Buchanan Lab

Research efforts in the Buchanan laboratory are focused on understanding basic mechanisms of epilepsy and sleep-wake regulation. We are particularly interested in the effects of seizures and vigilance state on cardio-respiratory control and how these may interact to lead to death following a seizure, or sudden unexpected death in epilepsy (SUDEP).

We employ basic behavioral, surgical, electrophysiological, molecular, and immunohistological techniques in conjunction with a variety of seizure induction methods to address our research questions.

Our goal is to understand factors that render a given seizure fatal in an effort to help prevent SUDEP.

Research

Our research is divided into two main projects:

  1. Mechanisms of hypercapnia-induced arousal from sleep
  2. Mechanisms of seizure-related death with relevance to sudden unexpected death in epilepsy (SUDEP)

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