Topher Carroll, PhD

Assistant Professor of Cell Biology

Departments & Organizations

Cell Biology: Carroll Lab

Office of Student Research

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology: DNA Dynamics; Membrane Biology and Motion; Transcriptional Regulation | Molecular Cell Biology, Genetics and Development: Genetics and Genomics; Membrane Proteins; Nucleic Acids


The eukaryotic genome is highly organized within the nucleus. This organization occurs at several different spatial scales, ranging from local interactions between proximal nucleosomes to the global positioning of large chromosomal domains within specific nuclear compartments. The Carroll lab is interested in understanding the molecular mechanisms that that control nuclear organization, and further, how these mechanisms are integrated to ensure the integrity and proper expression of the genome. We take an interdisciplinary approach using biochemistry, cell biology, genomics, and proteomics to address these questions.

I first became interested in chromosome structure and dynamics as a graduate student in Dr. David Morgan's lab at UCSF where I studied the molecular mechanisms that control chromosome segregation during mitosis. I then moved to Stanford University School of Medicine to do a postdoc for Dr. Aaron Straight. As a postdoc, I developed biochemical and cell biological methods to dissect how the specialized chromatin environment of the centromere directs kinetochore assembly during mitosis. It was during this time that I became interested in understanding how specific regions of chromosomes are specialized for particular functions, and in particular, how the spatial organization of the genome influences these decisions.

Education & Training

PhD University of California-San Francisco (2005)
BS University of California at Santa Cruz (1997)
Postdoctoral Fellow Stanford School of Medicine

Honors & Recognition

  • Postdoctoral FellowshipAmerican Heart Association (2009)

  • Postdoctoral FellowshipHelen Hay Whitney Foundation (2006)

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Contact Info

Topher Carroll, PhD
Mailing Address
SHM C223333 Cedar St.
New Haven, CT 06510

Carroll Lab