Jie Yao, PhD

Assistant Professor of Cell Biology

Research Interests

Biochemistry; Biophysics; Cell Nucleus; Chromatin; Cell Biology; Transcription Factors; Gene Expression

Research Organizations

Cell Biology

Stem Cell Center, Yale

Research Summary

Gene expression is exquisitely regulated during cellular growth and differentiation. Importantly, how the nuclear structure and dynamics encode additional regulatory information is not well understood. Single cell analysis such as advanced cell imaging has the potential to bridge the significant gap between biochemistry and genetics and to enable the analysis of gene regulation within its native nuclear environment. Our laboratory combines cellular imaging and molecular methods to characterize nuclear structure and dynamics, and to explore its functional implications.

Specialized Terms: Transcription regulation; Chromatin; Nuclear periphery; Nuclear compartmentalization; Protein dynamics; Cellular biophysics and imaging

Extensive Research Description

Selected Publications

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Contact Info

Jie Yao, PhD
Lab Location
Sterling Hall of Medicine, C-Wing
333 Cedar Street, Ste C232

New Haven, CT 06510
Office Location
Sterling Hall of Medicine, C-Wing
333 Cedar Street, Ste C230A

New Haven, CT 06510
Mailing Address
Department of Cell BiologyPO Box 208002
333 Cedar Street

New Haven, CT 06520-8002

Yao Lab