News from the Lab

Schizophrenia Markers Hidden in Brain-wide Signals - Anticevic Lab Publishes a Study Characterizing Global Signal in Schizophrenia

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A study reported online ahead of print by Yang et al. in the Proceedings of the National Academy of Sciencesidentified elevated global brain signal variability in schizophrenia, but not bipolar illness. This variability was re- lated to schizophrenia symptoms. A commonly used analytic procedure in neuroimaging, global signal regression, attenuated clinical effects and altered inferences. Furthermore, local voxel-wise variance was increased in schizophrenia, independent of global signal regression. Finally, neurobiologically grounded computational modeling suggests a putative mechanism, whereby altered overall connection strength in schizophrenia may underlie observed empirical results. Read the Yale press release here. Read the Yale Psychiatry news here.

PsychiatryNews: Same Brain Circuits Linked With Psychosis in Two Disorders

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Anticevic Lab research featured on PsychiatryNews, reporting a new study recently published in Schizophrenia Bulletintitled "Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness from Psychotic Bipolar Disorder and Schizophrenia". The brains of schizophrenia patients and of those with bipolar disorder who experience psychotic episodes show similar connectivity patterns, which points to a common mechanism that may be associated with psychotic symptoms in the two disorders. “The findings reported here are striking and may be very important,” J. Raymond DePaulo Jr., M.D., a professor of psychiatry at Johns Hopkins University and a bipolar disorder expert said in an interview with Psychiatric News. “The findings are a step toward making functional sense of some of psychiatry’s diagnostic groupings and, if confirmed and extended, would contribute to the scientific substrate from which laboratory methods could be introduced into the psychiatric assessments of the future.”

Genevieve Yang Receives CSH Fellowship for Computational and Cognitive Neuroscience Summer School

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Congratulations to Genevieve Yang for being awarded a fellowship to attend the 2014 Cold Spring Harbor Computational and Cognitive Neuroscience Summer School led by Dr. Xiao-Jing Wang and taught by our collaborator Dr. John Murray. The 5th Computational and Cognitive Neuroscience (CCN) summer school will be held in Shanghai, China. Designed to emphasize higher cognitive functions and their underlying neural circuit mechanisms, the course aims at training talented and highly motivated students and postdoctoral fellows from Asia and other countries in the world. Read more here

Dr. Anticevic Recives Janet Taylor Spence Award For Transformative Early Career Contributions

The Association for Psychological Science (APS) has recognized our lab's research through the APS Janet Taylor Spence Award For Transformative Early Career Contributions. The APS Janet Taylor Spence Award recognizes transformative early career contributions to psychological science. Award winners should reflect the best of the many new and cutting edge ideas coming out of our most creative and promising investigators who, together, embody the future of psychological science. Dr. Anticevic will receive the award at the 26th APS Annual Convention.

Anticevic Lab Presentations at SOBP 2014

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We are looking forward to the 2014 Society for Biological Psychiatry Meeting (SOBP). Our lab is presenting a total of 5 posters and 2 oral presentations, focusing on novel findings detailing connectivity alterations in schizophrenia as a function of illness progression. To find more details about our upcoming presentations please see the 2014 SOBP meeting online planner.

Anticevic Lab Presenting at CNS 2014

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Genevieve Yang will present our latest work at the upcoming 2014 Cognitive Neuroscience Society meeting in Boston. Her work focuses on understanding large-scale neural systems in psychiatric disease with the aim of refining neuroimaging-derived biomarkers, in combination with computational modeling. The work represents an ongoing collaboration with the Wang Lab, in particular Dr. John Murray.

SIRS 2014 - Dr. Anticevic Presented Lab Research at Two Symposia

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Dr. Anticevic presented lab's research in two symposia at the 2014 Bi-Annual Schizophrenia International Research Society Conference. The presentations focused on the efforts to integrate non-invasive neuroimaging methods along with pharmacological and computational approaches. In addition, Dr. Anticevic discussed the need to improve the harmonization of functional neuroimaging methods in schizophrenia research, focusing in particular on resting-state connectivity approaches and methods.

Anticevic Lab Research Featured on the Cover of Biological Psychiatry

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An article by Anticevic and colleague appeared in a recent issue of Biological Psychiatry titled Obsessive-Compulsive Disorder and the Connectome. In collaboration with PittLab, we applied a recently developed, fully-data driven approach towards resting-state connectivity to uncover novel foci of 'dysconnectivity' in OCD. This work was also reviewed in the same issue by Hendler and colleagues.

Dr. Youngsun Cho selected for the Detre Award

Congratulations to Dr. Youngsun Cho for being selected for the Yale Department of Psychiatry Detre Award to advance our understanding of the neural networks involved in working memory and reward. The Detre will provide vital support to Youngsun for a translational neuroscience project in collaboration with the Anticevic Lab. An anonymous gift from an alumnus has established three one-year research fellowships in memory of Thomas Detre, MD, an internationally renowned academic psychiatrist and distinguished alumnus of Yale Psychiatry. John Krystal, MD, the Robert L. McNeil, Jr. Professor of Translational Research and psychiatry department chair, has created a fourth award named the McNeil Fellowship. The Detre and McNeil Fellowships will support the translational research endeavors of residents through the Neuroscience Research Training Program. Read more here.

Anticevic Lab publishes a theoretical review article on multi-disciplinary approaches to understand functional dysconnectivity in schizophrenia

Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia 

Anticevic Labpublishes a theoretical and review article in Frontiers in Psychiatry, detailing recent findings in functional connectivity in schizophrenia. The review specifically discusses two complementary approaches to better understand system-level alterations in schizophrenia. The first is pharmacological manipulations in healthy volunteers, which transiently mimic some cardinal features of psychiatric conditions. Second, the review discusses the combination of human pharmacological imaging with biophysically informed computational models developed to guide the interpretation of functional imaging studies and to inform the development of pathophysiologic hypotheses. 

Anticevic, A., Cole, M.W., Repovs, G., Savic, A., Driesen, N.R., Yang, G., Cho, Y.T., Murray, J.D., Glahn, D.C., Wang, X-J. and Krystal, J.H. (2013) Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Front. Psychiatry 4:169. doi: 10.3389/fpsyt.2013.00169. [Link]

Anticevic Lab publishes a novel investigation characterizing amygdala functional connectivity across early course and chronic schizophrenia stages

A novel study by Anticevic Lab, in collaboration with Fei Wang, examines amygdala connectivity across distinct stages of schizophrenia. Specifically, the study focused on cross-sectionally comparing 1st episode schizophrenia patients with chronic patients and individuals at high risk of developing the illness. The principal finding suggests that amygdala coupling with bilateral orbitofrontal cortex is significantly reduced in all individuals with schizophrenia, irrespective of illness duration, but not in individuals at risk who have not gone on to develop frank psychosis. In contrast, high risk individuals exhibited elevated coupling between the amygdala and a brain stem region implicated in stress response. 

Anticevic, A.*, Tang, Y.*, Repovs, G., Savic, A., Xu, K., Krystal, J.H., & Wang, F. (2013) Amygdala connectivity at rest distinguishes between chronic, 1st episode and individuals at high risk for developing schizophrenia. *Denotes Equal Contribution. Schizophrenia Bulletin. [Link].

Anticevic Lab, in collaboration with PittLab, publishes a data-driven investigation of brain-wide neural dysconnectivity in OCD

Anticevic Lab and PittLab characterize prefrontal and whole-brain connectivity via data-driven resting-state functional neuroimaging in obsessive-compulsive disorder. Results suggest prefrontal connectivity abnormalities with the rest of prefrontal cortex as well as whole-brain global alterations in connectivity. Specifically, subcortical structures showed aberrant increases in coupling with the rest of the brain, while prefrontal structures showed aberrant connectivity reductions, which predicted symptoms relevant to OCD. These findings implicate complex prefrontal connectivity alterations in the pathophysiology of OCD. 

Anticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M.W., Bednarski, S., Krystal, J.H., Bloch, M.B., Li, R.C-S., Pittenger, C. (2013). Global resting-state fMRI analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biological Psychiatry. [Link]

Dr. Anticevic presents neuroimaging research at Harmonizing Studies of the Psychosis Prodrome Symposium

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Dr. Anticevic presented lab neuroimaging efforts at ACNP focused symposium titled: "Harmonizing Studies of the Psychosis Prodrome: Toward the Validation of Biomarkers for Clinical Trials". The purpose of the meeting was to achieve maximal standardization of biomarkers across studies examining conversion to psychosis. The symposium was organized by NIMH and co-led by Dr. Tom Insel and Dr. Steve Hyman.

Dr. Anticevic presents research at Martinos Center BrainMap Seminar

Dr. Anticevic presented lab research. BrainMap seminars are by and for researchers using neuroimaging to study human brain structure and function, and for anyone interested in learning about neuroimaging. We aim to cover the most recent neuroimaging techniques from modalities that include MRI, EEG/MEG, optical imaging and PET. The seminars are presented by Martinos Center researchers, collaborators, and outside speakers. The attendance is about 20-30 people, typically physicists, methodologists, neurologists, radiologists and neuropsychologists. The talks are about 40 minutes long, plus 15 minutes of discussion. Read more here.

NIMH highlights Anticevic Lab research in a sampling of summer science

Thomas Insel, MD, director of the National Institute of Mental Health, discusses Yale-led research by Anticevic Lab as offering "real promise for understanding how cortical function becomes dysregulated in people prone to psychosis" and as an important step towards detecting risk for schizophrenia. 

Citation: Anticevic, A. et al. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness. Cereb Cortex. 2013 Jul 3. doi:10.1093/cercor/bht165 [Epub ahead of print]. [Link]

Anticevic Lab publishes two chapters on the neurobiology of schizophrenia

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LEFT: Anticevic, A., Dowd, E.C., & Barch, D.M. (2013). Cognitive and motivational neuroscience of psychotic disorders. In “Neurobiology of Mental Illness, 4th Edition”. Eds. Dennis Charney, Eric Nestler, Pamela Sklar, & Joseph Buxbaum. Oxford University Press. [Link]

RIGHT: Anticevic, A., Krystal, J.H., & Barch, D.M. (2013). Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches towards understanding cognitive deficits. In “Cognitive impairment in schizophrenia: characteristics, assessment, and treatment”. Ed. Phil Harvey. Cambridge University Press. [Link]

Anticevic Lab published two chapters on the neurobiology of schizophrenia focusing on motivational and cognitive deficits in schizophrenia (LEFT) and the need for translational studies to better understand the neurobiology of cognitive impairments in schizophrenia (RIGHT). 

Anticevic, A., Dowd, E.C., & Barch, D.M. (2013). Cognitive and motivational neuroscience of psychotic disorders. In “Neurobiology of Mental Illness, 4th Edition”. Eds. Dennis Charney, Eric Nestler, Pamela Sklar, & Joseph Buxbaum. Oxford University Press. [Link

Anticevic, A., Krystal, J.H., & Barch, D.M. (2013). Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches towards understanding cognitive deficits. In “Cognitive impairment in schizophrenia: characteristics, assessment, and treatment”. Ed. Phil Harvey. Cambridge University Press. [Link]

Dr. Anticevic presents lab research at Vanderbilt Brain Institute

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Towards mechanistic understanding of neural system dysfunction in schizophrenia via connectivity, pharmacology and computation.

Read more about the Vanderbilt Brain Institute here.

Multi-task connectivity reveals flexible hubs for adaptive task control

A study by Michael Cole and colleagues, in collaboration with Anticevic Lab, tested a novel hypothesis for how humans are able to implement highly adaptive behavior, such as rapidly learning new tasks from instructions. This hypothesis suggests select regions of the brain are 'flexible hubs' that coordinate brain networks to perform new tasks (e.g., orchestrating visual and motor information in a novel visuo-motor task). Read more details about the study here. Read the WashU press release here

Citation:  Cole, M.W., Reynolds, J.R., Power, J.D., Repovs, G., Anticevic, A., Braver, T.S. (2013). Multi-task connectivity reveals flexible hubs for adaptive task control. Nature Neuroscience. doi: 10.1038/nn.3470. [Link]

Anticevic and colleagues characterize thalamo-cortical dysconnectivity in schizophrenia and bipolar illness

alt textThe image represents findings from Anticevic et al. (Cerebral Cortex) where authors characterized alterations in thalamo-cortical connectivity in one of the largest samples of schizophrenia patients in the literature. The authors discovered and then replicated robust alterations in thalamo-cortical systems whereby schizophrenia was associated with increased connectivity between the thalamus and all sensory-motor cortices. In contrast, schizophrenia was associated with reduced connectivity between the thalamus and higher-order cortical regions, the basal ganglia and the cerebellum. These effects represent one of the most robust markers of large-scale neural system alterations observed in schizophrenia.

Yale Researchers Shed Light on Large-scale Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness

Anticevic Lab along with a team of Yale researchers has used state-of-the-art non-invasive functional neuroimaging in one of the largest samples of patients diagnosed with schizophrenia and bipolar illness to better understand how large-scale neural communication may be altered in these severe and disabling psychiatric conditions. The results are reported online ahead of print in Cerebral Cortex. The Yale University press release can be found here.

Anticevic Lab receives the NIH 2012 NIH Director’s Early Independence Award

PROJECT: Characterizing Cognitive Impairment in Schizophrenia via Computational Modeling and Pharmacological Neuroimaging

Anticevic Lab is awarded a 5-year grant to better characterize the neural mechanisms behind cognitive impairment in schizophrenia via the combination of pharmacological neuroimaging, computational modeling and non-invasive neuroimaging of clinical populations. The pharmacological work is done collaboratively with Dr. John H. Krystal and Dr. Peter T. Morgan. Computational modeling is being developed collaboratively with Dr. Xiao-Jing Wang and John D. MurrayRead the Yale Press ReleaseRead the NIH Press ReleaseSee the full list of 2012 EIA RecipientsLearn more about the NIH Director’s Early Independence Award (DP5)Read the WashU Press Release.

Connectivity Study Focused on Prefrontal Cortex to Appear on Biological Psychiatry Cover

Anticevic and colleagues characterize global prefrontal and frontal-limbic connectivity using resting-state functional magnetic resonance imaging in bipolar disorder with and without psychosis history. The authors found evidence for medial prefrontal connectivity abnormalities with the rest of prefrontal cortex and the amygdala. Moreover, observed dysconnectivity predicted positive psychotic symptoms. These findings, using convergent resting-state techniques, implicate medial prefrontal cortex - a core emotion regulation region - in the pathophysiology of bipolar illness.

Citation: Anticevic, A., Brumbaugh, M.S., Winkler, A.M., Lombardo, L.E., Barrett, J., Corlett, P.R., Kober, H., Gruber, J., Repovs, G., Cole, M.W., Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2013). Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biological Psychiatry. 73(6):565-73. [Link]

ICANA-3 Conference held at Yale University

alt textTHE 3rd INTERNATIONAL CONFERENCE ON APPLICATIONS OF NEUROIMAGING TO ALCOHOLISM (ICANA-3)  was held on the Medical Campus of Yale University in New Haven, CT, USA, on February 15-18, 2013. ICANA is supported by the NIAAA Center for the Translational Neuroscience of Alcoholism (CTNA) and a donation from Siemens. Cutting edge functional and molecular neuroimaging and clinical correlates were highlighted. Sessions combined focus on neuroimaging methodology and clinical applications.

Yale and CTNA host 3rd International Conference on Applications of Neuroimaging to Alcoholism (ICANA-3)

Dr. Alan Anticevic co-organized ICANA-3 with Dr. John Krystal, which brought together neuroimagers with diverse technical and clinical expertise to consider methodological applications to alcoholism. A distinctive feature of the design of this meeting is its focus on multi-modality imaging (sMRI, DTI, fMRI, MRS, PET, SPECT), promoting interdisciplinary crosstalk with clinical applications. As with past conferences, ICANA-3 highlights “hot” issues in the field for special focus and emerging technologies within each neuroimaging modality. Plenary lectures were given by Dr. David Van Essen, Dr. Nora Volkow and Dr. Alan Koretsky. Complete conference program can be found here.

Dr. Anticevic met with NIH Director - Dr. Francis Collins

alt textDr. Anticevic is officially awarded the 5 year $1.25M grant to support research focused on characterizing cognitive deficits in schizophrenia.
2nd Annual NIH Director’s Early Independence Award (DP5) Symposium

Dr. Anticevic is officially awarded the 5 year $1.25M grant to support research focused on characterizing cognitive deficits in schizophrenia. For more details and pictures from the 2012 EIA Symposium go here.

Dr. Anticevic wins the 2013 International Congress on Schizophrenia Research Young Investigator Award


The INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCH is a biennial meeting where scientists representing the broad range of disciplines involved with discovery in schizophrenia gather to exchange data, techniques, and ideas. Anticevic Lab will present a talk titled:"Elucidating Mechanisms of Cognitive Impairment in Schizophrenia via Pharmacological Neuroimaging and Computational Modeling"

Anticevic Lab interviewed by Pittsburgh Post-Gazette

Mysteries of the Mind: Researchers take aim at schizophrenia's thinking problems

Some research suggests that people with [schizophrenia] have a particular network in their brains that is too noisy. Alan Anticevic, a research scientist at Yale University, said that the better people can suppress their default network, the more they can focus on a demanding task. While even some people without mental illness have trouble accomplishing this switch, those with schizophrenia seem to have a particularly difficult time, he said. Read more

Relevant publication:
Anticevic, A., Cole, M.W., Murray, J. D., Corlett, P.R., Wang, X-J., & Krystal, J.H. (2012). The role of default network deactivation in cognition and disease. Trends in Cognitive Sciences. 16(12):584-92.

Dozen young Yale scientists honored for promising mental health research

Anticevic Lab awarded the NARSAD 2012 YI Award

Twelve Yale investigators were among 202 researchers to receive Young Investigator Grants from the Brain & Behavior Research Foundation (formerly NARSAD). The $11.9 million program helps support researchers with promising ideas about how to understand and treat mental illness. Receiving up to $60,000 over two years, the investigators pursue brain and behavior research related to depression, bipolar disorder, schizophrenia, autism, attention-deficit hyperactivity disorder, and anxiety disorders like obsessive-compulsive and post-traumatic stress disorders. “The NARSAD Young Investigator Grants have led to groundbreaking and important new research that has improved the lives of people living with mental illness through enhanced treatments and therapies and a better understanding of the causes of mental illness,” said Benita Shobe, president and CEO of the Brain & Behavior Research Foundation. NARSAD Young Investigator Grants have proven to be catalysts for additional funding once the Young Investigators have “proof of concept” for their hypotheses. Read more