Yasuko Iwakiri PhD

Associate Professor of Medicine (Digestive Diseases)

Research Interests

Portal hypertension; Nitric oxide; S-nitrosylation; CD147 (EMMPRIN, Basigin); Reticulon 4B (Nogo-B); Liver fibrosis; Liver regeneration; Vascular biology

Current Projects

  1. Arterial remodeling in chronic liver diseases.
  2. Role of S-nitrosylation of the Golgi proteins in the function of endothelial cells.
  3. The mechanisms of the development of the hyperdynamic circulatory syndrome in patients with liver diseases.
  4. Role of Nogo-B in liver fibrosis and regeneration.
  5. Role of EMMPRIN (extracellular matrix metalloprotease inducer) in the pathogenesis of liver diseases.

Research Summary

  1. Portal hypertension in liver diseases
  2. Liver fibrosis and regeneration
  3. Nitric oxide signaling

Extensive Research Description

    Selected Publications

    • Iwakiri, Y. Pathophysiology of portal hypertension. Clinics Digestive Diseases. 2014 (in press).
    • Jozsef, L., Tashiro, K., Kuo, A., Park, E., Skoura, A., Albinsson, S., Rivera-Molina, F., Harrison, K.D., Iwakiri, Y., Toomre, D., and Sessa, W.C. Reticluon 4 is necessary for ER tubulation, STIM1-Orai1 coupling and store-operated calcium entry.J Biol Chem. 2014; 289(13):9380-95.
    • Gattu, A.K., Birkenfeld, A.L., Protiva, P., Church, C., Jay, S., Saltzman, M., Doll, J., Cornwell, M., Crawford, S.E., Iwakiri, Y., Samuel, V.T., and Chung, C. Pigment Epithelium-Derived Factor (PEDF) Blunts IL-1ß-Mediated Inflammation in Hepatocytes to Maintain Metabolic Homeostasis. Endocrinology.2014; 155(4):1373-85.
    • DiLorenzo, A., Lin, M., Murata, T., Landskroner-Eiger, S., Schleicher, M., Kothiya, M., Iwakiri, Y., Yu, J., Huang, P., and Sessa, W. eNOS derived nitric oxide regulates endothelial barrier function via VE cadherin and Rho GTPases. Journal of Cell Science. 2014;127(Pt 9):2120
    • Gattu, A., Iwakiri, Y., Chung, C. et al. Determination of Mesenchymal Stem Cell Fate by Pigment Epithelium-Derived Factor (PEDF) Results in Increased Adiposity & Reduced Bone Mineral Content. FASEB J. 2013;27(11):4384-94.
    • Chung, C. and Iwakiri, Y. The lymphatic vascular system in liver diseases: its role in ascites formation. Clinical and Molecular Hepatology. 2013;19:82-86.
    • Bryniarski, K., Ptak, W., Jayakumar, A., Tuschl, T., Hafner, M., Püllmann, K., Caplan, M., Chairoungdua, A., Lu, J., Adams, B., Sikora, E., Nazimek, K., Marques, S., Kleinstein, S.H., Sangwung, P., Iwakiri, Y., Delgato, E., Redegeld, F., Wojcikowski, J., Daniel, A.W., Kormelink, T.G., and Askenase, P.W. Antibody light chain coated antigen specific exosomes deliver suppressor T cell-derived miRNA-150 to inhibit effector T cells. J Allergy Clinical Immunology. 2013;132(1):170-181.
    • Gao, L., Utsumi, U., Tashiro, K., Liu. B., Zhang, D., Swenson, E.S., and Iwakiri, Y. Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration. Hepatology 2013; 57(5):1992-2003.
    • Tashiro, K., Satoh, A., Utsumi, T., Chung, C., and Iwakiri, Y. Absence of Nogo-B (Reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. Am J Pathology 2013; 182(3):786-95.
    • Chung, C. and Iwakiri, Y. Activated hepatic stellate cells: Negative regulators of hepatocyte proliferation in liver diseases. Hepatology. 2012;51(1):389-391.


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