Welcome to the Bhandari Lab
The Bhandari lab is a developmental biology lab focused on understanding the pathogenesis of hyperoxia-induced injury and repair in the developing lungs. Using murine models of bronchopulmonary dysplasia (BPD) and hyperoxic acute lung injury (HALI), we primarily study how molecular mediators and signaling pathways of inflammation, vascularization, and cell death contribute to disease phenotypes. The ultimate aim of the lab is to be able to translate our work into a better understanding of the pathogenesis of BPD in the premature infant to allow improved targeting of therapeutic interventions.
Members of the lab are also working on clinical and translational projects related to the genetic susceptibility to BPD, improvements in non-invasive ventilation of neonates, and screening for biomarkers for neonatal sepsis.