Jie Yao PhD
Assistant Professor of Cell Biology
Transcription regulation; chromatin; nuclear periphery; nuclear compartmentalization; protein dynamics; cellular biophysics and imaging
Gene expression is exquisitely regulated during cellular growth and differentiation. Importantly, how the nuclear structure and dynamics encode additional regulatory information is not well understood. Single cell analysis such as advanced cell imaging has the potential to bridge the significant gap between biochemistry and genetics and to enable the analysis of gene regulation within its native nuclear environment. Our laboratory combines cellular imaging and molecular methods to characterize nuclear structure and dynamics, and to explore its functional implications.
Extensive Research Description