Multiple Sclerosis (MS) is a common inflammatory disease of the central nervous system. MS has a prominent neurodegenerative component that is most visible in the progressive phase of the disease. The causes of neurodegeneration in MS are poorly understood and are currently not treatable. Our research goal is to better understand the molecular and cellular mechanisms of MS-related neurodegeneration and to translate these insights into therapeutic options.
We are currently studying the impact of genetic MS risk variants that were identified in genome wide association studies, on innate CNS inflammation and neurodegeneration using induced pluripotent stem cell-derived astrocytes, neurons and microglia.
In addition, we are exploring the impact of chronic activation of microglia on tissue injury. For this we are studying autoptic MS tissue and iPSC-derived microglial and perform MS patient imaging with a novel MRI method that detects chronically activated microglia.
My laboratory currently focuses on 2 main areas: