Vikki M Abrahams, PhD

Associate Professor of Obstetrics, Gynecology, and Reproductive Sciences

Research Interests

Autoimmune Diseases; Fetal Membranes, Premature Rupture; Immunity, Innate; Placenta; Pregnancy Complications; Pregnancy Complications, Infectious; Pregnancy in Diabetics; Antiphospholipid Syndrome; Antibodies, Antiphospholipid; MicroRNAs; Toll-Like Receptors; Nod Signaling Adaptor Proteins; Exosomes; Immune System Processes; Inflammasomes

Research Organizations

Obstetrics, Gynecology & Reproductive Sciences: Maternal-Fetal Medicine | Perinatal Research | Reproductive Sciences: Abrahams Lab; Discovery to Cure Internship

HTI

SWIM

Office of Cooperative Research

Research Summary

Dr. Abrahams' lab studies Reproductive Immunology with a focus on the impact the immune system and immunological processes have on pregnancy outcome. Her research is concentrated on three areas:

(1) Innate immune responses to infection at the maternal-fetal interface: A primary focus of the lab is to investigate the function of innate immune pattern recognition receptors at the maternal-fetal interface in order to understand how gestational tissues respond to infection, and how these responses play a role in adverse pregnancy outcomes, such as preterm birth. Our studies have found that the placental trophoblast and the fetal membranes express Toll-like receptors (TLRs), Nod-like receptors (NLRs), and inflammasome components. We also study these immune systems in the context of non-infectious stimuli during pregnancy. Through these innate immune pathways, these tissues/cells elicit a wide range of effects; ranging from specific antiviral/microbial responses and inflammation to apoptosis.

(2) Mechanisms of antiphospholipid antibody-induced pregnancy complications. Another major area of interest to the lab is the impact antiphospholipid antibodies (aPL) have on a woman's chance of reproductive success. Women with antiphospholipid syndrome are at risk for recurrent pregnancy loss and preeclampsia. aPL are known to directly target the placenta. Studies in the lab characterize the mechanisms by which aPL alter trophoblast function. We use mechanistic findings to identify new predictors of adverse pregnancy outcomes in these pateints, We also use our in vitro studies to test the efficacy of various therapeutic agents on trophoblast resposnes to aPL in order to determine better ways to prevent obstetrical problems in these patients.

(3) The role of placental microparticles in the pathogenesis of preeclampsia. Normal pregnancy is associated with the presence of circulating placental microvesicles (MV) and exosomes and increased shedding and altered immune activation are seen in patients with preeclampsia, suggesting that placental MV and exosomes may play a role in the pathophysiology of this disease. Studies by the lab have found that placental-derived MV express high levels of the human endogenous retrovirus (HERV), syncytin-1, and have demonstrated a functional role for this protein through its interactions with immune cells.We have also identified microRNAs enriched in trophoblast-derived exosomes and are examining their biological function.

Selected Publications

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Contact Info

Vikki M Abrahams, PhD
Mailing Address
310 Cedar Street
New Haven, CT 06510

Abrahams's Lab