News from the Lab
Dr. Youngsun Cho selected for the Detre Award
Anticevic Lab publishes a theoretical review article on multi-disciplinary approaches to understand functional dysconnectivity in schizophrenia
Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia
Anticevic Labpublishes a theoretical and review article in Frontiers in Psychiatry, detailing recent findings in functional connectivity in schizophrenia. The review specifically discusses two complementary approaches to better understand system-level alterations in schizophrenia. The first is pharmacological manipulations in healthy volunteers, which transiently mimic some cardinal features of psychiatric conditions. Second, the review discusses the combination of human pharmacological imaging with biophysically informed computational models developed to guide the interpretation of functional imaging studies and to inform the development of pathophysiologic hypotheses.Anticevic, A., Cole, M.W., Repovs, G., Savic, A., Driesen, N.R., Yang, G., Cho, Y.T., Murray, J.D., Glahn, D.C., Wang, X-J. and Krystal, J.H. (2013) Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Front. Psychiatry 4:169. doi: 10.3389/fpsyt.2013.00169. [Link]
Anticevic Lab publishes a novel investigation characterizing amygdala functional connectivity across early course and chronic schizophrenia stages
A novel study by Anticevic Lab, in collaboration with Fei Wang, examines amygdala connectivity across distinct stages of schizophrenia. Specifically, the study focused on cross-sectionally comparing 1st episode schizophrenia patients with chronic patients and individuals at high risk of developing the illness. The principal finding suggests that amygdala coupling with bilateral orbitofrontal cortex is significantly reduced in all individuals with schizophrenia, irrespective of illness duration, but not in individuals at risk who have not gone on to develop frank psychosis. In contrast, high risk individuals exhibited elevated coupling between the amygdala and a brain stem region implicated in stress response.Anticevic, A.*, Tang, Y.*, Repovs, G., Savic, A., Xu, K., Krystal, J.H., & Wang, F. (2013) Amygdala connectivity at rest distinguishes between chronic, 1st episode and individuals at high risk for developing schizophrenia. *Denotes Equal Contribution. Schizophrenia Bulletin. [Link].
Anticevic Lab, in collaboration with PittLab, publishes a data-driven investigation of brain-wide neural dysconnectivity in OCD
Anticevic and colleagues characterize prefrontal and whole-brain connectivity via data-driven resting-state functional neuroimaging in obsessive-compulsive disorder. Results suggest prefrontal connectivity abnormalities with the rest of prefrontal cortex as well as whole-brain global alterations in connectivity. Specifically, subcortical structures showed aberrant increases in coupling with the rest of the brain, while prefrontal structures showed aberrant connectivity reductions, which predicted symptoms relevant to OCD. These findings implicate complex prefrontal connectivity alterations in the pathophysiology of OCD.
Anticevic Lab and PittLab characterize prefrontal and whole-brain connectivity via data-driven resting-state functional neuroimaging in obsessive-compulsive disorder. Results suggest prefrontal connectivity abnormalities with the rest of prefrontal cortex as well as whole-brain global alterations in connectivity. Specifically, subcortical structures showed aberrant increases in coupling with the rest of the brain, while prefrontal structures showed aberrant connectivity reductions, which predicted symptoms relevant to OCD. These findings implicate complex prefrontal connectivity alterations in the pathophysiology of OCD.Anticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M.W., Bednarski, S., Krystal, J.H., Bloch, M.B., Li, R.C-S., Pittenger, C. (2013). Global resting-state fMRI analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biological Psychiatry. [Link]
Dr. Anticevic presents neuroimaging research at Harmonizing Studies of the Psychosis Prodrome Symposium
Dr. Anticevic presents research at Martinos Center BrainMap Seminar
NIMH highlights Anticevic Lab research in a sampling of summer science
Thomas Insel, MD, director of the National Institute of Mental Health, discusses Yale-led research by Anticevic Lab as offering "real promise for understanding how cortical function becomes dysregulated in people prone to psychosis" and as an important step towards detecting risk for schizophrenia.
Citation: Anticevic, A. et al. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness. Cereb Cortex. 2013 Jul 3. doi:10.1093/cercor/bht165 [Epub ahead of print]. [Link]
Anticevic Lab publishes two chapters on the neurobiology of schizophrenia
Anticevic Lab published two chapters on the neurobiology of schizophrenia focusing on motivational and cognitive deficits in schizophrenia (LEFT) and the need for translational studies to better understand the neurobiology of cognitive impairments in schizophrenia (RIGHT).
Anticevic, A., Dowd, E.C., & Barch, D.M. (2013). Cognitive and motivational neuroscience of psychotic disorders. In “Neurobiology of Mental Illness, 4th Edition”. Eds. Dennis Charney, Eric Nestler, Pamela Sklar, & Joseph Buxbaum. Oxford University Press. [Link]
Anticevic, A., Krystal, J.H., & Barch, D.M. (2013). Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches towards understanding cognitive deficits. In “Cognitive impairment in schizophrenia: characteristics, assessment, and treatment”. Ed. Phil Harvey. Cambridge University Press. [Link]
Dr. Anticevic presents lab research at Vanderbilt Brain Institute
Towards mechanistic understanding of neural system dysfunction in schizophrenia via connectivity, pharmacology and computation.
Read more about the Vanderbilt Brain Institute here.
Multi-task connectivity reveals flexible hubs for adaptive task control
A study by Michael Cole and colleagues, in collaboration with Anticevic Lab, tested a novel hypothesis for how humans are able to implement highly adaptive behavior, such as rapidly learning new tasks from instructions. This hypothesis suggests select regions of the brain are 'flexible hubs' that coordinate brain networks to perform new tasks (e.g., orchestrating visual and motor information in a novel visuo-motor task). Read more details about the study here. Read the WashU press release here.
Citation: Cole, M.W., Reynolds, J.R., Power, J.D., Repovs, G., Anticevic, A., Braver, T.S. (2013). Multi-task connectivity reveals flexible hubs for adaptive task control. Nature Neuroscience. doi: 10.1038/nn.3470. [Link]
Anticevic and colleagues characterize thalamo-cortical dysconnectivity in schizophrenia and bipolar illness
Yale Researchers Shed Light on Large-scale Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness
Anticevic Lab along with a team of Yale researchers has used state-of-the-art non-invasive functional neuroimaging in one of the largest samples of patients diagnosed with schizophrenia and bipolar illness to better understand how large-scale neural communication may be altered in these severe and disabling psychiatric conditions. The results are reported online ahead of print in Cerebral Cortex. The Yale University press release can be found here.
Anticevic Lab receives the NIH 2012 NIH Director’s Early Independence Award
Recent trends show an increase in the length of the traditional scientific training period with a concomitant increase in the age at which scientists establish independent research careers. Although traditional post-doctoral training is likely to be appropriate for the large majority of new Ph.D.s and M.D.s, there is a pool of talented junior scientists who have the intellect, scientific creativity, drive and maturity to flourish independently without the need for traditional post-doctoral training. Reducing the amount of time these scientists spend in training would provide them the opportunity to start highly innovative research programs as early in their careers as possible. It would also allow host institutions to invigorate their scientific communities by integrating the fresh perspectives brought by the junior investigators.
Anticevic Lab is awarded a 5-year grant to better characterize the neural mechanisms behind cognitive impairment in schizophrenia via the combination of pharmacological neuroimaging, computational modeling and non-invasive neuroimaging of clinical populations. The pharmacological work is done collaboratively with Dr. John H. Krystal and Dr. Peter T. Morgan. Computational modeling is being developed collaboratively with Dr. Xiao-Jing Wang and John D. Murray. Read the Yale Press Release. Read the NIH Press Release. See the full list of 2012 EIA Recipients. Learn more about the NIH Director’s Early Independence Award (DP5). Read the WashU Press Release.
Connectivity Study Focused on Prefrontal Cortex to Appear on Biological Psychiatry Cover
Anticevic and colleagues characterize global prefrontal and frontal-limbic connectivity using resting-state functional magnetic resonance imaging in bipolar disorder with and without psychosis history. The authors found evidence for medial prefrontal connectivity abnormalities with the rest of prefrontal cortex and the amygdala. Moreover, observed dysconnectivity predicted positive psychotic symptoms. These findings, using convergent resting-state techniques, implicate medial prefrontal cortex - a core emotion regulation region - in the pathophysiology of bipolar illness.
Citation: Anticevic, A., Brumbaugh, M.S., Winkler, A.M., Lombardo, L.E., Barrett, J., Corlett, P.R., Kober, H., Gruber, J., Repovs, G., Cole, M.W., Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2013). Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biological Psychiatry. 73(6):565-73. [Link]
ICANA-3 Conference held at Yale University
Yale and CTNA host 3rd International Conference on Applications of Neuroimaging to Alcoholism (ICANA-3)
Dr. Alan Anticevic co-organized ICANA-3 with Dr. John Krystal, which brought together neuroimagers with diverse technical and clinical expertise to consider methodological applications to alcoholism. A distinctive feature of the design of this meeting is its focus on multi-modality imaging (sMRI, DTI, fMRI, MRS, PET, SPECT), promoting interdisciplinary crosstalk with clinical applications. As with past conferences, ICANA-3 highlights “hot” issues in the field for special focus and emerging technologies within each neuroimaging modality. Plenary lectures were given by Dr. David Van Essen, Dr. Nora Volkow and Dr. Alan Koretsky. Complete conference program can be found here.
Dr. Anticevic met with NIH Director - Dr. Francis Collins
Dr. Anticevic wins the 2013 International Congress on Schizophrenia Research Young Investigator Award
Dr. Anticevic to present at The INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCHThe INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCH is a biennial meeting where scientists representing the broad range of disciplines involved with discovery in schizophrenia gather to exchange data, techniques, and ideas. Anticevic Lab will present a talk titled:"Elucidating Mechanisms of Cognitive Impairment in Schizophrenia via Pharmacological Neuroimaging and Computational Modeling"
Anticevic Lab interviewed by Pittsburgh Post-Gazette
Mysteries of the Mind: Researchers take aim at schizophrenia's thinking problems
Dozen young Yale scientists honored for promising mental health research
Anticevic Lab awarded the NARSAD 2012 YI Award
Twelve Yale investigators were among 202 researchers to receive Young Investigator Grants from the Brain & Behavior Research Foundation (formerly NARSAD). The $11.9 million program helps support researchers with promising ideas about how to understand and treat mental illness. Receiving up to $60,000 over two years, the investigators pursue brain and behavior research related to depression, bipolar disorder, schizophrenia, autism, attention-deficit hyperactivity disorder, and anxiety disorders like obsessive-compulsive and post-traumatic stress disorders. “The NARSAD Young Investigator Grants have led to groundbreaking and important new research that has improved the lives of people living with mental illness through enhanced treatments and therapies and a better understanding of the causes of mental illness,” said Benita Shobe, president and CEO of the Brain & Behavior Research Foundation. NARSAD Young Investigator Grants have proven to be catalysts for additional funding once the Young Investigators have “proof of concept” for their hypotheses. Read more