News from the Lab
Dr. Youngsun Cho selected for the Detre Award
NIMH highlights Anticevic Lab research in a sampling of summer science
Thomas Insel, MD, director of the National Institute of Mental Health, discusses Yale-led research by Anticevic Lab as offering "real promise for understanding how cortical function becomes dysregulated in people prone to psychosis" and as an important step towards detecting risk for schizophrenia.
Dr. Anticevic presents lab research at Vanderbilt Brain Institute
Towards mechanistic understanding of neural system dysfunction in schizophrenia via connectivity, pharmacology and computation.
Read more about the Vanderbilt Brain Institute here.
Multi-task connectivity reveals flexible hubs for adaptive task control
A study by Michael Cole and colleagues, in collaboration with Anticevic Lab, tested a novel hypothesis for how humans are able to implement highly adaptive behavior, such as rapidly learning new tasks from instructions. This hypothesis suggests select regions of the brain are 'flexible hubs' that coordinate brain networks to perform new tasks (e.g., orchestrating visual and motor information in a novel visuo-motor task). Read more details about the study here. Read the WashU press release here.
Citation: Cole MW, Reynolds JR, Power JD, Repovs G, Anticevic, A, Braver TS. Multi-task connectivity reveals flexible hubs for adaptive task control. 2013 Jul 28. doi: 10.1038/nn.3470. [Epub ahead of print]
Anticevic and colleagues characterize thalamo-cortical dysconnectivity in schizophrenia and bipolar illness
Yale Researchers Shed Light on Large-scale Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness
Anticevic Lab along with a team of Yale researchers has used state-of-the-art non-invasive functional neuroimaging in one of the largest samples of patients diagnosed with schizophrenia and bipolar illness to better understand how large-scale neural communication may be altered in these severe and disabling psychiatric conditions. The results are reported online ahead of print in Cerebral Cortex. The Yale University press release can be found here.
Anticevic Lab receives the NIH 2012 NIH Director’s Early Independence Award
Recent trends show an increase in the length of the traditional scientific training period with a concomitant increase in the age at which scientists establish independent research careers. Although traditional post-doctoral training is likely to be appropriate for the large majority of new Ph.D.s and M.D.s, there is a pool of talented junior scientists who have the intellect, scientific creativity, drive and maturity to flourish independently without the need for traditional post-doctoral training. Reducing the amount of time these scientists spend in training would provide them the opportunity to start highly innovative research programs as early in their careers as possible. It would also allow host institutions to invigorate their scientific communities by integrating the fresh perspectives brought by the junior investigators.
Anticevic Lab is awarded a 5-year grant to better characterize the neural mechanisms behind cognitive impairment in schizophrenia via the combination of pharmacological neuroimaging, computational modeling and non-invasive neuroimaging of clinical populations. The pharmacological work is done collaboratively with Dr. John H. Krystal and Dr. Peter T. Morgan. Computational modeling is being developed collaboratively with Dr. Xiao-Jing Wang and John D. Murray. Read the Yale Press Release. Read the NIH Press Release. See the full list of 2012 EIA Recipients. Learn more about the NIH Director’s Early Independence Award (DP5). Read the WashU Press Release.
Connectivity Study Focused on Prefrontal Cortex to Appear on Biological Psychiatry Cover
Manuscript: Anticevic, A., Brumbaugh, M.S., Winkler, A.M., Lombardo, L.E., Barrett, J., Corlett, P.R., Kober, H., Gruber, J., Repovs, G., Cole, M.W., Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2013). Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biological Psychiatry. 73(6):565-73. [LINK]
Abstract: BACKGROUND: Pathophysiological models of bipolar disorder postulate that mood dysregulation arises from fronto-limbic dysfunction, marked by reduced prefrontal cortex (PFC) inhibitory control. This might occur due to both disruptions within PFC networks and abnormal inhibition over subcortical structures involved in emotional processing. However, no study has examined global PFC dysconnectivity in bipolar disorder and tested whether regions with within-PFC dysconnectivity also exhibit fronto-limbic connectivity deficits. Furthermore, no study has investigated whether such connectivity disruptions differ for bipolar patients with psychosis history, who might exhibit a more severe clinical course. METHODS: We collected resting-state functional magnetic resonance imaging at 3T in 68 remitted bipolar I patients (34 with psychosis history) and 51 demographically matched healthy participants. We employed a recently developed global brain connectivity method, restricted to PFC (rGBC). We also independently tested connectivity between anatomically defined amygdala and PFC. RESULTS: Bipolar patients exhibited reduced medial prefrontal cortex (mPFC) rGBC, increased amygdala-mPFC connectivity, and reduced connectivity between amygdala and dorsolateral PFC. All effects were driven by psychosis history. Moreover, the magnitude of observed effects was significantly associated with lifetime psychotic symptom severity. CONCLUSIONS: This convergence between rGBC, seed-based amygdala findings, and symptom severity analyses highlights that mPFC, a core emotion regulation region, exhibits both within-PFC dysconnectivity and connectivity abnormalities with limbic structures in bipolar illness. Furthermore, lateral PFC dysconnectivity in patients with psychosis history converges with published work in schizophrenia, indicating possible shared risk factors. Observed dysconnectivity in remitted patients suggests a bipolar trait characteristic and might constitute a risk factor for phasic features of the disorder.
ICANA-3 Conference held at Yale University
Yale and CTNA host 3rd International Conference on Applications of Neuroimaging to Alcoholism (ICANA-3)
Dr. Alan Anticevic co-organized ICANA-3 with Dr. John Krystal, which brought together neuroimagers with diverse technical and clinical expertise to consider methodological applications to alcoholism. A distinctive feature of the design of this meeting is its focus on multi-modality imaging (sMRI, DTI, fMRI, MRS, PET, SPECT), promoting interdisciplinary crosstalk with clinical applications. As with past conferences, ICANA-3 highlights “hot” issues in the field for special focus and emerging technologies within each neuroimaging modality. Plenary lectures were given by Dr. David Van Essen, Dr. Nora Volkow and Dr. Alan Koretsky. Complete conference program can be found here.
Dr. Anticevic met with NIH Director - Dr. Francis Collins
Dr. Anticevic wins the 2013 International Congress on Schizophrenia Research Young Investigator Award
Dr. Anticevic to present at The INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCHThe INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCH is a biennial meeting where scientists representing the broad range of disciplines involved with discovery in schizophrenia gather to exchange data, techniques, and ideas. Anticevic Lab will present a talk titled:"Elucidating Mechanisms of Cognitive Impairment in Schizophrenia via Pharmacological Neuroimaging and Computational Modeling"
Anticevic Lab interviewed by Pittsburgh Post-Gazette
Mysteries of the Mind: Researchers take aim at schizophrenia's thinking problems
Dozen young Yale scientists honored for promising mental health research
Anticevic Lab awarded the NARSAD 2012 YI Award
Twelve Yale investigators were among 202 researchers to receive Young Investigator Grants from the Brain & Behavior Research Foundation (formerly NARSAD). The $11.9 million program helps support researchers with promising ideas about how to understand and treat mental illness. Receiving up to $60,000 over two years, the investigators pursue brain and behavior research related to depression, bipolar disorder, schizophrenia, autism, attention-deficit hyperactivity disorder, and anxiety disorders like obsessive-compulsive and post-traumatic stress disorders. “The NARSAD Young Investigator Grants have led to groundbreaking and important new research that has improved the lives of people living with mental illness through enhanced treatments and therapies and a better understanding of the causes of mental illness,” said Benita Shobe, president and CEO of the Brain & Behavior Research Foundation. NARSAD Young Investigator Grants have proven to be catalysts for additional funding once the Young Investigators have “proof of concept” for their hypotheses. Read more