Large Scale Peptide Synthesis

Synthetic peptides can be made routinely up to 40 residues and often, depending on sequence, up to 70 residues. All peptides that can be purified are chromatographed on a preparative C-18 or C-4 RP-HPLC system and delivered as a lyophilized material. Yields for normal peptides under 40 residues are "guaranteed" at 50 mg or more and at 90+% purity. Yields and purity are often higher, varying with the peptide sequence and length. For peptides over 40 residues or for peptides with unusual sequences, the "guaranteed" yields and purity will be considered on an individual basis.

All peptides made in the facility at the 0.5 mmole scale are done by tBOC chemistry. For the incorporation of unusual amino acids, such as non-radioactive isotopes, the appropriate tBOC and side-chain protected material must be supplied by the submitter at a level of 2 mmoles/residue.

The turn-around time is 3-4 weeks/peptide/laboratory (P.I.), on the average. The purified pepties are characterized by analytical RP-HPLC and mass spectroscopy.