Publications

Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro J, Huang F, Floyd RW, Yang H, Hamilton W, Bewersdorf J, Xiong Y, Calderwood DA and Mothes W: TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014 Jul 11; Epub 2014 Jul 11. PMID: 25015296


Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P and Sessa WC: Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development. 2014 Apr;141 (7) :1465-72. Epub 2014 Mar 5. PMID: 24598168


Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J and Ishibe S: Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. J Clin Invest. 2014 Mar 3;124 (3) :1098-113. Epub 2014 Feb 17. PMID: 24531545


Draheim KM, Fisher OS, Boggon TJ and Calderwood DA: Cerebral cavernous malformation proteins at a glance. J Cell Sci. 2014 Feb 15;127 (Pt 4) :701-7. Epub 2014 Jan 30. PMID: 24481819


Morse EM, Brahme NN and Calderwood DA: Integrin cytoplasmic tail interactions. Biochemistry. 2014 Feb 11;53 (5) :810-20. Epub 2014 Jan 27. PMID: 24467163

Brahme NN, Harburger DS, Kemp-O'Brien K, Stewart R, Raghavan S, Parsons M and Calderwood DA: Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. J Biol Chem. 2013 Dec 6;288 (49) :35604-16. Epub 2013 Oct 28. PMID: 24165133


Razinia Z, Baldassarre M, Cantelli G and Calderwood DA: ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain. J Biol Chem. 2013 Nov 1;288 (44) :32093-105. Epub 2013 Sep 19. PMID: 24052262


Calderwood DA, Campbell ID and Critchley DR: Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol. 2013 Aug;14 (8) :503-17. Epub 2013 Jul 17. PMID: 23860236


Liu W, Draheim KM, Zhang R, Calderwood DA and Boggon TJ: Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Mol Cell. 2013 Feb 21;49 (4) :719-29. Epub 2013 Jan 11. PMID: 23317506


Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE and Boggon TJ: Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. PLoS One. 2013;8 (10) :e77818. Epub 2013 Oct 28. PMID: 24204982


Stiegler AL, Grant TD, Luft JR, Calderwood DA, Snell EH and Boggon TJ: Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex. PLoS One. 2013;8 (1) :e55591. Epub 2013 Jan 31. PMID: 23383235

Yates LA, Lumb CN, Brahme NN, Zalyte R, Bird LE, De Colibus L, Owens RJ, Calderwood DA, Sansom MS and Gilbert RJ: Structural and functional characterization of the kindlin-1 pleckstrin homology domain. J Biol Chem. 2012 Dec 21;287 (52) :43246-61. Epub 2012 Nov 6. PMID: 23132860


Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schöck F and Calderwood DA: Zasp regulates integrin activation. J Cell Sci. 2012 Dec 1;125 (Pt 23) :5647-57. Epub 2012 Sep 19. PMID: 22992465


Coyer SR, Singh A, Dumbauld DW, Calderwood DA, Craig SW, Delamarche E and García AJ: Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. J Cell Sci. 2012 Nov 1;125 (Pt 21) :5110-23. Epub 2012 Aug 16. PMID: 22899715


Stiegler AL, Draheim KM, Li X, Chayen NE, Calderwood DA and Boggon TJ: Structural basis for paxillin binding and focal adhesion targeting of β-parvin. J Biol Chem. 2012 Sep 21;287 (39) :32566-77. Epub 2012 Aug 6. PMID: 22869380


Brahme NN and Calderwood DA: Cell adhesion: a FERM grasp of the tail sorts out integrins. Curr Biol. 2012 Sep 11;22 (17) :R692-4. PMID: 22974999


Baldassarre M, Razinia Z, Brahme NN, Buccione R and Calderwood DA: Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells. J Cell Sci. 2012 Aug 15;125 (Pt 16) :3858-69. Epub 2012 May 17. PMID: 22595522


Li X, Zhang R, Draheim KM, Liu W, Calderwood DA and Boggon TJ: Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). J Biol Chem. 2012 Jun 22;287 (26) :22317-27. Epub 2012 May 10. PMID: 22577140


Bandyopadhyay A, Rothschild G, Kim S, Calderwood DA and Raghavan S: Functional differences between kindlin-1 and kindlin-2 in keratinocytes. J Cell Sci. 2012 May 1;125 (Pt 9) :2172-84. Epub 2012 Feb 10. PMID: 22328497


Guiet R, Vérollet C, Lamsoul I, Cougoule C, Poincloux R, Labrousse A, Calderwood DA, Glogauer M, Lutz PG and Maridonneau-Parini I: Macrophage mesenchymal migration requires podosome stabilization by filamin A. J Biol Chem. 2012 Apr 13;287 (16) :13051-62. Epub 2012 Feb 9. PMID: 22334688


Bouaouina M, Goult BT, Huet-Calderwood C, Bate N, Brahme NN, Barsukov IL, Critchley DR and Calderwood DA: A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation. J Biol Chem. 2012 Mar 2;287 (10) :6979-90. Epub 2012 Jan 10. PMID: 22235127


Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA and Schlaepfer DD: FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol. 2012 Jan 23;196 (2) :223-32. PMID: 22270917


Razinia Z, Mäkelä T, Ylänne J and Calderwood DA: Filamins in mechanosensing and signaling. Annu Rev Biophys. 2012;41 :227-46. Epub 2012 Feb 23. PMID: 22404683


Bouaouina M, Harburger DS and Calderwood DA: Talin and signaling through integrins. Methods Mol Biol. 2012;757 :325-47. PMID: 21909921

Lamsoul I, Burande CF, Razinia Z, Houles TC, Menoret D, Baldassarre M, Erard M, Moog-Lutz C, Calderwood DA and Lutz PG: Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells. J Biol Chem. 2011 Sep 2;286 (35) :30571-81. Epub 2011 Jul 7. PMID: 21737450


Razinia Z, Baldassarre M, Bouaouina M, Lamsoul I, Lutz PG and Calderwood DA: The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain. J Cell Sci. 2011 Aug 1;124 (Pt 15) :2631-41. Epub 2011 Jul 12. PMID: 21750192


Bouaouina M and Calderwood DA: Kindlins. Curr Biol. 2011 Feb 8;21 (3) :R99-101. PMID: 21300280

Chiswell BP, Stiegler AL, Razinia Z, Nalibotski E, Boggon TJ and Calderwood DA: Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. J Struct Biol. 2010 Apr;170 (1) :157-63. Epub 2009 Dec 4. PMID: 19963065


Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR and Barsukov IL: Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J. 2010 Mar 17;29 (6) :1069-80. Epub 2010 Feb 11. PMID: 20150896

Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC and Critchley DR: The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J Mol Biol. 2009 Dec 18;394 (5) :944-56. Epub 2009 Oct 3. PMID: 19804783


Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG and Calderwood DA: Filamins regulate cell spreading and initiation of cell migration. PLoS One. 2009 Nov 13;4 (11) :e7830. Epub 2009 Nov 13. PMID: 19915675


Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA and Keely PJ: Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell. 2009 Jul;20 (14) :3224-38. Epub 2009 May 20. PMID: 19458194


Bello NF, Lamsoul I, Heuzé ML, Métais A, Moreaux G, Calderwood DA, Duprez D, Moog-Lutz C and Lutz PG: The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Cell Death Differ. 2009 Jun;16 (6) :921-32. Epub 2009 Mar 20. PMID: 19300455


Harburger DS, Bouaouina M and Calderwood DA: Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem. 2009 Apr 24;284 (17) :11485-97. Epub 2009 Feb 23. PMID: 19240021


Shifrin Y, Arora PD, Ohta Y, Calderwood DA and McCulloch CA: The role of FilGAP-filamin A interactions in mechanoprotection. Mol Biol Cell. 2009 Mar;20 (5) :1269-79. Epub 2009 Jan 14. PMID: 19144823


Harburger DS and Calderwood DA: Integrin signalling at a glance. J Cell Sci. 2009 Jan 15;122 (Pt 2) :159-63. PMID: 19118207

Chiswell BP, Zhang R, Murphy JW, Boggon TJ and Calderwood DA: The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci U S A. 2008 Dec 30;105 (52) :20677-82. Epub 2008 Dec 12. PMID: 19074270


Heuzé ML, Lamsoul I, Baldassarre M, Lad Y, Lévêque S, Razinia Z, Moog-Lutz C, Calderwood DA and Lutz PG: ASB2 targets filamins A and B to proteasomal degradation. Blood. 2008 Dec 15;112 (13) :5130-40. Epub 2008 Sep 17. PMID: 18799729


Luissint AC, Lutz PG, Calderwood DA, Couraud PO and Bourdoulous S: JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J Cell Biol. 2008 Dec 15;183 (6) :1159-73. Epub 2008 Dec 8. PMID: 19064666


Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylänne J, Campbell ID and Calderwood DA: Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem. 2008 Dec 12;283 (50) :35154-63. Epub 2008 Sep 30. PMID: 18829455


Bouaouina M, Lad Y and Calderwood DA: The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins. J Biol Chem. 2008 Mar 7;283 (10) :6118-25. Epub 2007 Dec 28. PMID: 18165225

Lad Y, Kiema T, Jiang P, Pentikäinen OT, Coles CH, Campbell ID, Calderwood DA and Ylänne J: Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J. 2007 Sep 5;26 (17) :3993-4004. Epub 2007 Aug 9. PMID: 17690686


Evans EA and Calderwood DA: Forces and bond dynamics in cell adhesion. Science. 2007 May 25;316 (5828) :1148-53. PMID: 17525329


Lad Y, Harburger DS and Calderwood DA: Integrin cytoskeletal interactions. Methods Enzymol. 2007;426 :69-84. PMID: 17697880

Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ and Ginsberg MH: Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19;16 (18) :1796-806. PMID: 16979556


Monniaux D, Huet-Calderwood C, Le Bellego F, Fabre S, Monget P and Calderwood DA: Integrins in the ovary. Semin Reprod Med. 2006 Sep;24 (4) :251-61. PMID: 16944422


Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J and Calderwood DA: The molecular basis of filamin binding to integrins and competition with talin. Mol Cell. 2006 Feb 3;21 (3) :337-47. PMID: 16455489

Calderwood DA, Tai V, Di Paolo G, De Camilli P and Ginsberg MH: Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem. 2004 Jul 9;279 (28) :28889-95. Epub 2004 May 13. PMID: 15143061


Calderwood DA: Talin controls integrin activation. Biochem Soc Trans. 2004 Jun;32 (Pt3) :434-7. PMID: 15157154


Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA and Beckerle MC: The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem. 2004 Feb 20;279 (8) :6824-33. Epub 2003 Nov 21. PMID: 14634021


Calderwood DA: Integrin activation. J Cell Sci. 2004 Feb 15;117 (Pt 5) :657-66. PMID: 14754902

Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH and Calderwood DA: Talin binding to integrin beta tails: a final common step in integrin activation. Science. 2003 Oct 3;302 (5642) :103-6. PMID: 14526080


Calderwood DA and Ginsberg MH: Talin forges the links between integrins and actin. Nat Cell Biol. 2003 Aug;5 (8) :694-7. PMID: 12894175


Ulmer TS, Calderwood DA, Ginsberg MH and Campbell ID: Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry. 2003 Jul 15;42 (27) :8307-12. PMID: 12846579


Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC and Ginsberg MH: Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A. 2003 Mar 4;100 (5) :2272-7. Epub 2003 Feb 26. PMID: 12606711


García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH and Liddington RC: Structural determinants of integrin recognition by talin. Mol Cell. 2003 Jan;11 (1) :49-58. PMID: 12535520

Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ and Ginsberg MH: The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem. 2002 Oct 18;277 (42) :39401-8. Epub 2002 Aug 8. PMID: 12171941


Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC and Ginsberg MH: The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem. 2002 Jun 14;277 (24) :21749-58. Epub 2002 Apr 3. PMID: 11932255

Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA and Ginsberg MH: Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Nat Cell Biol. 2001 Dec;3 (12) :1060-8. PMID: 11781567


Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH and Chneiweiss H: PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev Cell. 2001 Aug;1 (2) :239-50. PMID: 11702783


Yan B, Calderwood DA, Yaspan B and Ginsberg MH: Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J Biol Chem. 2001 Jul 27;276 (30) :28164-70. Epub 2001 May 29. PMID: 11382782


Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C and Ginsberg MH: Distinct domains of CD98hc regulate integrins and amino acid transport. J Biol Chem. 2001 Mar 23;276 (12) :8746-52. Epub 2000 Dec 19. PMID: 11121428

Liu S, Calderwood DA and Ginsberg MH: Integrin cytoplasmic domain-binding proteins. J Cell Sci. 2000 Oct;113 ( Pt 20) :3563-71. PMID: 11017872


Calderwood DA, Shattil SJ and Ginsberg MH: Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem. 2000 Jul 28;275 (30) :22607-10. PMID: 10801899


Zent R, Fenczik CA, Calderwood DA, Liu S, Dellos M and Ginsberg MH: Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains. J Biol Chem. 2000 Feb 18;275 (7) :5059-64. PMID: 10671548

Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO and Ginsberg MH: The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem. 1999 Oct 1;274 (40) :28071-4. PMID: 10497155

Davies D, Tuckwell DS, Calderwood DA, Weston SA, Takigawa M and Humphries MJ: Molecular characterisation of integrin-procollagen C-propeptide interactions. Eur J Biochem. 1997 Jun 1;246 (2) :274-82. PMID: 9208915


Calderwood DA, Tuckwell DS, Eble J, Kühn K and Humphries MJ: The integrin alpha1 A-domain is a ligand binding site for collagens and laminin. J Biol Chem. 1997 May 9;272 (19) :12311-7. PMID: 9139675

Calderwood DA, Tuckwell DS and Humphries MJ: Specificity of integrin I-domain-ligand binding. Biochem Soc Trans. 1995 Nov;23 (4) :504S. PMID: 8654689


Tuckwell D, Calderwood DA, Green LJ and Humphries MJ: Integrin alpha 2 I-domain is a binding site for collagens. J Cell Sci. 1995 Apr;108 ( Pt 4) :1629-37. PMID: 7615681