Mass Spectrometers

Mass Spectrometers
Manufacturer
Use
9.4 T APEXQe FT-ICR & Ultimate Bruker Daltonics LC Packings Exact mass for small molecule (i.e. organic compounds, lipids, oligosaccharides, peptides, glycans, drugs, etc.), PTM (i.e. Cys modification, palmitoylation, methylation, ubiquitinylation, SUMOylation, etc.), structural elucidation and relative quantitation for small molecule
LTQ-Orbitrap XL & nanoACQUITY Thermo Scientific Waters Corp. Phosphorylation site determination and other PTM id entification, SILAC analysis, MudPIT and LC-MS/MS Protein Identification
4800 MALDI Tof/Tof Applied Biosystems MALDI-Tof/Tof protein Identification of DIGE spots, peptide mass fingerprint mapping, sequencing of beta peptides, intact protein masses etc.
4000 Q-Trap & nanoACQUITY Applied Biosystems Waters Corp. Targeted Proteomics using multiple reaction monitoring; small molecule quantitation
Q-Star ELITE & nanoACQUITY Applied Biosystems Waters Corp. iTRAQ and ICAT Protein Profiling, MudPIT
Q-Star XL & PE Series 275 HRes LC System Applied Biosystems Perkin Elmer iTRAQ and ICAT Protein Profiling, MudPIT
Q-Tof Micro & capLC Waters Corp. ESI, LC-MS of intact proteins, oligonucleotides and small molecules
Q-Tof Ultima & nanoACQUITY Waters Corp. LC-MS/MS Protein Identification and de novo MS/MS
Q-Star XL (ion mobility)1 Applied Biosystems Small molecules and peptide analysis

1Equipped with a Waters nanoACQUITY UPLC system
2This mass spectrometer belongs to Dr. Juan Fernandez de la Mora, from Yale Mechanical Engineering Department, and services/collaborations are offered to the research community. Please contact juan.delamora@yale.edu or erol.gulcicek@yale.edu for information.