Publications

Paardekooper Overman J, Yi JS, Bonetti M, Soulsby M, Preisinger C, Stokes MP, Hui L, Silva JC, Overvoorde J, Giansanti P, Heck AJ, Kontaridis MI, den Hertog J and Bennett AM: PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice. Mol Cell Biol. 2014 Aug 1;34 (15) :2874-89. Epub 2014 May 27. PMID: 24865967

Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y and Huang Y: The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 2013 Oct 10;52 (1) :101-12. Epub 2013 Sep 19. PMID: 24055342


Shi H, Verma M, Zhang L, Dong C, Flavell RA and Bennett AM: Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5. J Clin Invest. 2013 May 1;123 (5) :2064-77. Epub 2013 Apr 1. PMID: 23543058


Lee H and Bennett AM: Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. Mol Cell Biol. 2013 Apr;33 (7) :1430-41. Epub 2013 Jan 28. PMID: 23358419


Lawan A, Shi H, Gatzke F and Bennett AM: Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions. Cell Mol Life Sci. 2013 Jan;70 (2) :223-37. Epub 2012 Jun 14. PMID: 22695679


Mercan F, Lee H, Kolli S and Bennett AM: Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol Cell Biol. 2013 Jan;33 (2) :293-306. Epub 2012 Nov 5. PMID: 23129808

Timmerman I, Hoogenboezem M, Bennett AM, Geerts D, Hordijk PL and van Buul JD: The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. Mol Biol Cell. 2012 Nov;23 (21) :4212-25. Epub 2012 Sep 5. PMID: 22956765


Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR 3rd and Yang X: O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metab. 2012 Aug 8;16 (2) :226-37. PMID: 22883232

Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB and Horvath TL: Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med. 2011 Aug 28;17 (9) :1121-7. Epub 2011 Aug 28. PMID: 21873987


Flach RJ, Qin H, Zhang L and Bennett AM: Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem. 2011 Jun 24;286 (25) :22195-202. Epub 2011 Apr 26. PMID: 21521693

Roth Flach RJ and Bennett AM: Mitogen-activated protein kinase phosphatase-1 - a potential therapeutic target in metabolic disease. Expert Opin Ther Targets. 2010 Dec;14 (12) :1323-32. PMID: 21058921


Jeanneteau F, Deinhardt K, Miyoshi G, Bennett AM and Chao MV: The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nat Neurosci. 2010 Nov;13 (11) :1373-9. Epub 2010 Oct 10. PMID: 20935641


Shi H, Boadu E, Mercan F, Le AM, Flach RJ, Zhang L, Tyner KJ, Olwin BB and Bennett AM: MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy. FASEB J. 2010 Aug;24 (8) :2985-97. Epub 2010 Apr 6. PMID: 20371627


Mercan F and Bennett AM: Analysis of protein tyrosine phosphatases and substrates. Curr Protoc Mol Biol. 2010 Jul;Chapter 18 :Unit 18.16. PMID: 20583096


Flach RJ and Bennett AM: MAP kinase phosphatase-1--a new player at the nexus between sarcopenia and metabolic disease. Aging (Albany NY). 2010 Apr 6;2 (3) :170-6. Epub 2010 Apr 6. PMID: 20375469

Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI and Bennett AM: MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. J Clin Invest. 2009 Dec;119 (12) :3817-29. Epub 2009 Nov 16. PMID: 19920356


Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM and Vignery A: Role of MKP-1 in osteoclasts and bone homeostasis. Am J Pathol. 2009 Oct;175 (4) :1564-73. Epub 2009 Sep 17. PMID: 19762714


Soulsby M and Bennett AM: Physiological signaling specificity by protein tyrosine phosphatases. Physiology (Bethesda). 2009 Oct;24 :281-9. PMID: 19815854


Yu L, Min W, He Y, Qin L, Zhang H, Bennett AM and Chen H: JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. J Biol Chem. 2009 May 15;284 (20) :13481-8. Epub 2009 Mar 13. PMID: 19287004

Eminaga S and Bennett AM: Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. J Biol Chem. 2008 May 30;283 (22) :15328-38. Epub 2008 Mar 31. PMID: 18378677


Ha CH, Bennett AM and Jin ZG: A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. J Biol Chem. 2008 Mar 14;283 (11) :7261-70. Epub 2008 Jan 7. PMID: 18180305


Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM and Nathanson MH: c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem. 2008 Feb 15;283 (7) :4344-51. Epub 2007 Dec 11. PMID: 18073207

Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, Lam W, Cheng YC, Bennett AM and Nathanson MH: Nucleoplasmic calcium is required for cell proliferation. J Biol Chem. 2007 Jun 8;282 (23) :17061-8. Epub 2007 Apr 9. PMID: 17420246


Zito CI, Qin H, Blenis J and Bennett AM: SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem. 2007 Mar 9;282 (10) :6946-53. Epub 2007 Jan 17. PMID: 17229738


Tiganis T and Bennett AM: Protein tyrosine phosphatase function: the substrate perspective. Biochem J. 2007 Feb 15;402 (1) :1-15. PMID: 17238862

Fornaro M, Burch PM, Yang W, Zhang L, Hamilton CE, Kim JH, Neel BG and Bennett AM: SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol. 2006 Oct 9;175 (1) :87-97. Epub 2006 Oct 2. PMID: 17015617


Wu JJ, Roth RJ, Anderson EJ, Hong EG, Lee MK, Choi CS, Neufer PD, Shulman GI, Kim JK and Bennett AM: Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab. 2006 Jul;4 (1) :61-73. PMID: 16814733


Gomes DA, Leite MF, Bennett AM and Nathanson MH: Calcium signaling in the nucleus. Can J Physiol Pharmacol. 2006 Mar-Apr;84 (3-4) :325-32. PMID: 16902580


Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM and Flavell RA: Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A. 2006 Feb 14;103 (7) :2274-9. Epub 2006 Feb 6. PMID: 16461893


Uhlén P, Burch PM, Zito CI, Estrada M, Ehrlich BE and Bennett AM: Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Proc Natl Acad Sci U S A. 2006 Feb 14;103 (7) :2160-5. Epub 2006 Feb 3. PMID: 16461457

Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP and Kim JK: Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes. 2005 Sep;54 (9) :2514-24. PMID: 16123338


Wu JJ, Zhang L and Bennett AM: The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation. Mol Cell Biol. 2005 Jun;25 (11) :4792-803. PMID: 15899879


Wu JJ and Bennett AM: Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. J Biol Chem. 2005 Apr 22;280 (16) :16461-6. Epub 2005 Feb 17. PMID: 15722358

Chauvet V, Tian X, Husson H, Grimm DH, Wang T, Hiesberger T, Igarashi P, Bennett AM, Ibraghimov-Beskrovnaya O, Somlo S and Caplan MJ: Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest. 2004 Nov;114 (10) :1433-43. PMID: 15545994


Kolli S, Zito CI, Mossink MH, Wiemer EA and Bennett AM: The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem. 2004 Jul 9;279 (28) :29374-85. Epub 2004 May 7. PMID: 15133037


Kontaridis MI, Eminaga S, Fornaro M, Zito CI, Sordella R, Settleman J and Bennett AM: SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol. 2004 Jun;24 (12) :5340-52. PMID: 15169898


Ivins Zito C, Kontaridis MI, Fornaro M, Feng GS and Bennett AM: SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol. 2004 May;199 (2) :227-36. PMID: 15040005

Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH and Bennett AM: Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem. 2002 Jul 26;277 (30) :27517-27. Epub 2002 Apr 23. PMID: 11971908


Kontaridis MI, Liu X, Zhang L and Bennett AM: Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol Cell Biol. 2002 Jun;22 (11) :3875-91. PMID: 11997521