Anticoagulants; Child; Critical Care; Glucose; Hyperglycemia; Hypoglycemia; Pediatrics; Thromboembolism; Clinical Trial; Venous Thrombosis
Dr. Faustino studies treatment strategies that could improve the outcomes of critically ill children. He is currently focusing on the prevention of blood clots in these children. His also working on blood glucose control in this population. He conducts observational and interventional studies.
Specialized Terms: venous thrombosis; thromboembolism; anticoagulation; hyperglycemia; hypoglycemia; glucose control; clinical trial; biomarker; critical care; child
Extensive Research Description
Dr. Faustino is a patient-oriented researcher who focuses on improving the outcomes of critically ill children. He is currently working on the prevention of deep venous thrombosis and its complications in critically ill children. His goals are (1) to conduct multicenter randomized clinical trials because these are the studies that can provide the greatest impact on the prevention of thrombosis, and (2) to discover and validate biomarkers that may allow the development of a risk-stratified approach to the prevention of thrombosis. He is also studying the effects of controlling blood glucose in critically ill children.
Dr. Faustino initially studied the impact of glucose dysregulation in critically ill children. He conducted observational studies that described the morbidity and mortality associated with hyperglycemia and hypoglycemia in critically ill children. He is currently a co-investigator on a multicenter trial on the effects of blood glucose control in critically ill children.
Dr. Faustino is currently focusing his research on catheter-related thrombosis because the use of central venous catheters is the most common cause of thrombosis in children. He has conducted studies on the epidemiology of catheter-related thrombosis in critically ill children, completed surveys on thromboprophylaxis in pediatric intensive care units, and established collaborations with other researchers invested in the prevention of thrombosis. He is preparing to conduct randomized clinical trials that will test interventions to prevent catheter-related thrombosis in critically ill children.
Recently, Dr. Faustino has become interested in biomarkers because they may identify children at high risk of thrombosis. It is difficult to identify children who would develop DVT based on clinical characteristics alone. He has studied the use of blood glucose, clot strength and factor VIII to predict thrombosis in critically ill children. He is currently validating additional biomarkers that may identify children at high risk of thrombosis.
1. Deep venous thrombosis in critically ill adolescents. The goal of this study is to describe the epidemiology of deep venous thrombosis in critically ill adolescents. We will also determine whether markers of coagulation and inflammation can identify critically ill adolescents who will develop thrombosis.
2. Bleeding in critically ill children. The goals of this study are (1) to determine the reliability of a novel bleeding assessment tool, and (2) to determine the epidemiology of bleeding in critically ill children. We will determine the incidence of, identify factors associated with bleeding, and describe the complications of bleeding.
3. Heart and Lung Failure-Pediatric Insulin Titration (HALF-PINT) trial. The goal of this study is to determine the comparative effectiveness of 2 blood glucose ranges on hospital mortality and length of stay in the intensive care unit in hyperglycemic critically ill children with cardiovascular and/or respiratory failure.
4.Coagulation and Fibrinolysis in Pediatric Insulin Titration (CAF-PINT) Trial. The goal of this study is to understand potential mechanisms through which normalizing blood glucose provides benefit in critically ill children.
- Neshat-Vahid S, Pierce R, Hersey D, Raffini LJ, Faustino EV. Association of thrombophilia and catheter-associated thrombosis in children: a systematic review and meta-analysis. J Thromb Haemost 14(9):1749-58, 2016.
- Marquez A, Shabanova V, Faustino EV; Northeast Pediatric Critical Care Research Consortium. Prediction of catheter-associated thrombosis in critically ill children. Pediatr Crit Care Med. 2016 Sep 22. [Epub ahead of print]
- Vidal E, Sharathkumar A, Glover J and Faustino EV. Central venous catheter-related thrombosis and thromboprophylaxis in children: A systematic review and meta-analysis. J Thromb Haemost 12:1096-1109, 2014.
- Faustino EV, Hanson S, Spinella PC, Tucci M, O’Brien SH, Nunez AR, Yung M, Truemper E, Qin L, Li S, Marohn K, Randolph G, on behalf of the PROphylaxis against ThRombosis prACTice (PROTRACT) Study Investigators of the PALISI BloodNet. A multi-national study of thromboprophylaxis practice in critically ill children. Crit Care Med 42:1232-40, 2014.
- Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L and Silva CT. (2013) Incidence and acute complications of asymptomatic central venous catheter-related deep venous thrombosis in critically ill children.
- Faustino EV, Patel S, Thiagarajan RR, Cook, DJ, Northrup V and Randolph AG. Survey of pharmacologic thromboprophylaxis in critically ill children. Crit Care Med 39: 1773-78, 2011.
- Faustino EV, Lawson KA, Northrup V and Higgerson RA. Mortality-adjusted duration of mechanical ventilation in critically ill children with symptomatic central venous line-related deep venous thrombosis. Crit Care Med 39: 1151-56, 2011.
- Faustino EV and Bogue CW. Relationship between hypoglycemia and mortality in critically ill children. Pediatr Crit Care Med 11:690-98, 2010.
- Faustino EV and Apkon M. Persistent hyperglycemia in critically ill children. J Pediatr 146:30-34, 2005.