Recent Publications

Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM and Braddock DT: Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem. 2014 Feb 7;289 (6) :3294-306. Epub 2013 Dec 12. PMID: 24338010

Broer PN, Walker ME, Goldberg C, Buonocore S, Braddock DT, Lazova R, Narayan D and Ariyan S: Desmoplastic melanoma: a 12-year experience with sentinel lymph node biopsy. Eur J Surg Oncol. 2013 Jul;39 (7) :681-5. Epub 2013 Mar 22. PMID: 23522951

Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM and Braddock DT: NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120 (22) :4432-40. Epub 2012 Sep 20. PMID: 22995898

Saunders LP, Cao W, Chang WC, Albright RA, Braddock DT and De La Cruz EM: Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution. J Biol Chem. 2011 Aug 26;286 (34) :30130-41. Epub 2011 Jun 30. PMID: 21719699

Hsiao HH, Nath A, Lin CY, Folta-Stogniew EJ, Rhoades E and Braddock DT: Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. Biochemistry. 2010 Jun 8;49 (22) :4620-34. PMID: 20420426

Braddock DT: Autotaxin and lipid signaling pathways as anticancer targets. Curr Opin Investig Drugs. 2010 Jun;11 (6) :629-37. PMID: 20496257

Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, De La Cruz EM and Braddock DT: Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Mol Cancer Ther. 2008 Oct;7 (10) :3352-62. PMID: 18852138

Ornstein DL, Bifulco CB, Braddock DT and Howe JG: Histopathologic and molecular aspects of CD56+ natural killer/ T-cell lymphoma of the testis. Int J Surg Pathol. 2008 Jul;16 (3) :291-300. PMID: 18573785

Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D and Hajduk PJ: NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter. J Med Chem. 2004 Sep 23;47 (20) :4851-7. PMID: 15369388

Braddock DT, Baber JL, Levens D and Clore GM: Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA. EMBO J. 2002 Jul 1;21 (13) :3476-85. PMID: 12093748

Braddock DT, Louis JM, Baber JL, Levens D and Clore GM: Structure and dynamics of KH domains from FBP bound to single-stranded DNA. Nature. 2002 Feb 28;415 (6875) :1051-6. PMID: 11875576

Braddock DT, Cai M, Baber JL, Huang Y and Clore GM: Rapid identification of medium- to large-scale interdomain motion in modular proteins using dipolar couplings. J Am Chem Soc. 2001 Sep 5;123 (35) :8634-5. PMID: 11525687

Caffrey M, Braddock DT, Louis JM, Abu-Asab MA, Kingma D, Liotta L, Tsokos M, Tresser N, Pannell LK, Watts N, Steven AC, Simon MN, Stahl SJ, Wingfield PT and Clore GM: Biophysical characterization of gp41 aggregates suggests a model for the molecular mechanism of HIV-associated neurological damage and dementia. J Biol Chem. 2000 Jun 30;275 (26) :19877-82. PMID: 10747981

Kalantaridou SN, Braddock DT, Patronas NJ and Nelson LM: Treatment of autoimmune premature ovarian failure. Hum Reprod. 1999 Jul;14 (7) :1777-82. PMID: 10402388

Benzinger TL, Braddock DT, Dominguez SR, Burkoth TS, Miller-Auer H, Subramanian RM, Fless GM, Jones DN, Lynn DG and Meredith SC: Structure-function relationships in side chain lactam cross-linked peptide models of a conserved N-terminal domain of apolipoprotein E. Biochemistry. 1998 Sep 22;37 (38) :13222-9. PMID: 9748329

Braddock DT, Mercurius KO, Subramanian RM, Dominguez SR, Davies PF and Meredith SC: Conformationally specific enhancement of receptor-mediated LDL binding and internalization by peptide models of a conserved anionic N-terminal domain of human apolipoprotein E. Biochemistry. 1996 Nov 5;35 (44) :13975-84. PMID: 8909295

Luo P, Braddock DT, Subramanian RM, Meredith SC and Lynn DG: Structural and thermodynamic characterization of a bioactive peptide model of apolipoprotein E: side-chain lactam bridges to constrain the conformation. Biochemistry. 1994 Oct 18;33 (41) :12367-77. PMID: 7918459