Xian-Yong Ma PhD

Associate Research Scientist in Pathology

Research Interests

How do the key target proteins determine the status of cell differentiation and proliferation? How do the modifications of gene structure (DNA and core histone) cause global changes of gene expression pattern? My research employed multitude of molecular, cellular, physiological and bioinformatics techniques to investigate the molecular mechnisms and physiological function of interferon induced P202a, acute megakaryoblastic leukemia associated transcription factorRBM15, and Polycomb Repressive Group proteins SUZ12. The ongoing research topics including global interferes for binding pattern caused by fusion of polycomb protein JJAZ1 to transcription repressor JAZF1 and genome-wide exploration of cis regulatory regions bond with transcription factor JAZF1 using CHIP-sequencing analysis.


Selected Publications

  • Ma, X.Y., Wang L., Jie Tang, et al (2012). “SPOC Domain of Mint Protein Induces Hematopoietic Differentiation Via BMP4/Smad5 pathway.” American Journal of Molecular Biology. 2(4) 304-317
  • Ma, X.Y., Renda M.J. Wang L. et al. (2007).Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myelopid Differentiation. Mol. Cell. Biol. 27,3056-3064
  • Ma, X.Y., Wang, H., Ding B. et al. (2003).The interferon-inducible p202a protein modulates NF-kappa B activity by inhibiting the binding to DNA of p50/p65 heterodimers,while enhancing the binding of p50 homodimers J. Biol. Chem. 278, 23008-23019.
  • Ma, X.Y., Husain T., Peng Hui., et al.(2002).Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library. Blood. 100, 833-844.
  • Ma, X.Y., Yao, K.T. (1998).Cloning of the Epstein Barr Virus Gene BNLF-1 and Its Expression in PA317 cells. Acta Biochimica et Biophysica Sinica 30: 81-85.
  • Ma, X.Y., Yao, S.D., Wang, W.F. et al.(1998).Study on Transient Products Induced by Pulse Radiolysis of Cytosine Aqueous Solution Saturated with N2O. Chinese Journal of Chemical Physics 11: 130-133.
  • Ma X.Y., Yao, S.D., Wang, W. F. et al. (1997).Study on Transient Products Induced by Pulse Radiolysis of Cytosine Aqueous Solutions. Acta Physico-Chimica Sinica. 13:833-837.
  • Ma, X.Y., Tang, J., Lin, N.Y. (1997). ESR of Spin Trapped Radicals by Hydryl Radical Separated with Sep-pakC18 in Aqueous Solution of Cytosine. Acta Biophysica Sinica 13,833-837.
  • Li, H., Ma, X.Y., Wang, J.L., et al (2007). Rearrangements and Alleleic Expression of the JJAZ1/Suz12 Gene: Effects on Cell Proliferation, Apoptosis, and Tumor Progression in Endometrial Stromal Tumors. Proc. Natl. Acad. Sci. USA 104, 20001-20006.

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