: Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med. 2001 Sep 17;194 (6) :809-21. PMID: 11560996

Lee CG, Yoon HJ, Zhu Z, Link H, Wang Z, Gwaltney JM, Landry M and Elias JA: Respiratory syncytial virus stimulation of vascular endothelial cell growth Factor/Vascular permeability factor. Am J Respir Cell Mol Biol. 2000 Nov;23 (5) :662-9. PMID: 11062145


Corne J, Chupp G, Lee CG, Homer RJ, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman AB and Elias JA: IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. J Clin Invest. 2000 Sep;106 (6) :783-91. PMID: 10995789


Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S and Elias JA: IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. J Immunol. 2000 Aug 15;165 (4) :2222-31. PMID: 10925310