Recent Publications

Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM and Slack FJ: MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature. 2015 Feb 5;518 (7537) :107-10. Epub 2014 Nov 17. PMID: 25409146

Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG and Shulman GI: Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014 Jun 26;510 (7506) :542-6. Epub 2014 May 21. PMID: 24847880

Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM and Braddock DT: Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem. 2014 Feb 7;289 (6) :3294-306. Epub 2013 Dec 12. PMID: 24338010

Broer PN, Walker ME, Goldberg C, Buonocore S, Braddock DT, Lazova R, Narayan D and Ariyan S: Desmoplastic melanoma: a 12-year experience with sentinel lymph node biopsy. Eur J Surg Oncol. 2013 Jul;39 (7) :681-5. Epub 2013 Mar 22. PMID: 23522951

Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM and Braddock DT: NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120 (22) :4432-40. Epub 2012 Sep 20. PMID: 22995898

Saunders LP, Cao W, Chang WC, Albright RA, Braddock DT and De La Cruz EM: Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution. J Biol Chem. 2011 Aug 26;286 (34) :30130-41. Epub 2011 Jun 30. PMID: 21719699

Hsiao HH, Nath A, Lin CY, Folta-Stogniew EJ, Rhoades E and Braddock DT: Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. Biochemistry. 2010 Jun 8;49 (22) :4620-34. PMID: 20420426

Braddock DT: Autotaxin and lipid signaling pathways as anticancer targets. Curr Opin Investig Drugs. 2010 Jun;11 (6) :629-37. PMID: 20496257

Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, De La Cruz EM and Braddock DT: Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Mol Cancer Ther. 2008 Oct;7 (10) :3352-62. PMID: 18852138

Ornstein DL, Bifulco CB, Braddock DT and Howe JG: Histopathologic and molecular aspects of CD56+ natural killer/ T-cell lymphoma of the testis. Int J Surg Pathol. 2008 Jul;16 (3) :291-300. PMID: 18573785

Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D and Hajduk PJ: NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter. J Med Chem. 2004 Sep 23;47 (20) :4851-7. PMID: 15369388

Braddock DT, Baber JL, Levens D and Clore GM: Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA. EMBO J. 2002 Jul 1;21 (13) :3476-85. PMID: 12093748

Braddock DT, Louis JM, Baber JL, Levens D and Clore GM: Structure and dynamics of KH domains from FBP bound to single-stranded DNA. Nature. 2002 Feb 28;415 (6875) :1051-6. PMID: 11875576

Braddock DT, Cai M, Baber JL, Huang Y and Clore GM: Rapid identification of medium- to large-scale interdomain motion in modular proteins using dipolar couplings. J Am Chem Soc. 2001 Sep 5;123 (35) :8634-5. PMID: 11525687

Caffrey M, Braddock DT, Louis JM, Abu-Asab MA, Kingma D, Liotta L, Tsokos M, Tresser N, Pannell LK, Watts N, Steven AC, Simon MN, Stahl SJ, Wingfield PT and Clore GM: Biophysical characterization of gp41 aggregates suggests a model for the molecular mechanism of HIV-associated neurological damage and dementia. J Biol Chem. 2000 Jun 30;275 (26) :19877-82. PMID: 10747981

Kalantaridou SN, Braddock DT, Patronas NJ and Nelson LM: Treatment of autoimmune premature ovarian failure. Hum Reprod. 1999 Jul;14 (7) :1777-82. PMID: 10402388

Benzinger TL, Braddock DT, Dominguez SR, Burkoth TS, Miller-Auer H, Subramanian RM, Fless GM, Jones DN, Lynn DG and Meredith SC: Structure-function relationships in side chain lactam cross-linked peptide models of a conserved N-terminal domain of apolipoprotein E. Biochemistry. 1998 Sep 22;37 (38) :13222-9. PMID: 9748329

Braddock DT, Mercurius KO, Subramanian RM, Dominguez SR, Davies PF and Meredith SC: Conformationally specific enhancement of receptor-mediated LDL binding and internalization by peptide models of a conserved anionic N-terminal domain of human apolipoprotein E. Biochemistry. 1996 Nov 5;35 (44) :13975-84. PMID: 8909295

Luo P, Braddock DT, Subramanian RM, Meredith SC and Lynn DG: Structural and thermodynamic characterization of a bioactive peptide model of apolipoprotein E: side-chain lactam bridges to constrain the conformation. Biochemistry. 1994 Oct 18;33 (41) :12367-77. PMID: 7918459