Dr. Lee’s laboratory has been focused to develop transgenic animal models (transgenic and null mutant KO mice) to investigate the in vivo role and effector function of cytokines and mediators in the pathogenesis of asthma, acute lung injury, pulmonary vascular disease, pulmonary fibrosis and emphysema. Working in a close collaboration with Dr. Jack A Elias, a number of lung-specific transgenic and null mutant mice has been successfully generated and used by a number of investigators around the world. They include IL-10, VEGF, TGF-beta, IL-18, IL-15, Chi3l1/BRP-39, Chitotriosidase (Chitinase1) transgenic and null mutant mice.
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