Publications

Bench Research

Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Shuang Y, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PLoS ONE 2013 (in press).

Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ and Bhandari V: Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. Am J Respir Cell Mol Biol. 2013 Jun;48 (6) :749-57. PMID: 23470621


Ghelfi E, Yu CW, Elmasri H, Terwelp M, Lee CG, Bhandari V, Comhair SA, Erzurum SC, Hotamisligil GS, Elias JA and Cataltepe S: Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. Am J Pathol. 2013 Apr;182 (4) :1425-33. Epub 2013 Feb 4. PMID: 23391391


Sun H, Choo-Wing R, Fan J, Leng L, Syed MA, Hare AA, Jorgensen WL, Bucala R and Bhandari V: Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia. Respir Res. 2013 Feb 28;14 :27. Epub 2013 Feb 28. PMID: 23448134

Rajasekaran D, Keeler C, Syed MA, Jones MC, Harrison JK, Wu D, Bhandari V, Hodsdon ME and Lolis EJ: A model of GAG/MIP-2/CXCR2 interfaces and its functional effects. Biochemistry. 2012 Jul 17;51 (28) :5642-54. Epub 2012 Jul 2. PMID: 22686371


Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ and Elias JA: Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. Am J Respir Cell Mol Biol. 2012 May;46 (5) :668-76. Epub 2012 Jan 6. PMID: 22227562

Li Z, Choo-Wing R, Sun H, Sureshbabu A, Sakurai R, Rehan VK and Bhandari V: A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung. BMC Cell Biol. 2011 Dec 15;12 :54. Epub 2011 Dec 15. PMID: 22172122


Harijith A, Choo-Wing R, Cataltepe S, Yasumatsu R, Aghai ZH, Janér J, Andersson S, Homer RJ and Bhandari V: A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2011 May;44 (5) :621-30. Epub 2011 Jan 7. PMID: 21216975


Maheshwari A, Kelly DR, Nicola T, Ambalavanan N, Jain SK, Murphy-Ullrich J, Athar M, Shimamura M, Bhandari V, Aprahamian C, Dimmitt RA, Serra R and Ohls RK: TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology. 2011 Jan;140 (1) :242-53. Epub 2010 Sep 24. PMID: 20875417

Sohn MH, Kang MJ, Matsuura H, Bhandari V, Chen NY, Lee CG and Elias JA: The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury. Am J Respir Crit Care Med. 2010 Oct 1;182 (7) :918-28. Epub 2010 Jun 17. PMID: 20558631

Ahmed A, Fujisawa T, Niu XL, Ahmad S, Al-Ani B, Chudasama K, Abbas A, Potluri R, Bhandari V, Findley CM, Lam GK, Huang J, Hewett PW, Cudmore M and Kontos CD: Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. Circ Res. 2009 Jun 19;104 (12) :1333-6. Epub 2009 May 21. PMID: 19461044

Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ and Elias JA: Developmental regulation of NO-mediated VEGF-induced effects in the lung. Am J Respir Cell Mol Biol. 2008 Oct;39 (4) :420-30. Epub 2008 Apr 25. PMID: 18441284


Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O'Connor CL, Aghai ZH, Donnelly SC, Bazzy-Asaad A and Bucala RJ: A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. J Immunol. 2008 Jan 1;180 (1) :601-8. PMID: 18097062

Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA and Bhandari V: Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293 (1) :L142-50. Epub 2007 Mar 30. PMID: 17400600


Bhandari V, Choo-Wing R, Homer RJ and Elias JA: Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice. J Immunol. 2007 Apr 15;178 (8) :4993-5000. PMID: 17404281

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR and Elias JA: Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov;12 (11) :1286-93. Epub 2006 Nov 5. PMID: 17086189


Kirwin SM, Bhandari V, Dimatteo D, Barone C, Johnson L, Paul S, Spitzer AR, Chander A, Hassink SG and Funanage VL: Leptin enhances lung maturity in the fetal rat. Pediatr Res. 2006 Aug;60 (2) :200-4. PMID: 16864704

Clinical Research

Bhandari V, Bhandari A. Featured Cases: Bronchopulmonary dysplasia (BPD) – Long-term outcomes. eNeonatal Review (Podcast) 2013;9:8.

Bhandari V, Bhandari A. Bronchopulmonary dysplasia (BPD) – Long-term outcomes. eNeonatal Review 2013;9:7.

Bhandari A and Bhandari V: Biomarkers in bronchopulmonary dysplasia. Paediatr Respir Rev. 2013 Sep;14 (3) :173-9. Epub 2013 Mar 21. PMID: 23523392


Aghai ZH, Saslow JG, Mody K, Eydelman R, Bhat V, Stahl G, Pyon K and Bhandari V: IFN-γ and IP-10 in tracheal aspirates from premature infants: relationship with bronchopulmonary dysplasia. Pediatr Pulmonol. 2013 Jan;48 (1) :8-13. Epub 2012 Mar 19. PMID: 22431160

Mody K, Saslow JG, Kathiravan S, Eydelman R, Bhat V, Stahl GE, Pyon K, Bhandari V and Aghai ZH: Sirtuin1 in tracheal aspirate leukocytes: possible role in the development of bronchopulmonary dysplasia in premature infants. J Matern Fetal Neonatal Med. 2012 Aug;25 (8) :1483-7. Epub 2012 Jan 25. PMID: 22272724


Dumpa V, Katz K, Northrup V and Bhandari V: SNIPPV vs NIPPV: does synchronization matter? J Perinatol. 2012 Jun;32 (6) :438-42. Epub 2011 Nov 24. PMID: 22116527


Meneses J, Bhandari V and Alves JG: Nasal intermittent positive-pressure ventilation vs nasal continuous positive airway pressure for preterm infants with respiratory distress syndrome: a systematic review and meta-analysis. Arch Pediatr Adolesc Med. 2012 Apr;166 (4) :372-6. PMID: 22474063

Dumpa V, Northrup V and Bhandari V: Type and timing of ventilation in the first postnatal week is associated with bronchopulmonary dysplasia/death. Am J Perinatol. 2011 Apr;28 (4) :321-30. Epub 2010 Nov 16. PMID: 21082539


Meneses J, Bhandari V, Alves JG and Herrmann D: Noninvasive ventilation for respiratory distress syndrome: a randomized controlled trial. Pediatrics. 2011 Feb;127 (2) :300-7. Epub 2011 Jan 24. PMID: 21262883

Aghai ZH, Saslow JG, Meniru C, Porter C, Eydelman R, Bhat V, Stahl G, Sannoh S, Pyon K, Hewitt C and Bhandari V: High-mobility group box-1 protein in tracheal aspirates from premature infants: relationship with bronchopulmonary dysplasia and steroid therapy. J Perinatol. 2010 Sep;30 (9) :610-5. Epub 2010 Feb 25. PMID: 20182437


Bhandari V: Nasal intermittent positive pressure ventilation in the newborn: review of literature and evidence-based guidelines. J Perinatol. 2010 Aug;30 (8) :505-12. Epub 2009 Oct 22. PMID: 19847188


Finer NN, Carlo WA, Walsh MC, Rich W, Gantz MG, Laptook AR, Yoder BA, Faix RG, Das A, Poole WK, Donovan EF, Newman NS, Ambalavanan N, Frantz ID 3rd, Buchter S, Sánchez PJ, Kennedy KA, Laroia N, Poindexter BB, Cotten CM, Van Meurs KP, Duara S, Narendran V, Sood BG, O'Shea TM, Bell EF, Bhandari V, Watterberg KL and Higgins RD: Early CPAP versus surfactant in extremely preterm infants. N Engl J Med. 2010 May 27;362 (21) :1970-9. Epub 2010 May 16. PMID: 20472939

Levit O, Jiang Y, Bizzarro MJ, Hussain N, Buhimschi CS, Gruen JR, Zhang H and Bhandari V: The genetic susceptibility to respiratory distress syndrome. Pediatr Res. 2009 Dec;66 (6) :693-7. PMID: 19687775


Bhandari V, Finer NN, Ehrenkranz RA, Saha S, Das A, Walsh MC, Engle WA and VanMeurs KP: Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes. Pediatrics. 2009 Aug;124 (2) :517-26. Epub 2009 Jul 27. PMID: 19651577


Bhandari A and Bhandari V: Pitfalls, problems, and progress in bronchopulmonary dysplasia. Pediatrics. 2009 Jun;123 (6) :1562-73. PMID: 19482769

Aghai ZH, Faqiri S, Saslow JG, Nakhla T, Farhath S, Kumar A, Eydelman R, Strande L, Stahl G, Leone P and Bhandari V: Angiopoietin 2 concentrations in infants developing bronchopulmonary dysplasia: attenuation by dexamethasone. J Perinatol. 2008 Feb;28 (2) :149-55. Epub 2007 Nov 22. PMID: 18033304

Bhandari V, Gavino RG, Nedrelow JH, Pallela P, Salvador A, Ehrenkranz RA and Brodsky NL: A randomized controlled trial of synchronized nasal intermittent positive pressure ventilation in RDS. J Perinatol. 2007 Nov;27 (11) :697-703. Epub 2007 Aug 16. PMID: 17703184

Bizzarro MJ, Hussain N, Jonsson B, Feng R, Ment LR, Gruen JR, Zhang H and Bhandari V: Genetic susceptibility to retinopathy of prematurity. Pediatrics. 2006 Nov;118 (5) :1858-63. PMID: 17079555


Bhandari V, Bizzarro MJ, Shetty A, Zhong X, Page GP, Zhang H, Ment LR and Gruen JR: Familial and genetic susceptibility to major neonatal morbidities in preterm twins. Pediatrics. 2006 Jun;117 (6) :1901-6. PMID: 16740829

Neonatal Sepsis


Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz RA, Rinder HM and Bhandari V: Neutrophil CD64 with hematologic criteria for diagnosis of neonatal sepsis. Am J Perinatol. 2014 Jan;31 (1) :21-30. Epub 2013 Mar 1. PMID: 23456906

Wang X, Buhimschi CS, Temoin S, Bhandari V, Han YW and Buhimschi IA: Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis. PLoS One. 2013;8 (2) :e56131. Epub 2013 Feb 20. PMID: 23437088

Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz R, Rinder HM and Bhandari V: Neutrophil CD64 as a diagnostic marker in neonatal sepsis. Pediatr Infect Dis J. 2012 Jul;31 (7) :777-81. PMID: 22481422

Bizzarro MJ, Jiang Y, Hussain N, Gruen JR, Bhandari V and Zhang H: The impact of environmental and genetic factors on neonatal late-onset sepsis. J Pediatr. 2011 Feb;158 (2) :234-8.e1. Epub 2010 Sep 17. PMID: 20850766


Buhimschi CS, Bhandari V, Dulay AT, Nayeri UA, Abdel-Razeq SS, Pettker CM, Thung S, Zhao G, Han YW, Bizzarro M and Buhimschi IA: Proteomics mapping of cord blood identifies haptoglobin "switch-on" pattern as biomarker of early-onset neonatal sepsis in preterm newborns. PLoS One. 2011;6 (10) :e26111. Epub 2011 Oct 10. PMID: 22028810

Buhimschi CS, Bhandari V, Dulay AT, Thung S, Razeq SS, Rosenberg V, Han CS, Ali UA, Zambrano E, Zhao G, Funai EF and Buhimschi IA: Amniotic fluid angiopoietin-1, angiopoietin-2, and soluble receptor tunica interna endothelial cell kinase-2 levels and regulation in normal pregnancy and intraamniotic inflammation-induced preterm birth. J Clin Endocrinol Metab. 2010 Jul;95 (7) :3428-36. Epub 2010 Apr 21. PMID: 20410222

Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA and Buhimschi IA: Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury. Am J Pathol. 2009 Sep;175 (3) :958-75. Epub 2009 Aug 13. PMID: 19679874


Siner JM, Bhandari V, Engle KM, Elias JA and Siegel MD: Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock. 2009 Apr;31 (4) :348-53. PMID: 18791490

Bhandari V, Wang C, Rinder C and Rinder H: Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics. 2008 Jan;121 (1) :129-34. PMID: 18166566

Buhimschi CS, Buhimschi IA, Abdel-Razeq S, Rosenberg VA, Thung SF, Zhao G, Wang E and Bhandari V: Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. Pediatr Res. 2007 Mar;61 (3) :318-24. PMID: 17314690


Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, Magloire L, Funai E, Norwitz ER, Paidas M, Copel JA, Weiner CP, Lockwood CJ and Buhimschi IA: Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis. PLoS Med. 2007 Jan;4 (1) :e18. PMID: 17227133