Udeme D Ekong, MBBS, MPH

Associate Professor of Pediatrics (Gastroenterology)

Research Interests

Gastroenterology; Hepatitis; Immune Tolerance; Liver Diseases; Pediatrics; Liver Transplantation

Research Organizations

Liver Center

Pediatrics: Pediatric Gastroenterology & Hepatology

Research Summary

Dr Ekong is interested in developing ways to predict children who can discontinue their anti-rejection medications (immunosuppression) following liver transplantation and prior to joining the faculty at Yale, she was the center Principal Investigator on a clinical study on Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients, conducted by the Immune Tolerance Network (ITN) and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).

Specialized Terms: Immune tolerance following pediatric liver transplantation; Immune dysregulation in autoimmune hepatitis; Immune mediated liver disease.

Extensive Research Description

Dr Ekong's research interest includes immune tolerance following liver transplantation and prior to joining the faculty at Yale, was the center Principal Investigator on a clinical study on Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients, conducted by the Immune Tolerance Network (ITN) and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). She is also interested in the role regulatory T cell dysfunction in the immune pathogenesis of de novo autoimmune hepatitis and autoimmune hepatitis.

  1. The role of sodium chloride and the Treg/Th17 axis in Autoimmune Hepatitis

This project is investigating if a salt restriction protocol will improve immune parameters in patients with autoimmune hepatitis in vivo?

  1. De NovoAutoimmune Hepatitis in Pediatric Liver Transplantation

This project is investigating if excess dietary salt functions as an environmental trigger for the development of autoimmunity.

  1. Studies of Pediatric Liver Transplantation (SPLIT)

The mission of the Studies of Pediatric Liver Transplantation is to improve the outcome, and provide educational and advocacy resources for children who require, or have received, liver transplantation in the United States and Canada.

Selected Publications

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Contact Info

Udeme D Ekong, MBBS, MPH
Patient Care Location
Yale Pediatric SpecialtyYale Physicians Building
800 Howard Avenue, Ste 4th floor

New Haven, CT 06519
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Mailing Address
Yale Pediatric GI/HepatologyPO Box 208064
New Haven, CT 06820-8064

Curriculum Vitae

Ekong Lab

Research Image 1

Hematoxylin and Eosin stains of liver biopsies with de novo autoimmune hepatitis. Portal tracts containing inflammation, which is predominantly lymphocytic, and foci of interface hepatitis (IH). Bile ducts (BD) show no significant infiltration of the epithelium by inflammatory cells or other injury. Portal vein branches show no significant endothelialitis or other injury. Original magnification of all images = 100X.